full name
DNA methyltransferase 3 alpha

synonyms
DNMT3A2, M.HsaIIIA, DNMT3A, ENSG00000119772

HGNC
HGNC:2978

Entrez Gene
Gene:1788

ENSEMBL
ENSG00000119772

location
chr: 2
start: 25451421
stop: 25565459
strand: -

OMIM
OMIM:602769: DNMT3A
OMIM:601626: Acute myeloid leukemia, somatic
OMIM:618724: Heyn-Sproul-Jackson syndrome
OMIM:615879: Tatton-Brown-Rahman syndrome

transcripts
NM_175629.2
NM_022552.4
NM_153759.3
NM_175630.1

pathways
Chromatin modifying enzymes [NCBI:1270434] [REACTOME:R-HSA-3247509]
Chromatin organization [NCBI:1270433] [REACTOME:R-HSA-4839726] [PUBMED:21342762] [PUBMED:15598472]
Cysteine and methionine metabolism [NCBI:104488] [KEGG:hsa00270] [PUBMED:18391471] [PUBMED:14551435] [PUBMED:15102328] [PUBMED:12644499] [PUBMED:12670965] [PUBMED:18625006] [PUBMED:19270684] [PUBMED:17169919] [PUBMED:17030798] [PUBMED:10613873] [PUBMED:18520135] [PUBMED:12022921]
DNA methylation [NCBI:1269740] [REACTOME:R-HSA-5334118] [PUBMED:24560929] [PUBMED:21243710] [PUBMED:23587238] [PUBMED:23938249] [PUBMED:22781841] [PUBMED:24214338] [PUBMED:16403636] [PUBMED:24589714] [PUBMED:23687512] [PUBMED:23166392] [PUBMED:19657014] [PUBMED:7079182] [PUBMED:24059801]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Methionine degradation [NCBI:413353] [KEGG:hsa_M00035]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
PRC2 methylates histones and DNA [NCBI:1269735] [REACTOME:R-HSA-212300] [PUBMED:23473600] [PUBMED:18974828] [PUBMED:24096405] [PUBMED:21248841] [PUBMED:19738629] [PUBMED:21941108]
RMTs methylate histone arginines [NCBI:1270439] [REACTOME:R-HSA-3214858] [PUBMED:19150423] [PUBMED:23235912]
Validated targets of C-MYC transcriptional repression [NCBI:169353] [Pathway Interaction Database:myc_represspathway] [PUBMED:17082179] [PUBMED:11282029] [PUBMED:9869632] [PUBMED:15021909] [PUBMED:16167342] [PUBMED:18056446] [PUBMED:18045875] [PUBMED:1670896] [PUBMED:18393360] [PUBMED:7556187] [PUBMED:11313917] [PUBMED:17471507] [PUBMED:12418961] [PUBMED:9927431] [PUBMED:9924025] [PUBMED:18483244] [PUBMED:14716294] [PUBMED:15506972] [PUBMED:15616584] [PUBMED:12729735] [PUBMED:19219026] [PUBMED:12747840] [PUBMED:2182320] [PUBMED:12545156] [PUBMED:15367674] [PUBMED:11283613] [PUBMED:12384701] [PUBMED:18066065] [PUBMED:18455888] [PUBMED:10920185] [PUBMED:17881732] [PUBMED:20190815] [PUBMED:16352593] [PUBMED:17050536] [PUBMED:11283614] [PUBMED:16391002] [PUBMED:11804592] [PUBMED:7870572] [PUBMED:16940161] [PUBMED:12695333] [PUBMED:17159920] [PUBMED:8972190] [PUBMED:9312026] [PUBMED:17485441] [PUBMED:16288014]