full name
caspase 8
synonyms
ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, CASP8, ENSG00000064012
HGNC
HGNC:1509
Entrez Gene
Gene:841
ENSEMBL
ENSG00000064012
location
chr: 2
start: 202098166
stop: 202152434
strand: +
OMIM
OMIM:601763:
CASP8
(Autosomal recessive inheritance)
OMIM:607271:
?Autoimmune lymphoproliferative syndrome, type IIB
OMIM:114550:
Hepatocellular carcinoma, somatic
OMIM:114480:
{Breast cancer, protection against}
OMIM:211980:
{Lung cancer, protection against}
transcripts
NM_001228.4
NM_001080124.1
NM_033355.3
NM_033358.3
NM_001080125.1
NM_033356.3
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Activation, myristolyation of BID and translocation to mitochondria
[NCBI:1270269]
[REACTOME:R-HSA-75108]
[PUBMED:9727492]
[PUBMED:14634621]
Alzheimer's disease
[NCBI:83097]
[KEGG:hsa05010]
[PUBMED:18782350]
[PUBMED:18035450]
[PUBMED:15177383]
[PUBMED:10527810]
[PUBMED:15363492]
[PUBMED:16677790]
[PUBMED:15295589]
[PUBMED:17055782]
[PUBMED:15864339]
[PUBMED:15750290]
[PUBMED:18675468]
[PUBMED:15232608]
[PUBMED:9848086]
[PUBMED:11484003]
[PUBMED:10830966]
[PUBMED:16529745]
[PUBMED:17568632]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Apoptosis - multiple species
[NCBI:1384747]
[KEGG:hsa04215]
[PUBMED:23457257]
[PUBMED:11858838]
[PUBMED:15963254]
[PUBMED:20041301]
[PUBMED:24393571]
[PUBMED:21150934]
[PUBMED:15107838]
[PUBMED:10578171]
[PUBMED:15082313]
[PUBMED:19659442]
[PUBMED:20479784]
[PUBMED:22689371]
[PUBMED:20978240]
[PUBMED:25862972]
[PUBMED:20028968]
[PUBMED:25991373]
Apoptotic cleavage of cellular proteins
[NCBI:1270288]
[REACTOME:R-HSA-111465]
[PUBMED:17254298]
[PUBMED:17599937]
[PUBMED:12655297]
Apoptotic execution phase
[NCBI:1270287]
[REACTOME:R-HSA-75153]
[PUBMED:12655297]
C-type lectin receptors (CLRs)
[NCBI:1269303]
[REACTOME:R-HSA-5621481]
[PUBMED:19521399]
[PUBMED:24330199]
CASP8 activity is inhibited
[NCBI:1270301]
[REACTOME:R-HSA-5218900]
[PUBMED:9087414]
[PUBMED:12181749]
[PUBMED:23410748]
[PUBMED:21737330]
CLEC7A (Dectin-1) signaling
[NCBI:1269304]
[REACTOME:R-HSA-5607764]
[PUBMED:12719478]
[PUBMED:19223162]
CLEC7A/inflammasome pathway
[NCBI:1269307]
[REACTOME:R-HSA-5660668]
[PUBMED:22267217]
[PUBMED:21531876]
Caspase activation via extrinsic apoptotic signalling pathway
[NCBI:1270263]
[REACTOME:R-HSA-5357769]
[PUBMED:11048727]
Caspase cascade in apoptosis
[NCBI:137974]
[Pathway Interaction Database:caspase_pathway]
[PUBMED:7774019]
[PUBMED:8626669]
[PUBMED:9850096]
[PUBMED:11803376]
[PUBMED:15189451]
[PUBMED:10564664]
[PUBMED:9642276]
[PUBMED:10567584]
[PUBMED:12419244]
[PUBMED:11423904]
[PUBMED:9422506]
[PUBMED:11438643]
[PUBMED:9070648]
[PUBMED:9588194]
[PUBMED:11085743]
[PUBMED:9298992]
[PUBMED:9933635]
[PUBMED:9528810]
[PUBMED:9323209]
[PUBMED:10809769]
[PUBMED:8700869]
[PUBMED:9463409]
[PUBMED:10497198]
[PUBMED:11953316]
[PUBMED:9422513]
[PUBMED:10409650]
[PUBMED:11463840]
[PUBMED:10611247]
[PUBMED:8605870]
Caspase-mediated cleavage of cytoskeletal proteins
[NCBI:1270289]
[REACTOME:R-HSA-264870]
[PUBMED:17254298]
[PUBMED:12655297]
[PUBMED:17599937]
Ceramide signaling pathway
[NCBI:138023]
[Pathway Interaction Database:ceramide_pathway]
[PUBMED:11350735]
[PUBMED:10400650]
[PUBMED:9287216]
[PUBMED:9488730]
[PUBMED:8702918]
[PUBMED:10969079]
[PUBMED:10433354]
[PUBMED:14739942]
[PUBMED:9446561]
[PUBMED:8808629]
[PUBMED:8681376]
[PUBMED:7477354]
[PUBMED:14689449]
[PUBMED:12866359]
[PUBMED:9873064]
[PUBMED:8933152]
[PUBMED:10438487]
[PUBMED:15881228]
[PUBMED:10508159]
[PUBMED:7519779]
[PUBMED:8387486]
[PUBMED:12154098]
[PUBMED:7559390]
[PUBMED:12486111]
[PUBMED:14670935]
[PUBMED:15901738]
[PUBMED:15051724]
[PUBMED:8393446]
[PUBMED:9094715]
[PUBMED:11723139]
[PUBMED:10395296]
[PUBMED:8681377]
[PUBMED:11148216]
[PUBMED:12566438]
[PUBMED:15164763]
[PUBMED:10026132]
[PUBMED:10962008]
Chagas disease (American trypanosomiasis)
[NCBI:147809]
[KEGG:hsa05142]
[PUBMED:12377585]
[PUBMED:9794425]
[PUBMED:1717552]
[PUBMED:16238097]
[PUBMED:10066513]
[PUBMED:12874238]
[PUBMED:12036740]
[PUBMED:15917295]
[PUBMED:12055254]
[PUBMED:17651955]
[PUBMED:1396957]
[PUBMED:16175174]
[PUBMED:2194668]
[PUBMED:9190942]
[PUBMED:12377942]
[PUBMED:12427093]
[PUBMED:10234174]
[PUBMED:16030288]
[PUBMED:15223603]
[PUBMED:17110955]
Coregulation of Androgen receptor activity
[NCBI:138085]
[Pathway Interaction Database:ar_pathway]
[PUBMED:16724108]
[PUBMED:16027218]
[PUBMED:11818503]
[PUBMED:17277772]
[PUBMED:11719514]
[PUBMED:15833840]
[PUBMED:16384856]
[PUBMED:14645241]
[PUBMED:12218053]
[PUBMED:11016951]
[PUBMED:12621049]
[PUBMED:15784617]
[PUBMED:16446156]
[PUBMED:17110431]
[PUBMED:16254014]
[PUBMED:17698582]
[PUBMED:15131260]
[PUBMED:16705743]
[PUBMED:11682623]
[PUBMED:17192406]
[PUBMED:15882980]
[PUBMED:10934038]
[PUBMED:12165860]
[PUBMED:11856738]
[PUBMED:16720717]
[PUBMED:9710597]
[PUBMED:14609956]
[PUBMED:17170703]
[PUBMED:10383460]
[PUBMED:14576337]
[PUBMED:12941811]
[PUBMED:14612401]
[PUBMED:17975004]
[PUBMED:12799378]
[PUBMED:15790678]
[PUBMED:8643607]
[PUBMED:11792840]
[PUBMED:16603237]
[PUBMED:16079795]
[PUBMED:16951154]
[PUBMED:15166229]
[PUBMED:17142810]
[PUBMED:12361945]
[PUBMED:11439351]
[PUBMED:15640154]
[PUBMED:17909037]
[PUBMED:15539430]
[PUBMED:11792709]
[PUBMED:11931767]
[PUBMED:10344732]
[PUBMED:10428808]
Death Receptor Signalling
[NCBI:1269644]
[REACTOME:R-HSA-73887]
Dimerization of procaspase-8
[NCBI:1270265]
[REACTOME:R-HSA-69416]
[PUBMED:20308068]
[PUBMED:19851329]
[PUBMED:12620240]
FAS (CD95) signaling pathway
[NCBI:138081]
[Pathway Interaction Database:faspathway]
[PUBMED:9765224]
[PUBMED:11717445]
[PUBMED:9727491]
[PUBMED:11279218]
[PUBMED:12110583]
[PUBMED:11739735]
[PUBMED:8521815]
[PUBMED:9184224]
[PUBMED:20153221]
[PUBMED:9126929]
[PUBMED:10200443]
[PUBMED:16033886]
[PUBMED:8681377]
[PUBMED:9880544]
[PUBMED:9501089]
[PUBMED:10535980]
[PUBMED:9727492]
[PUBMED:7523573]
[PUBMED:11101870]
[PUBMED:9321399]
[PUBMED:9362518]
[PUBMED:12724420]
[PUBMED:16498403]
[PUBMED:11583996]
[PUBMED:15557123]
[PUBMED:7536343]
[PUBMED:12832037]
[PUBMED:9576928]
[PUBMED:9228058]
[PUBMED:7538908]
[PUBMED:18635548]
[PUBMED:20038679]
[PUBMED:10894163]
[PUBMED:12545171]
[PUBMED:16619028]
[PUBMED:9351817]
[PUBMED:9045686]
[PUBMED:15289496]
FasL/ CD95L signaling
[NCBI:1269645]
[REACTOME:R-HSA-75157]
[PUBMED:11048727]
HIV-1 Nef: Negative effector of Fas and TNF-alpha
[NCBI:137995]
[Pathway Interaction Database:hivnefpathway]
[PUBMED:9740801]
[PUBMED:10224289]
[PUBMED:10940292]
[PUBMED:9915703]
[PUBMED:9564042]
[PUBMED:9743501]
[PUBMED:9873064]
[PUBMED:12748303]
[PUBMED:9867840]
[PUBMED:11298454]
[PUBMED:9184224]
[PUBMED:9294162]
[PUBMED:9727492]
[PUBMED:9244310]
[PUBMED:10318789]
[PUBMED:12887920]
[PUBMED:9230442]
[PUBMED:9020361]
[PUBMED:9108473]
[PUBMED:9215629]
[PUBMED:9384571]
Hepatitis B
[NCBI:694606]
[KEGG:hsa05161]
[PUBMED:19854353]
[PUBMED:11604508]
[PUBMED:11325602]
[PUBMED:18931690]
[PUBMED:16891440]
[PUBMED:17158882]
[PUBMED:11099494]
[PUBMED:9325306]
[PUBMED:18024894]
[PUBMED:11483993]
[PUBMED:15107488]
[PUBMED:11278872]
[PUBMED:21647825]
[PUBMED:11287574]
[PUBMED:18481805]
[PUBMED:17188775]
[PUBMED:19784739]
[PUBMED:19263472]
[PUBMED:16203685]
[PUBMED:18605975]
[PUBMED:10454581]
[PUBMED:22504921]
[PUBMED:21334391]
[PUBMED:20657822]
[PUBMED:18046710]
[PUBMED:9843511]
[PUBMED:15542625]
[PUBMED:21618535]
[PUBMED:15132991]
[PUBMED:15173177]
[PUBMED:12771941]
[PUBMED:21994545]
[PUBMED:8764004]
[PUBMED:16459163]
[PUBMED:9738022]
[PUBMED:11821950]
[PUBMED:12839924]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
Huntington's disease
[NCBI:83100]
[KEGG:hsa05016]
[PUBMED:15336977]
[PUBMED:11738471]
[PUBMED:11807533]
[PUBMED:15996546]
[PUBMED:14526190]
[PUBMED:15242639]
[PUBMED:17041811]
[PUBMED:15996541]
[PUBMED:18951640]
[PUBMED:15459747]
[PUBMED:16288298]
[PUBMED:17081970]
[PUBMED:15695335]
[PUBMED:12372277]
[PUBMED:11839795]
IL-17 signaling pathway
[NCBI:1474301]
[KEGG:hsa04657]
[PUBMED:17921324]
[PUBMED:24011563]
[PUBMED:21349428]
[PUBMED:20383173]
[PUBMED:20514051]
[PUBMED:20177959]
[PUBMED:18178098]
[PUBMED:21074482]
[PUBMED:21130872]
[PUBMED:17027518]
[PUBMED:23917206]
[PUBMED:23116200]
[PUBMED:18701318]
[PUBMED:26252407]
[PUBMED:22851696]
[PUBMED:21155836]
[PUBMED:25145755]
[PUBMED:17177681]
[PUBMED:19575028]
[PUBMED:23557798]
[PUBMED:21852080]
[PUBMED:22324470]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Integrins in angiogenesis
[NCBI:137999]
[Pathway Interaction Database:avb3_integrin_pathway]
[PUBMED:10837460]
[PUBMED:9182576]
[PUBMED:12642872]
[PUBMED:15711558]
[PUBMED:10037797]
[PUBMED:10196194]
[PUBMED:11877390]
[PUBMED:16418218]
[PUBMED:16600665]
[PUBMED:16982628]
[PUBMED:15479743]
[PUBMED:16720645]
[PUBMED:11684710]
[PUBMED:10821695]
[PUBMED:12237112]
[PUBMED:12750158]
[PUBMED:11551924]
[PUBMED:8794870]
[PUBMED:10022831]
[PUBMED:15187087]
[PUBMED:16195423]
[PUBMED:16760434]
[PUBMED:12682293]
[PUBMED:9420328]
[PUBMED:15247219]
[PUBMED:9490736]
[PUBMED:11313365]
Intrinsic Pathway for Apoptosis
[NCBI:1270268]
[REACTOME:R-HSA-109606]
[PUBMED:12042762]
[PUBMED:11711427]
[PUBMED:15077149]
Legionellosis
[NCBI:469200]
[KEGG:hsa05134]
[PUBMED:19021631]
[PUBMED:19157961]
[PUBMED:20375353]
[PUBMED:19478083]
[PUBMED:18284575]
[PUBMED:19386084]
[PUBMED:19666608]
[PUBMED:15972519]
[PUBMED:18549456]
[PUBMED:1721820]
[PUBMED:17124169]
[PUBMED:19687203]
[PUBMED:18363881]
[PUBMED:19343209]
[PUBMED:20941588]
[PUBMED:16824952]
[PUBMED:18281405]
[PUBMED:18048909]
[PUBMED:16495539]
[PUBMED:12427954]
Ligand-dependent caspase activation
[NCBI:1270264]
[REACTOME:R-HSA-140534]
[PUBMED:12620240]
[PUBMED:14644197]
[PUBMED:20308068]
[PUBMED:19851329]
[PUBMED:12620239]
MyD88-independent TLR3/TLR4 cascade
[NCBI:1269220]
[REACTOME:R-HSA-166166]
[PUBMED:15276183]
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
[NCBI:1269261]
[REACTOME:R-HSA-933543]
[PUBMED:16618810]
[PUBMED:16127453]
[PUBMED:16585540]
[PUBMED:12884866]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
NOD1/2 Signaling Pathway
[NCBI:1269252]
[REACTOME:R-HSA-168638]
[PUBMED:18928408]
[PUBMED:18585455]
[PUBMED:18414735]
Non-alcoholic fatty liver disease (NAFLD)
[NCBI:862188]
[KEGG:hsa04932]
[PUBMED:21038418]
[PUBMED:17498512]
[PUBMED:19352614]
[PUBMED:23299992]
[PUBMED:22570745]
[PUBMED:9285483]
[PUBMED:12891546]
[PUBMED:18061659]
[PUBMED:22705006]
[PUBMED:16364488]
[PUBMED:18242193]
[PUBMED:16374858]
[PUBMED:22940046]
[PUBMED:20619513]
[PUBMED:20303879]
[PUBMED:14685853]
[PUBMED:16406828]
[PUBMED:23545492]
[PUBMED:21145844]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
[NCBI:1269251]
[REACTOME:R-HSA-168643]
[PUBMED:18928408]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Programmed Cell Death
[NCBI:1270261]
[REACTOME:R-HSA-5357801]
[PUBMED:25236395]
RIG-I-like receptor signaling pathway
[NCBI:117292]
[KEGG:hsa04622]
[PUBMED:19224920]
[PUBMED:19076341]
[PUBMED:18549796]
[PUBMED:18591413]
[PUBMED:19615405]
[PUBMED:19120475]
[PUBMED:18439848]
[PUBMED:19120476]
[PUBMED:15208624]
[PUBMED:19539500]
[PUBMED:18272355]
[PUBMED:18984593]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
[NCBI:1269259]
[REACTOME:R-HSA-168928]
[PUBMED:17395582]
[PUBMED:17942531]
[PUBMED:18701081]
[PUBMED:17683970]
[PUBMED:18989317]
[PUBMED:16214811]
RIPK1-mediated regulated necrosis
[NCBI:1270299]
[REACTOME:R-HSA-5213460]
[PUBMED:24773756]
[PUBMED:24452471]
Regulated Necrosis
[NCBI:1270298]
[REACTOME:R-HSA-5218859]
[PUBMED:23770045]
[PUBMED:24563506]
[PUBMED:24452471]
Regulation by c-FLIP
[NCBI:1270266]
[REACTOME:R-HSA-3371378]
[PUBMED:9217161]
[PUBMED:21235526]
[PUBMED:19416807]
Regulation of TNFR1 signaling
[NCBI:1309094]
[REACTOME:R-HSA-5357905]
[PUBMED:22435550]
[PUBMED:11432772]
[PUBMED:12724336]
Regulation of necroptotic cell death
[NCBI:1270300]
[REACTOME:R-HSA-5675482]
[PUBMED:18570872]
[PUBMED:21737330]
[PUBMED:18621737]
[PUBMED:12110583]
[PUBMED:20218968]
[PUBMED:15701649]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
TNF receptor signaling pathway
[NCBI:138053]
[Pathway Interaction Database:tnfpathway]
[PUBMED:17024246]
[PUBMED:7923351]
[PUBMED:9774977]
[PUBMED:15258597]
[PUBMED:11429546]
[PUBMED:10848577]
[PUBMED:12917689]
[PUBMED:11031259]
[PUBMED:8974401]
[PUBMED:7758105]
[PUBMED:10510344]
[PUBMED:15793306]
[PUBMED:12391233]
[PUBMED:18450452]
[PUBMED:15218148]
[PUBMED:8692885]
[PUBMED:10026132]
[PUBMED:9275185]
[PUBMED:11684013]
[PUBMED:8521496]
[PUBMED:12917690]
[PUBMED:10795740]
[PUBMED:16603398]
[PUBMED:9405407]
[PUBMED:2158863]
[PUBMED:16260783]
[PUBMED:8808629]
[PUBMED:9034190]
[PUBMED:16543241]
[PUBMED:12077366]
[PUBMED:9384583]
[PUBMED:8612133]
[PUBMED:9712898]
[PUBMED:1313189]
[PUBMED:8069916]
[PUBMED:11907583]
[PUBMED:9639556]
[PUBMED:12917691]
[PUBMED:9115275]
[PUBMED:8681376]
[PUBMED:10356400]
[PUBMED:10801798]
[PUBMED:10097111]
[PUBMED:8565075]
[PUBMED:10187805]
[PUBMED:15357952]
[PUBMED:9915703]
[PUBMED:9564042]
[PUBMED:8943045]
TNF signaling
[NCBI:1269646]
[REACTOME:R-HSA-75893]
[PUBMED:12040173]
TNF signaling pathway
[NCBI:812256]
[KEGG:hsa04668]
[PUBMED:20489699]
[PUBMED:14532286]
[PUBMED:21232019]
[PUBMED:11897488]
[PUBMED:22296764]
[PUBMED:10581243]
[PUBMED:23085193]
[PUBMED:23531747]
TNFR1-induced proapoptotic signaling
[NCBI:1269647]
[REACTOME:R-HSA-5357786]
[PUBMED:12752666]
[PUBMED:12887920]
[PUBMED:12505355]
TRAIL signaling
[NCBI:1269648]
[REACTOME:R-HSA-75158]
[PUBMED:14634624]
TRAIL signaling pathway
[NCBI:137920]
[Pathway Interaction Database:trail_pathway]
[PUBMED:10958661]
[PUBMED:9430226]
[PUBMED:9311998]
[PUBMED:16227629]
[PUBMED:10521396]
[PUBMED:9242610]
[PUBMED:12668516]
[PUBMED:15105837]
[PUBMED:11461927]
[PUBMED:16319225]
[PUBMED:9082980]
[PUBMED:9430227]
[PUBMED:16980609]
[PUBMED:10894160]
[PUBMED:16940186]
[PUBMED:16636669]
[PUBMED:10783243]
[PUBMED:11278665]
[PUBMED:11376335]
[PUBMED:9314565]
[PUBMED:10521444]
[PUBMED:10894161]
TRIF-mediated TLR3/TLR4 signaling
[NCBI:1269221]
[REACTOME:R-HSA-937061]
[PUBMED:15814722]
[PUBMED:12855817]
[PUBMED:14739303]
TRIF-mediated programmed cell death
[NCBI:1269224]
[REACTOME:R-HSA-2562578]
[PUBMED:12181749]
[PUBMED:15814722]
[PUBMED:20019748]
[PUBMED:22421964]
[PUBMED:21737329]
[PUBMED:14739303]
[PUBMED:21737330]
Toll Like Receptor 3 (TLR3) Cascade
[NCBI:1269219]
[REACTOME:R-HSA-168164]
[PUBMED:19627256]
[PUBMED:15733829]
[PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Toll-like receptor signaling pathway
[NCBI:83076]
[KEGG:hsa04620]
[PUBMED:16924467]
[PUBMED:17395581]
[PUBMED:17637696]
[PUBMED:12734364]
[PUBMED:17507094]
[PUBMED:14698224]
[PUBMED:11101877]
[PUBMED:16497588]
[PUBMED:14751764]
[PUBMED:17275323]
[PUBMED:17457343]
[PUBMED:16932750]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
[PUBMED:15452270]
[PUBMED:18948197]
[PUBMED:16760382]
[PUBMED:10793105]
[PUBMED:21084867]
[PUBMED:16308315]
[PUBMED:16155604]
[PUBMED:16381817]
[PUBMED:16828973]
[PUBMED:15342967]
[PUBMED:15692053]
[PUBMED:10855768]
[PUBMED:19078975]
[PUBMED:12379483]
[PUBMED:15310405]
[PUBMED:8223437]
[PUBMED:16939421]
[PUBMED:12910250]
[PUBMED:16039586]
[PUBMED:18201576]
[PUBMED:21102637]
[PUBMED:21743832]
[PUBMED:20592731]
[PUBMED:10644344]
[PUBMED:10074132]
[PUBMED:19715458]
[PUBMED:16155601]
[PUBMED:11604508]
[PUBMED:15919895]
[PUBMED:11099494]
[PUBMED:18385245]
[PUBMED:19854353]
[PUBMED:12101418]
Viral myocarditis
[NCBI:125138]
[KEGG:hsa05416]
[PUBMED:19357408]
[PUBMED:18545064]
[PUBMED:18357777]
[PUBMED:11524405]
[PUBMED:12920582]
[PUBMED:14522402]
[PUBMED:17200452]
[PUBMED:18039131]
[PUBMED:16413486]
[PUBMED:12439638]
[PUBMED:16817756]
[PUBMED:16845885]
[PUBMED:10051305]
[PUBMED:10904843]
p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
[PUBMED:16557269]
[PUBMED:10714958]
[PUBMED:12505356]
[PUBMED:16915296]
[PUBMED:16697662]
[PUBMED:15116721]
[PUBMED:11313928]
[PUBMED:11747320]
[PUBMED:17409411]
[PUBMED:15838523]