full name
ribonucleotide reductase regulatory subunit M2

synonyms
R2, RR2, RR2M, RRM2, ENSG00000171848

HGNC
HGNC:10452

Entrez Gene
Gene:6241

ENSEMBL
ENSG00000171848

location
chr: 2
start: 10262695
stop: 10271546
strand: +

transcripts
NM_001165931.1
NM_001034.3

pathways
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12393009] [PUBMED:12726857] [PUBMED:12473340]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:11034215] [PUBMED:8832394] [PUBMED:7479977] [PUBMED:12077144] [PUBMED:11274364] [PUBMED:8618861] [PUBMED:11857079] [PUBMED:7958837] [PUBMED:15014447] [PUBMED:9774682] [PUBMED:9704927] [PUBMED:9271400] [PUBMED:8334989] [PUBMED:16288221] [PUBMED:10766737] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11101847] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9192872] [PUBMED:9778043] [PUBMED:12766778] [PUBMED:15510213] [PUBMED:11418595] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:11904439] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:11719808] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:19491197] [PUBMED:15713665] [PUBMED:16357170] [PUBMED:9689056] [PUBMED:12748276] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:12697828] [PUBMED:12101096] [PUBMED:11799067] [PUBMED:15133492] [PUBMED:16892051] [PUBMED:8943353] [PUBMED:9724731] [PUBMED:10030670] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:18348985] [PUBMED:9020173] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:15306814] [PUBMED:10688648] [PUBMED:12611887] [PUBMED:9191053] [PUBMED:10373518] [PUBMED:10187822]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G1/S-Specific Transcription [NCBI:1269772] [REACTOME:R-HSA-69205]
Glutathione metabolism [NCBI:82973] [KEGG:hsa00480] [PUBMED:18395526] [PUBMED:15537651] [PUBMED:12466271] [PUBMED:9677355] [PUBMED:11157967] [PUBMED:12675513] [PUBMED:18482986] [PUBMED:8892297] [PUBMED:12751784] [PUBMED:12750367] [PUBMED:14982633] [PUBMED:11150302] [PUBMED:12121990] [PUBMED:15610825] [PUBMED:17922848] [PUBMED:12049631] [PUBMED:12949079] [PUBMED:7813456] [PUBMED:9851611] [PUBMED:6798961] [PUBMED:10713147] [PUBMED:12967709] [PUBMED:14583094] [PUBMED:12446213]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of nucleotides [NCBI:1270133] [REACTOME:R-HSA-15869] [PUBMED:17266529] [PUBMED:8283301] [PUBMED:20494131]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Purine metabolism [NCBI:82944] [KEGG:hsa00230] [NCBI:1270134] [REACTOME:R-HSA-73847] [PUBMED:4620886] [PUBMED:10986234] [PUBMED:10601204]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
Synthesis and interconversion of nucleotide di- and triphosphates [NCBI:1270142] [REACTOME:R-HSA-499943] [PUBMED:177353] [PUBMED:11008000] [PUBMED:5940]
adenosine deoxyribonucleotides de novo biosynthesis [NCBI:835388] [BIOCYC:HUMAN_PWY-7227]
guanosine deoxyribonucleotides de novo biosynthesis [NCBI:835387] [BIOCYC:HUMAN_PWY-7226]
guanosine nucleotides de novo biosynthesis [NCBI:907941] [BIOCYC:HUMAN_PWY-7228] [PUBMED:2404765]
p53 signaling pathway [NCBI:83055] [KEGG:hsa04115] [PUBMED:16557269] [PUBMED:10714958] [PUBMED:12505356] [PUBMED:16915296] [PUBMED:16697662] [PUBMED:15116721] [PUBMED:11313928] [PUBMED:11747320] [PUBMED:17409411] [PUBMED:15838523]
purine nucleotides de novo biosynthesis [NCBI:142277] [BIOCYC:HUMAN_PWY-841] [PUBMED:23575936] [PUBMED:22955281] [PUBMED:18365665] [PUBMED:20575936] [PUBMED:20157113] [PUBMED:18712276] [PUBMED:23359685] [PUBMED:8938402] [PUBMED:20615962] [PUBMED:18388293]
pyrimidine deoxyribonucleotides biosynthesis from CTP [NCBI:782381] [BIOCYC:HUMAN_PWY-7210]
pyrimidine deoxyribonucleotides de novo biosynthesis [NCBI:782380] [BIOCYC:HUMAN_PWY-7184]
superpathway of purine nucleotide salvage [NCBI:907942] [BIOCYC:HUMAN_PWY66-409] [PUBMED:18712276] [PUBMED:18365665] [PUBMED:16176880] [PUBMED:23575936] [PUBMED:1301916]
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis [NCBI:782390] [BIOCYC:HUMAN_PWY-7211] [PUBMED:9042911] [PUBMED:2767686] [PUBMED:6893554] [PUBMED:3279416] [PUBMED:6574608]