full name
phospholipase A2 group VI

synonyms
CaI-PLA2, GVI, INAD1, iPLA2, IPLA2-VIA, iPLA2beta, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, PLA2G6, ENSG00000184381

HGNC
HGNC:9039

Entrez Gene
Gene:8398

ENSEMBL
ENSG00000184381

location
chr: 22
start: 38507502
stop: 38577857
strand: -

OMIM
OMIM:603604: PLA2G6 (Autosomal recessive inheritance)
OMIM:256600: Infantile neuroaxonal dystrophy 1
OMIM:610217: Neurodegeneration with brain iron accumulation 2B
OMIM:612953: Parkinson disease 14, autosomal recessive

transcripts
NM_001199562.1
NM_001004426.1
NM_003560.2

pathways
Acyl chain remodeling of CL [NCBI:1270071] [REACTOME:R-HSA-1482798] [PUBMED:19075029] [PUBMED:19741254] [PUBMED:19737925] [PUBMED:19416660] [PUBMED:15152008] [PUBMED:9487141] [PUBMED:14551214]
Acyl chain remodelling of PC [NCBI:1270062] [REACTOME:R-HSA-1482788] [PUBMED:20705608] [PUBMED:18458083] [PUBMED:12359733] [PUBMED:18195019]
Acyl chain remodelling of PE [NCBI:1270058] [REACTOME:R-HSA-1482839] [PUBMED:18458083] [PUBMED:12359733] [PUBMED:18195019] [PUBMED:18287005] [PUBMED:20705608]
Arachidonic acid metabolism [NCBI:82991] [KEGG:hsa00590] [NCBI:1270087] [REACTOME:R-HSA-2142753] [PUBMED:14622984] [PUBMED:15292194] [PUBMED:10908295] [PUBMED:15205388] [PUBMED:9812980] [PUBMED:14660610] [PUBMED:11328810] [PUBMED:14636671] [PUBMED:14626496] [PUBMED:11679404] [PUBMED:19244215]
COPI-independent Golgi-to-ER retrograde traffic [NCBI:1383043] [REACTOME:R-HSA-6811436] [PUBMED:23783758] [PUBMED:9671731] [PUBMED:25233431] [PUBMED:22130221] [PUBMED:10559986] [PUBMED:12447383] [PUBMED:10562278]
Ether lipid metabolism [NCBI:82990] [KEGG:hsa00565] [PUBMED:11015622] [PUBMED:11275267] [PUBMED:15788404]
Fc gamma R-mediated phagocytosis [NCBI:114228] [KEGG:hsa04666] [PUBMED:11304556] [PUBMED:11244038] [PUBMED:10755615] [PUBMED:17308335] [PUBMED:12821647] [PUBMED:15466916] [PUBMED:17050193] [PUBMED:11228151] [PUBMED:12488490] [PUBMED:10224668] [PUBMED:11708889] [PUBMED:9581795] [PUBMED:10586078] [PUBMED:9417101] [PUBMED:15485887] [PUBMED:18322649] [PUBMED:10577498] [PUBMED:10376013] [PUBMED:10601359] [PUBMED:9545263]
Fcgamma receptor (FCGR) dependent phagocytosis [NCBI:1269279] [REACTOME:R-HSA-2029480] [PUBMED:8541526] [PUBMED:12488490] [PUBMED:16413920] [PUBMED:17050193]
Glycerophospholipid biosynthesis [NCBI:1270054] [REACTOME:R-HSA-1483206] [PUBMED:21220505] [PUBMED:19703651] [PUBMED:20823909] [PUBMED:21683693] [PUBMED:21382416] [PUBMED:21704024]
Glycerophospholipid metabolism [NCBI:82989] [KEGG:hsa00564] [PUBMED:14663079] [PUBMED:15522832] [PUBMED:10938271] [PUBMED:10092508] [PUBMED:1649829] [PUBMED:10542045] [PUBMED:1512203] [PUBMED:12431977]
Golgi-to-ER retrograde transport [NCBI:1383041] [REACTOME:R-HSA-8856688] [PUBMED:23732476] [PUBMED:23378591] [PUBMED:25233431]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Inflammatory mediator regulation of TRP channels [NCBI:948277] [KEGG:hsa04750] [PUBMED:21841075] [PUBMED:15820689] [PUBMED:16776582] [PUBMED:12838328] [PUBMED:17548207] [PUBMED:16319926] [PUBMED:18427980] [PUBMED:20932256] [PUBMED:18615141] [PUBMED:17124270] [PUBMED:17684094] [PUBMED:22470230] [PUBMED:19074743] [PUBMED:23000387] [PUBMED:24099085] [PUBMED:17321113]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Intra-Golgi and retrograde Golgi-to-ER traffic [NCBI:1383038] [REACTOME:R-HSA-6811442] [PUBMED:11756463] [PUBMED:23839779] [PUBMED:21436057] [PUBMED:22013193] [PUBMED:21421921] [PUBMED:25233431] [PUBMED:16157178] [PUBMED:12121415] [PUBMED:25343031] [PUBMED:24068461] [PUBMED:19575639]
Linoleic acid metabolism [NCBI:82992] [KEGG:hsa00591] [PUBMED:12226220] [PUBMED:1634517] [PUBMED:11302930] [PUBMED:8765137] [PUBMED:12909723] [PUBMED:9694817] [PUBMED:14757320] [PUBMED:12324235]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Phospholipid metabolism [NCBI:1270053] [REACTOME:R-HSA-1483257] [PUBMED:9242906]
Ras signaling pathway [NCBI:868085] [KEGG:hsa04014] [PUBMED:23506953] [PUBMED:18437264] [PUBMED:15062121] [PUBMED:22189424] [PUBMED:22233291] [PUBMED:12778136] [PUBMED:11313946] [PUBMED:17428555] [PUBMED:19091743] [PUBMED:18568040] [PUBMED:20420946] [PUBMED:12217381] [PUBMED:14663478] [PUBMED:21686117] [PUBMED:12642680] [PUBMED:21196257] [PUBMED:16869784] [PUBMED:21111786] [PUBMED:16966426] [PUBMED:10712923] [PUBMED:22020205] [PUBMED:17384584] [PUBMED:15572660] [PUBMED:18413813]
Role of phospholipids in phagocytosis [NCBI:1269282] [REACTOME:R-HSA-2029485] [PUBMED:10224668] [PUBMED:20400677]
Vascular smooth muscle contraction [NCBI:96530] [KEGG:hsa04270] [PUBMED:16870827] [PUBMED:10911373] [PUBMED:11679404] [PUBMED:16339747] [PUBMED:10221985] [PUBMED:12689814] [PUBMED:11165670] [PUBMED:18552454] [PUBMED:12060106] [PUBMED:9458738] [PUBMED:15725705] [PUBMED:18040024] [PUBMED:12693609] [PUBMED:11773611] [PUBMED:17158339] [PUBMED:17458653] [PUBMED:15026027] [PUBMED:19120701] [PUBMED:15269340] [PUBMED:18703404] [PUBMED:11709400] [PUBMED:17200683]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
alpha-Linolenic acid metabolism [NCBI:82993] [KEGG:hsa00592] [PUBMED:17172287] [PUBMED:15141068] [PUBMED:14522973] [PUBMED:17215350] [PUBMED:16116284] [PUBMED:15670154]