full name
BRISC and BRCA1 A complex member 2

synonyms
BRCC4, BRCC45, BRE, BABAM2, ENSG00000158019

HGNC
HGNC:1106

Entrez Gene
Gene:9577

ENSEMBL
ENSG00000158019

location
chr: 2
start: 28113482
stop: 28561768
strand: +

transcripts
NM_199193.2
NM_199194.2
NM_199192.2
NM_004899.4
NM_199191.2
NM_001261840.1

pathways
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
DNA Double Strand Break Response [NCBI:1309096] [REACTOME:R-HSA-5693606] [PUBMED:20965415]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint [NCBI:1269754] [REACTOME:R-HSA-69473]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
Homologous recombination [NCBI:83046] [KEGG:hsa03440] [PUBMED:12589470] [PUBMED:15902993] [PUBMED:16935872] [PUBMED:17395553] [PUBMED:18086882] [PUBMED:17571595] [PUBMED:18430459]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Metalloprotease DUBs [NCBI:1427865] [REACTOME:R-HSA-5689901] [PUBMED:14737182]
Nonhomologous End-Joining (NHEJ) [NCBI:1309110] [REACTOME:R-HSA-5693571] [PUBMED:10802669] [PUBMED:21293379] [PUBMED:16914548] [PUBMED:12509254] [PUBMED:12607005] [PUBMED:17470781] [PUBMED:12364621] [PUBMED:11493912] [PUBMED:23333306] [PUBMED:22179609] [PUBMED:25512557] [PUBMED:22529269] [PUBMED:23505375] [PUBMED:15574327] [PUBMED:12077346] [PUBMED:11030616] [PUBMED:14561766] [PUBMED:8422676] [PUBMED:23727112] [PUBMED:17525340] [PUBMED:23306437] [PUBMED:10757784] [PUBMED:16439205] [PUBMED:10959836] [PUBMED:15790808] [PUBMED:16377563] [PUBMED:11955432] [PUBMED:22373579] [PUBMED:19001859] [PUBMED:12023295] [PUBMED:15451442] [PUBMED:16093244] [PUBMED:10572166]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Processing of DNA double-strand break ends [NCBI:1309101] [REACTOME:R-HSA-5693607] [PUBMED:25122754] [PUBMED:18171670] [PUBMED:20965415] [PUBMED:22231403] [PUBMED:25558984] [PUBMED:19357644] [PUBMED:21325134] [PUBMED:21240188] [PUBMED:21659603] [PUBMED:23468639] [PUBMED:25659039]
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [NCBI:1309098] [REACTOME:R-HSA-5693565] [PUBMED:18483401] [PUBMED:21293379] [PUBMED:10866324] [PUBMED:9488723] [PUBMED:18001825] [PUBMED:18006705] [PUBMED:11571274] [PUBMED:12364621] [PUBMED:22234877] [PUBMED:10802669] [PUBMED:17553757] [PUBMED:10550055] [PUBMED:23333306] [PUBMED:20023648] [PUBMED:18077395] [PUBMED:19203578] [PUBMED:22373579] [PUBMED:19203579] [PUBMED:19234442] [PUBMED:16377563] [PUBMED:15201865] [PUBMED:19092802] [PUBMED:17525340] [PUBMED:22589545] [PUBMED:11025670] [PUBMED:16651405] [PUBMED:19001859] [PUBMED:18001824]