full name
signal transducing adaptor molecule 2

synonyms
Hbp, STAM2A, STAM2B, STAM2, ENSG00000115145

HGNC
HGNC:11358

Entrez Gene
Gene:10254

ENSEMBL
ENSG00000115145

location
chr: 2
start: 152973315
stop: 153032506
strand: -

transcripts
NM_005843.4

pathways
Cargo recognition for clathrin-mediated endocytosis [NCBI:1427859] [REACTOME:R-HSA-8856825] [PUBMED:24186068] [PUBMED:12952941] [PUBMED:19696796] [PUBMED:14985334] [PUBMED:20448150] [PUBMED:20485680] [PUBMED:16382132] [PUBMED:23482940] [PUBMED:16870701]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
EGFR downregulation [NCBI:1269385] [REACTOME:R-HSA-182971] [PUBMED:11283727] [PUBMED:15021893] [PUBMED:14641021]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Endosomal Sorting Complex Required For Transport (ESCRT) [NCBI:1269895] [REACTOME:R-HSA-917729] [PUBMED:19345195] [PUBMED:17450176] [PUBMED:17988873]
IL2-mediated signaling events [NCBI:137976] [Pathway Interaction Database:il2_1pathway] [PUBMED:7568005] [PUBMED:10962026] [PUBMED:1545122] [PUBMED:10602027] [PUBMED:15170389] [PUBMED:9092570] [PUBMED:7509794] [PUBMED:15356145] [PUBMED:9973481] [PUBMED:10899310] [PUBMED:9195132] [PUBMED:7544001] [PUBMED:7777534] [PUBMED:12681450] [PUBMED:7665592] [PUBMED:8702919] [PUBMED:1708096] [PUBMED:8643566] [PUBMED:7988557] [PUBMED:7737351] [PUBMED:1532814] [PUBMED:8262551] [PUBMED:8025955] [PUBMED:10993906] [PUBMED:3095922] [PUBMED:8805624] [PUBMED:9391116] [PUBMED:7973658] [PUBMED:11331873] [PUBMED:10421845] [PUBMED:8119884] [PUBMED:7781605] [PUBMED:12543077] [PUBMED:9133424] [PUBMED:1618313] [PUBMED:1940342] [PUBMED:9382798] [PUBMED:10514520] [PUBMED:7973659] [PUBMED:1639773] [PUBMED:9029085] [PUBMED:7760801] [PUBMED:1460037] [PUBMED:9202126] [PUBMED:1652056] [PUBMED:12393431] [PUBMED:8397196] [PUBMED:2047859] [PUBMED:7688728] [PUBMED:8700888] [PUBMED:7528668] [PUBMED:9305919] [PUBMED:2303462] [PUBMED:7568001] [PUBMED:9822600] [PUBMED:7543676] [PUBMED:7499365] [PUBMED:10843677] [PUBMED:7600304] [PUBMED:7719937] [PUBMED:9590209] [PUBMED:9794391] [PUBMED:10849428] [PUBMED:8294403] [PUBMED:10373548] [PUBMED:2590941] [PUBMED:9512511] [PUBMED:6434688] [PUBMED:9697832] [PUBMED:10982827] [PUBMED:10214954] [PUBMED:10825200] [PUBMED:1535827] [PUBMED:10369681] [PUBMED:7719938] [PUBMED:1655887] [PUBMED:8376945] [PUBMED:1996324] [PUBMED:7479881] [PUBMED:10962581] [PUBMED:7973657] [PUBMED:1631559] [PUBMED:10066828] [PUBMED:9169478] [PUBMED:8552611] [PUBMED:8483935] [PUBMED:2106566] [PUBMED:16199887]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
InlB-mediated entry of Listeria monocytogenes into host cell [NCBI:1470919] [REACTOME:R-HSA-8875360] [PUBMED:20670691] [PUBMED:11081636] [PUBMED:19900460] [PUBMED:19432801] [PUBMED:17662939] [PUBMED:16113677]
Jak-STAT signaling pathway [NCBI:83077] [KEGG:hsa04630] [PUBMED:21034406] [PUBMED:22339650] [PUBMED:16204702] [PUBMED:25587654] [PUBMED:24069565] [PUBMED:22383755] [PUBMED:24606160] [PUBMED:10851053] [PUBMED:23735217] [PUBMED:25217450] [PUBMED:21372217]
Listeria monocytogenes entry into host cells [NCBI:1470917] [REACTOME:R-HSA-8876384] [PUBMED:23125201] [PUBMED:21921683] [PUBMED:23376167] [PUBMED:25624443] [PUBMED:19191787] [PUBMED:20485518] [PUBMED:15337781]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Negative regulation of MET activity [NCBI:1457805] [REACTOME:R-HSA-6807004] [PUBMED:24828152] [PUBMED:11894096] [PUBMED:14684163] [PUBMED:12475979] [PUBMED:23208509] [PUBMED:9001234] [PUBMED:11420688] [PUBMED:18819921] [PUBMED:11741535] [PUBMED:15314156]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by MET [NCBI:1457794] [REACTOME:R-HSA-6806834] [PUBMED:1846706] [PUBMED:12948444] [PUBMED:16782899] [PUBMED:15249655] [PUBMED:22270953] [PUBMED:15167892] [PUBMED:7708691] [PUBMED:11081636] [PUBMED:8384622] [PUBMED:21102609] [PUBMED:16461907] [PUBMED:9407027] [PUBMED:7854453] [PUBMED:7651534] [PUBMED:9070211] [PUBMED:8208547] [PUBMED:24518591] [PUBMED:6590967] [PUBMED:15180923] [PUBMED:20802513] [PUBMED:10521801] [PUBMED:9038378] [PUBMED:17403932] [PUBMED:1655790] [PUBMED:12006644] [PUBMED:7513258] [PUBMED:18614017] [PUBMED:10753869] [PUBMED:17662939] [PUBMED:14685170] [PUBMED:10734310] [PUBMED:1827664] [PUBMED:7731718] [PUBMED:19996456] [PUBMED:11430831] [PUBMED:8302603] [PUBMED:15218027] [PUBMED:9140397] [PUBMED:2423252] [PUBMED:16113677] [PUBMED:12147692] [PUBMED:10648629] [PUBMED:7854452] [PUBMED:15070743] [PUBMED:15301554] [PUBMED:19881549] [PUBMED:25992381] [PUBMED:10871282] [PUBMED:12726861]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]