full name
nuclear receptor coactivator 1

synonyms
bHLHe42, bHLHe74, F-SRC-1, KAT13A, RIP160, SRC1, NCOA1, ENSG00000084676

HGNC
HGNC:7668

Entrez Gene
Gene:8648

ENSEMBL
ENSG00000084676

location
chr: 2
start: 24714919
stop: 24993571
strand: +

transcripts
NM_147223.2
NM_003743.4
NM_147233.2

pathways
Activation of gene expression by SREBF (SREBP) [NCBI:1270039] [REACTOME:R-HSA-2426168] [PUBMED:15589694] [PUBMED:9748295] [PUBMED:15457548]
BMAL1:CLOCK,NPAS2 activates circadian gene expression [NCBI:1269872] [REACTOME:R-HSA-1368108] [PUBMED:12868535] [PUBMED:9616112]
Bile acid and bile salt metabolism [NCBI:1270040] [REACTOME:R-HSA-194068] [PUBMED:12543708] [PUBMED:12663868] [PUBMED:14699511] [PUBMED:11969205]
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
Breast cancer [NCBI:1435207] [KEGG:hsa05224] [PUBMED:24649067] [PUBMED:26040571] [PUBMED:11879567] [PUBMED:22722193] [PUBMED:26028978] [PUBMED:25013431] [PUBMED:11737884] [PUBMED:23702927] [PUBMED:21076461] [PUBMED:21898546] [PUBMED:27390604] [PUBMED:24291072] [PUBMED:26968398] [PUBMED:20087430] [PUBMED:23000897] [PUBMED:25544707] [PUBMED:24596345] [PUBMED:23988612] [PUBMED:24111892] [PUBMED:25907219] [PUBMED:15343273] [PUBMED:21965336] [PUBMED:23881035] [PUBMED:23196196] [PUBMED:22178455] [PUBMED:20436504] [PUBMED:19088017] [PUBMED:16113099] [PUBMED:20971825]
Chromatin modifying enzymes [NCBI:1270434] [REACTOME:R-HSA-3247509]
Chromatin organization [NCBI:1270433] [REACTOME:R-HSA-4839726] [PUBMED:21342762] [PUBMED:15598472]
Circadian Clock [NCBI:1269871] [REACTOME:R-HSA-400253] [PUBMED:18775307] [PUBMED:18802415] [PUBMED:18786386] [PUBMED:16987893]
Cytochrome P450 - arranged by substrate type [NCBI:1270191] [REACTOME:R-HSA-211897] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:12369887]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Endogenous sterols [NCBI:1270192] [REACTOME:R-HSA-211976] [PUBMED:16872679] [PUBMED:15102545] [PUBMED:16584116]
Fatty acid, triacylglycerol, and ketone body metabolism [NCBI:1270010] [REACTOME:R-HSA-535734]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Glucocorticoid receptor regulatory network [NCBI:138014] [Pathway Interaction Database:reg_gr_pathway] [PUBMED:8943293] [PUBMED:1708774] [PUBMED:15826950] [PUBMED:11027313] [PUBMED:12118039] [PUBMED:9388207] [PUBMED:11751894] [PUBMED:12151000] [PUBMED:9765258] [PUBMED:9407028] [PUBMED:19074285] [PUBMED:2838908] [PUBMED:15817653] [PUBMED:9722596] [PUBMED:12917342] [PUBMED:1387550] [PUBMED:10974006] [PUBMED:15790729] [PUBMED:10825196] [PUBMED:10623828] [PUBMED:2169352] [PUBMED:9315653] [PUBMED:7759501] [PUBMED:8290595] [PUBMED:2905764] [PUBMED:12351702] [PUBMED:11080152] [PUBMED:8428574] [PUBMED:9215863] [PUBMED:15459252] [PUBMED:10400612] [PUBMED:9426156] [PUBMED:17440046] [PUBMED:18838540] [PUBMED:2169353] [PUBMED:10820245] [PUBMED:12511605] [PUBMED:2586521] [PUBMED:1740658] [PUBMED:11555652] [PUBMED:11562347] [PUBMED:9482836] [PUBMED:18337589] [PUBMED:10958685] [PUBMED:9388192] [PUBMED:15834420] [PUBMED:15657031] [PUBMED:8878484] [PUBMED:10760263] [PUBMED:12730237] [PUBMED:8702844] [PUBMED:2169351] [PUBMED:17215482] [PUBMED:8898375]
HATs acetylate histones [NCBI:1270435] [REACTOME:R-HSA-3214847] [PUBMED:18722564]
HIF-1-alpha transcription factor network [NCBI:138045] [Pathway Interaction Database:hif1_tfpathway] [PUBMED:11707426] [PUBMED:9242677] [PUBMED:9038135] [PUBMED:15310764] [PUBMED:11278891] [PUBMED:8816435] [PUBMED:8663540] [PUBMED:15235127] [PUBMED:12042299] [PUBMED:15312748] [PUBMED:14612449] [PUBMED:11342587] [PUBMED:12615703] [PUBMED:9632793] [PUBMED:12228247] [PUBMED:15044468] [PUBMED:8408001] [PUBMED:9822602] [PUBMED:15252039] [PUBMED:13679920] [PUBMED:11877282] [PUBMED:15235597] [PUBMED:15199161] [PUBMED:15104534] [PUBMED:10594042] [PUBMED:12354771] [PUBMED:10446188] [PUBMED:9436976] [PUBMED:11823643] [PUBMED:12370277] [PUBMED:8955077] [PUBMED:12879018] [PUBMED:14645546] [PUBMED:9486205] [PUBMED:9887100] [PUBMED:8089148] [PUBMED:15466858] [PUBMED:11708773] [PUBMED:15611046] [PUBMED:14742449] [PUBMED:15280364] [PUBMED:12215445] [PUBMED:15611089] [PUBMED:10777486] [PUBMED:9707622] [PUBMED:8917528] [PUBMED:15563275] [PUBMED:12067980] [PUBMED:10353251]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Mitochondrial biogenesis [NCBI:1268839] [REACTOME:R-HSA-1592230] [PUBMED:18430751] [PUBMED:19262508] [PUBMED:22265687] [PUBMED:20533901] [PUBMED:20933024] [PUBMED:21757760] [PUBMED:19575678] [PUBMED:19008463] [PUBMED:21629705] [PUBMED:21543634] [PUBMED:22817841] [PUBMED:20649548] [PUBMED:22146081] [PUBMED:19276888] [PUBMED:19682549] [PUBMED:15744310] [PUBMED:19076454]
Notch-mediated HES/HEY network [NCBI:169347] [Pathway Interaction Database:hes_heypathway] [PUBMED:15546612] [PUBMED:11038350] [PUBMED:12065598] [PUBMED:11741889] [PUBMED:10851137] [PUBMED:10205173] [PUBMED:10747963] [PUBMED:10913198] [PUBMED:11101851] [PUBMED:16201968] [PUBMED:12488457] [PUBMED:12370315] [PUBMED:19116245] [PUBMED:16025100] [PUBMED:11486044] [PUBMED:15607978] [PUBMED:15467735] [PUBMED:14739937] [PUBMED:9694793] [PUBMED:8749394] [PUBMED:16782059] [PUBMED:12972610] [PUBMED:17392792] [PUBMED:11334435] [PUBMED:11486045] [PUBMED:16753023] [PUBMED:15485867] [PUBMED:15866158] [PUBMED:16199874] [PUBMED:12374742] [PUBMED:9570950] [PUBMED:10964718] [PUBMED:16682003] [PUBMED:16287852] [PUBMED:10692439] [PUBMED:11095750] [PUBMED:11287612] [PUBMED:15314183] [PUBMED:15156153] [PUBMED:15684393] [PUBMED:7566092] [PUBMED:11604511] [PUBMED:9819403] [PUBMED:15563463] [PUBMED:15870295]
Organelle biogenesis and maintenance [NCBI:1268838] [REACTOME:R-HSA-1852241] [PUBMED:8608592] [PUBMED:16103713]
PPARA activates gene expression [NCBI:1270030] [REACTOME:R-HSA-1989781] [PUBMED:10529898] [PUBMED:18288277] [PUBMED:11330046] [PUBMED:20936127] [PUBMED:14999402]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
RORA activates gene expression [NCBI:1269873] [REACTOME:R-HSA-1368082] [PUBMED:7926749]
RXR and RAR heterodimerization with other nuclear receptor [NCBI:137975] [Pathway Interaction Database:rxr_vdr_pathway] [PUBMED:8394351] [PUBMED:15284334] [PUBMED:9223286] [PUBMED:8389594] [PUBMED:15650024] [PUBMED:7744246] [PUBMED:11741944] [PUBMED:12359143] [PUBMED:8060315] [PUBMED:16611854] [PUBMED:15731112] [PUBMED:15509776] [PUBMED:16181625] [PUBMED:17595322] [PUBMED:7705655] [PUBMED:8621574] [PUBMED:7760852] [PUBMED:11287605] [PUBMED:15187081] [PUBMED:8164684] [PUBMED:8381967] [PUBMED:10858438] [PUBMED:7958963]
Recycling of bile acids and salts [NCBI:1270045] [REACTOME:R-HSA-159418] [PUBMED:621437] [PUBMED:8034703]
Regulation of Androgen receptor activity [NCBI:138027] [Pathway Interaction Database:ar_tf_pathway] [PUBMED:15650026] [PUBMED:17045208] [PUBMED:10364196] [PUBMED:16860317] [PUBMED:10611280] [PUBMED:10930412] [PUBMED:1525041] [PUBMED:10779504] [PUBMED:12514133] [PUBMED:1985913] [PUBMED:11931767] [PUBMED:17011549] [PUBMED:15640443] [PUBMED:16322096] [PUBMED:15923603] [PUBMED:14985354] [PUBMED:15743818] [PUBMED:12949936] [PUBMED:11994312] [PUBMED:10567371] [PUBMED:11875111] [PUBMED:15604291] [PUBMED:12890669] [PUBMED:14729952] [PUBMED:9211894] [PUBMED:9162033] [PUBMED:16705743] [PUBMED:16849544] [PUBMED:16923962] [PUBMED:11591700] [PUBMED:16051670] [PUBMED:8643509] [PUBMED:17108144] [PUBMED:16914734] [PUBMED:12682292] [PUBMED:3353726] [PUBMED:11585838] [PUBMED:16282370] [PUBMED:10381882] [PUBMED:15199155] [PUBMED:16455820] [PUBMED:14612401] [PUBMED:10625666] [PUBMED:17679089] [PUBMED:16461774]
Regulation of cholesterol biosynthesis by SREBP (SREBF) [NCBI:1270038] [REACTOME:R-HSA-1655829] [PUBMED:15457548] [PUBMED:19933148] [PUBMED:18974038]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) [NCBI:1270029] [REACTOME:R-HSA-400206] [PUBMED:18288277] [PUBMED:10529898] [PUBMED:16476485] [PUBMED:16503871]
Regulation of nuclear SMAD2/3 signaling [NCBI:137963] [Pathway Interaction Database:smad2_3nuclearpathway] [PUBMED:15009097] [PUBMED:11790301] [PUBMED:11836524] [PUBMED:10995736] [PUBMED:11114293] [PUBMED:10973944] [PUBMED:10022869] [PUBMED:11058129] [PUBMED:9722503] [PUBMED:12904571] [PUBMED:14993291] [PUBMED:11013220] [PUBMED:15363409] [PUBMED:9702197] [PUBMED:12718878] [PUBMED:11331591] [PUBMED:12167862] [PUBMED:14729983] [PUBMED:9707553] [PUBMED:10878024] [PUBMED:9679060] [PUBMED:10887155] [PUBMED:10199400] [PUBMED:12631740] [PUBMED:11555647] [PUBMED:15688032] [PUBMED:12150994] [PUBMED:12374795] [PUBMED:9606191] [PUBMED:9702198] [PUBMED:10518526] [PUBMED:10575014] [PUBMED:10485843] [PUBMED:11283614] [PUBMED:10722728] [PUBMED:10037600] [PUBMED:15241418] [PUBMED:14691252] [PUBMED:10748032] [PUBMED:12551947] [PUBMED:14671321] [PUBMED:11427533] [PUBMED:11711431] [PUBMED:10531362] [PUBMED:11571228] [PUBMED:10085140] [PUBMED:17478422] [PUBMED:15044954] [PUBMED:10964912] [PUBMED:11707452] [PUBMED:11801598] [PUBMED:17074756] [PUBMED:12226080] [PUBMED:10557285] [PUBMED:10843994] [PUBMED:15084259] [PUBMED:10531062] [PUBMED:16959612] [PUBMED:9679056] [PUBMED:10652350] [PUBMED:9618481] [PUBMED:11927558] [PUBMED:9732876]
Retinoic acid receptors-mediated signaling [NCBI:138039] [Pathway Interaction Database:retinoic_acid_pathway] [PUBMED:9192892] [PUBMED:16417524] [PUBMED:7476969] [PUBMED:12032153] [PUBMED:8145770] [PUBMED:12824162] [PUBMED:10938135] [PUBMED:9351827] [PUBMED:15608670] [PUBMED:8855229] [PUBMED:16456540] [PUBMED:16613989] [PUBMED:15688020] [PUBMED:16275922] [PUBMED:15657432] [PUBMED:11467847] [PUBMED:16038797] [PUBMED:12885766] [PUBMED:14535629] [PUBMED:10608897] [PUBMED:12110588] [PUBMED:9230306] [PUBMED:16093479] [PUBMED:16723356] [PUBMED:11955452] [PUBMED:16769902] [PUBMED:10748061] [PUBMED:8164684] [PUBMED:17088940] [PUBMED:10938283] [PUBMED:7791761] [PUBMED:12032135] [PUBMED:11006275] [PUBMED:10383391] [PUBMED:11606411]
Synthesis of bile acids and bile salts [NCBI:1270041] [REACTOME:R-HSA-192105] [PUBMED:12543708] [PUBMED:11969205]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol [NCBI:1270044] [REACTOME:R-HSA-193807] [PUBMED:10428977] [PUBMED:12543708] [PUBMED:11969205] [PUBMED:8078928]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [NCBI:1270042] [REACTOME:R-HSA-193368] [PUBMED:12543708]
Thyroid hormone signaling pathway [NCBI:946598] [KEGG:hsa04919] [PUBMED:20005976] [PUBMED:17983645] [PUBMED:15345678] [PUBMED:16951130] [PUBMED:16214361] [PUBMED:18329679] [PUBMED:20051527] [PUBMED:17574003] [PUBMED:19716314] [PUBMED:19755667] [PUBMED:20868274] [PUBMED:21835053] [PUBMED:16051672] [PUBMED:19295177] [PUBMED:23021374] [PUBMED:22484490]
Transcriptional activation of mitochondrial biogenesis [NCBI:1268841] [REACTOME:R-HSA-2151201] [PUBMED:22265687] [PUBMED:20933024] [PUBMED:19575678] [PUBMED:22817841] [PUBMED:19682549]
Transcriptional regulation of white adipocyte differentiation [NCBI:1270345] [REACTOME:R-HSA-381340] [PUBMED:21082419] [PUBMED:17956727] [PUBMED:17475546] [PUBMED:1840554] [PUBMED:17139329] [PUBMED:15860371] [PUBMED:18518822] [PUBMED:10603305] [PUBMED:7531665] [PUBMED:20054179] [PUBMED:7838715] [PUBMED:16054042] [PUBMED:17060461] [PUBMED:17011499] [PUBMED:16380219] [PUBMED:8970730]
YAP1- and WWTR1 (TAZ)-stimulated gene expression [NCBI:1269653] [REACTOME:R-HSA-2032785] [PUBMED:16332960] [PUBMED:20452772]