full name
Rho guanine nucleotide exchange factor 4

synonyms
ASEF, ASEF1, GEF4, STM6, ARHGEF4, ENSG00000136002

HGNC
HGNC:684

Entrez Gene
Gene:50649

ENSEMBL
ENSG00000136002

location
chr: 2
start: 131594489
stop: 131804826
strand: +

transcripts
NM_015320.3
NM_032995.2

pathways
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
G alpha (12/13) signalling events [NCBI:1269579] [REACTOME:R-HSA-416482] [PUBMED:18814923] [PUBMED:19212140]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
NRAGE signals death through JNK [NCBI:1269448] [REACTOME:R-HSA-193648] [PUBMED:12376548]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
Rho GTPase cycle [NCBI:1269508] [REACTOME:R-HSA-194840] [PUBMED:17222083] [PUBMED:9308960]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) [NCBI:137930] [Pathway Interaction Database:met_pathway] [PUBMED:10793146] [PUBMED:8906793] [PUBMED:11929826] [PUBMED:10022866] [PUBMED:11532961] [PUBMED:12475979] [PUBMED:1718989] [PUBMED:1846706] [PUBMED:10970810] [PUBMED:10516287] [PUBMED:12138161] [PUBMED:11046147] [PUBMED:18073207] [PUBMED:12951049] [PUBMED:15494312] [PUBMED:9001234] [PUBMED:11352916] [PUBMED:11896055] [PUBMED:9440692] [PUBMED:8607979] [PUBMED:12244132] [PUBMED:11162460] [PUBMED:11809798] [PUBMED:9693375] [PUBMED:14636584] [PUBMED:17297451] [PUBMED:17682062] [PUBMED:19628037] [PUBMED:11069926] [PUBMED:18819921] [PUBMED:16423831] [PUBMED:10558875] [PUBMED:16858414] [PUBMED:10995442] [PUBMED:20332103] [PUBMED:11146548] [PUBMED:18346875] [PUBMED:17894413] [PUBMED:9252406] [PUBMED:17635922] [PUBMED:11134526] [PUBMED:2005882] [PUBMED:19609305] [PUBMED:8380735] [PUBMED:16537482] [PUBMED:10618718] [PUBMED:9591773] [PUBMED:12894582] [PUBMED:9748249] [PUBMED:11741535] [PUBMED:17881575] [PUBMED:10713050] [PUBMED:1655790] [PUBMED:11784715] [PUBMED:10753869] [PUBMED:10713700] [PUBMED:11118451] [PUBMED:16952352] [PUBMED:15314156] [PUBMED:19272169] [PUBMED:12802068] [PUBMED:17363898] [PUBMED:7513258] [PUBMED:1827664] [PUBMED:2541345] [PUBMED:8387483] [PUBMED:16620780] [PUBMED:11445578] [PUBMED:10734310] [PUBMED:16227611] [PUBMED:12941962] [PUBMED:15735664] [PUBMED:19071214] [PUBMED:7731718] [PUBMED:19289496] [PUBMED:11438654] [PUBMED:11896612] [PUBMED:11894096] [PUBMED:11896575] [PUBMED:7499247] [PUBMED:12147692] [PUBMED:11948414] [PUBMED:19881549] [PUBMED:19525225] [PUBMED:14684163] [PUBMED:17055484] [PUBMED:9668053] [PUBMED:10531383] [PUBMED:9681449] [PUBMED:1655405] [PUBMED:12686592] [PUBMED:19109251] [PUBMED:10679787] [PUBMED:9487126] [PUBMED:9886295] [PUBMED:12058075] [PUBMED:15452053] [PUBMED:9184210] [PUBMED:10871282] [PUBMED:17329361] [PUBMED:2554238]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]