full name
ribosomal protein S6 kinase A3
synonyms
CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, p90-RSK2, pp90RSK2, RSK, RSK2, S6K-alpha3, RPS6KA3, ENSG00000177189
HGNC
HGNC:10432
Entrez Gene
Gene:6197
ENSEMBL
ENSG00000177189
location
chr: X
start: 20168029
stop: 20285523
strand: -
OMIM
OMIM:300075:
RPS6KA3
(X-linked dominant inheritance)
OMIM:303600:
Coffin-Lowry syndrome
OMIM:300844:
Mental retardation, X-linked 19
transcripts
NM_004586.2
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Activation of NMDA receptor upon glutamate binding and postsynaptic events
[NCBI:1268798]
[REACTOME:R-HSA-442755]
[PUBMED:18616423]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
CREB phosphorylation
[NCBI:1269217]
[REACTOME:R-HSA-199920]
CREB phosphorylation through the activation of Ras
[NCBI:1268801]
[REACTOME:R-HSA-442742]
[PUBMED:12819448]
Cellular Senescence
[NCBI:1270426]
[REACTOME:R-HSA-2559583]
[PUBMED:21078816]
[PUBMED:18711403]
[PUBMED:22048312]
[PUBMED:19818705]
[PUBMED:17662938]
[PUBMED:23746838]
[PUBMED:9282108]
[PUBMED:17667954]
[PUBMED:13905658]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Coregulation of Androgen receptor activity
[NCBI:138085]
[Pathway Interaction Database:ar_pathway]
[PUBMED:16724108]
[PUBMED:16027218]
[PUBMED:11818503]
[PUBMED:17277772]
[PUBMED:11719514]
[PUBMED:15833840]
[PUBMED:16384856]
[PUBMED:14645241]
[PUBMED:12218053]
[PUBMED:11016951]
[PUBMED:12621049]
[PUBMED:15784617]
[PUBMED:16446156]
[PUBMED:17110431]
[PUBMED:16254014]
[PUBMED:17698582]
[PUBMED:15131260]
[PUBMED:16705743]
[PUBMED:11682623]
[PUBMED:17192406]
[PUBMED:15882980]
[PUBMED:10934038]
[PUBMED:12165860]
[PUBMED:11856738]
[PUBMED:16720717]
[PUBMED:9710597]
[PUBMED:14609956]
[PUBMED:17170703]
[PUBMED:10383460]
[PUBMED:14576337]
[PUBMED:12941811]
[PUBMED:14612401]
[PUBMED:17975004]
[PUBMED:12799378]
[PUBMED:15790678]
[PUBMED:8643607]
[PUBMED:11792840]
[PUBMED:16603237]
[PUBMED:16079795]
[PUBMED:16951154]
[PUBMED:15166229]
[PUBMED:17142810]
[PUBMED:12361945]
[PUBMED:11439351]
[PUBMED:15640154]
[PUBMED:17909037]
[PUBMED:15539430]
[PUBMED:11792709]
[PUBMED:11931767]
[PUBMED:10344732]
[PUBMED:10428808]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
ERK/MAPK targets
[NCBI:1269215]
[REACTOME:R-HSA-198753]
ErbB1 downstream signaling
[NCBI:138057]
[Pathway Interaction Database:erbb1_downstream_pathway]
[PUBMED:1330321]
[PUBMED:7939666]
[PUBMED:9448004]
[PUBMED:3497813]
[PUBMED:7680434]
[PUBMED:18567582]
[PUBMED:12503606]
[PUBMED:12183455]
[PUBMED:8073291]
[PUBMED:17563371]
[PUBMED:8378775]
[PUBMED:19219045]
[PUBMED:1990291]
[PUBMED:15550174]
[PUBMED:16508002]
[PUBMED:17881733]
[PUBMED:11278353]
[PUBMED:9889102]
[PUBMED:14699061]
[PUBMED:8248196]
[PUBMED:8262053]
[PUBMED:11319218]
[PUBMED:19595761]
[PUBMED:17360704]
[PUBMED:15048123]
[PUBMED:19341767]
[PUBMED:9837959]
[PUBMED:14993287]
[PUBMED:19710016]
[PUBMED:18516090]
[PUBMED:9733714]
[PUBMED:8052307]
[PUBMED:10567369]
[PUBMED:9335504]
[PUBMED:9580112]
[PUBMED:11018520]
[PUBMED:10499589]
[PUBMED:19706684]
[PUBMED:8910287]
[PUBMED:10469645]
[PUBMED:11073940]
[PUBMED:9315636]
[PUBMED:2189103]
[PUBMED:14765121]
[PUBMED:14970219]
[PUBMED:8332195]
[PUBMED:16239230]
[PUBMED:8621729]
[PUBMED:11889038]
[PUBMED:11029289]
[PUBMED:11152283]
[PUBMED:8071311]
[PUBMED:12932319]
[PUBMED:19541618]
[PUBMED:2123453]
[PUBMED:9384584]
[PUBMED:8140422]
[PUBMED:10644690]
[PUBMED:18156174]
[PUBMED:15718470]
[PUBMED:12172553]
[PUBMED:10082559]
[PUBMED:17079732]
[PUBMED:12446727]
[PUBMED:9989263]
[PUBMED:12551925]
[PUBMED:10856237]
[PUBMED:8013650]
[PUBMED:7600581]
[PUBMED:8688081]
[PUBMED:8397445]
[PUBMED:16135787]
[PUBMED:7637810]
[PUBMED:9438848]
[PUBMED:12515821]
[PUBMED:12881422]
[PUBMED:9305638]
[PUBMED:15284024]
[PUBMED:3136398]
[PUBMED:10597268]
[PUBMED:10648629]
[PUBMED:9790194]
[PUBMED:9797479]
[PUBMED:16093354]
[PUBMED:7741752]
[PUBMED:10891480]
[PUBMED:17052213]
[PUBMED:8221888]
[PUBMED:9593664]
[PUBMED:16892053]
[PUBMED:8413226]
[PUBMED:9407138]
[PUBMED:9710644]
[PUBMED:8248197]
[PUBMED:12414794]
[PUBMED:1653949]
[PUBMED:12181570]
[PUBMED:9550702]
[PUBMED:12110590]
[PUBMED:10400627]
[PUBMED:9927426]
[PUBMED:12242303]
[PUBMED:10480933]
[PUBMED:9665134]
[PUBMED:11238956]
[PUBMED:16984645]
[PUBMED:7761091]
[PUBMED:17322878]
[PUBMED:12640115]
[PUBMED:14963038]
[PUBMED:17486115]
[PUBMED:8503013]
[PUBMED:16155590]
[PUBMED:16628218]
[PUBMED:1406636]
[PUBMED:9430728]
[PUBMED:19401591]
[PUBMED:17053785]
[PUBMED:7992057]
[PUBMED:14609431]
[PUBMED:9346240]
[PUBMED:8626780]
[PUBMED:8940018]
[PUBMED:12454019]
[PUBMED:10441128]
[PUBMED:14747473]
[PUBMED:11777939]
[PUBMED:8614832]
[PUBMED:8378774]
[PUBMED:19121340]
[PUBMED:18775988]
[PUBMED:15039778]
[PUBMED:9770464]
[PUBMED:10567531]
[PUBMED:8180183]
[PUBMED:10675331]
[PUBMED:1545823]
[PUBMED:7958858]
[PUBMED:11948693]
[PUBMED:2109185]
[PUBMED:8942998]
[PUBMED:1637333]
[PUBMED:14690430]
[PUBMED:11134016]
[PUBMED:12429840]
[PUBMED:8621573]
[PUBMED:7600582]
[PUBMED:8226933]
[PUBMED:10201527]
[PUBMED:12832467]
[PUBMED:3492494]
[PUBMED:15034142]
[PUBMED:9596579]
[PUBMED:7889942]
[PUBMED:8524316]
[PUBMED:7731720]
[PUBMED:8386592]
[PUBMED:16407412]
[PUBMED:6334806]
[PUBMED:11703925]
[PUBMED:11099046]
[PUBMED:7876145]
[PUBMED:14498832]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin resistance
[NCBI:1272486]
[KEGG:hsa04931]
[PUBMED:17130651]
[PUBMED:20466550]
[PUBMED:16364488]
[PUBMED:12765939]
[PUBMED:15166380]
[PUBMED:7666792]
[PUBMED:16756496]
[PUBMED:23647930]
[PUBMED:10923637]
[PUBMED:17141630]
[PUBMED:9886945]
[PUBMED:8048519]
[PUBMED:18309108]
[PUBMED:15107844]
[PUBMED:20526383]
[PUBMED:22360800]
[PUBMED:16186396]
[PUBMED:22675355]
[PUBMED:22677645]
L1CAM interactions
[NCBI:1270323]
[REACTOME:R-HSA-373760]
[PUBMED:9211984]
[PUBMED:18760361]
[PUBMED:14709786]
[PUBMED:17189949]
[PUBMED:19356150]
Long-term potentiation
[NCBI:83085]
[KEGG:hsa04720]
[PUBMED:9697848]
[PUBMED:15652868]
[PUBMED:15803158]
[PUBMED:11378299]
[PUBMED:10652548]
[PUBMED:15857686]
[PUBMED:14715912]
MAP kinase activation in TLR cascade
[NCBI:1269211]
[REACTOME:R-HSA-450294]
[PUBMED:17637696]
[PUBMED:11861597]
[PUBMED:19196711]
[PUBMED:11242034]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
MAPK targets/ Nuclear events mediated by MAP kinases
[NCBI:1269214]
[REACTOME:R-HSA-450282]
[PUBMED:17158707]
[PUBMED:16393692]
[PUBMED:12471242]
MyD88 cascade initiated on plasma membrane
[NCBI:1269207]
[REACTOME:R-HSA-975871]
[PUBMED:15728506]
[PUBMED:16239509]
MyD88 dependent cascade initiated on endosome
[NCBI:1269228]
[REACTOME:R-HSA-975155]
[PUBMED:20237413]
[PUBMED:15276183]
[PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade
[NCBI:1269220]
[REACTOME:R-HSA-166166]
[PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane
[NCBI:1269237]
[REACTOME:R-HSA-166058]
[PUBMED:15276183]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Neuronal System
[NCBI:1268763]
[REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
[NCBI:1268786]
[REACTOME:R-HSA-112314]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
Nuclear Events (kinase and transcription factor activation)
[NCBI:1269477]
[REACTOME:R-HSA-198725]
[PUBMED:8833451]
Oocyte meiosis
[NCBI:126909]
[KEGG:hsa04114]
[PUBMED:16760654]
[PUBMED:17480229]
[PUBMED:15136768]
[PUBMED:18946022]
[PUBMED:18598214]
[PUBMED:16518630]
[PUBMED:18631137]
[PUBMED:15182704]
[PUBMED:15182701]
[PUBMED:16554437]
[PUBMED:14691134]
[PUBMED:18550795]
[PUBMED:18096427]
[PUBMED:14517314]
[PUBMED:18311174]
Post NMDA receptor activation events
[NCBI:1268800]
[REACTOME:R-HSA-438064]
[PUBMED:18616423]
Progesterone-mediated oocyte maturation
[NCBI:119304]
[KEGG:hsa04914]
[PUBMED:10497333]
[PUBMED:12084906]
[PUBMED:12045215]
[PUBMED:11063930]
[PUBMED:12477927]
[PUBMED:11148128]
[PUBMED:11730319]
[PUBMED:12374568]
RSK activation
[NCBI:1268803]
[REACTOME:R-HSA-444257]
[PUBMED:18813292]
Recycling pathway of L1
[NCBI:1270324]
[REACTOME:R-HSA-437239]
[PUBMED:10804209]
[PUBMED:11717353]
[PUBMED:14709786]
Senescence-Associated Secretory Phenotype (SASP)
[NCBI:1270431]
[REACTOME:R-HSA-2559582]
[PUBMED:18411265]
[PUBMED:21979375]
[PUBMED:18267069]
[PUBMED:19597488]
[PUBMED:19218920]
[PUBMED:20818427]
[PUBMED:11114305]
[PUBMED:8617720]
[PUBMED:22178396]
[PUBMED:19805069]
[PUBMED:23770676]
[PUBMED:8384717]
[PUBMED:18555777]
[PUBMED:21686281]
[PUBMED:20351173]
[PUBMED:8688489]
[PUBMED:19053174]
[PUBMED:8234276]
[PUBMED:18555778]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[NCBI:1269229]
[REACTOME:R-HSA-975138]
[PUBMED:22511786]
[PUBMED:18794297]
TRIF-mediated TLR3/TLR4 signaling
[NCBI:1269221]
[REACTOME:R-HSA-937061]
[PUBMED:15814722]
[PUBMED:12855817]
[PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade
[NCBI:1269206]
[REACTOME:R-HSA-168142]
[PUBMED:15728506]
[PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade
[NCBI:1269238]
[REACTOME:R-HSA-181438]
[PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade
[NCBI:1269219]
[REACTOME:R-HSA-168164]
[PUBMED:19627256]
[PUBMED:15733829]
[PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade
[NCBI:1269226]
[REACTOME:R-HSA-168176]
[PUBMED:11489966]
[PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade
[NCBI:1269227]
[REACTOME:R-HSA-168181]
[PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade
[NCBI:1269233]
[REACTOME:R-HSA-168138]
[PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade
[NCBI:1269239]
[REACTOME:R-HSA-168179]
[PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade
[NCBI:1269240]
[REACTOME:R-HSA-168188]
[PUBMED:14977973]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Transmission across Chemical Synapses
[NCBI:1268766]
[REACTOME:R-HSA-112315]
mTOR signaling pathway
[NCBI:83059]
[KEGG:hsa04150]
[NCBI:138001]
[Pathway Interaction Database:mtor_4pathway]
[PUBMED:17277771]
[PUBMED:15341740]
[PUBMED:12172553]
[PUBMED:15718470]
[PUBMED:14651849]
[PUBMED:15268862]
[PUBMED:15306821]
[PUBMED:26046644]
[PUBMED:12869586]
[PUBMED:24556838]
[PUBMED:17928295]
[PUBMED:9427642]
[PUBMED:18046414]
[PUBMED:12912918]
[PUBMED:16286006]
[PUBMED:26658722]
[PUBMED:24842496]
[PUBMED:23465396]
[PUBMED:17709744]
[PUBMED:17599906]
[PUBMED:16919458]
[PUBMED:10364159]
[PUBMED:15342917]
[PUBMED:11500364]
[PUBMED:19812304]
[PUBMED:12482958]
[PUBMED:11729323]
[PUBMED:16962653]
[PUBMED:18952604]
[PUBMED:9465032]
[PUBMED:1496022]
[PUBMED:10567431]
[PUBMED:19114562]
[PUBMED:17510057]
[PUBMED:18604198]
[PUBMED:15545625]
[PUBMED:11914378]
[PUBMED:17461779]
[PUBMED:9445476]
[PUBMED:18497260]
[PUBMED:12604610]
[PUBMED:15071500]
[PUBMED:18925875]
[PUBMED:12906785]
[PUBMED:11287630]
[PUBMED:15004009]
[PUBMED:16756488]
[PUBMED:17043309]
[PUBMED:18198340]
[PUBMED:12820960]
[PUBMED:12747827]
[PUBMED:17053147]
[PUBMED:15851026]
[PUBMED:15467718]
[PUBMED:18762023]
[PUBMED:25242279]
[PUBMED:24698685]
[PUBMED:11175345]
[PUBMED:27304501]
[PUBMED:18411301]
[PUBMED:11500365]
[PUBMED:17693255]
[PUBMED:23694989]
[PUBMED:12231510]
[PUBMED:19446321]
[PUBMED:11418588]
[PUBMED:19258318]
[PUBMED:18439900]
[PUBMED:19225151]
[PUBMED:26185979]
[PUBMED:10357815]
[PUBMED:26269525]
[PUBMED:23421405]
[PUBMED:9271440]
[PUBMED:16915281]
[PUBMED:17141160]
[PUBMED:15249583]
[PUBMED:12912989]
[PUBMED:27027448]
[PUBMED:18423201]
[PUBMED:19211835]
[PUBMED:9204908]
[PUBMED:26700098]
[PUBMED:18566587]
[PUBMED:17386266]