full name
small ubiquitin-like modifier 1

synonyms
DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1, SUMO1, ENSG00000116030

HGNC
HGNC:12502

Entrez Gene
Gene:7341

ENSEMBL
ENSG00000116030

location
chr: 2
start: 203070903
stop: 203103322
strand: -

OMIM
OMIM:601912: SUMO1
OMIM:613705: ?Orofacial cleft 10

transcripts
NM_001005782.1
NM_001005781.1
NM_003352.4

pathways
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DNA Double Strand Break Response [NCBI:1309096] [REACTOME:R-HSA-5693606] [PUBMED:20965415]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
Formation of Incision Complex in GG-NER [NCBI:1309114] [REACTOME:R-HSA-5696395] [PUBMED:17948053] [PUBMED:17466626] [PUBMED:11511374] [PUBMED:9716411] [PUBMED:17000769] [PUBMED:15590680] [PUBMED:19940136] [PUBMED:14517266] [PUBMED:16491090] [PUBMED:23038248]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint [NCBI:1269754] [REACTOME:R-HSA-69473]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Global Genome Nucleotide Excision Repair (GG-NER) [NCBI:1309112] [REACTOME:R-HSA-5696399] [PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
Interferon gamma signaling [NCBI:1269314] [REACTOME:R-HSA-877300] [PUBMED:9462485] [PUBMED:18929502] [PUBMED:9143700] [PUBMED:14525967]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Negative regulation of activity of TFAP2 (AP-2) family transcription factors [NCBI:1427845] [REACTOME:R-HSA-8866904] [PUBMED:12072434] [PUBMED:19115315] [PUBMED:25114211] [PUBMED:23382213] [PUBMED:15548692] [PUBMED:21375726] [PUBMED:24835590] [PUBMED:20805990]
Nonhomologous End-Joining (NHEJ) [NCBI:1309110] [REACTOME:R-HSA-5693571] [PUBMED:10802669] [PUBMED:21293379] [PUBMED:16914548] [PUBMED:12509254] [PUBMED:12607005] [PUBMED:17470781] [PUBMED:12364621] [PUBMED:11493912] [PUBMED:23333306] [PUBMED:22179609] [PUBMED:25512557] [PUBMED:22529269] [PUBMED:23505375] [PUBMED:15574327] [PUBMED:12077346] [PUBMED:11030616] [PUBMED:14561766] [PUBMED:8422676] [PUBMED:23727112] [PUBMED:17525340] [PUBMED:23306437] [PUBMED:10757784] [PUBMED:16439205] [PUBMED:10959836] [PUBMED:15790808] [PUBMED:16377563] [PUBMED:11955432] [PUBMED:22373579] [PUBMED:19001859] [PUBMED:12023295] [PUBMED:15451442] [PUBMED:16093244] [PUBMED:10572166]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Processing and activation of SUMO [NCBI:1268739] [REACTOME:R-HSA-3215018] [PUBMED:16253240] [PUBMED:17591783] [PUBMED:11896061] [PUBMED:19923268] [PUBMED:16738315] [PUBMED:12192048] [PUBMED:20462400] [PUBMED:17099700] [PUBMED:17768054] [PUBMED:20674646] [PUBMED:21102611] [PUBMED:17099698] [PUBMED:16738331] [PUBMED:14563852]
Processing of DNA double-strand break ends [NCBI:1309101] [REACTOME:R-HSA-5693607] [PUBMED:25122754] [PUBMED:18171670] [PUBMED:20965415] [PUBMED:22231403] [PUBMED:25558984] [PUBMED:19357644] [PUBMED:21325134] [PUBMED:21240188] [PUBMED:21659603] [PUBMED:23468639] [PUBMED:25659039]
RNA transport [NCBI:177876] [KEGG:hsa03013] [PUBMED:10872469] [PUBMED:17401408] [PUBMED:20733056] [PUBMED:11018020] [PUBMED:15519698] [PUBMED:16314458] [PUBMED:15901496] [PUBMED:9548260] [PUBMED:18313922]
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [NCBI:1309098] [REACTOME:R-HSA-5693565] [PUBMED:18483401] [PUBMED:21293379] [PUBMED:10866324] [PUBMED:9488723] [PUBMED:18001825] [PUBMED:18006705] [PUBMED:11571274] [PUBMED:12364621] [PUBMED:22234877] [PUBMED:10802669] [PUBMED:17553757] [PUBMED:10550055] [PUBMED:23333306] [PUBMED:20023648] [PUBMED:18077395] [PUBMED:19203578] [PUBMED:22373579] [PUBMED:19203579] [PUBMED:19234442] [PUBMED:16377563] [PUBMED:15201865] [PUBMED:19092802] [PUBMED:17525340] [PUBMED:22589545] [PUBMED:11025670] [PUBMED:16651405] [PUBMED:19001859] [PUBMED:18001824]
Regulation of IFNG signaling [NCBI:1269315] [REACTOME:R-HSA-877312] [PUBMED:10526574] [PUBMED:18031232] [PUBMED:12645661]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMO is conjugated to E1 (UBA2:SAE1) [NCBI:1268741] [REACTOME:R-HSA-3065676] [PUBMED:20164921] [PUBMED:19923268] [PUBMED:21102611] [PUBMED:20674646]
SUMO is proteolytically processed [NCBI:1268740] [REACTOME:R-HSA-3065679] [PUBMED:20462400] [PUBMED:16608850] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:14563852] [PUBMED:16253240] [PUBMED:16738331] [PUBMED:11896061] [PUBMED:17591783] [PUBMED:19923268] [PUBMED:12192048] [PUBMED:16738315]
SUMO is transferred from E1 to E2 (UBE2I, UBC9) [NCBI:1268742] [REACTOME:R-HSA-3065678] [PUBMED:20462400] [PUBMED:20674646] [PUBMED:21102611] [PUBMED:19923268]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of DNA damage response and repair proteins [NCBI:1268744] [REACTOME:R-HSA-3108214] [PUBMED:22018829] [PUBMED:24926426] [PUBMED:23122649] [PUBMED:23781231] [PUBMED:23416108] [PUBMED:21486569] [PUBMED:23746258] [PUBMED:21896653] [PUBMED:22357966] [PUBMED:21664912]
SUMOylation of DNA replication proteins [NCBI:1339113] [REACTOME:R-HSA-4615885] [PUBMED:22812528] [PUBMED:17031663] [PUBMED:22918591] [PUBMED:22732495] [PUBMED:16368276]
SUMOylation of RNA binding proteins [NCBI:1339112] [REACTOME:R-HSA-4570464] [PUBMED:23979992] [PUBMED:15161980]
SUMOylation of transcription factors [NCBI:1339110] [REACTOME:R-HSA-3232118] [PUBMED:16095902] [PUBMED:21892772] [PUBMED:19107415] [PUBMED:19616654] [PUBMED:15209380] [PUBMED:18031228]
Signaling events mediated by HDAC Class I [NCBI:137997] [Pathway Interaction Database:hdac_classi_pathway] [PUBMED:9885572] [PUBMED:14701748] [PUBMED:10888618] [PUBMED:12393750] [PUBMED:9804427] [PUBMED:9139820] [PUBMED:12408818] [PUBMED:16809764] [PUBMED:12788099] [PUBMED:11533489] [PUBMED:15831498] [PUBMED:15701600] [PUBMED:11532945] [PUBMED:12183469] [PUBMED:16428440] [PUBMED:9150134] [PUBMED:12972430] [PUBMED:11486036] [PUBMED:15920470] [PUBMED:9150135] [PUBMED:9651585] [PUBMED:11960997] [PUBMED:9326634] [PUBMED:11278251] [PUBMED:14521922] [PUBMED:9197243] [PUBMED:9346952] [PUBMED:16371367] [PUBMED:10444591] [PUBMED:15653507] [PUBMED:15920471] [PUBMED:11919195]
Signaling events mediated by HDAC Class II [NCBI:138062] [Pathway Interaction Database:hdac_classii_pathway] [PUBMED:15916966] [PUBMED:10869435] [PUBMED:10898795] [PUBMED:16051668] [PUBMED:12032081] [PUBMED:12606581] [PUBMED:11804585] [PUBMED:11466315] [PUBMED:11567998] [PUBMED:16767219] [PUBMED:12024216] [PUBMED:16166628] [PUBMED:16221676] [PUBMED:11948178] [PUBMED:10220385] [PUBMED:12663674] [PUBMED:14668799] [PUBMED:16236793]
Sumoylation by RanBP2 regulates transcriptional repression [NCBI:138029] [Pathway Interaction Database:ranbp2pathway] [PUBMED:11960997] [PUBMED:12393906] [PUBMED:8978815] [PUBMED:9456312] [PUBMED:12032081] [PUBMED:9019411] [PUBMED:9427648] [PUBMED:9108047] [PUBMED:12393750] [PUBMED:10892746] [PUBMED:9323132] [PUBMED:10454574]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors [NCBI:1427839] [REACTOME:R-HSA-8864260] [PUBMED:2010091] [PUBMED:11744733] [PUBMED:24469049] [PUBMED:23382213] [PUBMED:19798054] [PUBMED:9162057] [PUBMED:21084835] [PUBMED:22735262] [PUBMED:21375726] [PUBMED:14744778] [PUBMED:10648798] [PUBMED:26832794] [PUBMED:24835590] [PUBMED:9687504] [PUBMED:20805990] [PUBMED:10497269] [PUBMED:16420676] [PUBMED:12072434] [PUBMED:9850080] [PUBMED:9182571] [PUBMED:8988173] [PUBMED:1998122] [PUBMED:22371483] [PUBMED:15870067] [PUBMED:12586840] [PUBMED:8895516] [PUBMED:7891714] [PUBMED:11694877] [PUBMED:19115315] [PUBMED:15475956] [PUBMED:25114211]