full name
protein tyrosine kinase 6

synonyms
BRK, PTK6, ENSG00000101213

HGNC
HGNC:9617

Entrez Gene
Gene:5753

ENSEMBL
ENSG00000101213

location
chr: 20
start: 62159766
stop: 62168723
strand: -

transcripts
NM_001256358.1
NM_005975.3

pathways
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cyclin A:Cdk2-associated events at S phase entry [NCBI:1269778] [REACTOME:R-HSA-69656] [PUBMED:7629134] [PUBMED:11231585] [PUBMED:1396589] [PUBMED:15014502] [PUBMED:10454565] [PUBMED:11907280]
Cyclin E associated events during G1/S transition [NCBI:1269769] [REACTOME:R-HSA-69202]
ERBB2 Activates PTK6 Signaling [NCBI:1383024] [REACTOME:R-HSA-8847993] [PUBMED:20687930] [PUBMED:1349015] [PUBMED:26247733] [PUBMED:18719096] [PUBMED:8940083] [PUBMED:21847121]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
PTK6 Activates STAT3 [NCBI:1383027] [REACTOME:R-HSA-8849474] [PUBMED:19393627] [PUBMED:16568091] [PUBMED:20929863] [PUBMED:21205088]
PTK6 Down-Regulation [NCBI:1383033] [REACTOME:R-HSA-8849472] [PUBMED:23814047] [PUBMED:25897081]
PTK6 Expression [NCBI:1383026] [REACTOME:R-HSA-8849473] [PUBMED:23928995] [PUBMED:25019382]
PTK6 Regulates Cell Cycle [NCBI:1383028] [REACTOME:R-HSA-8849470] [PUBMED:25733683] [PUBMED:20162673]
PTK6 Regulates Proteins Involved in RNA Processing [NCBI:1383030] [REACTOME:R-HSA-8849468] [PUBMED:16179349] [PUBMED:15471878] [PUBMED:10913193] [PUBMED:19439179]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases [NCBI:1383029] [REACTOME:R-HSA-8849471] [PUBMED:18829532] [PUBMED:17483331] [PUBMED:22084245] [PUBMED:15572663]
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 [NCBI:1383031] [REACTOME:R-HSA-8849469] [PUBMED:20606012] [PUBMED:22231447] [PUBMED:11114724] [PUBMED:15539407] [PUBMED:24523872] [PUBMED:20554524] [PUBMED:23814047] [PUBMED:23352614]
PTK6 promotes HIF1A stabilization [NCBI:1383032] [REACTOME:R-HSA-8857538] [PUBMED:26751287]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
SCF(Skp2)-mediated degradation of p27/p21 [NCBI:1269770] [REACTOME:R-HSA-187577] [PUBMED:7624798] [PUBMED:14532004] [PUBMED:12730199]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by ERBB2 [NCBI:1269489] [REACTOME:R-HSA-1227986]
Signaling by PTK6 [NCBI:1383025] [REACTOME:R-HSA-8848021] [PUBMED:15539407] [PUBMED:15572663] [PUBMED:25999240] [PUBMED:20929863] [PUBMED:23352614] [PUBMED:20554524] [PUBMED:23814047] [PUBMED:21205088] [PUBMED:18172307] [PUBMED:25897081] [PUBMED:18829532] [PUBMED:24788754] [PUBMED:25019382] [PUBMED:8940083] [PUBMED:19393627] [PUBMED:18719096] [PUBMED:22547065] [PUBMED:21847121] [PUBMED:19439179] [PUBMED:22231447] [PUBMED:25733683] [PUBMED:20606012] [PUBMED:18077133] [PUBMED:15471878] [PUBMED:20687930] [PUBMED:23928995] [PUBMED:16179349] [PUBMED:26247733] [PUBMED:11114724] [PUBMED:17483331] [PUBMED:22084245] [PUBMED:10913193]