full name
eukaryotic translation initiation factor 2 alpha kinase 2

synonyms
EIF2AK1, PKR, PRKR, EIF2AK2, ENSG00000055332

HGNC
HGNC:9437

Entrez Gene
Gene:5610

ENSEMBL
ENSG00000055332

location
chr: 2
start: 37332281
stop: 37384190
strand: -

OMIM
OMIM:176871: EIF2AK2
OMIM:618877: Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome

transcripts
NM_001135651.2
NM_002759.3
NM_001135652.2

pathways
Antiviral mechanism by IFN-stimulated genes [NCBI:1269316] [REACTOME:R-HSA-1169410]
Ceramide signaling pathway [NCBI:138023] [Pathway Interaction Database:ceramide_pathway] [PUBMED:11350735] [PUBMED:10400650] [PUBMED:9287216] [PUBMED:9488730] [PUBMED:8702918] [PUBMED:10969079] [PUBMED:10433354] [PUBMED:14739942] [PUBMED:9446561] [PUBMED:8808629] [PUBMED:8681376] [PUBMED:7477354] [PUBMED:14689449] [PUBMED:12866359] [PUBMED:9873064] [PUBMED:8933152] [PUBMED:10438487] [PUBMED:15881228] [PUBMED:10508159] [PUBMED:7519779] [PUBMED:8387486] [PUBMED:12154098] [PUBMED:7559390] [PUBMED:12486111] [PUBMED:14670935] [PUBMED:15901738] [PUBMED:15051724] [PUBMED:8393446] [PUBMED:9094715] [PUBMED:11723139] [PUBMED:10395296] [PUBMED:8681377] [PUBMED:11148216] [PUBMED:12566438] [PUBMED:15164763] [PUBMED:10026132] [PUBMED:10962008]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
Hepatitis C [NCBI:173973] [KEGG:hsa05160] [PUBMED:19708811] [PUBMED:16314558] [PUBMED:17467654] [PUBMED:19515018] [PUBMED:18514579] [PUBMED:16107833] [PUBMED:19074178] [PUBMED:12691459] [PUBMED:15302943] [PUBMED:20537953] [PUBMED:11991644] [PUBMED:19148799] [PUBMED:19187070] [PUBMED:12655344]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
Host Interactions with Influenza Factors [NCBI:1269130] [REACTOME:R-HSA-168253]
ISG15 antiviral mechanism [NCBI:1269317] [REACTOME:R-HSA-1169408] [PUBMED:20153823] [PUBMED:12582176] [PUBMED:16009940] [PUBMED:20946978] [PUBMED:15970528]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Influenza A [NCBI:217173] [KEGG:hsa05164] [PUBMED:17267598] [PUBMED:18049471] [PUBMED:16882036] [PUBMED:11907320] [PUBMED:17944269] [PUBMED:20629046] [PUBMED:17072332] [PUBMED:18588994] [PUBMED:19864182] [PUBMED:19290913] [PUBMED:19420020] [PUBMED:17213831] [PUBMED:9060654] [PUBMED:19481124] [PUBMED:16494716] [PUBMED:21147034] [PUBMED:18980544] [PUBMED:20020828] [PUBMED:15502848] [PUBMED:19782761]
Influenza Infection [NCBI:1269108] [REACTOME:R-HSA-168254]
Inhibition of PKR [NCBI:1269135] [REACTOME:R-HSA-169131]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
Measles [NCBI:213306] [KEGG:hsa05162] [PUBMED:16237742] [PUBMED:12804771] [PUBMED:19198562] [PUBMED:20376484] [PUBMED:11385511] [PUBMED:16963735] [PUBMED:19198566] [PUBMED:18922877] [PUBMED:19203114] [PUBMED:12620806] [PUBMED:16690907] [PUBMED:17720800] [PUBMED:20636817] [PUBMED:12410527] [PUBMED:11582511] [PUBMED:19203109] [PUBMED:19203113] [PUBMED:14585342] [PUBMED:12805463]
NS1 Mediated Effects on Host Pathways [NCBI:1269131] [REACTOME:R-HSA-168276]
Protein processing in endoplasmic reticulum [NCBI:167325] [KEGG:hsa04141] [PUBMED:20347046] [PUBMED:18023214] [PUBMED:20219571] [PUBMED:19491040] [PUBMED:20112977]
Signaling events mediated by TCPTP [NCBI:169350] [Pathway Interaction Database:tcptp_pathway] [PUBMED:12612081] [PUBMED:18716132] [PUBMED:19171783] [PUBMED:9488479] [PUBMED:15592458] [PUBMED:9261175] [PUBMED:16431927] [PUBMED:15632081] [PUBMED:12359225] [PUBMED:12138178] [PUBMED:7593185] [PUBMED:18840653] [PUBMED:15696169] [PUBMED:18691551] [PUBMED:20484139] [PUBMED:11773439] [PUBMED:16595549] [PUBMED:18948751] [PUBMED:16971512] [PUBMED:12171910] [PUBMED:18819921] [PUBMED:15192089] [PUBMED:17210636] [PUBMED:10488121] [PUBMED:16705167] [PUBMED:14966296] [PUBMED:11909529] [PUBMED:11479308]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]