full name
protein phosphatase 1 catalytic subunit beta

synonyms
PP-1B, PP1B, PP1beta, PPP1CD, PPP1CB, ENSG00000213639

HGNC
HGNC:9282

Entrez Gene
Gene:5500

ENSEMBL
ENSG00000213639

location
chr: 2
start: 28974614
stop: 29025806
strand: +

OMIM
OMIM:600590: PPP1CB
OMIM:617506: Noonan syndrome-like disorder with loose anagen hair 2

transcripts
NM_206876.1
NM_002709.2

pathways
Adrenergic signaling in cardiomyocytes [NCBI:908257] [KEGG:hsa04261] [PUBMED:15232578] [PUBMED:20923637] [PUBMED:10571541] [PUBMED:11604549] [PUBMED:17988210] [PUBMED:11805843] [PUBMED:15142747] [PUBMED:21212391] [PUBMED:20658186] [PUBMED:16765984] [PUBMED:19874988] [PUBMED:19883653] [PUBMED:15979723] [PUBMED:18407781] [PUBMED:22022314] [PUBMED:12439640] [PUBMED:17826821] [PUBMED:15765137]
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:16776597] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:18632938] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:10774721] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:16151049] [PUBMED:18440072] [PUBMED:19199083] [PUBMED:10414964]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Circadian Clock [NCBI:1269871] [REACTOME:R-HSA-400253] [PUBMED:18775307] [PUBMED:18802415] [PUBMED:18786386] [PUBMED:16987893]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Downregulation of TGF-beta receptor signaling [NCBI:1269525] [REACTOME:R-HSA-2173788] [PUBMED:10519551] [PUBMED:16027725] [PUBMED:9215638] [PUBMED:20937913] [PUBMED:20129061] [PUBMED:11158580] [PUBMED:9335507] [PUBMED:15781469] [PUBMED:12519765] [PUBMED:16061177] [PUBMED:10757800] [PUBMED:11278251] [PUBMED:12151385] [PUBMED:20061380] [PUBMED:22045334] [PUBMED:14701756] [PUBMED:15496141] [PUBMED:19758997] [PUBMED:14718519] [PUBMED:22344298] [PUBMED:11163210]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:14756624] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:15034601] [PUBMED:12235283] [PUBMED:14519391] [PUBMED:11146675] [PUBMED:11229600] [PUBMED:15688067] [PUBMED:14744429] [PUBMED:11882383]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
Hippo signaling pathway [NCBI:749777] [KEGG:hsa04390] [PUBMED:18955139] [PUBMED:20439427] [PUBMED:20951342] [PUBMED:21138973] [PUBMED:18328423] [PUBMED:21324984] [PUBMED:23034192] [PUBMED:21808241] [PUBMED:17975546] [PUBMED:22750148] [PUBMED:21084559] [PUBMED:19846288] [PUBMED:22895435] [PUBMED:22683405] [PUBMED:22658639] [PUBMED:22153608] [PUBMED:20945341] [PUBMED:22830020] [PUBMED:21874053] [PUBMED:21376238]
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis [NCBI:1270009] [REACTOME:R-HSA-163560] [PUBMED:12364542] [PUBMED:10940339]
Inflammatory mediator regulation of TRP channels [NCBI:948277] [KEGG:hsa04750] [PUBMED:21841075] [PUBMED:15820689] [PUBMED:16776582] [PUBMED:12838328] [PUBMED:17548207] [PUBMED:16319926] [PUBMED:18427980] [PUBMED:20932256] [PUBMED:18615141] [PUBMED:17124270] [PUBMED:17684094] [PUBMED:22470230] [PUBMED:19074743] [PUBMED:23000387] [PUBMED:24099085] [PUBMED:17321113]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
Lipid digestion, mobilization, and transport [NCBI:1270002] [REACTOME:R-HSA-73923]
Long-term potentiation [NCBI:83085] [KEGG:hsa04720] [PUBMED:9697848] [PUBMED:15652868] [PUBMED:15803158] [PUBMED:11378299] [PUBMED:10652548] [PUBMED:15857686] [PUBMED:14715912]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Oocyte meiosis [NCBI:126909] [KEGG:hsa04114] [PUBMED:16760654] [PUBMED:17480229] [PUBMED:15136768] [PUBMED:18946022] [PUBMED:18598214] [PUBMED:16518630] [PUBMED:18631137] [PUBMED:15182704] [PUBMED:15182701] [PUBMED:16554437] [PUBMED:14691134] [PUBMED:18550795] [PUBMED:18096427] [PUBMED:14517314] [PUBMED:18311174]
Oxytocin signaling pathway [NCBI:952859] [KEGG:hsa04921] [PUBMED:23356278] [PUBMED:9219843] [PUBMED:20626426] [PUBMED:18555543] [PUBMED:22190926] [PUBMED:21981277] [PUBMED:9575824] [PUBMED:22227279] [PUBMED:19840865] [PUBMED:11861513] [PUBMED:9326674] [PUBMED:12433531] [PUBMED:18655881] [PUBMED:23335873] [PUBMED:22902539] [PUBMED:16156781] [PUBMED:20141572] [PUBMED:14715914] [PUBMED:12009385] [PUBMED:16787565] [PUBMED:16966388]
PLK1 signaling events [NCBI:138007] [Pathway Interaction Database:plk1_pathway] [PUBMED:15070733] [PUBMED:18418076] [PUBMED:15350223] [PUBMED:16885021] [PUBMED:12167714] [PUBMED:16966375] [PUBMED:18615013] [PUBMED:18662541] [PUBMED:18521620] [PUBMED:7790358] [PUBMED:8428596] [PUBMED:12852857] [PUBMED:18427546] [PUBMED:17446864] [PUBMED:16760428] [PUBMED:15148369] [PUBMED:16885022] [PUBMED:9734353] [PUBMED:18331714] [PUBMED:16980960] [PUBMED:18378770] [PUBMED:16860740] [PUBMED:15964272] [PUBMED:10980711] [PUBMED:11050165] [PUBMED:16580887] [PUBMED:17360533] [PUBMED:15678101] [PUBMED:11897663] [PUBMED:16418575] [PUBMED:17218258] [PUBMED:14734534] [PUBMED:18566290] [PUBMED:17081991] [PUBMED:15469984] [PUBMED:11447294] [PUBMED:17351640] [PUBMED:16934469] [PUBMED:18552834] [PUBMED:17488623] [PUBMED:8991084] [PUBMED:17785528] [PUBMED:18477460] [PUBMED:19351716] [PUBMED:12939256] [PUBMED:12852856] [PUBMED:15737063]
Platelet activation [NCBI:952858] [KEGG:hsa04611] [PUBMED:20002545] [PUBMED:18363565] [PUBMED:18544684] [PUBMED:18174460] [PUBMED:23106920] [PUBMED:18550847] [PUBMED:22119499] [PUBMED:19630797] [PUBMED:19286885] [PUBMED:17158345] [PUBMED:20089227] [PUBMED:22701130] [PUBMED:21071698] [PUBMED:23805129] [PUBMED:16149014] [PUBMED:18641368]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases Activate ROCKs [NCBI:1269510] [REACTOME:R-HSA-5627117] [PUBMED:8662509] [PUBMED:8816443] [PUBMED:11018042] [PUBMED:8702756] [PUBMED:20803696] [PUBMED:8617235] [PUBMED:17151359] [PUBMED:10652353]
RHO GTPases activate PAKs [NCBI:1269511] [REACTOME:R-HSA-5627123] [PUBMED:7559638] [PUBMED:9535855] [PUBMED:19513348] [PUBMED:16204230] [PUBMED:10470034] [PUBMED:22340718] [PUBMED:11804587] [PUBMED:21098037] [PUBMED:11278486] [PUBMED:8107774] [PUBMED:10975528]
RHO GTPases activate PKNs [NCBI:1269512] [REACTOME:R-HSA-5625740] [PUBMED:21351730] [PUBMED:21749319] [PUBMED:10753910] [PUBMED:18429822] [PUBMED:9175763] [PUBMED:12783890] [PUBMED:14514689] [PUBMED:10924361] [PUBMED:7673228] [PUBMED:10619026] [PUBMED:10467162] [PUBMED:11134534] [PUBMED:9030526] [PUBMED:9988689] [PUBMED:19723632] [PUBMED:24128008] [PUBMED:18006505]
Regulation of PLK1 Activity at G2/M Transition [NCBI:1269803] [REACTOME:R-HSA-2565942] [PUBMED:12207013] [PUBMED:18615013] [PUBMED:13678582] [PUBMED:18378770] [PUBMED:18566290] [PUBMED:18477460] [PUBMED:22365832]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signaling by TGF-beta Receptor Complex [NCBI:1269523] [REACTOME:R-HSA-170834] [PUBMED:19648010]
TGF-beta receptor signaling activates SMADs [NCBI:1269524] [REACTOME:R-HSA-2173789] [PUBMED:9346966] [PUBMED:15350224] [PUBMED:7737999] [PUBMED:11100470] [PUBMED:7693660] [PUBMED:9670020] [PUBMED:15564041] [PUBMED:9233797] [PUBMED:20207738] [PUBMED:11779505] [PUBMED:18243111] [PUBMED:8947046] [PUBMED:1333888] [PUBMED:9311995] [PUBMED:12482908] [PUBMED:8980228] [PUBMED:8242743] [PUBMED:9865696] [PUBMED:8047140] [PUBMED:21423151]
Vascular smooth muscle contraction [NCBI:96530] [KEGG:hsa04270] [PUBMED:16870827] [PUBMED:10911373] [PUBMED:11679404] [PUBMED:16339747] [PUBMED:10221985] [PUBMED:12689814] [PUBMED:11165670] [PUBMED:18552454] [PUBMED:12060106] [PUBMED:9458738] [PUBMED:15725705] [PUBMED:18040024] [PUBMED:12693609] [PUBMED:11773611] [PUBMED:17158339] [PUBMED:17458653] [PUBMED:15026027] [PUBMED:19120701] [PUBMED:15269340] [PUBMED:18703404] [PUBMED:11709400] [PUBMED:17200683]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]
mRNA surveillance pathway [NCBI:193328] [KEGG:hsa03015] [PUBMED:16723977] [PUBMED:18158581] [PUBMED:16715045] [PUBMED:17183357] [PUBMED:15040442]