full name
protein C, inactivator of coagulation factors Va and VIIIa

synonyms
APC, PC, PROC1, THPH3, THPH4, PROC, ENSG00000115718

HGNC
HGNC:9451

Entrez Gene
Gene:5624

ENSEMBL
ENSG00000115718

location
chr: 2
start: 128175996
stop: 128186822
strand: +

OMIM
OMIM:612283: PROC (Autosomal dominant inheritance)
OMIM:176860: Thrombophilia due to protein C deficiency, autosomal dominant
OMIM:612304: Thrombophilia due to protein C deficiency, autosomal recessive

transcripts
NM_000312.3

pathways
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Common Pathway of Fibrin Clot Formation [NCBI:1269371] [REACTOME:R-HSA-140875] [PUBMED:1931959]
Complement and coagulation cascades [NCBI:83073] [KEGG:hsa04610] [PUBMED:23564577] [PUBMED:25309880] [PUBMED:26082779] [PUBMED:23110467] [PUBMED:20027185] [PUBMED:25568220] [PUBMED:26324800] [PUBMED:25705421] [PUBMED:21811895] [PUBMED:23911436] [PUBMED:23564578] [PUBMED:24924409] [PUBMED:26489954] [PUBMED:17635716]
Formation of Fibrin Clot (Clotting Cascade) [NCBI:1269368] [REACTOME:R-HSA-140877] [PUBMED:1931959] [PUBMED:12524220]
Gamma carboxylation, hypusine formation and arylsulfatase activation [NCBI:1268702] [REACTOME:R-HSA-163841]
Gamma-carboxylation of protein precursors [NCBI:1268704] [REACTOME:R-HSA-159740] [PUBMED:10917896] [PUBMED:10068650] [PUBMED:11071668] [PUBMED:11513608] [PUBMED:9845520]
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins [NCBI:1268703] [REACTOME:R-HSA-159854]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Intrinsic Pathway of Fibrin Clot Formation [NCBI:1269370] [REACTOME:R-HSA-140837] [PUBMED:1931959] [PUBMED:7598447] [PUBMED:12231555] [PUBMED:14691562]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Removal of aminoterminal propeptides from gamma-carboxylated proteins [NCBI:1268706] [REACTOME:R-HSA-159782] [PUBMED:8846780] [PUBMED:1629222] [PUBMED:8473289] [PUBMED:9108399] [PUBMED:8463288]
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus [NCBI:1268705] [REACTOME:R-HSA-159763] [PUBMED:11252894]