full name
monoamine oxidase A

synonyms
MAO-A, MAOA, ENSG00000189221

HGNC
HGNC:6833

Entrez Gene
Gene:4128

ENSEMBL
ENSG00000189221

location
chr: X
start: 43514155
stop: 43606071
strand: +

OMIM
OMIM:309850: MAOA (X-linked inheritance)
OMIM:300615: Brunner syndrome
OMIM:300615: {Antisocial behavior}

transcripts
NM_001270458.1
NM_000240.3

pathways
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Amine Oxidase reactions [NCBI:1270203] [REACTOME:R-HSA-140179] [PUBMED:9443166] [PUBMED:11468017]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:16776597] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:18632938] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:10774721] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:16151049] [PUBMED:18440072] [PUBMED:19199083] [PUBMED:10414964]
Arginine and proline metabolism [NCBI:82957] [KEGG:hsa00330] [PUBMED:15590624] [PUBMED:5288244] [PUBMED:16499623]
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB [NCBI:1270204] [REACTOME:R-HSA-141333] [PUBMED:9443166] [PUBMED:11468017]
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
Cocaine addiction [NCBI:546258] [KEGG:hsa05030] [PUBMED:15091342] [PUBMED:16278489] [PUBMED:14566342] [PUBMED:12064476] [PUBMED:16251986] [PUBMED:18440072] [PUBMED:19403004] [PUBMED:11595774] [PUBMED:11268215] [PUBMED:15582154] [PUBMED:12818179] [PUBMED:14746512] [PUBMED:10234039]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Dopamine clearance from the synaptic cleft [NCBI:1268779] [REACTOME:R-HSA-379401]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Drug metabolism - cytochrome P450 [NCBI:83032] [KEGG:hsa00982] [PUBMED:16550168] [PUBMED:10575324] [PUBMED:11226815] [PUBMED:16393888] [PUBMED:12399158] [PUBMED:11504799] [PUBMED:16038189] [PUBMED:10901707] [PUBMED:18043895] [PUBMED:18463198] [PUBMED:9698084] [PUBMED:12386121] [PUBMED:10859160]
Enzymatic degradation of Dopamine by monoamine oxidase [NCBI:1268781] [REACTOME:R-HSA-379398]
Enzymatic degradation of dopamine by COMT [NCBI:1268780] [REACTOME:R-HSA-379397] [PUBMED:17185601]
GABA biosynthesis, eukaryotes, putrescine => GABA [NCBI:413399] [KEGG:hsa_M00135]
Glycine, serine and threonine metabolism [NCBI:82949] [KEGG:hsa00260] [PUBMED:7639721] [PUBMED:15520012] [PUBMED:11823218] [PUBMED:15470257] [PUBMED:10473374] [PUBMED:16707670] [PUBMED:17636255] [PUBMED:11341914]
Histidine metabolism [NCBI:82958] [KEGG:hsa00340]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interleukin-4 and 13 signaling [NCBI:1470923] [REACTOME:R-HSA-6785807] [PUBMED:12704343] [PUBMED:10358772]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of serotonin [NCBI:1268783] [REACTOME:R-HSA-380612]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Clearance In The Synaptic Cleft [NCBI:1268778] [REACTOME:R-HSA-112311]
Neurotransmitter Release Cycle [NCBI:1268768] [REACTOME:R-HSA-112310] [PUBMED:15217342] [PUBMED:16819626] [PUBMED:17880890] [PUBMED:16865347]
Norepinephrine Neurotransmitter Release Cycle [NCBI:1268769] [REACTOME:R-HSA-181430] [PUBMED:17891149] [PUBMED:17478680] [PUBMED:12519779]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
Phenylalanine metabolism [NCBI:82960] [KEGG:hsa00360] [PUBMED:19016485] [PUBMED:10537203] [PUBMED:20660314] [PUBMED:9098055] [PUBMED:9603882]
Serotonergic synapse [NCBI:525336] [KEGG:hsa04726] [PUBMED:9658404] [PUBMED:15034221] [PUBMED:11043573] [PUBMED:9651340] [PUBMED:9542727] [PUBMED:18676031] [PUBMED:12543273] [PUBMED:15710402] [PUBMED:16826372] [PUBMED:19545642] [PUBMED:11916537] [PUBMED:11701344] [PUBMED:12676358] [PUBMED:20561690] [PUBMED:16896947]
Serotonin clearance from the synaptic cleft [NCBI:1268782] [REACTOME:R-HSA-380615]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
Tryptophan metabolism [NCBI:82964] [KEGG:hsa00380] [PUBMED:15749753]
Tyrosine metabolism [NCBI:82959] [KEGG:hsa00350] [PUBMED:8550403] [PUBMED:1194238] [PUBMED:11171088] [PUBMED:18435614]
dopamine degradation [NCBI:142324] [BIOCYC:HUMAN_PWY6666-2] [PUBMED:10404831] [PUBMED:15317907] [PUBMED:7034733] [PUBMED:13575440] [PUBMED:9360553]
melatonin degradation II [NCBI:545357] [BIOCYC:HUMAN_PWY-6399] [PUBMED:12662344] [PUBMED:16793870] [PUBMED:9181522] [PUBMED:11485009] [PUBMED:15981996] [PUBMED:18155917] [PUBMED:18344019] [PUBMED:12899443] [PUBMED:8436983] [PUBMED:7396831] [PUBMED:15677341] [PUBMED:17198536] [PUBMED:16219483] [PUBMED:16217127]
noradrenaline and adrenaline degradation [NCBI:545354] [BIOCYC:HUMAN_PWY-6342] [PUBMED:9360553] [PUBMED:12649306] [PUBMED:3466164] [PUBMED:3996536] [PUBMED:15317907]
putrescine degradation III [NCBI:545337] [BIOCYC:HUMAN_PWY-0] [PUBMED:2185470] [PUBMED:3157043] [PUBMED:4873311] [PUBMED:8223591] [PUBMED:4156831] [PUBMED:1409623]
serotonin degradation [NCBI:545353] [BIOCYC:HUMAN_PWY-6313] [PUBMED:14678785] [PUBMED:17908235] [PUBMED:12231396] [PUBMED:12899690] [PUBMED:19264685] [PUBMED:16537538] [PUBMED:3459671] [PUBMED:17877637] [PUBMED:7752817] [PUBMED:18651566] [PUBMED:15677341]
superpathway of melatonin degradation [NCBI:545359] [BIOCYC:HUMAN_PWY-6402]
superpathway of tryptophan utilization [NCBI:835392] [BIOCYC:HUMAN_PWY66-401]