full name
zeta chain of T-cell receptor associated protein kinase 70

synonyms
SRK, STCD, STD, TZK, ZAP-70, ZAP70, ENSG00000115085

HGNC
HGNC:12858

Entrez Gene
Gene:7535

ENSEMBL
ENSG00000115085

location
chr: 2
start: 98330031
stop: 98356990
strand: +

OMIM
OMIM:176947: ZAP70 (Autosomal recessive inheritance)
OMIM:617006: Autoimmune disease, multisystem, infantile-onset, 2
OMIM:269840: Immunodeficiency 48

transcripts
NM_001079.3
NM_207519.1

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Generation of second messenger molecules [NCBI:1269175] [REACTOME:R-HSA-202433] [PUBMED:15084594]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
Natural killer cell mediated cytotoxicity [NCBI:83079] [KEGG:hsa04650] [PUBMED:12530970] [PUBMED:15567854] [PUBMED:8942070] [PUBMED:11905813] [PUBMED:9143705] [PUBMED:9862693] [PUBMED:11895890] [PUBMED:12205470] [PUBMED:11836514] [PUBMED:15607806] [PUBMED:16002670] [PUBMED:15618404] [PUBMED:11390470] [PUBMED:11062493] [PUBMED:14710949] [PUBMED:12752668] [PUBMED:15607802] [PUBMED:16109839] [PUBMED:12766758] [PUBMED:16177799]
Primary immunodeficiency [NCBI:83125] [KEGG:hsa05340] [PUBMED:11941303] [PUBMED:18093537] [PUBMED:11058677] [PUBMED:17952897] [PUBMED:14699405] [PUBMED:15661024] [PUBMED:14647478] [PUBMED:17960151] [PUBMED:16261175]
Ras signaling pathway [NCBI:868085] [KEGG:hsa04014] [PUBMED:23506953] [PUBMED:18437264] [PUBMED:15062121] [PUBMED:22189424] [PUBMED:22233291] [PUBMED:12778136] [PUBMED:11313946] [PUBMED:17428555] [PUBMED:19091743] [PUBMED:18568040] [PUBMED:20420946] [PUBMED:12217381] [PUBMED:14663478] [PUBMED:21686117] [PUBMED:12642680] [PUBMED:21196257] [PUBMED:16869784] [PUBMED:21111786] [PUBMED:16966426] [PUBMED:10712923] [PUBMED:22020205] [PUBMED:17384584] [PUBMED:15572660] [PUBMED:18413813]
T cell receptor signaling pathway [NCBI:83080] [KEGG:hsa04660] [PUBMED:17395537] [PUBMED:15308211] [PUBMED:15928679] [PUBMED:14656980] [PUBMED:17187070] [PUBMED:15084594] [PUBMED:16799472] [PUBMED:12669022] [PUBMED:15286727] [PUBMED:15122199] [PUBMED:19132916] [PUBMED:15489916] [PUBMED:11905831] [PUBMED:12195013] [PUBMED:15343367] [PUBMED:12133805] [PUBMED:14647476] [PUBMED:15771581] [PUBMED:15099566] [PUBMED:14617194] [PUBMED:19290929] [PUBMED:15345216]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
TCR signaling in naive CD4+ T cells [NCBI:137998] [Pathway Interaction Database:tcr_pathway] [PUBMED:11376344] [PUBMED:9094314] [PUBMED:8083187] [PUBMED:11994416] [PUBMED:16365455] [PUBMED:10072079] [PUBMED:12361955] [PUBMED:12755691] [PUBMED:8642247] [PUBMED:15125833] [PUBMED:7509360] [PUBMED:11353765] [PUBMED:12941616] [PUBMED:8700169] [PUBMED:11120819] [PUBMED:15899849] [PUBMED:8990121] [PUBMED:8702662] [PUBMED:8164687] [PUBMED:2141684] [PUBMED:11567141] [PUBMED:9846481] [PUBMED:9489702] [PUBMED:10811803] [PUBMED:11368773] [PUBMED:14557276] [PUBMED:2548204] [PUBMED:10318843] [PUBMED:15536066] [PUBMED:10652356] [PUBMED:7568038] [PUBMED:11175263] [PUBMED:9438848] [PUBMED:9692882] [PUBMED:10209031] [PUBMED:7509083] [PUBMED:12874226] [PUBMED:8673706] [PUBMED:16733527] [PUBMED:9822663] [PUBMED:12738795] [PUBMED:11904433] [PUBMED:8084588] [PUBMED:8114715] [PUBMED:9312162] [PUBMED:8790380] [PUBMED:9677202] [PUBMED:15802604] [PUBMED:14702343] [PUBMED:10903746] [PUBMED:10807788] [PUBMED:8176201] [PUBMED:9207119] [PUBMED:10790433] [PUBMED:8892604] [PUBMED:9665884] [PUBMED:1639064] [PUBMED:12421919] [PUBMED:8246987] [PUBMED:9710204] [PUBMED:8146197] [PUBMED:2190221] [PUBMED:10229072] [PUBMED:10021361] [PUBMED:9924026] [PUBMED:12186560] [PUBMED:16649996] [PUBMED:11287959] [PUBMED:12917261] [PUBMED:7545666] [PUBMED:11250890] [PUBMED:12842872] [PUBMED:15879121] [PUBMED:11567140] [PUBMED:10209041] [PUBMED:10556826] [PUBMED:8183372] [PUBMED:12397360] [PUBMED:10506192] [PUBMED:10861059] [PUBMED:12507424] [PUBMED:12845325] [PUBMED:10745081] [PUBMED:8195151] [PUBMED:12024036] [PUBMED:7524075] [PUBMED:1464315] [PUBMED:12138205] [PUBMED:7544353] [PUBMED:16906149] [PUBMED:9637919] [PUBMED:2470098] [PUBMED:3919143] [PUBMED:16005298] [PUBMED:10918068] [PUBMED:8636141] [PUBMED:16921383] [PUBMED:8479536] [PUBMED:7556092] [PUBMED:16582901] [PUBMED:8805223] [PUBMED:15933714] [PUBMED:10224278] [PUBMED:9819387] [PUBMED:12881521] [PUBMED:14988727] [PUBMED:16849481] [PUBMED:11390650]
TCR signaling in naive CD8+ T cells [NCBI:138055] [Pathway Interaction Database:cd8tcrpathway] [PUBMED:9094314] [PUBMED:15125833] [PUBMED:11994416] [PUBMED:7509360] [PUBMED:12755691] [PUBMED:8642247] [PUBMED:12361955] [PUBMED:11956228] [PUBMED:10072079] [PUBMED:8977171] [PUBMED:2141684] [PUBMED:8700169] [PUBMED:8164687] [PUBMED:9489702] [PUBMED:8702662] [PUBMED:2548204] [PUBMED:11175263] [PUBMED:8114715] [PUBMED:10209031] [PUBMED:15536066] [PUBMED:7678351] [PUBMED:8673703] [PUBMED:7830771] [PUBMED:7509083] [PUBMED:16733527] [PUBMED:9438848] [PUBMED:8790380] [PUBMED:1639064] [PUBMED:15980863] [PUBMED:8084588] [PUBMED:14702343] [PUBMED:10790433] [PUBMED:10807788] [PUBMED:16169499] [PUBMED:15802604] [PUBMED:8892604] [PUBMED:2114552] [PUBMED:12421919] [PUBMED:12917261] [PUBMED:8146197] [PUBMED:1335364] [PUBMED:10021361] [PUBMED:8183372] [PUBMED:8627172] [PUBMED:8898939] [PUBMED:2190221] [PUBMED:9710204] [PUBMED:11287959] [PUBMED:14764585] [PUBMED:12954628] [PUBMED:10209041] [PUBMED:1464315] [PUBMED:12507424] [PUBMED:12732656] [PUBMED:8195151] [PUBMED:12138205] [PUBMED:16005298] [PUBMED:9312149] [PUBMED:7544353] [PUBMED:16906149] [PUBMED:9637919] [PUBMED:12845325] [PUBMED:2470098] [PUBMED:10918068] [PUBMED:16116204] [PUBMED:16921383] [PUBMED:10562325] [PUBMED:9819387] [PUBMED:16582901] [PUBMED:8034711] [PUBMED:8479536] [PUBMED:10640739] [PUBMED:3919143] [PUBMED:10224278] [PUBMED:10811865]
Th1 and Th2 cell differentiation [NCBI:1458885] [KEGG:hsa04658] [PUBMED:15819694] [PUBMED:12171942] [PUBMED:19165228] [PUBMED:23336087] [PUBMED:26044597] [PUBMED:19151746] [PUBMED:19362457] [PUBMED:22044277] [PUBMED:11752608] [PUBMED:23405903] [PUBMED:19375293] [PUBMED:24113868] [PUBMED:19151747] [PUBMED:23624818] [PUBMED:22566933] [PUBMED:11121747] [PUBMED:20969597] [PUBMED:20065998]
Th17 cell differentiation [NCBI:1469482] [KEGG:hsa04659] [PUBMED:23325835] [PUBMED:23036716] [PUBMED:20488727] [PUBMED:21151104] [PUBMED:21084214] [PUBMED:20054607] [PUBMED:22754770] [PUBMED:22640807] [PUBMED:19379825] [PUBMED:22133865] [PUBMED:22324470] [PUBMED:17768419] [PUBMED:18408735] [PUBMED:21776333] [PUBMED:26253381] [PUBMED:16200068] [PUBMED:18362914] [PUBMED:24325586] [PUBMED:19381306] [PUBMED:18166487]
Translocation of ZAP-70 to Immunological synapse [NCBI:1269174] [REACTOME:R-HSA-202430] [PUBMED:10375551]