full name
DNA polymerase alpha 1, catalytic subunit

synonyms
p180, POLA, POLA1, ENSG00000101868

HGNC
HGNC:9173

Entrez Gene
Gene:5422

ENSEMBL
ENSG00000101868

location
chr: X
start: 24712038
stop: 25015103
strand: +

OMIM
OMIM:312040: POLA1
OMIM:301220: Pigmentary disorder, reticulate, with systemic manifestations, X-linked
OMIM:301030: Van Esch-O'Driscoll syndrome

transcripts
NM_016937.3

pathways
Activation of the pre-replicative complex [NCBI:1269773] [REACTOME:R-HSA-68962] [PUBMED:10402192] [PUBMED:11779870] [PUBMED:10801458] [PUBMED:12169736] [PUBMED:11323433] [PUBMED:9038340] [PUBMED:9765232] [PUBMED:9829972] [PUBMED:10970868] [PUBMED:9353276] [PUBMED:7502077] [PUBMED:11459976] [PUBMED:11395502]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
DNA replication [NCBI:83039] [KEGG:hsa03030] [PUBMED:9759502] [PUBMED:8087839]
DNA replication initiation [NCBI:1269780] [REACTOME:R-HSA-68952] [PUBMED:6693436] [PUBMED:11395402]
DNA strand elongation [NCBI:1269784] [REACTOME:R-HSA-69190] [PUBMED:9081985] [PUBMED:1976634] [PUBMED:7623835] [PUBMED:1536007] [PUBMED:8594377]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12393009] [PUBMED:12726857] [PUBMED:12473340]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:11034215] [PUBMED:8832394] [PUBMED:7479977] [PUBMED:12077144] [PUBMED:11274364] [PUBMED:8618861] [PUBMED:11857079] [PUBMED:7958837] [PUBMED:15014447] [PUBMED:9774682] [PUBMED:9704927] [PUBMED:9271400] [PUBMED:8334989] [PUBMED:16288221] [PUBMED:10766737] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11101847] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9192872] [PUBMED:9778043] [PUBMED:12766778] [PUBMED:15510213] [PUBMED:11418595] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:11904439] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:11719808] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:19491197] [PUBMED:15713665] [PUBMED:16357170] [PUBMED:9689056] [PUBMED:12748276] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:12697828] [PUBMED:12101096] [PUBMED:11799067] [PUBMED:15133492] [PUBMED:16892051] [PUBMED:8943353] [PUBMED:9724731] [PUBMED:10030670] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:18348985] [PUBMED:9020173] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:15306814] [PUBMED:10688648] [PUBMED:12611887] [PUBMED:9191053] [PUBMED:10373518] [PUBMED:10187822]
Extension of Telomeres [NCBI:1269857] [REACTOME:R-HSA-180786] [PUBMED:15189140]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G1/S-Specific Transcription [NCBI:1269772] [REACTOME:R-HSA-69205]
Inhibition of replication initiation of damaged DNA by RB1/E2F1 [NCBI:1269775] [REACTOME:R-HSA-113501]
Lagging Strand Synthesis [NCBI:1269788] [REACTOME:R-HSA-69186] [PUBMED:9081985]
Leading Strand Synthesis [NCBI:1269786] [REACTOME:R-HSA-69109] [PUBMED:2175912] [PUBMED:7378348] [PUBMED:9191022]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Polymerase switching [NCBI:1269787] [REACTOME:R-HSA-69091] [PUBMED:1967833] [PUBMED:1671046] [PUBMED:1670772]
Polymerase switching on the C-strand of the telomere [NCBI:1269861] [REACTOME:R-HSA-174411] [PUBMED:1967833] [PUBMED:1671046] [PUBMED:1670772]
Processive synthesis on the lagging strand [NCBI:1269789] [REACTOME:R-HSA-69183] [PUBMED:1671046]
Purine metabolism [NCBI:82944] [KEGG:hsa00230] [NCBI:1270134] [REACTOME:R-HSA-73847] [PUBMED:4620886] [PUBMED:10986234] [PUBMED:10601204]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
Removal of the Flap Intermediate [NCBI:1269790] [REACTOME:R-HSA-69166] [PUBMED:7926735] [PUBMED:8131753] [PUBMED:7644470]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis [NCBI:1269859] [REACTOME:R-HSA-174417] [PUBMED:15189140]
Telomere C-strand synthesis initiation [NCBI:1269860] [REACTOME:R-HSA-174430] [PUBMED:11327863] [PUBMED:11395402] [PUBMED:6693436]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]