full name
heme oxygenase 1

synonyms
bK286B10, HMOX1D, HO-1, HSP32, HMOX1, ENSG00000100292

HGNC
HGNC:5013

Entrez Gene
Gene:3162

ENSEMBL
ENSG00000100292

location
chr: 22
start: 35777060
stop: 35790207
strand: +

OMIM
OMIM:141250: HMOX1 (Autosomal recessive inheritance)
OMIM:614034: Heme oxygenase-1 deficiency
OMIM:606963: {Pulmonary disease, chronic obstructive, susceptibility to}

transcripts
NM_002133.2

pathways
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Ferroptosis [NCBI:1510435] [KEGG:hsa04216] [PUBMED:27314071] [PUBMED:28066232] [PUBMED:27048822] [PUBMED:27791175] [PUBMED:26725301] [PUBMED:27842067] [PUBMED:26775689] [PUBMED:27842066] [PUBMED:22632964] [PUBMED:26405158] [PUBMED:28082232] [PUBMED:26794443] [PUBMED:26436293] [PUBMED:27860262] [PUBMED:28129536] [PUBMED:26653790]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
HIF-1 signaling pathway [NCBI:695200] [KEGG:hsa04066] [PUBMED:11902584] [PUBMED:20965423] [PUBMED:20679415] [PUBMED:15031665] [PUBMED:18259201] [PUBMED:22205687] [PUBMED:19364912] [PUBMED:19147540] [PUBMED:15448722] [PUBMED:16234508] [PUBMED:18505681] [PUBMED:20836033] [PUBMED:19861159] [PUBMED:17955264] [PUBMED:22562152]
HIF-1-alpha transcription factor network [NCBI:138045] [Pathway Interaction Database:hif1_tfpathway] [PUBMED:11707426] [PUBMED:9242677] [PUBMED:9038135] [PUBMED:15310764] [PUBMED:11278891] [PUBMED:8816435] [PUBMED:8663540] [PUBMED:15235127] [PUBMED:12042299] [PUBMED:15312748] [PUBMED:14612449] [PUBMED:11342587] [PUBMED:12615703] [PUBMED:9632793] [PUBMED:12228247] [PUBMED:15044468] [PUBMED:8408001] [PUBMED:9822602] [PUBMED:15252039] [PUBMED:13679920] [PUBMED:11877282] [PUBMED:15235597] [PUBMED:15199161] [PUBMED:15104534] [PUBMED:10594042] [PUBMED:12354771] [PUBMED:10446188] [PUBMED:9436976] [PUBMED:11823643] [PUBMED:12370277] [PUBMED:8955077] [PUBMED:12879018] [PUBMED:14645546] [PUBMED:9486205] [PUBMED:9887100] [PUBMED:8089148] [PUBMED:15466858] [PUBMED:11708773] [PUBMED:15611046] [PUBMED:14742449] [PUBMED:15280364] [PUBMED:12215445] [PUBMED:15611089] [PUBMED:10777486] [PUBMED:9707622] [PUBMED:8917528] [PUBMED:15563275] [PUBMED:12067980] [PUBMED:10353251]
Heme degradation [NCBI:1270188] [REACTOME:R-HSA-189483] [PUBMED:12909459]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interleukin-4 and 13 signaling [NCBI:1470923] [REACTOME:R-HSA-6785807] [PUBMED:12704343] [PUBMED:10358772]
Iron uptake and transport [NCBI:1269948] [REACTOME:R-HSA-917937] [PUBMED:20495089] [PUBMED:19381358] [PUBMED:18259769]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of porphyrins [NCBI:1270186] [REACTOME:R-HSA-189445]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
Mineral absorption [NCBI:212237] [KEGG:hsa04978] [PUBMED:20120011] [PUBMED:12520535] [PUBMED:15618484] [PUBMED:17194590] [PUBMED:21054167] [PUBMED:19448074] [PUBMED:18779302] [PUBMED:18598134] [PUBMED:18277073] [PUBMED:18301276] [PUBMED:19400752] [PUBMED:16431934] [PUBMED:19729436] [PUBMED:18636652] [PUBMED:17943492] [PUBMED:16565477] [PUBMED:18779306]
Porphyrin and chlorophyll metabolism [NCBI:83021] [KEGG:hsa00860] [PUBMED:12195810] [PUBMED:11283349] [PUBMED:10217486] [PUBMED:11007789] [PUBMED:10518530] [PUBMED:12055304] [PUBMED:12196148] [PUBMED:17506685] [PUBMED:16245042] [PUBMED:23922391] [PUBMED:23042036] [PUBMED:9461500]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
Validated transcriptional targets of AP1 family members Fra1 and Fra2 [NCBI:169349] [Pathway Interaction Database:fra_pathway] [PUBMED:20386569] [PUBMED:1827665] [PUBMED:17510314] [PUBMED:17001307] [PUBMED:19419315] [PUBMED:12121977] [PUBMED:15790882] [PUBMED:18435914] [PUBMED:1406676] [PUBMED:20543861] [PUBMED:19687301] [PUBMED:9651314] [PUBMED:20392257] [PUBMED:20472895] [PUBMED:16554298] [PUBMED:17496887] [PUBMED:19995753] [PUBMED:8058317] [PUBMED:2497053] [PUBMED:8798756] [PUBMED:17347653] [PUBMED:18331200] [PUBMED:19966854] [PUBMED:17882273] [PUBMED:9858556] [PUBMED:3130660] [PUBMED:19289495] [PUBMED:11756554] [PUBMED:1945831] [PUBMED:15688012] [PUBMED:8441422] [PUBMED:17371847] [PUBMED:10421804] [PUBMED:2110368] [PUBMED:18548006] [PUBMED:20353950] [PUBMED:15229648] [PUBMED:11425864] [PUBMED:15601844] [PUBMED:10918580] [PUBMED:9858557] [PUBMED:19716794] [PUBMED:9819396] [PUBMED:17052890] [PUBMED:20398633] [PUBMED:20371606] [PUBMED:10359014] [PUBMED:15143165] [PUBMED:15618352] [PUBMED:9160889] [PUBMED:12052899] [PUBMED:9409785] [PUBMED:15291758] [PUBMED:1923525] [PUBMED:7759510] [PUBMED:15608675] [PUBMED:14519134] [PUBMED:20053986] [PUBMED:15256456] [PUBMED:19923172] [PUBMED:15558021] [PUBMED:12773579]
heme degradation [NCBI:545346] [BIOCYC:HUMAN_PWY-5874] [PUBMED:3029864] [PUBMED:8631357] [PUBMED:10467099] [PUBMED:14637193] [PUBMED:18338802] [PUBMED:8424666] [PUBMED:4378982] [PUBMED:8033927] [PUBMED:7929092] [PUBMED:8799475]