full name
CASP8 and FADD like apoptosis regulator

synonyms
c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASH, CASP8AP1, Casper, CLARP, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, CFLAR, ENSG00000003402

HGNC
HGNC:1876

Entrez Gene
Gene:8837

ENSEMBL
ENSG00000003402

location
chr: 2
start: 201980877
stop: 202037411
strand: +

transcripts
NM_003879.5
NM_001202516.1
NM_001202519.1
NM_001202517.1
NM_001127184.2
NM_001127183.2
NM_001202518.1
NM_001202515.1

pathways
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Autophagy - animal [NCBI:83058] [KEGG:hsa04140] [PUBMED:16200202] [PUBMED:15325588] [PUBMED:24343578] [PUBMED:15978794] [PUBMED:19802558] [PUBMED:16099218] [PUBMED:11099404] [PUBMED:19653858] [PUBMED:15325584] [PUBMED:20034776] [PUBMED:15928708] [PUBMED:21801009] [PUBMED:25948417] [PUBMED:16125113] [PUBMED:21187343]
CASP8 activity is inhibited [NCBI:1270301] [REACTOME:R-HSA-5218900] [PUBMED:9087414] [PUBMED:12181749] [PUBMED:23410748] [PUBMED:21737330]
Caspase activation via extrinsic apoptotic signalling pathway [NCBI:1270263] [REACTOME:R-HSA-5357769] [PUBMED:11048727]
Chagas disease (American trypanosomiasis) [NCBI:147809] [KEGG:hsa05142] [PUBMED:12377585] [PUBMED:9794425] [PUBMED:1717552] [PUBMED:16238097] [PUBMED:10066513] [PUBMED:12874238] [PUBMED:12036740] [PUBMED:15917295] [PUBMED:12055254] [PUBMED:17651955] [PUBMED:1396957] [PUBMED:16175174] [PUBMED:2194668] [PUBMED:9190942] [PUBMED:12377942] [PUBMED:12427093] [PUBMED:10234174] [PUBMED:16030288] [PUBMED:15223603] [PUBMED:17110955]
Death Receptor Signalling [NCBI:1269644] [REACTOME:R-HSA-73887]
Dimerization of procaspase-8 [NCBI:1270265] [REACTOME:R-HSA-69416] [PUBMED:20308068] [PUBMED:19851329] [PUBMED:12620240]
FAS (CD95) signaling pathway [NCBI:138081] [Pathway Interaction Database:faspathway] [PUBMED:9765224] [PUBMED:11717445] [PUBMED:9727491] [PUBMED:11279218] [PUBMED:12110583] [PUBMED:11739735] [PUBMED:8521815] [PUBMED:9184224] [PUBMED:20153221] [PUBMED:9126929] [PUBMED:10200443] [PUBMED:16033886] [PUBMED:8681377] [PUBMED:9880544] [PUBMED:9501089] [PUBMED:10535980] [PUBMED:9727492] [PUBMED:7523573] [PUBMED:11101870] [PUBMED:9321399] [PUBMED:9362518] [PUBMED:12724420] [PUBMED:16498403] [PUBMED:11583996] [PUBMED:15557123] [PUBMED:7536343] [PUBMED:12832037] [PUBMED:9576928] [PUBMED:9228058] [PUBMED:7538908] [PUBMED:18635548] [PUBMED:20038679] [PUBMED:10894163] [PUBMED:12545171] [PUBMED:16619028] [PUBMED:9351817] [PUBMED:9045686] [PUBMED:15289496]
HIV-1 Nef: Negative effector of Fas and TNF-alpha [NCBI:137995] [Pathway Interaction Database:hivnefpathway] [PUBMED:9740801] [PUBMED:10224289] [PUBMED:10940292] [PUBMED:9915703] [PUBMED:9564042] [PUBMED:9743501] [PUBMED:9873064] [PUBMED:12748303] [PUBMED:9867840] [PUBMED:11298454] [PUBMED:9184224] [PUBMED:9294162] [PUBMED:9727492] [PUBMED:9244310] [PUBMED:10318789] [PUBMED:12887920] [PUBMED:9230442] [PUBMED:9020361] [PUBMED:9108473] [PUBMED:9215629] [PUBMED:9384571]
Ligand-dependent caspase activation [NCBI:1270264] [REACTOME:R-HSA-140534] [PUBMED:12620240] [PUBMED:14644197] [PUBMED:20308068] [PUBMED:19851329] [PUBMED:12620239]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
RIPK1-mediated regulated necrosis [NCBI:1270299] [REACTOME:R-HSA-5213460] [PUBMED:24773756] [PUBMED:24452471]
Regulated Necrosis [NCBI:1270298] [REACTOME:R-HSA-5218859] [PUBMED:23770045] [PUBMED:24563506] [PUBMED:24452471]
Regulation by c-FLIP [NCBI:1270266] [REACTOME:R-HSA-3371378] [PUBMED:9217161] [PUBMED:21235526] [PUBMED:19416807]
Regulation of necroptotic cell death [NCBI:1270300] [REACTOME:R-HSA-5675482] [PUBMED:18570872] [PUBMED:21737330] [PUBMED:18621737] [PUBMED:12110583] [PUBMED:20218968] [PUBMED:15701649]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
TNF signaling pathway [NCBI:812256] [KEGG:hsa04668] [PUBMED:20489699] [PUBMED:14532286] [PUBMED:21232019] [PUBMED:11897488] [PUBMED:22296764] [PUBMED:10581243] [PUBMED:23085193] [PUBMED:23531747]
TRAIL signaling [NCBI:1269648] [REACTOME:R-HSA-75158] [PUBMED:14634624]
TRAIL signaling pathway [NCBI:137920] [Pathway Interaction Database:trail_pathway] [PUBMED:10958661] [PUBMED:9430226] [PUBMED:9311998] [PUBMED:16227629] [PUBMED:10521396] [PUBMED:9242610] [PUBMED:12668516] [PUBMED:15105837] [PUBMED:11461927] [PUBMED:16319225] [PUBMED:9082980] [PUBMED:9430227] [PUBMED:16980609] [PUBMED:10894160] [PUBMED:16940186] [PUBMED:16636669] [PUBMED:10783243] [PUBMED:11278665] [PUBMED:11376335] [PUBMED:9314565] [PUBMED:10521444] [PUBMED:10894161]
Validated targets of C-MYC transcriptional repression [NCBI:169353] [Pathway Interaction Database:myc_represspathway] [PUBMED:17082179] [PUBMED:11282029] [PUBMED:9869632] [PUBMED:15021909] [PUBMED:16167342] [PUBMED:18056446] [PUBMED:18045875] [PUBMED:1670896] [PUBMED:18393360] [PUBMED:7556187] [PUBMED:11313917] [PUBMED:17471507] [PUBMED:12418961] [PUBMED:9927431] [PUBMED:9924025] [PUBMED:18483244] [PUBMED:14716294] [PUBMED:15506972] [PUBMED:15616584] [PUBMED:12729735] [PUBMED:19219026] [PUBMED:12747840] [PUBMED:2182320] [PUBMED:12545156] [PUBMED:15367674] [PUBMED:11283613] [PUBMED:12384701] [PUBMED:18066065] [PUBMED:18455888] [PUBMED:10920185] [PUBMED:17881732] [PUBMED:20190815] [PUBMED:16352593] [PUBMED:17050536] [PUBMED:11283614] [PUBMED:16391002] [PUBMED:11804592] [PUBMED:7870572] [PUBMED:16940161] [PUBMED:12695333] [PUBMED:17159920] [PUBMED:8972190] [PUBMED:9312026] [PUBMED:17485441] [PUBMED:16288014]