full name
nuclear receptor coactivator 1
synonyms
bHLHe42, bHLHe74, F-SRC-1, KAT13A, RIP160, SRC1, NCOA1, ENSG00000084676
HGNC
HGNC:7668
Entrez Gene
Gene:8648
ENSEMBL
ENSG00000084676
location
chr: 2
start: 24714919
stop: 24993571
strand: +
transcripts
NM_147223.2
NM_003743.4
NM_147233.2
pathways
Activation of gene expression by SREBF (SREBP)
[NCBI:1270039]
[REACTOME:R-HSA-2426168]
[PUBMED:15589694]
[PUBMED:9748295]
[PUBMED:15457548]
BMAL1:CLOCK,NPAS2 activates circadian gene expression
[NCBI:1269872]
[REACTOME:R-HSA-1368108]
[PUBMED:12868535]
[PUBMED:9616112]
Bile acid and bile salt metabolism
[NCBI:1270040]
[REACTOME:R-HSA-194068]
[PUBMED:12543708]
[PUBMED:12663868]
[PUBMED:14699511]
[PUBMED:11969205]
Biological oxidations
[NCBI:1270189]
[REACTOME:R-HSA-211859]
Breast cancer
[NCBI:1435207]
[KEGG:hsa05224]
[PUBMED:24649067]
[PUBMED:26040571]
[PUBMED:11879567]
[PUBMED:22722193]
[PUBMED:26028978]
[PUBMED:25013431]
[PUBMED:11737884]
[PUBMED:23702927]
[PUBMED:21076461]
[PUBMED:21898546]
[PUBMED:27390604]
[PUBMED:24291072]
[PUBMED:26968398]
[PUBMED:20087430]
[PUBMED:23000897]
[PUBMED:25544707]
[PUBMED:24596345]
[PUBMED:23988612]
[PUBMED:24111892]
[PUBMED:25907219]
[PUBMED:15343273]
[PUBMED:21965336]
[PUBMED:23881035]
[PUBMED:23196196]
[PUBMED:22178455]
[PUBMED:20436504]
[PUBMED:19088017]
[PUBMED:16113099]
[PUBMED:20971825]
Chromatin modifying enzymes
[NCBI:1270434]
[REACTOME:R-HSA-3247509]
Chromatin organization
[NCBI:1270433]
[REACTOME:R-HSA-4839726]
[PUBMED:21342762]
[PUBMED:15598472]
Circadian Clock
[NCBI:1269871]
[REACTOME:R-HSA-400253]
[PUBMED:18775307]
[PUBMED:18802415]
[PUBMED:18786386]
[PUBMED:16987893]
Cytochrome P450 - arranged by substrate type
[NCBI:1270191]
[REACTOME:R-HSA-211897]
[PUBMED:16584116]
[PUBMED:15102545]
[PUBMED:12369887]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Endogenous sterols
[NCBI:1270192]
[REACTOME:R-HSA-211976]
[PUBMED:16872679]
[PUBMED:15102545]
[PUBMED:16584116]
Fatty acid, triacylglycerol, and ketone body metabolism
[NCBI:1270010]
[REACTOME:R-HSA-535734]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Glucocorticoid receptor regulatory network
[NCBI:138014]
[Pathway Interaction Database:reg_gr_pathway]
[PUBMED:8943293]
[PUBMED:1708774]
[PUBMED:15826950]
[PUBMED:11027313]
[PUBMED:12118039]
[PUBMED:9388207]
[PUBMED:11751894]
[PUBMED:12151000]
[PUBMED:9765258]
[PUBMED:9407028]
[PUBMED:19074285]
[PUBMED:2838908]
[PUBMED:15817653]
[PUBMED:9722596]
[PUBMED:12917342]
[PUBMED:1387550]
[PUBMED:10974006]
[PUBMED:15790729]
[PUBMED:10825196]
[PUBMED:10623828]
[PUBMED:2169352]
[PUBMED:9315653]
[PUBMED:7759501]
[PUBMED:8290595]
[PUBMED:2905764]
[PUBMED:12351702]
[PUBMED:11080152]
[PUBMED:8428574]
[PUBMED:9215863]
[PUBMED:15459252]
[PUBMED:10400612]
[PUBMED:9426156]
[PUBMED:17440046]
[PUBMED:18838540]
[PUBMED:2169353]
[PUBMED:10820245]
[PUBMED:12511605]
[PUBMED:2586521]
[PUBMED:1740658]
[PUBMED:11555652]
[PUBMED:11562347]
[PUBMED:9482836]
[PUBMED:18337589]
[PUBMED:10958685]
[PUBMED:9388192]
[PUBMED:15834420]
[PUBMED:15657031]
[PUBMED:8878484]
[PUBMED:10760263]
[PUBMED:12730237]
[PUBMED:8702844]
[PUBMED:2169351]
[PUBMED:17215482]
[PUBMED:8898375]
HATs acetylate histones
[NCBI:1270435]
[REACTOME:R-HSA-3214847]
[PUBMED:18722564]
HIF-1-alpha transcription factor network
[NCBI:138045]
[Pathway Interaction Database:hif1_tfpathway]
[PUBMED:11707426]
[PUBMED:9242677]
[PUBMED:9038135]
[PUBMED:15310764]
[PUBMED:11278891]
[PUBMED:8816435]
[PUBMED:8663540]
[PUBMED:15235127]
[PUBMED:12042299]
[PUBMED:15312748]
[PUBMED:14612449]
[PUBMED:11342587]
[PUBMED:12615703]
[PUBMED:9632793]
[PUBMED:12228247]
[PUBMED:15044468]
[PUBMED:8408001]
[PUBMED:9822602]
[PUBMED:15252039]
[PUBMED:13679920]
[PUBMED:11877282]
[PUBMED:15235597]
[PUBMED:15199161]
[PUBMED:15104534]
[PUBMED:10594042]
[PUBMED:12354771]
[PUBMED:10446188]
[PUBMED:9436976]
[PUBMED:11823643]
[PUBMED:12370277]
[PUBMED:8955077]
[PUBMED:12879018]
[PUBMED:14645546]
[PUBMED:9486205]
[PUBMED:9887100]
[PUBMED:8089148]
[PUBMED:15466858]
[PUBMED:11708773]
[PUBMED:15611046]
[PUBMED:14742449]
[PUBMED:15280364]
[PUBMED:12215445]
[PUBMED:15611089]
[PUBMED:10777486]
[PUBMED:9707622]
[PUBMED:8917528]
[PUBMED:15563275]
[PUBMED:12067980]
[PUBMED:10353251]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins
[NCBI:1270001]
[REACTOME:R-HSA-556833]
Mitochondrial biogenesis
[NCBI:1268839]
[REACTOME:R-HSA-1592230]
[PUBMED:18430751]
[PUBMED:19262508]
[PUBMED:22265687]
[PUBMED:20533901]
[PUBMED:20933024]
[PUBMED:21757760]
[PUBMED:19575678]
[PUBMED:19008463]
[PUBMED:21629705]
[PUBMED:21543634]
[PUBMED:22817841]
[PUBMED:20649548]
[PUBMED:22146081]
[PUBMED:19276888]
[PUBMED:19682549]
[PUBMED:15744310]
[PUBMED:19076454]
Notch-mediated HES/HEY network
[NCBI:169347]
[Pathway Interaction Database:hes_heypathway]
[PUBMED:15546612]
[PUBMED:11038350]
[PUBMED:12065598]
[PUBMED:11741889]
[PUBMED:10851137]
[PUBMED:10205173]
[PUBMED:10747963]
[PUBMED:10913198]
[PUBMED:11101851]
[PUBMED:16201968]
[PUBMED:12488457]
[PUBMED:12370315]
[PUBMED:19116245]
[PUBMED:16025100]
[PUBMED:11486044]
[PUBMED:15607978]
[PUBMED:15467735]
[PUBMED:14739937]
[PUBMED:9694793]
[PUBMED:8749394]
[PUBMED:16782059]
[PUBMED:12972610]
[PUBMED:17392792]
[PUBMED:11334435]
[PUBMED:11486045]
[PUBMED:16753023]
[PUBMED:15485867]
[PUBMED:15866158]
[PUBMED:16199874]
[PUBMED:12374742]
[PUBMED:9570950]
[PUBMED:10964718]
[PUBMED:16682003]
[PUBMED:16287852]
[PUBMED:10692439]
[PUBMED:11095750]
[PUBMED:11287612]
[PUBMED:15314183]
[PUBMED:15156153]
[PUBMED:15684393]
[PUBMED:7566092]
[PUBMED:11604511]
[PUBMED:9819403]
[PUBMED:15563463]
[PUBMED:15870295]
Organelle biogenesis and maintenance
[NCBI:1268838]
[REACTOME:R-HSA-1852241]
[PUBMED:8608592]
[PUBMED:16103713]
PPARA activates gene expression
[NCBI:1270030]
[REACTOME:R-HSA-1989781]
[PUBMED:10529898]
[PUBMED:18288277]
[PUBMED:11330046]
[PUBMED:20936127]
[PUBMED:14999402]
Phase 1 - Functionalization of compounds
[NCBI:1270190]
[REACTOME:R-HSA-211945]
[PUBMED:12369887]
[PUBMED:17125408]
[PUBMED:16584116]
RORA activates gene expression
[NCBI:1269873]
[REACTOME:R-HSA-1368082]
[PUBMED:7926749]
RXR and RAR heterodimerization with other nuclear receptor
[NCBI:137975]
[Pathway Interaction Database:rxr_vdr_pathway]
[PUBMED:8394351]
[PUBMED:15284334]
[PUBMED:9223286]
[PUBMED:8389594]
[PUBMED:15650024]
[PUBMED:7744246]
[PUBMED:11741944]
[PUBMED:12359143]
[PUBMED:8060315]
[PUBMED:16611854]
[PUBMED:15731112]
[PUBMED:15509776]
[PUBMED:16181625]
[PUBMED:17595322]
[PUBMED:7705655]
[PUBMED:8621574]
[PUBMED:7760852]
[PUBMED:11287605]
[PUBMED:15187081]
[PUBMED:8164684]
[PUBMED:8381967]
[PUBMED:10858438]
[PUBMED:7958963]
Recycling of bile acids and salts
[NCBI:1270045]
[REACTOME:R-HSA-159418]
[PUBMED:621437]
[PUBMED:8034703]
Regulation of Androgen receptor activity
[NCBI:138027]
[Pathway Interaction Database:ar_tf_pathway]
[PUBMED:15650026]
[PUBMED:17045208]
[PUBMED:10364196]
[PUBMED:16860317]
[PUBMED:10611280]
[PUBMED:10930412]
[PUBMED:1525041]
[PUBMED:10779504]
[PUBMED:12514133]
[PUBMED:1985913]
[PUBMED:11931767]
[PUBMED:17011549]
[PUBMED:15640443]
[PUBMED:16322096]
[PUBMED:15923603]
[PUBMED:14985354]
[PUBMED:15743818]
[PUBMED:12949936]
[PUBMED:11994312]
[PUBMED:10567371]
[PUBMED:11875111]
[PUBMED:15604291]
[PUBMED:12890669]
[PUBMED:14729952]
[PUBMED:9211894]
[PUBMED:9162033]
[PUBMED:16705743]
[PUBMED:16849544]
[PUBMED:16923962]
[PUBMED:11591700]
[PUBMED:16051670]
[PUBMED:8643509]
[PUBMED:17108144]
[PUBMED:16914734]
[PUBMED:12682292]
[PUBMED:3353726]
[PUBMED:11585838]
[PUBMED:16282370]
[PUBMED:10381882]
[PUBMED:15199155]
[PUBMED:16455820]
[PUBMED:14612401]
[PUBMED:10625666]
[PUBMED:17679089]
[PUBMED:16461774]
Regulation of cholesterol biosynthesis by SREBP (SREBF)
[NCBI:1270038]
[REACTOME:R-HSA-1655829]
[PUBMED:15457548]
[PUBMED:19933148]
[PUBMED:18974038]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
[NCBI:1270029]
[REACTOME:R-HSA-400206]
[PUBMED:18288277]
[PUBMED:10529898]
[PUBMED:16476485]
[PUBMED:16503871]
Regulation of nuclear SMAD2/3 signaling
[NCBI:137963]
[Pathway Interaction Database:smad2_3nuclearpathway]
[PUBMED:15009097]
[PUBMED:11790301]
[PUBMED:11836524]
[PUBMED:10995736]
[PUBMED:11114293]
[PUBMED:10973944]
[PUBMED:10022869]
[PUBMED:11058129]
[PUBMED:9722503]
[PUBMED:12904571]
[PUBMED:14993291]
[PUBMED:11013220]
[PUBMED:15363409]
[PUBMED:9702197]
[PUBMED:12718878]
[PUBMED:11331591]
[PUBMED:12167862]
[PUBMED:14729983]
[PUBMED:9707553]
[PUBMED:10878024]
[PUBMED:9679060]
[PUBMED:10887155]
[PUBMED:10199400]
[PUBMED:12631740]
[PUBMED:11555647]
[PUBMED:15688032]
[PUBMED:12150994]
[PUBMED:12374795]
[PUBMED:9606191]
[PUBMED:9702198]
[PUBMED:10518526]
[PUBMED:10575014]
[PUBMED:10485843]
[PUBMED:11283614]
[PUBMED:10722728]
[PUBMED:10037600]
[PUBMED:15241418]
[PUBMED:14691252]
[PUBMED:10748032]
[PUBMED:12551947]
[PUBMED:14671321]
[PUBMED:11427533]
[PUBMED:11711431]
[PUBMED:10531362]
[PUBMED:11571228]
[PUBMED:10085140]
[PUBMED:17478422]
[PUBMED:15044954]
[PUBMED:10964912]
[PUBMED:11707452]
[PUBMED:11801598]
[PUBMED:17074756]
[PUBMED:12226080]
[PUBMED:10557285]
[PUBMED:10843994]
[PUBMED:15084259]
[PUBMED:10531062]
[PUBMED:16959612]
[PUBMED:9679056]
[PUBMED:10652350]
[PUBMED:9618481]
[PUBMED:11927558]
[PUBMED:9732876]
Retinoic acid receptors-mediated signaling
[NCBI:138039]
[Pathway Interaction Database:retinoic_acid_pathway]
[PUBMED:9192892]
[PUBMED:16417524]
[PUBMED:7476969]
[PUBMED:12032153]
[PUBMED:8145770]
[PUBMED:12824162]
[PUBMED:10938135]
[PUBMED:9351827]
[PUBMED:15608670]
[PUBMED:8855229]
[PUBMED:16456540]
[PUBMED:16613989]
[PUBMED:15688020]
[PUBMED:16275922]
[PUBMED:15657432]
[PUBMED:11467847]
[PUBMED:16038797]
[PUBMED:12885766]
[PUBMED:14535629]
[PUBMED:10608897]
[PUBMED:12110588]
[PUBMED:9230306]
[PUBMED:16093479]
[PUBMED:16723356]
[PUBMED:11955452]
[PUBMED:16769902]
[PUBMED:10748061]
[PUBMED:8164684]
[PUBMED:17088940]
[PUBMED:10938283]
[PUBMED:7791761]
[PUBMED:12032135]
[PUBMED:11006275]
[PUBMED:10383391]
[PUBMED:11606411]
Synthesis of bile acids and bile salts
[NCBI:1270041]
[REACTOME:R-HSA-192105]
[PUBMED:12543708]
[PUBMED:11969205]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
[NCBI:1270044]
[REACTOME:R-HSA-193807]
[PUBMED:10428977]
[PUBMED:12543708]
[PUBMED:11969205]
[PUBMED:8078928]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
[NCBI:1270042]
[REACTOME:R-HSA-193368]
[PUBMED:12543708]
Thyroid hormone signaling pathway
[NCBI:946598]
[KEGG:hsa04919]
[PUBMED:20005976]
[PUBMED:17983645]
[PUBMED:15345678]
[PUBMED:16951130]
[PUBMED:16214361]
[PUBMED:18329679]
[PUBMED:20051527]
[PUBMED:17574003]
[PUBMED:19716314]
[PUBMED:19755667]
[PUBMED:20868274]
[PUBMED:21835053]
[PUBMED:16051672]
[PUBMED:19295177]
[PUBMED:23021374]
[PUBMED:22484490]
Transcriptional activation of mitochondrial biogenesis
[NCBI:1268841]
[REACTOME:R-HSA-2151201]
[PUBMED:22265687]
[PUBMED:20933024]
[PUBMED:19575678]
[PUBMED:22817841]
[PUBMED:19682549]
Transcriptional regulation of white adipocyte differentiation
[NCBI:1270345]
[REACTOME:R-HSA-381340]
[PUBMED:21082419]
[PUBMED:17956727]
[PUBMED:17475546]
[PUBMED:1840554]
[PUBMED:17139329]
[PUBMED:15860371]
[PUBMED:18518822]
[PUBMED:10603305]
[PUBMED:7531665]
[PUBMED:20054179]
[PUBMED:7838715]
[PUBMED:16054042]
[PUBMED:17060461]
[PUBMED:17011499]
[PUBMED:16380219]
[PUBMED:8970730]
YAP1- and WWTR1 (TAZ)-stimulated gene expression
[NCBI:1269653]
[REACTOME:R-HSA-2032785]
[PUBMED:16332960]
[PUBMED:20452772]
