full name
porcupine O-acyltransferase

synonyms
DHOF, FODH, MG61, por, PORC, PPN, PORCN, ENSG00000102312

HGNC
HGNC:17652

Entrez Gene
Gene:64840

ENSEMBL
ENSG00000102312
ENSG00000268138

location
chr: X
start: 48367347
stop: 48379202
strand: +

OMIM
OMIM:300651: PORCN (X-linked dominant inheritance)
OMIM:305600: Focal dermal hypoplasia

transcripts
NM_203473.1
NM_022825.2
NM_203475.1
NM_203474.1

pathways
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by WNT in cancer [NCBI:1268906] [REACTOME:R-HSA-4791275] [PUBMED:7749328] [PUBMED:6318122] [PUBMED:22438566] [PUBMED:17510365] [PUBMED:10700176] [PUBMED:10733430] [PUBMED:17143297] [PUBMED:18311776] [PUBMED:11375957]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
WNT ligand biogenesis and trafficking [NCBI:1269595] [REACTOME:R-HSA-3238698] [PUBMED:19837038] [PUBMED:22653731] [PUBMED:16678096] [PUBMED:21725318] [PUBMED:17141155] [PUBMED:21768372] [PUBMED:22983114] [PUBMED:22952392] [PUBMED:23256519] [PUBMED:17108000] [PUBMED:21554866] [PUBMED:22796206] [PUBMED:16678095] [PUBMED:23260141]
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 [NCBI:1268926] [REACTOME:R-HSA-5340573] [PUBMED:21486121] [PUBMED:24277854] [PUBMED:19619488] [PUBMED:22438566] [PUBMED:10921899]
Wnt signaling pathway [NCBI:83061] [KEGG:hsa04310] [PUBMED:12446114] [PUBMED:14745971] [PUBMED:14530294] [PUBMED:15102436] [PUBMED:14635791] [PUBMED:19482104] [PUBMED:23256519] [PUBMED:12967557] [PUBMED:11433294] [PUBMED:18838381]