full name
checkpoint kinase 2
synonyms
CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53, CHEK2, ENSG00000183765
HGNC
HGNC:16627
Entrez Gene
Gene:11200
ENSEMBL
ENSG00000183765
location
chr: 22
start: 29083731
stop: 29137822
strand: -
OMIM
OMIM:604373:
CHEK2
(Autosomal dominant inheritance)
OMIM:609265:
Li-Fraumeni syndrome
OMIM:259500:
Osteosarcoma, somatic
OMIM:114480:
{Breast cancer, susceptibility to}
OMIM:176807:
{Prostate cancer, familial, susceptibility to}
transcripts
NM_145862.2
NM_007194.3
NM_001257387.1
NM_001005735.1
pathways
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell cycle
[NCBI:83054]
[KEGG:hsa04110]
[PUBMED:7973727]
[PUBMED:17568790]
[PUBMED:9832503]
[PUBMED:16936746]
[PUBMED:9029154]
[PUBMED:12573239]
[PUBMED:19020303]
[PUBMED:9618481]
[PUBMED:12809600]
[PUBMED:8242749]
[PUBMED:10385618]
[PUBMED:17426725]
[PUBMED:17018296]
[PUBMED:16212951]
[PUBMED:12925736]
[PUBMED:11099028]
[PUBMED:15568976]
[PUBMED:15838516]
[PUBMED:15838523]
[PUBMED:15876871]
[PUBMED:7908906]
[PUBMED:9889196]
DNA Double Strand Break Response
[NCBI:1309096]
[REACTOME:R-HSA-5693606]
[PUBMED:20965415]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
FOXM1 transcription factor network
[NCBI:137935]
[Pathway Interaction Database:foxm1pathway]
[PUBMED:17141659]
[PUBMED:12482952]
[PUBMED:16913845]
[PUBMED:16809346]
[PUBMED:15671063]
[PUBMED:16504183]
[PUBMED:15082532]
[PUBMED:15531365]
[PUBMED:17366632]
[PUBMED:16314512]
[PUBMED:17173139]
[PUBMED:16618419]
[PUBMED:15024056]
[PUBMED:11682060]
[PUBMED:15654331]
[PUBMED:15817462]
[PUBMED:17404569]
[PUBMED:16875671]
[PUBMED:16965535]
[PUBMED:17101782]
G1/S DNA Damage Checkpoints
[NCBI:1269743]
[REACTOME:R-HSA-69615]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint
[NCBI:1269754]
[REACTOME:R-HSA-69473]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
PLK3 signaling events
[NCBI:138042]
[Pathway Interaction Database:plk3_pathway]
[PUBMED:12242661]
[PUBMED:11551930]
[PUBMED:17264206]
[PUBMED:14968113]
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
[NCBI:1309098]
[REACTOME:R-HSA-5693565]
[PUBMED:18483401]
[PUBMED:21293379]
[PUBMED:10866324]
[PUBMED:9488723]
[PUBMED:18001825]
[PUBMED:18006705]
[PUBMED:11571274]
[PUBMED:12364621]
[PUBMED:22234877]
[PUBMED:10802669]
[PUBMED:17553757]
[PUBMED:10550055]
[PUBMED:23333306]
[PUBMED:20023648]
[PUBMED:18077395]
[PUBMED:19203578]
[PUBMED:22373579]
[PUBMED:19203579]
[PUBMED:19234442]
[PUBMED:16377563]
[PUBMED:15201865]
[PUBMED:19092802]
[PUBMED:17525340]
[PUBMED:22589545]
[PUBMED:11025670]
[PUBMED:16651405]
[PUBMED:19001859]
[PUBMED:18001824]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Methylation
[NCBI:1383082]
[REACTOME:R-HSA-6804760]
[PUBMED:18833288]
[PUBMED:17805299]
[PUBMED:15186775]
[PUBMED:11511361]
[PUBMED:16415881]
[PUBMED:22362889]
[PUBMED:20118233]
[PUBMED:15525938]
[PUBMED:21625555]
[PUBMED:15448695]
[PUBMED:20870725]
[PUBMED:10518217]
[PUBMED:17108971]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Regulation of TP53 Degradation
[NCBI:1383079]
[REACTOME:R-HSA-6804757]
[PUBMED:21730132]
[PUBMED:10570149]
[PUBMED:15563468]
[PUBMED:16845383]
[PUBMED:11923872]
[PUBMED:11883935]
[PUBMED:17290220]
[PUBMED:17121812]
[PUBMED:10673500]
[PUBMED:9843217]
[PUBMED:9529249]
[PUBMED:21730163]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:19838211]
[PUBMED:10608892]
[PUBMED:16474402]
[PUBMED:19450511]
[PUBMED:16163388]
[PUBMED:10722742]
[PUBMED:21986495]
[PUBMED:15788536]
[PUBMED:19816404]
[PUBMED:11359766]
[PUBMED:11504915]
[PUBMED:9733515]
[PUBMED:19756449]
[PUBMED:11983168]
[PUBMED:8319905]
[PUBMED:20438709]
Regulation of TP53 Expression and Degradation
[NCBI:1383077]
[REACTOME:R-HSA-6806003]
[PUBMED:11883935]
[PUBMED:11923872]
[PUBMED:19293287]
[PUBMED:23303139]
[PUBMED:17499002]
[PUBMED:15563468]
[PUBMED:17121812]
[PUBMED:21986495]
[PUBMED:15103385]
[PUBMED:9529249]
[PUBMED:21814038]
[PUBMED:19250907]
[PUBMED:8319905]
[PUBMED:7878469]
[PUBMED:12654245]
[PUBMED:16213212]
Stabilization of p53
[NCBI:1269746]
[REACTOME:R-HSA-69541]
[PUBMED:11331603]
[PUBMED:10673500]
[PUBMED:10673501]
[PUBMED:10710310]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
[NCBI:1269752]
[REACTOME:R-HSA-69601]
[PUBMED:10828887]
p53 pathway
[NCBI:138067]
[Pathway Interaction Database:p53regulationpathway]
[PUBMED:9153395]
[PUBMED:15448695]
[PUBMED:10734067]
[PUBMED:11340074]
[PUBMED:15525938]
[PUBMED:17189186]
[PUBMED:18454141]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:12963717]
[PUBMED:15989956]
[PUBMED:10581258]
[PUBMED:18566590]
[PUBMED:15029243]
[PUBMED:14612427]
[PUBMED:19011621]
[PUBMED:12842086]
[PUBMED:16377624]
[PUBMED:17268548]
[PUBMED:16845383]
[PUBMED:17534149]
[PUBMED:12397361]
[PUBMED:11740489]
[PUBMED:12110584]
[PUBMED:11713287]
[PUBMED:17646389]
[PUBMED:14654783]
[PUBMED:9153396]
[PUBMED:18243116]
[PUBMED:10673501]
[PUBMED:17719542]
[PUBMED:11983168]
[PUBMED:12397362]
[PUBMED:17189187]
[PUBMED:16757976]
[PUBMED:12667443]
[PUBMED:9733515]
[PUBMED:9878046]
[PUBMED:9363941]
[PUBMED:11504915]
[PUBMED:11359766]
[PUBMED:9529248]
[PUBMED:17936559]
[PUBMED:15210108]
[PUBMED:17293853]
[PUBMED:16107876]
[PUBMED:9724636]
[PUBMED:17707234]
[PUBMED:10606744]
[PUBMED:11780126]
[PUBMED:10821866]
[PUBMED:18485870]
[PUBMED:17110336]
[PUBMED:11046142]
[PUBMED:11331603]
[PUBMED:19597489]
[PUBMED:16163388]
[PUBMED:14671306]
[PUBMED:17108971]
[PUBMED:15242646]
[PUBMED:15314173]
[PUBMED:12654245]
[PUBMED:15308643]
[PUBMED:9744860]
[PUBMED:17906639]
[PUBMED:9891054]
[PUBMED:17098746]
[PUBMED:17349958]
[PUBMED:11030628]
[PUBMED:15103385]
[PUBMED:14744935]
[PUBMED:9529249]
[PUBMED:11283254]
[PUBMED:11606419]
[PUBMED:11078726]
[PUBMED:10611322]
[PUBMED:9288740]
[PUBMED:11127820]
[PUBMED:19357310]
[PUBMED:9450543]
p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
[PUBMED:16557269]
[PUBMED:10714958]
[PUBMED:12505356]
[PUBMED:16915296]
[PUBMED:16697662]
[PUBMED:15116721]
[PUBMED:11313928]
[PUBMED:11747320]
[PUBMED:17409411]
[PUBMED:15838523]
p53-Dependent G1 DNA Damage Response
[NCBI:1269745]
[REACTOME:R-HSA-69563]
[PUBMED:9153396]
[PUBMED:8247533]
[PUBMED:1423616]
[PUBMED:9153395]
p53-Dependent G1/S DNA damage checkpoint
[NCBI:1269744]
[REACTOME:R-HSA-69580]
[PUBMED:1323840]
p53-Independent DNA Damage Response
[NCBI:1269751]
[REACTOME:R-HSA-69610]
[PUBMED:11298456]
p53-Independent G1/S DNA damage checkpoint
[NCBI:1269750]
[REACTOME:R-HSA-69613]
[PUBMED:10827953]
