full name
phosphatidylinositol 4-kinase alpha

synonyms
PI4K-ALPHA, pi4K230, PIK4CA, PI4KA, ENSG00000241973

HGNC
HGNC:8983

Entrez Gene
Gene:5297

ENSEMBL
ENSG00000241973

location
chr: 22
start: 21061979
stop: 21213100
strand: -

OMIM
OMIM:600286: PI4KA
OMIM:616531: Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis

transcripts
NM_058004.3
NM_002650.2

pathways
3-phosphoinositide biosynthesis [NCBI:545314] [BIOCYC:HUMAN_PWY-6352] [PUBMED:9632630] [PUBMED:7798235] [PUBMED:2553693] [PUBMED:8086005] [PUBMED:9247130]
D-myo-inositol (1,4,5)-trisphosphate biosynthesis [NCBI:545326] [BIOCYC:HUMAN_PWY-6351] [PUBMED:6232463] [PUBMED:18341203] [PUBMED:438153] [PUBMED:6146314] [PUBMED:6605482] [PUBMED:164246] [PUBMED:9367159] [PUBMED:12897244] [PUBMED:12117804] [PUBMED:17895620] [PUBMED:11395409]
Inositol phosphate metabolism [NCBI:82987] [KEGG:hsa00562] [NCBI:1269988] [REACTOME:R-HSA-1483249] [PUBMED:17943301] [PUBMED:18310071] [PUBMED:20414202] [PUBMED:11331907] [PUBMED:20359876] [PUBMED:14993306] [PUBMED:16781889]
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [NCBI:413400] [KEGG:hsa_M00130]
Integrins in angiogenesis [NCBI:137999] [Pathway Interaction Database:avb3_integrin_pathway] [PUBMED:10837460] [PUBMED:9182576] [PUBMED:12642872] [PUBMED:15711558] [PUBMED:10037797] [PUBMED:10196194] [PUBMED:11877390] [PUBMED:16418218] [PUBMED:16600665] [PUBMED:16982628] [PUBMED:15479743] [PUBMED:16720645] [PUBMED:11684710] [PUBMED:10821695] [PUBMED:12237112] [PUBMED:12750158] [PUBMED:11551924] [PUBMED:8794870] [PUBMED:10022831] [PUBMED:15187087] [PUBMED:16195423] [PUBMED:16760434] [PUBMED:12682293] [PUBMED:9420328] [PUBMED:15247219] [PUBMED:9490736] [PUBMED:11313365]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
PI Metabolism [NCBI:1270073] [REACTOME:R-HSA-1483255] [PUBMED:17035995] [PUBMED:18216768] [PUBMED:17330069] [PUBMED:15170460] [PUBMED:16828287] [PUBMED:18726176] [PUBMED:20861159] [PUBMED:19196647] [PUBMED:20043944] [PUBMED:20192774] [PUBMED:18784754] [PUBMED:20559318] [PUBMED:18216767] [PUBMED:17605038] [PUBMED:15269334]
Phosphatidylinositol signaling system [NCBI:83052] [KEGG:hsa04070] [PUBMED:19439500] [PUBMED:19580826]
Phospholipid metabolism [NCBI:1270053] [REACTOME:R-HSA-1483257] [PUBMED:9242906]
Synthesis of PIPs at the ER membrane [NCBI:1270074] [REACTOME:R-HSA-1483248] [PUBMED:9148941] [PUBMED:14527956] [PUBMED:10101268] [PUBMED:12324459]
Synthesis of PIPs at the Golgi membrane [NCBI:1270075] [REACTOME:R-HSA-1660514] [PUBMED:11279162] [PUBMED:17556371] [PUBMED:10766823] [PUBMED:10559940] [PUBMED:10805725] [PUBMED:14527956] [PUBMED:18950639]
superpathway of inositol phosphate compounds [NCBI:547492] [BIOCYC:HUMAN_PWY-6371]