full name
interleukin 1 receptor associated kinase 1

synonyms
IRAK, pelle, IRAK1, ENSG00000184216

HGNC
HGNC:6112

Entrez Gene
Gene:3654

ENSEMBL
ENSG00000184216
ENSG00000268944

location
chr: X
start: 153275957
stop: 153285342
strand: -

transcripts
NM_001025243.1
NM_001025242.1
NM_001569.3

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Chagas disease (American trypanosomiasis) [NCBI:147809] [KEGG:hsa05142] [PUBMED:12377585] [PUBMED:9794425] [PUBMED:1717552] [PUBMED:16238097] [PUBMED:10066513] [PUBMED:12874238] [PUBMED:12036740] [PUBMED:15917295] [PUBMED:12055254] [PUBMED:17651955] [PUBMED:1396957] [PUBMED:16175174] [PUBMED:2194668] [PUBMED:9190942] [PUBMED:12377942] [PUBMED:12427093] [PUBMED:10234174] [PUBMED:16030288] [PUBMED:15223603] [PUBMED:17110955]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
IL1-mediated signaling events [NCBI:137944] [Pathway Interaction Database:il1pathway] [PUBMED:10854325] [PUBMED:11287640] [PUBMED:10747026] [PUBMED:11960013] [PUBMED:12150927] [PUBMED:1837145] [PUBMED:17197697] [PUBMED:9374458] [PUBMED:12721283] [PUBMED:8035875] [PUBMED:9261174] [PUBMED:9734363] [PUBMED:11460167] [PUBMED:7878046] [PUBMED:10373529] [PUBMED:2530587] [PUBMED:12538665] [PUBMED:10882101] [PUBMED:9360994] [PUBMED:9062194] [PUBMED:12242293] [PUBMED:8837778] [PUBMED:9430229] [PUBMED:7775431]
IRAK1 recruits IKK complex [NCBI:1269208] [REACTOME:R-HSA-937039] [PUBMED:14625308] [PUBMED:12856330] [PUBMED:16477006] [PUBMED:15767370] [PUBMED:18347055] [PUBMED:15695821] [PUBMED:14661019] [PUBMED:18276832]
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation [NCBI:1269230] [REACTOME:R-HSA-975144] [PUBMED:16477006] [PUBMED:15767370] [PUBMED:18347055] [PUBMED:15695821] [PUBMED:14661019] [PUBMED:18276832] [PUBMED:14625308] [PUBMED:12856330]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Interleukin-1 signaling [NCBI:1269320] [REACTOME:R-HSA-446652] [PUBMED:19302047] [PUBMED:19022706]
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 [NCBI:1269212] [REACTOME:R-HSA-450321] [PUBMED:15837794] [PUBMED:11460167]
Leishmaniasis [NCBI:144181] [KEGG:hsa05140] [PUBMED:11890722] [PUBMED:7916951] [PUBMED:10417174] [PUBMED:11298294] [PUBMED:10586030] [PUBMED:15322192] [PUBMED:15831826] [PUBMED:11728310] [PUBMED:15039466] [PUBMED:10462516] [PUBMED:10608501] [PUBMED:15721837] [PUBMED:15639739] [PUBMED:14762510] [PUBMED:18793215] [PUBMED:7591091] [PUBMED:12438359] [PUBMED:18070909] [PUBMED:17543969] [PUBMED:15983048] [PUBMED:16848789] [PUBMED:10770277] [PUBMED:9504340]
MAP kinase activation in TLR cascade [NCBI:1269211] [REACTOME:R-HSA-450294] [PUBMED:17637696] [PUBMED:11861597] [PUBMED:19196711] [PUBMED:11242034]
Measles [NCBI:213306] [KEGG:hsa05162] [PUBMED:16237742] [PUBMED:12804771] [PUBMED:19198562] [PUBMED:20376484] [PUBMED:11385511] [PUBMED:16963735] [PUBMED:19198566] [PUBMED:18922877] [PUBMED:19203114] [PUBMED:12620806] [PUBMED:16690907] [PUBMED:17720800] [PUBMED:20636817] [PUBMED:12410527] [PUBMED:11582511] [PUBMED:19203109] [PUBMED:19203113] [PUBMED:14585342] [PUBMED:12805463]
MyD88 cascade initiated on plasma membrane [NCBI:1269207] [REACTOME:R-HSA-975871] [PUBMED:15728506] [PUBMED:16239509]
MyD88 dependent cascade initiated on endosome [NCBI:1269228] [REACTOME:R-HSA-975155] [PUBMED:20237413] [PUBMED:15276183] [PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
NF-kB is activated and signals survival [NCBI:1269454] [REACTOME:R-HSA-209560] [PUBMED:16187223]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
NOD1/2 Signaling Pathway [NCBI:1269252] [REACTOME:R-HSA-168638] [PUBMED:18928408] [PUBMED:18585455] [PUBMED:18414735]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways [NCBI:1269251] [REACTOME:R-HSA-168643] [PUBMED:18928408]
Pertussis [NCBI:218111] [KEGG:hsa05133] [PUBMED:20610650] [PUBMED:12701623] [PUBMED:15201703] [PUBMED:18401006] [PUBMED:20210554] [PUBMED:16622221] [PUBMED:17148436] [PUBMED:21204863] [PUBMED:20404851] [PUBMED:10540218] [PUBMED:16999837] [PUBMED:16481212] [PUBMED:16863919] [PUBMED:16390441] [PUBMED:21423776] [PUBMED:17328678] [PUBMED:12915094]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex [NCBI:1269210] [REACTOME:R-HSA-445989] [PUBMED:15837794] [PUBMED:11460167]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling [NCBI:1269232] [REACTOME:R-HSA-975110] [PUBMED:16214811] [PUBMED:11070172]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [NCBI:1269229] [REACTOME:R-HSA-975138] [PUBMED:22511786] [PUBMED:18794297]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade [NCBI:1269206] [REACTOME:R-HSA-168142] [PUBMED:15728506] [PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade [NCBI:1269226] [REACTOME:R-HSA-168176] [PUBMED:11489966] [PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade [NCBI:1269227] [REACTOME:R-HSA-168181] [PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade [NCBI:1269233] [REACTOME:R-HSA-168138] [PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Toll-like receptor signaling pathway [NCBI:83076] [KEGG:hsa04620] [PUBMED:16924467] [PUBMED:17395581] [PUBMED:17637696] [PUBMED:12734364] [PUBMED:17507094] [PUBMED:14698224] [PUBMED:11101877] [PUBMED:16497588] [PUBMED:14751764] [PUBMED:17275323] [PUBMED:17457343] [PUBMED:16932750]
Toxoplasmosis [NCBI:169642] [KEGG:hsa05145] [PUBMED:18617274] [PUBMED:19400868] [PUBMED:17024357] [PUBMED:19744886] [PUBMED:19891610] [PUBMED:17110955] [PUBMED:12106793] [PUBMED:12580944] [PUBMED:12857995] [PUBMED:10234174] [PUBMED:18327664] [PUBMED:10525166] [PUBMED:18059289] [PUBMED:18775432] [PUBMED:14642303] [PUBMED:15361242] [PUBMED:16339966] [PUBMED:14987366] [PUBMED:15639739]
Tuberculosis [NCBI:213780] [KEGG:hsa05152] [PUBMED:20199890] [PUBMED:21274449] [PUBMED:17359235] [PUBMED:20415982] [PUBMED:18541216] [PUBMED:19369951] [PUBMED:15083155] [PUBMED:11378475] [PUBMED:15228522] [PUBMED:19634703] [PUBMED:21274433] [PUBMED:19563525] [PUBMED:18407066] [PUBMED:18288961] [PUBMED:16200082] [PUBMED:17785780] [PUBMED:11932234]
activated TAK1 mediates p38 MAPK activation [NCBI:1269213] [REACTOME:R-HSA-450302] [PUBMED:10878576] [PUBMED:8533096] [PUBMED:15837794]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]
p75(NTR)-mediated signaling [NCBI:138019] [Pathway Interaction Database:p75ntrpathway] [PUBMED:14673001] [PUBMED:14593116] [PUBMED:10545116] [PUBMED:11729324] [PUBMED:16252010] [PUBMED:11756426] [PUBMED:12414813] [PUBMED:2157470] [PUBMED:11777929] [PUBMED:1547788] [PUBMED:10764727] [PUBMED:8614802] [PUBMED:14960584] [PUBMED:12376548] [PUBMED:11756498] [PUBMED:8079174] [PUBMED:16498402] [PUBMED:15051733] [PUBMED:12682012] [PUBMED:14638693] [PUBMED:14966521] [PUBMED:9915784] [PUBMED:11487608] [PUBMED:10485890] [PUBMED:16630834] [PUBMED:11312266] [PUBMED:10985348] [PUBMED:11244088] [PUBMED:6093111] [PUBMED:10595511] [PUBMED:14985763] [PUBMED:12097334] [PUBMED:15548667] [PUBMED:15470142] [PUBMED:11279271] [PUBMED:8878481] [PUBMED:12422217] [PUBMED:15987945] [PUBMED:15668238] [PUBMED:10433815] [PUBMED:12692556] [PUBMED:2025430] [PUBMED:15930396] [PUBMED:11278287] [PUBMED:12034707]
p75NTR recruits signalling complexes [NCBI:1269453] [REACTOME:R-HSA-209543]
p75NTR signals via NF-kB [NCBI:1269452] [REACTOME:R-HSA-193639] [PUBMED:16997282]