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Genes
ATF4
Gene - ATF4
full name
activating transcription factor 4
synonyms
CREB-2, CREB2, TAXREB67, TXREB, ATF4, ENSG00000128272
HGNC
HGNC:786
Entrez Gene
Gene:468
ENSEMBL
ENSG00000128272
location
chr: 22
start: 39916569
stop: 39918691
strand: +
transcripts
NM_001675.2
NM_182810.1
pathways
ATF4 activates genes
[NCBI:1268762]
[REACTOME:R-HSA-380994]
[PUBMED:18840095]
[PUBMED:16931790]
[PUBMED:14742429]
[PUBMED:16687408]
[PUBMED:20022965]
[PUBMED:18426796]
[PUBMED:14630918]
[PUBMED:16912112]
ATF6 (ATF6-alpha) activates chaperone genes
[NCBI:1268758]
[REACTOME:R-HSA-381183]
[PUBMED:10866666]
[PUBMED:14973138]
[PUBMED:12014989]
[PUBMED:25821458]
[PUBMED:10856300]
[PUBMED:10958673]
ATF6 (ATF6-alpha) activates chaperones
[NCBI:1268757]
[REACTOME:R-HSA-381033]
[PUBMED:25821458]
[PUBMED:18048764]
[PUBMED:18038217]
[PUBMED:18436705]
Adrenergic signaling in cardiomyocytes
[NCBI:908257]
[KEGG:hsa04261]
[PUBMED:15232578]
[PUBMED:20923637]
[PUBMED:10571541]
[PUBMED:11604549]
[PUBMED:17988210]
[PUBMED:11805843]
[PUBMED:15142747]
[PUBMED:21212391]
[PUBMED:20658186]
[PUBMED:16765984]
[PUBMED:19874988]
[PUBMED:19883653]
[PUBMED:15979723]
[PUBMED:18407781]
[PUBMED:22022314]
[PUBMED:12439640]
[PUBMED:17826821]
[PUBMED:15765137]
Alcoholism
[NCBI:585563]
[KEGG:hsa05034]
[PUBMED:16764827]
[PUBMED:18616668]
[PUBMED:19077056]
[PUBMED:18991950]
[PUBMED:19756388]
[PUBMED:12068305]
[PUBMED:16102840]
[PUBMED:20947635]
[PUBMED:20729980]
[PUBMED:16278489]
[PUBMED:17270154]
[PUBMED:20626732]
[PUBMED:18310464]
[PUBMED:10774721]
[PUBMED:19342616]
[PUBMED:12605085]
[PUBMED:15500908]
[PUBMED:14729391]
[PUBMED:12085089]
[PUBMED:16776597]
Aldosterone synthesis and secretion
[NCBI:1272485]
[KEGG:hsa04925]
[PUBMED:15044681]
[PUBMED:10536682]
[PUBMED:24944029]
[PUBMED:25788893]
[PUBMED:15026188]
[PUBMED:22689262]
[PUBMED:22364774]
[PUBMED:18406824]
[PUBMED:14645496]
[PUBMED:21839803]
[PUBMED:22395411]
[PUBMED:23628605]
[PUBMED:21962440]
Amphetamine addiction
[NCBI:547607]
[KEGG:hsa05031]
[PUBMED:16776597]
[PUBMED:18617632]
[PUBMED:16724157]
[PUBMED:19222557]
[PUBMED:14746512]
[PUBMED:18632938]
[PUBMED:8630246]
[PUBMED:14622123]
[PUBMED:21338876]
[PUBMED:8753884]
[PUBMED:10774721]
[PUBMED:14529709]
[PUBMED:17728700]
[PUBMED:21989194]
[PUBMED:16151049]
[PUBMED:18440072]
[PUBMED:19199083]
[PUBMED:10414964]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Cholinergic synapse
[NCBI:217716]
[KEGG:hsa04725]
[PUBMED:20060019]
[PUBMED:11283752]
[PUBMED:15165747]
[PUBMED:12893537]
[PUBMED:11738031]
[PUBMED:21550798]
[PUBMED:19712465]
[PUBMED:12690458]
[PUBMED:12436417]
[PUBMED:19378880]
[PUBMED:11923408]
[PUBMED:20446119]
Cocaine addiction
[NCBI:546258]
[KEGG:hsa05030]
[PUBMED:15091342]
[PUBMED:16278489]
[PUBMED:14566342]
[PUBMED:12064476]
[PUBMED:16251986]
[PUBMED:18440072]
[PUBMED:19403004]
[PUBMED:11595774]
[PUBMED:11268215]
[PUBMED:15582154]
[PUBMED:12818179]
[PUBMED:14746512]
[PUBMED:10234039]
Dopaminergic synapse
[NCBI:469199]
[KEGG:hsa04728]
[PUBMED:20727368]
[PUBMED:10433257]
[PUBMED:17408758]
[PUBMED:15292232]
[PUBMED:9457173]
[PUBMED:17349698]
[PUBMED:15521361]
[PUBMED:18353279]
[PUBMED:21303898]
[PUBMED:19251795]
[PUBMED:15381316]
[PUBMED:15590733]
[PUBMED:20224735]
[PUBMED:19138563]
[PUBMED:12967774]
Estrogen signaling pathway
[NCBI:799177]
[KEGG:hsa04915]
[PUBMED:15695368]
[PUBMED:16112267]
[PUBMED:9278514]
[PUBMED:19187465]
[PUBMED:12421825]
[PUBMED:12650715]
[PUBMED:18253054]
[PUBMED:16516516]
[PUBMED:14573532]
[PUBMED:18755790]
[PUBMED:18538919]
[PUBMED:19767412]
[PUBMED:14993035]
[PUBMED:19549587]
[PUBMED:15862823]
[PUBMED:20694192]
[PUBMED:19464786]
[PUBMED:21779010]
[PUBMED:16270355]
[PUBMED:21742056]
[PUBMED:19700741]
[PUBMED:21844907]
Glucagon signaling pathway
[NCBI:1144996]
[KEGG:hsa04922]
[PUBMED:20735177]
[PUBMED:19912989]
[PUBMED:21941300]
[PUBMED:22249520]
[PUBMED:12626323]
[PUBMED:16601267]
[PUBMED:18669612]
[PUBMED:24393785]
[PUBMED:21346730]
[PUBMED:22550228]
[PUBMED:16479585]
[PUBMED:24692138]
[PUBMED:22495310]
[PUBMED:22796337]
[PUBMED:22004992]
[PUBMED:24238363]
[PUBMED:22503562]
GnRH signaling pathway
[NCBI:83091]
[KEGG:hsa04912]
[PUBMED:15080147]
[PUBMED:15982836]
[PUBMED:14596811]
[PUBMED:15613448]
[PUBMED:12943720]
[PUBMED:10707049]
[PUBMED:15350605]
[PUBMED:12963732]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Hepatitis B
[NCBI:694606]
[KEGG:hsa05161]
[PUBMED:19854353]
[PUBMED:11604508]
[PUBMED:11325602]
[PUBMED:18931690]
[PUBMED:16891440]
[PUBMED:17158882]
[PUBMED:11099494]
[PUBMED:9325306]
[PUBMED:18024894]
[PUBMED:11483993]
[PUBMED:15107488]
[PUBMED:11278872]
[PUBMED:21647825]
[PUBMED:11287574]
[PUBMED:18481805]
[PUBMED:17188775]
[PUBMED:19784739]
[PUBMED:19263472]
[PUBMED:16203685]
[PUBMED:18605975]
[PUBMED:10454581]
[PUBMED:22504921]
[PUBMED:21334391]
[PUBMED:20657822]
[PUBMED:18046710]
[PUBMED:9843511]
[PUBMED:15542625]
[PUBMED:21618535]
[PUBMED:15132991]
[PUBMED:15173177]
[PUBMED:12771941]
[PUBMED:21994545]
[PUBMED:8764004]
[PUBMED:16459163]
[PUBMED:9738022]
[PUBMED:11821950]
[PUBMED:12839924]
Insulin secretion
[NCBI:777534]
[KEGG:hsa04911]
[PUBMED:9715374]
[PUBMED:10605628]
[PUBMED:9914469]
[PUBMED:17306374]
[PUBMED:20055708]
[PUBMED:15655710]
[PUBMED:19817784]
[PUBMED:19074620]
[PUBMED:14693691]
[PUBMED:17084085]
[PUBMED:20551594]
[PUBMED:19036624]
[PUBMED:22970724]
[PUBMED:20225132]
[PUBMED:19817800]
[PUBMED:22974438]
[PUBMED:21934040]
[PUBMED:15271645]
[PUBMED:19660440]
[PUBMED:11522660]
Long-term potentiation
[NCBI:83085]
[KEGG:hsa04720]
[PUBMED:9697848]
[PUBMED:15652868]
[PUBMED:15803158]
[PUBMED:11378299]
[PUBMED:10652548]
[PUBMED:15857686]
[PUBMED:14715912]
Longevity regulating pathway
[NCBI:1319989]
[KEGG:hsa04211]
[PUBMED:21779512]
[PUBMED:23594965]
[PUBMED:25654554]
[PUBMED:25832544]
[PUBMED:24997879]
[PUBMED:22618766]
[PUBMED:20336132]
[PUBMED:24905167]
[PUBMED:25601466]
[PUBMED:20103737]
[PUBMED:18692468]
[PUBMED:20395504]
[PUBMED:25824609]
[PUBMED:17701476]
[PUBMED:23939249]
[PUBMED:20848587]
[PUBMED:22983298]
[PUBMED:19262508]
[PUBMED:20357764]
[PUBMED:18946478]
[PUBMED:23061800]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
Mitophagy - animal
[NCBI:1496831]
[KEGG:hsa04137]
[PUBMED:26611876]
[PUBMED:27443527]
[PUBMED:25995186]
[PUBMED:25611507]
[PUBMED:27021519]
[PUBMED:25999423]
[PUBMED:27701735]
[PUBMED:26882551]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
Non-alcoholic fatty liver disease (NAFLD)
[NCBI:862188]
[KEGG:hsa04932]
[PUBMED:21038418]
[PUBMED:17498512]
[PUBMED:19352614]
[PUBMED:23299992]
[PUBMED:22570745]
[PUBMED:9285483]
[PUBMED:12891546]
[PUBMED:18061659]
[PUBMED:22705006]
[PUBMED:16364488]
[PUBMED:18242193]
[PUBMED:16374858]
[PUBMED:22940046]
[PUBMED:20619513]
[PUBMED:20303879]
[PUBMED:14685853]
[PUBMED:16406828]
[PUBMED:23545492]
[PUBMED:21145844]
PERK regulates gene expression
[NCBI:1268761]
[REACTOME:R-HSA-381042]
[PUBMED:18048764]
[PUBMED:17956313]
[PUBMED:18038217]
[PUBMED:18436705]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
Prostate cancer
[NCBI:83111]
[KEGG:hsa05215]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11527574]
[PUBMED:11750244]
[PUBMED:16551847]
[PUBMED:10835690]
[PUBMED:8069858]
[PUBMED:15724144]
[PUBMED:10453277]
[PUBMED:15082523]
[PUBMED:9422516]
Protein processing in endoplasmic reticulum
[NCBI:167325]
[KEGG:hsa04141]
[PUBMED:20347046]
[PUBMED:18023214]
[PUBMED:20219571]
[PUBMED:19491040]
[PUBMED:20112977]
TNF signaling pathway
[NCBI:812256]
[KEGG:hsa04668]
[PUBMED:20489699]
[PUBMED:14532286]
[PUBMED:21232019]
[PUBMED:11897488]
[PUBMED:22296764]
[PUBMED:10581243]
[PUBMED:23085193]
[PUBMED:23531747]
Thyroid hormone synthesis
[NCBI:835410]
[KEGG:hsa04918]
[PUBMED:21448409]
[PUBMED:9086577]
[PUBMED:21986207]
[PUBMED:11137035]
[PUBMED:17666482]
[PUBMED:20407074]
[PUBMED:20093166]
[PUBMED:20122987]
[PUBMED:15611820]
[PUBMED:20378719]
[PUBMED:23438835]
[PUBMED:11717564]
[PUBMED:16870170]
[PUBMED:19196800]
[PUBMED:9538302]
[PUBMED:11029276]
[PUBMED:20167242]
[PUBMED:10893432]
[PUBMED:21683758]
Unfolded Protein Response (UPR)
[NCBI:1268756]
[REACTOME:R-HSA-381119]
[PUBMED:18436705]
[PUBMED:18038217]
[PUBMED:27067637]
[PUBMED:16365312]
[PUBMED:18048764]
[PUBMED:15952902]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
[PUBMED:15452270]
[PUBMED:18948197]
[PUBMED:16760382]
[PUBMED:10793105]
[PUBMED:21084867]
[PUBMED:16308315]
[PUBMED:16155604]
[PUBMED:16381817]
[PUBMED:16828973]
[PUBMED:15342967]
[PUBMED:15692053]
[PUBMED:10855768]
[PUBMED:19078975]
[PUBMED:12379483]
[PUBMED:15310405]
[PUBMED:8223437]
[PUBMED:16939421]
[PUBMED:12910250]
[PUBMED:16039586]
[PUBMED:18201576]
[PUBMED:21102637]
[PUBMED:21743832]
[PUBMED:20592731]
[PUBMED:10644344]
[PUBMED:10074132]
[PUBMED:19715458]
[PUBMED:16155601]
[PUBMED:11604508]
[PUBMED:15919895]
[PUBMED:11099494]
[PUBMED:18385245]
[PUBMED:19854353]
[PUBMED:12101418]
cGMP-PKG signaling pathway
[NCBI:983748]
[KEGG:hsa04022]
[PUBMED:18006449]
[PUBMED:9003029]
[PUBMED:18040025]
[PUBMED:19306895]
[PUBMED:21666108]
[PUBMED:12524221]
[PUBMED:16460276]
[PUBMED:20716671]
[PUBMED:22785374]
[PUBMED:11522789]
[PUBMED:16439998]
[PUBMED:16371594]
[PUBMED:20388537]
[PUBMED:18757523]
[PUBMED:16815627]
[PUBMED:23212367]
[PUBMED:21685243]
[PUBMED:20024580]
[PUBMED:15894227]
[PUBMED:22965426]
[PUBMED:17643091]
[PUBMED:19176601]
[PUBMED:19961855]