Logo
full name
ribosomal protein S6 kinase A3

synonyms
CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, p90-RSK2, pp90RSK2, RSK, RSK2, S6K-alpha3, RPS6KA3, ENSG00000177189

HGNC
HGNC:10432

Entrez Gene
Gene:6197

ENSEMBL
ENSG00000177189

location
chr: X
start: 20168029
stop: 20285523
strand: -

OMIM
OMIM:300075: RPS6KA3 (X-linked dominant inheritance)
OMIM:303600: Coffin-Lowry syndrome
OMIM:300844: Mental retardation, X-linked 19

transcripts
NM_004586.2

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Activation of NMDA receptor upon glutamate binding and postsynaptic events [NCBI:1268798] [REACTOME:R-HSA-442755] [PUBMED:18616423]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
CREB phosphorylation [NCBI:1269217] [REACTOME:R-HSA-199920]
CREB phosphorylation through the activation of Ras [NCBI:1268801] [REACTOME:R-HSA-442742] [PUBMED:12819448]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Coregulation of Androgen receptor activity [NCBI:138085] [Pathway Interaction Database:ar_pathway] [PUBMED:16724108] [PUBMED:16027218] [PUBMED:11818503] [PUBMED:17277772] [PUBMED:11719514] [PUBMED:15833840] [PUBMED:16384856] [PUBMED:14645241] [PUBMED:12218053] [PUBMED:11016951] [PUBMED:12621049] [PUBMED:15784617] [PUBMED:16446156] [PUBMED:17110431] [PUBMED:16254014] [PUBMED:17698582] [PUBMED:15131260] [PUBMED:16705743] [PUBMED:11682623] [PUBMED:17192406] [PUBMED:15882980] [PUBMED:10934038] [PUBMED:12165860] [PUBMED:11856738] [PUBMED:16720717] [PUBMED:9710597] [PUBMED:14609956] [PUBMED:17170703] [PUBMED:10383460] [PUBMED:14576337] [PUBMED:12941811] [PUBMED:14612401] [PUBMED:17975004] [PUBMED:12799378] [PUBMED:15790678] [PUBMED:8643607] [PUBMED:11792840] [PUBMED:16603237] [PUBMED:16079795] [PUBMED:16951154] [PUBMED:15166229] [PUBMED:17142810] [PUBMED:12361945] [PUBMED:11439351] [PUBMED:15640154] [PUBMED:17909037] [PUBMED:15539430] [PUBMED:11792709] [PUBMED:11931767] [PUBMED:10344732] [PUBMED:10428808]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
ERK/MAPK targets [NCBI:1269215] [REACTOME:R-HSA-198753]
ErbB1 downstream signaling [NCBI:138057] [Pathway Interaction Database:erbb1_downstream_pathway] [PUBMED:1330321] [PUBMED:7939666] [PUBMED:9448004] [PUBMED:3497813] [PUBMED:7680434] [PUBMED:18567582] [PUBMED:12503606] [PUBMED:12183455] [PUBMED:8073291] [PUBMED:17563371] [PUBMED:8378775] [PUBMED:19219045] [PUBMED:1990291] [PUBMED:15550174] [PUBMED:16508002] [PUBMED:17881733] [PUBMED:11278353] [PUBMED:9889102] [PUBMED:14699061] [PUBMED:8248196] [PUBMED:8262053] [PUBMED:11319218] [PUBMED:19595761] [PUBMED:17360704] [PUBMED:15048123] [PUBMED:19341767] [PUBMED:9837959] [PUBMED:14993287] [PUBMED:19710016] [PUBMED:18516090] [PUBMED:9733714] [PUBMED:8052307] [PUBMED:10567369] [PUBMED:9335504] [PUBMED:9580112] [PUBMED:11018520] [PUBMED:10499589] [PUBMED:19706684] [PUBMED:8910287] [PUBMED:10469645] [PUBMED:11073940] [PUBMED:9315636] [PUBMED:2189103] [PUBMED:14765121] [PUBMED:14970219] [PUBMED:8332195] [PUBMED:16239230] [PUBMED:8621729] [PUBMED:11889038] [PUBMED:11029289] [PUBMED:11152283] [PUBMED:8071311] [PUBMED:12932319] [PUBMED:19541618] [PUBMED:2123453] [PUBMED:9384584] [PUBMED:8140422] [PUBMED:10644690] [PUBMED:18156174] [PUBMED:15718470] [PUBMED:12172553] [PUBMED:10082559] [PUBMED:17079732] [PUBMED:12446727] [PUBMED:9989263] [PUBMED:12551925] [PUBMED:10856237] [PUBMED:8013650] [PUBMED:7600581] [PUBMED:8688081] [PUBMED:8397445] [PUBMED:16135787] [PUBMED:7637810] [PUBMED:9438848] [PUBMED:12515821] [PUBMED:12881422] [PUBMED:9305638] [PUBMED:15284024] [PUBMED:3136398] [PUBMED:10597268] [PUBMED:10648629] [PUBMED:9790194] [PUBMED:9797479] [PUBMED:16093354] [PUBMED:7741752] [PUBMED:10891480] [PUBMED:17052213] [PUBMED:8221888] [PUBMED:9593664] [PUBMED:16892053] [PUBMED:8413226] [PUBMED:9407138] [PUBMED:9710644] [PUBMED:8248197] [PUBMED:12414794] [PUBMED:1653949] [PUBMED:12181570] [PUBMED:9550702] [PUBMED:12110590] [PUBMED:10400627] [PUBMED:9927426] [PUBMED:12242303] [PUBMED:10480933] [PUBMED:9665134] [PUBMED:11238956] [PUBMED:16984645] [PUBMED:7761091] [PUBMED:17322878] [PUBMED:12640115] [PUBMED:14963038] [PUBMED:17486115] [PUBMED:8503013] [PUBMED:16155590] [PUBMED:16628218] [PUBMED:1406636] [PUBMED:9430728] [PUBMED:19401591] [PUBMED:17053785] [PUBMED:7992057] [PUBMED:14609431] [PUBMED:9346240] [PUBMED:8626780] [PUBMED:8940018] [PUBMED:12454019] [PUBMED:10441128] [PUBMED:14747473] [PUBMED:11777939] [PUBMED:8614832] [PUBMED:8378774] [PUBMED:19121340] [PUBMED:18775988] [PUBMED:15039778] [PUBMED:9770464] [PUBMED:10567531] [PUBMED:8180183] [PUBMED:10675331] [PUBMED:1545823] [PUBMED:7958858] [PUBMED:11948693] [PUBMED:2109185] [PUBMED:8942998] [PUBMED:1637333] [PUBMED:14690430] [PUBMED:11134016] [PUBMED:12429840] [PUBMED:8621573] [PUBMED:7600582] [PUBMED:8226933] [PUBMED:10201527] [PUBMED:12832467] [PUBMED:3492494] [PUBMED:15034142] [PUBMED:9596579] [PUBMED:7889942] [PUBMED:8524316] [PUBMED:7731720] [PUBMED:8386592] [PUBMED:16407412] [PUBMED:6334806] [PUBMED:11703925] [PUBMED:11099046] [PUBMED:7876145] [PUBMED:14498832]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
L1CAM interactions [NCBI:1270323] [REACTOME:R-HSA-373760] [PUBMED:9211984] [PUBMED:18760361] [PUBMED:14709786] [PUBMED:17189949] [PUBMED:19356150]
Long-term potentiation [NCBI:83085] [KEGG:hsa04720] [PUBMED:9697848] [PUBMED:15652868] [PUBMED:15803158] [PUBMED:11378299] [PUBMED:10652548] [PUBMED:15857686] [PUBMED:14715912]
MAP kinase activation in TLR cascade [NCBI:1269211] [REACTOME:R-HSA-450294] [PUBMED:17637696] [PUBMED:11861597] [PUBMED:19196711] [PUBMED:11242034]
MAPK signaling pathway [NCBI:83048] [KEGG:hsa04010] [PUBMED:11749383] [PUBMED:12566928] [PUBMED:12849693] [PUBMED:12676795] [PUBMED:12947395] [PUBMED:14597384] [PUBMED:11369511] [PUBMED:12191611] [PUBMED:12390245]
MAPK targets/ Nuclear events mediated by MAP kinases [NCBI:1269214] [REACTOME:R-HSA-450282] [PUBMED:17158707] [PUBMED:16393692] [PUBMED:12471242]
MyD88 cascade initiated on plasma membrane [NCBI:1269207] [REACTOME:R-HSA-975871] [PUBMED:15728506] [PUBMED:16239509]
MyD88 dependent cascade initiated on endosome [NCBI:1269228] [REACTOME:R-HSA-975155] [PUBMED:20237413] [PUBMED:15276183] [PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [NCBI:1268786] [REACTOME:R-HSA-112314]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
Nuclear Events (kinase and transcription factor activation) [NCBI:1269477] [REACTOME:R-HSA-198725] [PUBMED:8833451]
Oocyte meiosis [NCBI:126909] [KEGG:hsa04114] [PUBMED:16760654] [PUBMED:17480229] [PUBMED:15136768] [PUBMED:18946022] [PUBMED:18598214] [PUBMED:16518630] [PUBMED:18631137] [PUBMED:15182704] [PUBMED:15182701] [PUBMED:16554437] [PUBMED:14691134] [PUBMED:18550795] [PUBMED:18096427] [PUBMED:14517314] [PUBMED:18311174]
Post NMDA receptor activation events [NCBI:1268800] [REACTOME:R-HSA-438064] [PUBMED:18616423]
Progesterone-mediated oocyte maturation [NCBI:119304] [KEGG:hsa04914] [PUBMED:10497333] [PUBMED:12084906] [PUBMED:12045215] [PUBMED:11063930] [PUBMED:12477927] [PUBMED:11148128] [PUBMED:11730319] [PUBMED:12374568]
RSK activation [NCBI:1268803] [REACTOME:R-HSA-444257] [PUBMED:18813292]
Recycling pathway of L1 [NCBI:1270324] [REACTOME:R-HSA-437239] [PUBMED:10804209] [PUBMED:11717353] [PUBMED:14709786]
Senescence-Associated Secretory Phenotype (SASP) [NCBI:1270431] [REACTOME:R-HSA-2559582] [PUBMED:18411265] [PUBMED:21979375] [PUBMED:18267069] [PUBMED:19597488] [PUBMED:19218920] [PUBMED:20818427] [PUBMED:11114305] [PUBMED:8617720] [PUBMED:22178396] [PUBMED:19805069] [PUBMED:23770676] [PUBMED:8384717] [PUBMED:18555777] [PUBMED:21686281] [PUBMED:20351173] [PUBMED:8688489] [PUBMED:19053174] [PUBMED:8234276] [PUBMED:18555778]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [NCBI:1269229] [REACTOME:R-HSA-975138] [PUBMED:22511786] [PUBMED:18794297]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade [NCBI:1269206] [REACTOME:R-HSA-168142] [PUBMED:15728506] [PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade [NCBI:1269226] [REACTOME:R-HSA-168176] [PUBMED:11489966] [PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade [NCBI:1269227] [REACTOME:R-HSA-168181] [PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade [NCBI:1269233] [REACTOME:R-HSA-168138] [PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:17277771] [PUBMED:15341740] [PUBMED:12172553] [PUBMED:15718470] [PUBMED:14651849] [PUBMED:15268862] [PUBMED:15306821] [PUBMED:26046644] [PUBMED:12869586] [PUBMED:24556838] [PUBMED:17928295] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:26658722] [PUBMED:24842496] [PUBMED:23465396] [PUBMED:17709744] [PUBMED:17599906] [PUBMED:16919458] [PUBMED:10364159] [PUBMED:15342917] [PUBMED:11500364] [PUBMED:19812304] [PUBMED:12482958] [PUBMED:11729323] [PUBMED:16962653] [PUBMED:18952604] [PUBMED:9465032] [PUBMED:1496022] [PUBMED:10567431] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:18604198] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:17461779] [PUBMED:9445476] [PUBMED:18497260] [PUBMED:12604610] [PUBMED:15071500] [PUBMED:18925875] [PUBMED:12906785] [PUBMED:11287630] [PUBMED:15004009] [PUBMED:16756488] [PUBMED:17043309] [PUBMED:18198340] [PUBMED:12820960] [PUBMED:12747827] [PUBMED:17053147] [PUBMED:15851026] [PUBMED:15467718] [PUBMED:18762023] [PUBMED:25242279] [PUBMED:24698685] [PUBMED:11175345] [PUBMED:27304501] [PUBMED:18411301] [PUBMED:11500365] [PUBMED:17693255] [PUBMED:23694989] [PUBMED:12231510] [PUBMED:19446321] [PUBMED:11418588] [PUBMED:19258318] [PUBMED:18439900] [PUBMED:19225151] [PUBMED:26185979] [PUBMED:10357815] [PUBMED:26269525] [PUBMED:23421405] [PUBMED:9271440] [PUBMED:16915281] [PUBMED:17141160] [PUBMED:15249583] [PUBMED:12912989] [PUBMED:27027448] [PUBMED:18423201] [PUBMED:19211835] [PUBMED:9204908] [PUBMED:26700098] [PUBMED:18566587] [PUBMED:17386266]