full name
ISG15 ubiquitin-like modifier

synonyms
G1P2, hUCRP, IFI15, IP17, UCRP, ISG15, ENSG00000187608

HGNC
HGNC:4053

Entrez Gene
Gene:9636

ENSEMBL
ENSG00000187608

location
chr: 1
start: 948847
stop: 949920
strand: +

OMIM
OMIM:147571: ISG15 (Autosomal recessive inheritance)
OMIM:616126: Immunodeficiency 38

transcripts
NM_005101.3

pathways
Antiviral mechanism by IFN-stimulated genes [NCBI:1269316] [REACTOME:R-HSA-1169410]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DNA Damage Bypass [NCBI:1270367] [REACTOME:R-HSA-73893] [PUBMED:21605556] [PUBMED:10925197] [PUBMED:11595180] [PUBMED:12800216] [PUBMED:19225445] [PUBMED:25038291]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Host Interactions with Influenza Factors [NCBI:1269130] [REACTOME:R-HSA-168253]
ISG15 antiviral mechanism [NCBI:1269317] [REACTOME:R-HSA-1169408] [PUBMED:20153823] [PUBMED:12582176] [PUBMED:16009940] [PUBMED:20946978] [PUBMED:15970528]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Influenza Infection [NCBI:1269108] [REACTOME:R-HSA-168254]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
Interferon alpha/beta signaling [NCBI:1269312] [REACTOME:R-HSA-909733] [PUBMED:8621447] [PUBMED:8605876] [PUBMED:8702790] [PUBMED:17969444]
NS1 Mediated Effects on Host Pathways [NCBI:1269131] [REACTOME:R-HSA-168276]
Negative regulators of RIG-I/MDA5 signaling [NCBI:1269264] [REACTOME:R-HSA-936440] [PUBMED:18703349] [PUBMED:18549796]
RIG-I-like receptor signaling pathway [NCBI:117292] [KEGG:hsa04622] [PUBMED:19224920] [PUBMED:19076341] [PUBMED:18549796] [PUBMED:18591413] [PUBMED:19615405] [PUBMED:19120475] [PUBMED:18439848] [PUBMED:19120476] [PUBMED:15208624] [PUBMED:19539500] [PUBMED:18272355] [PUBMED:18984593]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways [NCBI:1269259] [REACTOME:R-HSA-168928] [PUBMED:17395582] [PUBMED:17942531] [PUBMED:18701081] [PUBMED:17683970] [PUBMED:18989317] [PUBMED:16214811]
Termination of translesion DNA synthesis [NCBI:1270374] [REACTOME:R-HSA-5656169] [PUBMED:24768535] [PUBMED:23000965]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template [NCBI:1270369] [REACTOME:R-HSA-110313] [PUBMED:10583946] [PUBMED:10856253] [PUBMED:24716551]