full name
Rap guanine nucleotide exchange factor 4

synonyms
CAMP-GEFII, CGEF2, EPAC2, Nbla00496, RAPGEF4, ENSG00000091428

HGNC
HGNC:16626

Entrez Gene
Gene:11069

ENSEMBL
ENSG00000091428

location
chr: 2
start: 173600525
stop: 173917621
strand: +

transcripts
NM_007023.3
NM_001100397.1

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Adrenergic signaling in cardiomyocytes [NCBI:908257] [KEGG:hsa04261] [PUBMED:15232578] [PUBMED:20923637] [PUBMED:10571541] [PUBMED:11604549] [PUBMED:17988210] [PUBMED:11805843] [PUBMED:15142747] [PUBMED:21212391] [PUBMED:20658186] [PUBMED:16765984] [PUBMED:19874988] [PUBMED:19883653] [PUBMED:15979723] [PUBMED:18407781] [PUBMED:22022314] [PUBMED:12439640] [PUBMED:17826821] [PUBMED:15765137]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion [NCBI:1270107] [REACTOME:R-HSA-381676] [PUBMED:8830891] [PUBMED:15569269] [PUBMED:17306374] [PUBMED:9914469] [PUBMED:17900700] [PUBMED:11078440] [PUBMED:12475787] [PUBMED:11815463]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Insulin secretion [NCBI:777534] [KEGG:hsa04911] [PUBMED:9715374] [PUBMED:10605628] [PUBMED:9914469] [PUBMED:17306374] [PUBMED:20055708] [PUBMED:15655710] [PUBMED:19817784] [PUBMED:19074620] [PUBMED:14693691] [PUBMED:17084085] [PUBMED:20551594] [PUBMED:19036624] [PUBMED:22970724] [PUBMED:20225132] [PUBMED:19817800] [PUBMED:22974438] [PUBMED:21934040] [PUBMED:15271645] [PUBMED:19660440] [PUBMED:11522660]
Integration of energy metabolism [NCBI:1270101] [REACTOME:R-HSA-163685] [PUBMED:15509864] [PUBMED:12721358] [PUBMED:12626323]
Integrin alphaIIb beta3 signaling [NCBI:1269359] [REACTOME:R-HSA-354192] [PUBMED:10605720] [PUBMED:14754902] [PUBMED:17624957] [PUBMED:16102042] [PUBMED:15205259] [PUBMED:10508650]
Leukocyte transendothelial migration [NCBI:83083] [KEGG:hsa04670] [PUBMED:15629883] [PUBMED:10975856] [PUBMED:14976004] [PUBMED:15265790] [PUBMED:15173832] [PUBMED:12540948] [PUBMED:15771581] [PUBMED:15604886] [PUBMED:14977592]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Phospholipase D signaling pathway [NCBI:1311074] [KEGG:hsa04072] [PUBMED:9310372] [PUBMED:9119890] [PUBMED:15310762] [PUBMED:18936782] [PUBMED:24990952] [PUBMED:14769825] [PUBMED:21936578] [PUBMED:10666319] [PUBMED:17210675] [PUBMED:19264150] [PUBMED:23076158] [PUBMED:17054901] [PUBMED:16622417] [PUBMED:10807766] [PUBMED:12217395] [PUBMED:11042115] [PUBMED:19815110] [PUBMED:24995811] [PUBMED:16143829] [PUBMED:8135758] [PUBMED:11991733] [PUBMED:19410013] [PUBMED:17245604]
Platelet Aggregation (Plug Formation) [NCBI:1269358] [REACTOME:R-HSA-76009] [PUBMED:18174460] [PUBMED:17585075]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Rap1 signaling pathway [NCBI:868086] [KEGG:hsa04015] [PUBMED:17624944] [PUBMED:12351703] [PUBMED:10579920] [PUBMED:19159611] [PUBMED:18363565] [PUBMED:12765839] [PUBMED:12508104] [PUBMED:11331911] [PUBMED:17182900] [PUBMED:15803158] [PUBMED:19615876] [PUBMED:21402149] [PUBMED:17624948] [PUBMED:17383543] [PUBMED:14607972] [PUBMED:15780587] [PUBMED:19710505]
Rap1 signalling [NCBI:1269202] [REACTOME:R-HSA-392517] [PUBMED:16076873]
Regulation of insulin secretion [NCBI:1270102] [REACTOME:R-HSA-422356] [PUBMED:18200017] [PUBMED:11078440] [PUBMED:16321791] [PUBMED:11815463] [PUBMED:16556766]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]