full name
prostaglandin I2 synthase

synonyms
CYP8, CYP8A1, PGIS, PTGI, PTGIS, ENSG00000124212

HGNC
HGNC:9603

Entrez Gene
Gene:5740

ENSEMBL
ENSG00000124212

location
chr: 20
start: 48120411
stop: 48184707
strand: -

OMIM
OMIM:601699: PTGIS (Multifactorial inheritance)
OMIM:145500: Hypertension, essential

transcripts
NM_000961.3

pathways
Arachidonic acid metabolism [NCBI:82991] [KEGG:hsa00590] [NCBI:1270087] [REACTOME:R-HSA-2142753] [PUBMED:14622984] [PUBMED:15292194] [PUBMED:10908295] [PUBMED:15205388] [PUBMED:9812980] [PUBMED:14660610] [PUBMED:11328810] [PUBMED:14636671] [PUBMED:14626496] [PUBMED:11679404] [PUBMED:19244215]
Bile acid and bile salt metabolism [NCBI:1270040] [REACTOME:R-HSA-194068] [PUBMED:12543708] [PUBMED:12663868] [PUBMED:14699511] [PUBMED:11969205]
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
Cytochrome P450 - arranged by substrate type [NCBI:1270191] [REACTOME:R-HSA-211897] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:12369887]
Eicosanoids [NCBI:1270198] [REACTOME:R-HSA-211979] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:7922394]
Endogenous sterols [NCBI:1270192] [REACTOME:R-HSA-211976] [PUBMED:16872679] [PUBMED:15102545] [PUBMED:16584116]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of vitamins and cofactors [NCBI:1270144] [REACTOME:R-HSA-196854]
Metabolism of water-soluble vitamins and cofactors [NCBI:1270145] [REACTOME:R-HSA-196849]
Nicotinamide salvaging [NCBI:1270155] [REACTOME:R-HSA-197264] [PUBMED:14704851] [PUBMED:24717514]
Nicotinate metabolism [NCBI:1270154] [REACTOME:R-HSA-196807] [PUBMED:14704851]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
Sterols are 12-hydroxylated by CYP8B1 [NCBI:1270193] [REACTOME:R-HSA-211994] [PUBMED:10051404]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [NCBI:1270088] [REACTOME:R-HSA-2162123] [PUBMED:20655950] [PUBMED:19244215]
Synthesis of bile acids and bile salts [NCBI:1270041] [REACTOME:R-HSA-192105] [PUBMED:12543708] [PUBMED:11969205]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol [NCBI:1270043] [REACTOME:R-HSA-193775] [PUBMED:9717719] [PUBMED:11969205] [PUBMED:12543708]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol [NCBI:1270044] [REACTOME:R-HSA-193807] [PUBMED:10428977] [PUBMED:12543708] [PUBMED:11969205] [PUBMED:8078928]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [NCBI:1270042] [REACTOME:R-HSA-193368] [PUBMED:12543708]