full name
glutaminase
synonyms
AAD20, GAC, GAM, GLS1, KGA, GLS, ENSG00000115419
HGNC
HGNC:4331
Entrez Gene
Gene:2744
ENSEMBL
ENSG00000115419
location
chr: 2
start: 191745547
stop: 191830278
strand: +
OMIM
OMIM:138280:
GLS
OMIM:618339:
?Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development
OMIM:618328:
Epileptic encephalopathy, early infantile, 71
OMIM:618412:
Global developmental delay, progressive ataxia, and elevated glutamine
transcripts
NM_014905.4
NM_001256310.1
pathways
Alanine, aspartate and glutamate metabolism
[NCBI:101142]
[KEGG:hsa00250]
[PUBMED:9687539]
Amino acid synthesis and interconversion (transamination)
[NCBI:1270159]
[REACTOME:R-HSA-70614]
Arginine biosynthesis
[NCBI:82943]
[KEGG:hsa00220]
Central carbon metabolism in cancer
[NCBI:1059538]
[KEGG:hsa05230]
[PUBMED:16982728]
[PUBMED:21127244]
[PUBMED:22349059]
[PUBMED:19270154]
[PUBMED:24113830]
[PUBMED:22156302]
[PUBMED:21801601]
[PUBMED:15916903]
[PUBMED:18177721]
[PUBMED:22237205]
[PUBMED:20520704]
[PUBMED:23018234]
[PUBMED:23897900]
[PUBMED:24398961]
[PUBMED:24079832]
[PUBMED:18538731]
[PUBMED:19460998]
[PUBMED:22307140]
[PUBMED:18766298]
[PUBMED:22101401]
[PUBMED:23071355]
[PUBMED:21508971]
[PUBMED:24738035]
[PUBMED:22750268]
[PUBMED:21258394]
[PUBMED:23279446]
[PUBMED:21340684]
D-Glutamine and D-glutamate metabolism
[NCBI:82971]
[KEGG:hsa00471]
GABAergic synapse
[NCBI:377263]
[KEGG:hsa04727]
[PUBMED:21555068]
[PUBMED:20655485]
[PUBMED:16932937]
[PUBMED:17499108]
[PUBMED:12086709]
[PUBMED:20655481]
[PUBMED:21376567]
[PUBMED:19374920]
[PUBMED:17499109]
[PUBMED:10780899]
[PUBMED:16787421]
[PUBMED:15210304]
[PUBMED:18382465]
[PUBMED:12888801]
[PUBMED:9364667]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Glutamate Neurotransmitter Release Cycle
[NCBI:1268771]
[REACTOME:R-HSA-210500]
[PUBMED:8825650]
[PUBMED:11001057]
[PUBMED:16990140]
[PUBMED:10440375]
[PUBMED:16704978]
[PUBMED:17478680]
[PUBMED:9701566]
Glutamatergic synapse
[NCBI:213818]
[KEGG:hsa04724]
[PUBMED:10481192]
[PUBMED:11561058]
[PUBMED:18425072]
[PUBMED:17706608]
[PUBMED:20055706]
[PUBMED:19112153]
[PUBMED:17663464]
[PUBMED:19110202]
[PUBMED:19559598]
[PUBMED:9665875]
[PUBMED:11672421]
[PUBMED:18464791]
[PUBMED:12399578]
[PUBMED:14684436]
Metabolic pathways
[NCBI:132956]
[KEGG:hsa01100]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives
[NCBI:1270158]
[REACTOME:R-HSA-71291]
MicroRNAs in cancer
[NCBI:852705]
[KEGG:hsa05206]
[PUBMED:23075324]
[PUBMED:21742789]
[PUBMED:22351564]
[PUBMED:18817506]
[PUBMED:22345301]
[PUBMED:21402473]
[PUBMED:22926415]
[PUBMED:23165235]
[PUBMED:19630570]
[PUBMED:21565290]
[PUBMED:23091478]
[PUBMED:23462054]
[PUBMED:23316212]
[PUBMED:19773200]
[PUBMED:22035854]
[PUBMED:20221895]
[PUBMED:20345848]
[PUBMED:22580099]
[PUBMED:20128019]
Neuronal System
[NCBI:1268763]
[REACTOME:R-HSA-112316]
Neurotransmitter Release Cycle
[NCBI:1268768]
[REACTOME:R-HSA-112310]
[PUBMED:15217342]
[PUBMED:16819626]
[PUBMED:17880890]
[PUBMED:16865347]
Proximal tubule bicarbonate reclamation
[NCBI:144182]
[KEGG:hsa04964]
[PUBMED:11826292]
[PUBMED:11385088]
[PUBMED:19721811]
[PUBMED:12138151]
[PUBMED:16914536]
[PUBMED:17557941]
[PUBMED:18056784]
[PUBMED:9550618]
[PUBMED:11045400]
[PUBMED:19948674]
[PUBMED:11533299]
[PUBMED:16352913]
TP53 Regulates Metabolic Genes
[NCBI:1269655]
[REACTOME:R-HSA-5628897]
[PUBMED:19822145]
[PUBMED:12453409]
[PUBMED:18344994]
[PUBMED:11545734]
[PUBMED:16839880]
[PUBMED:20399660]
[PUBMED:15105503]
[PUBMED:13298683]
[PUBMED:15665293]
[PUBMED:18198340]
[PUBMED:18692468]
[PUBMED:12203114]
[PUBMED:17409411]
[PUBMED:11959846]
[PUBMED:16728594]
[PUBMED:17486094]
[PUBMED:23484829]
[PUBMED:22682249]
[PUBMED:19696408]
[PUBMED:9926927]
[PUBMED:22864287]
[PUBMED:20378837]
[PUBMED:18391940]
[PUBMED:24366874]
[PUBMED:19439913]
[PUBMED:15059920]
[PUBMED:10716435]
[PUBMED:17540029]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Transmission across Chemical Synapses
[NCBI:1268766]
[REACTOME:R-HSA-112315]
glutamine degradation/glutamate biosynthesis
[NCBI:547502]
[BIOCYC:HUMAN_GLUTAMINDEG-PWY]
[PUBMED:11130979]
[PUBMED:6132422]
[PUBMED:22049910]
