full name
CD40 ligand
synonyms
CD154, CD40L, gp39, hCD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, CD40LG, ENSG00000102245
HGNC
HGNC:11935
Entrez Gene
Gene:959
ENSEMBL
ENSG00000102245
location
chr: X
start: 135730281
stop: 135742549
strand: +
OMIM
OMIM:300386:
CD40LG
(X-linked recessive inheritance)
OMIM:308230:
Immunodeficiency, X-linked, with hyper-IgM
transcripts
NM_000074.2
pathways
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Allograft rejection
[NCBI:83123]
[KEGG:hsa05330]
[PUBMED:8835634]
[PUBMED:12023610]
[PUBMED:12563298]
[PUBMED:17445565]
[PUBMED:12216939]
[PUBMED:14710779]
[PUBMED:10746853]
[PUBMED:10571983]
[PUBMED:10331992]
[PUBMED:10667806]
Asthma
[NCBI:83120]
[KEGG:hsa05310]
[PUBMED:11686879]
[PUBMED:17364144]
[PUBMED:10811837]
[PUBMED:11477111]
[PUBMED:18274559]
[PUBMED:11172168]
[PUBMED:18274560]
[PUBMED:10719286]
[PUBMED:12093011]
[PUBMED:17976144]
[PUBMED:17133123]
Autoimmune thyroid disease
[NCBI:83121]
[KEGG:hsa05320]
[PUBMED:15132715]
[PUBMED:12192541]
[PUBMED:17192582]
[PUBMED:9534029]
[PUBMED:11396701]
[PUBMED:11913070]
[PUBMED:15049952]
[PUBMED:11577986]
[PUBMED:15762980]
CD40/CD40L signaling
[NCBI:138061]
[Pathway Interaction Database:cd40_pathway]
[PUBMED:11967542]
[PUBMED:11304555]
[PUBMED:11714736]
[PUBMED:17878343]
[PUBMED:12354380]
[PUBMED:11406619]
[PUBMED:9133417]
[PUBMED:7527023]
[PUBMED:18997794]
[PUBMED:1374165]
[PUBMED:1385114]
[PUBMED:12958312]
[PUBMED:10764746]
[PUBMED:11909853]
[PUBMED:10318845]
[PUBMED:7533327]
[PUBMED:16260598]
[PUBMED:18997792]
[PUBMED:12818164]
[PUBMED:10748139]
[PUBMED:9718306]
[PUBMED:10395671]
[PUBMED:17878362]
[PUBMED:7544915]
[PUBMED:12370254]
[PUBMED:8910514]
[PUBMED:17143273]
[PUBMED:10433725]
[PUBMED:14981114]
[PUBMED:16622006]
[PUBMED:12122011]
[PUBMED:12133933]
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
[NCBI:137993]
[Pathway Interaction Database:nfat_tfpathway]
[PUBMED:11254715]
[PUBMED:11356833]
[PUBMED:12121669]
[PUBMED:10878360]
[PUBMED:11786533]
[PUBMED:8284217]
[PUBMED:10816557]
[PUBMED:11956291]
[PUBMED:7510691]
[PUBMED:9195954]
[PUBMED:8240350]
[PUBMED:12452838]
[PUBMED:8623163]
[PUBMED:15834410]
[PUBMED:10894164]
[PUBMED:10970869]
[PUBMED:10755616]
[PUBMED:14607827]
[PUBMED:12705856]
[PUBMED:12086671]
[PUBMED:7982959]
[PUBMED:9047239]
[PUBMED:12374808]
[PUBMED:14573767]
[PUBMED:12560487]
[PUBMED:10570264]
[PUBMED:8397339]
[PUBMED:12055628]
[PUBMED:15308098]
[PUBMED:12065418]
[PUBMED:7891702]
[PUBMED:7749982]
[PUBMED:14973438]
[PUBMED:8674125]
[PUBMED:16873067]
[PUBMED:12453415]
[PUBMED:8441422]
[PUBMED:1737937]
[PUBMED:10671476]
[PUBMED:8376940]
[PUBMED:9545284]
Calcium signaling in the CD4+ TCR pathway
[NCBI:137941]
[Pathway Interaction Database:tcrcalciumpathway]
[PUBMED:8284217]
[PUBMED:10816557]
[PUBMED:10970869]
[PUBMED:8240350]
[PUBMED:8623163]
[PUBMED:1715244]
[PUBMED:1715516]
[PUBMED:16406492]
[PUBMED:9655484]
[PUBMED:8397339]
[PUBMED:10861295]
[PUBMED:9047239]
[PUBMED:293720]
[PUBMED:7891702]
[PUBMED:12925851]
[PUBMED:9660798]
[PUBMED:1377362]
[PUBMED:12065418]
[PUBMED:8441422]
[PUBMED:7528941]
[PUBMED:1737937]
[PUBMED:12809556]
[PUBMED:9545284]
[PUBMED:11254715]
[PUBMED:10878360]
[PUBMED:10593895]
Cell adhesion molecules (CAMs)
[NCBI:83069]
[KEGG:hsa04514]
[PUBMED:15923648]
[PUBMED:12500939]
[PUBMED:15056568]
[PUBMED:14519386]
[PUBMED:12234363]
[PUBMED:10964748]
[PUBMED:15071551]
[PUBMED:15551862]
[PUBMED:14690046]
[PUBMED:9150551]
[PUBMED:14519398]
[PUBMED:14556710]
[PUBMED:11860281]
[PUBMED:10664064]
[PUBMED:9597126]
[PUBMED:11050419]
[PUBMED:12367625]
[PUBMED:10798271]
[PUBMED:16034094]
[PUBMED:15115723]
[PUBMED:15728677]
[PUBMED:11910893]
[PUBMED:15561584]
[PUBMED:15882774]
[PUBMED:12810109]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Cytokine-cytokine receptor interaction
[NCBI:83051]
[KEGG:hsa04060]
[PUBMED:11071910]
[PUBMED:12072446]
[PUBMED:7791754]
[PUBMED:15032600]
[PUBMED:12651226]
[PUBMED:11252892]
[PUBMED:11796220]
[PUBMED:11312110]
[PUBMED:9862719]
[PUBMED:12421671]
[PUBMED:12039028]
[PUBMED:9759503]
[PUBMED:9395284]
[PUBMED:11166270]
[PUBMED:10714678]
[PUBMED:12651221]
IL4-mediated signaling events
[NCBI:137933]
[Pathway Interaction Database:il4_2pathway]
[PUBMED:8602263]
[PUBMED:15199062]
[PUBMED:7705411]
[PUBMED:11160325]
[PUBMED:8557643]
[PUBMED:8134361]
[PUBMED:1948049]
[PUBMED:10843732]
[PUBMED:11034397]
[PUBMED:8624802]
[PUBMED:14557412]
[PUBMED:1997653]
[PUBMED:10586089]
[PUBMED:14634100]
[PUBMED:17541284]
[PUBMED:8124718]
[PUBMED:16210622]
[PUBMED:7822337]
[PUBMED:11572871]
[PUBMED:2147202]
[PUBMED:10228008]
[PUBMED:7675087]
[PUBMED:12574343]
[PUBMED:14603527]
[PUBMED:15659391]
[PUBMED:11160269]
[PUBMED:7760829]
[PUBMED:7973658]
[PUBMED:10072514]
[PUBMED:9013879]
[PUBMED:8624803]
[PUBMED:10490661]
[PUBMED:14978013]
[PUBMED:10364072]
[PUBMED:12459556]
[PUBMED:11714803]
[PUBMED:8602264]
[PUBMED:9811885]
[PUBMED:12776189]
[PUBMED:15728454]
[PUBMED:10601358]
[PUBMED:11739727]
[PUBMED:11160275]
[PUBMED:9852037]
[PUBMED:9670964]
[PUBMED:15004182]
[PUBMED:8266078]
[PUBMED:3144043]
[PUBMED:8992992]
[PUBMED:8089482]
[PUBMED:9651359]
[PUBMED:16810739]
[PUBMED:7499365]
[PUBMED:7721786]
[PUBMED:9065461]
[PUBMED:11241672]
[PUBMED:10950967]
[PUBMED:8810328]
[PUBMED:8624821]
[PUBMED:9110977]
[PUBMED:8609418]
[PUBMED:15187136]
[PUBMED:9414268]
[PUBMED:8916957]
[PUBMED:10201892]
[PUBMED:17200144]
[PUBMED:8458387]
[PUBMED:11544308]
[PUBMED:10657944]
[PUBMED:15153491]
[PUBMED:7544011]
[PUBMED:8266076]
[PUBMED:11801631]
[PUBMED:12044779]
[PUBMED:8621475]
[PUBMED:9697832]
[PUBMED:12242343]
[PUBMED:7694370]
[PUBMED:9380721]
[PUBMED:9541585]
[PUBMED:7807002]
[PUBMED:16537510]
[PUBMED:8258319]
[PUBMED:9799097]
[PUBMED:12023955]
[PUBMED:8085155]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
[NCBI:1269201]
[REACTOME:R-HSA-198933]
[PUBMED:17218381]
[PUBMED:16603343]
[PUBMED:16616474]
[PUBMED:11244041]
[PUBMED:16132082]
[PUBMED:18425107]
Intestinal immune network for IgA production
[NCBI:128760]
[KEGG:hsa04672]
[PUBMED:18483500]
[PUBMED:18838301]
[PUBMED:15971106]
[PUBMED:18243016]
[PUBMED:19079167]
[PUBMED:18549797]
[PUBMED:19079156]
[PUBMED:17161619]
[PUBMED:17182536]
[PUBMED:12511876]
Malaria
[NCBI:152665]
[KEGG:hsa05144]
[PUBMED:15106591]
[PUBMED:11224682]
[PUBMED:17630968]
[PUBMED:18250459]
[PUBMED:16138104]
[PUBMED:20091081]
[PUBMED:8920859]
[PUBMED:19101208]
[PUBMED:16019257]
[PUBMED:15464448]
[PUBMED:11832955]
[PUBMED:12364790]
[PUBMED:10885986]
[PUBMED:15094163]
[PUBMED:14737184]
[PUBMED:15463497]
[PUBMED:16468982]
[PUBMED:19967139]
NF-kappa B signaling pathway
[NCBI:634527]
[KEGG:hsa04064]
[PUBMED:22119011]
[PUBMED:16264088]
[PUBMED:21187855]
[PUBMED:15546385]
[PUBMED:17607554]
[PUBMED:21135871]
[PUBMED:16984817]
[PUBMED:17047224]
[PUBMED:19203223]
[PUBMED:20300215]
[PUBMED:14657271]
[PUBMED:17431096]
[PUBMED:15134788]
[PUBMED:16356770]
[PUBMED:21772278]
[PUBMED:12654254]
[PUBMED:22390971]
[PUBMED:22017435]
[PUBMED:17183360]
[PUBMED:21173796]
[PUBMED:15905862]
[PUBMED:19302050]
[PUBMED:17098202]
[PUBMED:21872579]
[PUBMED:22152226]
[PUBMED:18613837]
[PUBMED:19489733]
[PUBMED:11875461]
[PUBMED:19726767]
[PUBMED:22017430]
[PUBMED:21232019]
[PUBMED:18832076]
Primary immunodeficiency
[NCBI:83125]
[KEGG:hsa05340]
[PUBMED:11941303]
[PUBMED:18093537]
[PUBMED:11058677]
[PUBMED:17952897]
[PUBMED:14699405]
[PUBMED:15661024]
[PUBMED:14647478]
[PUBMED:17960151]
[PUBMED:16261175]
Systemic lupus erythematosus
[NCBI:83122]
[KEGG:hsa05322]
[PUBMED:12835292]
[PUBMED:12965173]
[PUBMED:16932712]
[PUBMED:10025913]
[PUBMED:15972354]
[PUBMED:17943287]
[PUBMED:10430616]
[PUBMED:18305268]
[PUBMED:15380523]
[PUBMED:8048228]
[PUBMED:15459673]
T cell receptor signaling pathway
[NCBI:83080]
[KEGG:hsa04660]
[PUBMED:17395537]
[PUBMED:15308211]
[PUBMED:15928679]
[PUBMED:14656980]
[PUBMED:17187070]
[PUBMED:15084594]
[PUBMED:16799472]
[PUBMED:12669022]
[PUBMED:15286727]
[PUBMED:15122199]
[PUBMED:19132916]
[PUBMED:15489916]
[PUBMED:11905831]
[PUBMED:12195013]
[PUBMED:15343367]
[PUBMED:12133805]
[PUBMED:14647476]
[PUBMED:15771581]
[PUBMED:15099566]
[PUBMED:14617194]
[PUBMED:19290929]
[PUBMED:15345216]
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
[NCBI:1269330]
[REACTOME:R-HSA-5676594]
[PUBMED:18997794]
[PUBMED:21173796]
[PUBMED:22017430]
TNFR2 non-canonical NF-kB pathway
[NCBI:1269329]
[REACTOME:R-HSA-5668541]
[PUBMED:19680262]
[PUBMED:24298274]
[PUBMED:21173796]
[PUBMED:20489699]
[PUBMED:24432023]
[PUBMED:21232019]
[PUBMED:22017430]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Viral myocarditis
[NCBI:125138]
[KEGG:hsa05416]
[PUBMED:19357408]
[PUBMED:18545064]
[PUBMED:18357777]
[PUBMED:11524405]
[PUBMED:12920582]
[PUBMED:14522402]
[PUBMED:17200452]
[PUBMED:18039131]
[PUBMED:16413486]
[PUBMED:12439638]
[PUBMED:16817756]
[PUBMED:16845885]
[PUBMED:10051305]
[PUBMED:10904843]