full name
succinate dehydrogenase complex iron sulfur subunit B

synonyms
CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, SDHB, ENSG00000117118

HGNC
HGNC:10681

Entrez Gene
Gene:6390

ENSEMBL
ENSG00000117118

location
chr: 1
start: 17345217
stop: 17380665
strand: -

OMIM
OMIM:185470: SDHB (Autosomal dominant inheritance)
OMIM:612359: Cowden syndrome 2
OMIM:606764: Gastrointestinal stromal tumor
OMIM:606864: Paraganglioma and gastric stromal sarcoma
OMIM:115310: Paragangliomas 4
OMIM:171300: Pheochromocytoma

transcripts
NM_003000.2

pathways
Alzheimer's disease [NCBI:83097] [KEGG:hsa05010] [PUBMED:18782350] [PUBMED:18035450] [PUBMED:10527810] [PUBMED:16677790] [PUBMED:15295589] [PUBMED:15363492] [PUBMED:15750290] [PUBMED:15864339] [PUBMED:18675468] [PUBMED:9848086] [PUBMED:11484003] [PUBMED:17568632] [PUBMED:15177383] [PUBMED:17055782] [PUBMED:15232608] [PUBMED:10830966] [PUBMED:16529745]
Carbon metabolism [NCBI:814926] [KEGG:hsa01200]
Citrate cycle (TCA cycle) [NCBI:82927] [KEGG:hsa00020]
Citrate cycle (TCA cycle, Krebs cycle) [NCBI:855811] [KEGG:hsa_M00009]
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [NCBI:413348] [KEGG:hsa_M00011]
Citric acid cycle (TCA cycle) [NCBI:1270125] [REACTOME:R-HSA-71403] [PUBMED:16746585] [PUBMED:16747180] [PUBMED:6773467]
Electron Transport Chain [NCBI:198860] [WikiPathways:WP111]
Huntington's disease [NCBI:83100] [KEGG:hsa05016] [PUBMED:15336977] [PUBMED:11738471] [PUBMED:11807533] [PUBMED:15996546] [PUBMED:14526190] [PUBMED:15242639] [PUBMED:15996541] [PUBMED:17041811] [PUBMED:18951640] [PUBMED:11839795] [PUBMED:17081970] [PUBMED:15459747] [PUBMED:16288298] [PUBMED:15695335] [PUBMED:12372277]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Non-alcoholic fatty liver disease (NAFLD) [NCBI:862188] [KEGG:hsa04932] [PUBMED:21038418] [PUBMED:17498512] [PUBMED:19352614] [PUBMED:12891546] [PUBMED:9285483] [PUBMED:23299992] [PUBMED:22570745] [PUBMED:16364488] [PUBMED:18061659] [PUBMED:22705006] [PUBMED:16374858] [PUBMED:18242193] [PUBMED:20303879] [PUBMED:22940046] [PUBMED:20619513] [PUBMED:16406828] [PUBMED:14685853] [PUBMED:23545492] [PUBMED:21145844]
Oxidative phosphorylation [NCBI:82942] [KEGG:hsa00190] [NCBI:198870] [WikiPathways:WP623] [PUBMED:7654171] [PUBMED:14641005] [PUBMED:11340051] [PUBMED:11771674] [PUBMED:15869601] [PUBMED:15490415] [PUBMED:3881803] [PUBMED:388618] [PUBMED:4291593] [PUBMED:4381909] [PUBMED:16469879] [PUBMED:16584177] [PUBMED:10600673]
Parkinson's disease [NCBI:83098] [KEGG:hsa05012] [PUBMED:12461550] [PUBMED:15767499] [PUBMED:21811441] [PUBMED:15525720] [PUBMED:16022590] [PUBMED:16495942] [PUBMED:15681812] [PUBMED:18426756] [PUBMED:12971891] [PUBMED:16278972] [PUBMED:11331916] [PUBMED:18680555] [PUBMED:15770999] [PUBMED:12938733] [PUBMED:12728264] [PUBMED:15054086] [PUBMED:22927178] [PUBMED:17911161] [PUBMED:20236221]
Pyruvate metabolism and Citric Acid (TCA) cycle [NCBI:1270122] [REACTOME:R-HSA-71406]
Respiratory electron transport [NCBI:1270128] [REACTOME:R-HSA-611105] [PUBMED:10647174] [PUBMED:2862839]
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. [NCBI:1270127] [REACTOME:R-HSA-163200]
TCA Cycle [NCBI:198787] [WikiPathways:WP78] [PUBMED:9765290] [PUBMED:7730304] [PUBMED:7060582] [PUBMED:10672230] [PUBMED:7730305] [PUBMED:15234968] [PUBMED:8187868] [PUBMED:12234803] [PUBMED:3052428] [PUBMED:949837] [PUBMED:13018271] [PUBMED:8506365] [PUBMED:3724458] [PUBMED:7961626]
TCA cycle [NCBI:782397] [BIOCYC:HUMAN_PWY66-398] [PUBMED:16746585] [PUBMED:16746397] [PUBMED:20167786] [PUBMED:15234968] [PUBMED:2198251] [PUBMED:16747930]
The citric acid (TCA) cycle and respiratory electron transport [NCBI:1270121] [REACTOME:R-HSA-1428517]
superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle [NCBI:835393] [BIOCYC:HUMAN_PWY66-407]