full name
small ubiquitin-like modifier 1
synonyms
DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1, SUMO1, ENSG00000116030
HGNC
HGNC:12502
Entrez Gene
Gene:7341
ENSEMBL
ENSG00000116030
location
chr: 2
start: 203070903
stop: 203103322
strand: -
OMIM
OMIM:601912:
SUMO1
OMIM:613705:
?Orofacial cleft 10
transcripts
NM_001005782.1
NM_001005781.1
NM_003352.4
pathways
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DNA Double Strand Break Response
[NCBI:1309096]
[REACTOME:R-HSA-5693606]
[PUBMED:20965415]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
Fluid shear stress and atherosclerosis
[NCBI:1474302]
[KEGG:hsa05418]
[PUBMED:23429585]
[PUBMED:21050140]
[PUBMED:17599600]
[PUBMED:24190880]
[PUBMED:22003002]
[PUBMED:24876354]
[PUBMED:24947523]
[PUBMED:23899566]
[PUBMED:26597822]
[PUBMED:20353494]
[PUBMED:22076424]
[PUBMED:20538799]
[PUBMED:25165867]
[PUBMED:20032497]
[PUBMED:23084990]
[PUBMED:26822720]
[PUBMED:24573382]
[PUBMED:23555159]
[PUBMED:26212910]
[PUBMED:21457103]
[PUBMED:19151844]
[PUBMED:15388638]
[PUBMED:16765337]
[PUBMED:27027326]
[PUBMED:25638487]
[PUBMED:21733876]
Formation of Incision Complex in GG-NER
[NCBI:1309114]
[REACTOME:R-HSA-5696395]
[PUBMED:17948053]
[PUBMED:17466626]
[PUBMED:11511374]
[PUBMED:9716411]
[PUBMED:17000769]
[PUBMED:15590680]
[PUBMED:19940136]
[PUBMED:14517266]
[PUBMED:16491090]
[PUBMED:23038248]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint
[NCBI:1269754]
[REACTOME:R-HSA-69473]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Global Genome Nucleotide Excision Repair (GG-NER)
[NCBI:1309112]
[REACTOME:R-HSA-5696399]
[PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
[NCBI:1309100]
[REACTOME:R-HSA-5693567]
[PUBMED:20965415]
Homology Directed Repair
[NCBI:1309099]
[REACTOME:R-HSA-5693538]
[PUBMED:11242102]
[PUBMED:20965415]
[PUBMED:11376695]
[PUBMED:12427531]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Interferon Signaling
[NCBI:1269311]
[REACTOME:R-HSA-913531]
[PUBMED:18929502]
[PUBMED:15607020]
[PUBMED:15864272]
[PUBMED:14525967]
[PUBMED:19059436]
Interferon gamma signaling
[NCBI:1269314]
[REACTOME:R-HSA-877300]
[PUBMED:9462485]
[PUBMED:18929502]
[PUBMED:9143700]
[PUBMED:14525967]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
[NCBI:1427845]
[REACTOME:R-HSA-8866904]
[PUBMED:12072434]
[PUBMED:19115315]
[PUBMED:25114211]
[PUBMED:23382213]
[PUBMED:15548692]
[PUBMED:21375726]
[PUBMED:24835590]
[PUBMED:20805990]
Nonhomologous End-Joining (NHEJ)
[NCBI:1309110]
[REACTOME:R-HSA-5693571]
[PUBMED:10802669]
[PUBMED:21293379]
[PUBMED:16914548]
[PUBMED:12509254]
[PUBMED:12607005]
[PUBMED:17470781]
[PUBMED:12364621]
[PUBMED:11493912]
[PUBMED:23333306]
[PUBMED:22179609]
[PUBMED:25512557]
[PUBMED:22529269]
[PUBMED:23505375]
[PUBMED:15574327]
[PUBMED:12077346]
[PUBMED:11030616]
[PUBMED:14561766]
[PUBMED:8422676]
[PUBMED:23727112]
[PUBMED:17525340]
[PUBMED:23306437]
[PUBMED:10757784]
[PUBMED:16439205]
[PUBMED:10959836]
[PUBMED:15790808]
[PUBMED:16377563]
[PUBMED:11955432]
[PUBMED:22373579]
[PUBMED:19001859]
[PUBMED:12023295]
[PUBMED:15451442]
[PUBMED:16093244]
[PUBMED:10572166]
Nucleotide Excision Repair
[NCBI:1309111]
[REACTOME:R-HSA-5696398]
[PUBMED:11900249]
[PUBMED:23906714]
[PUBMED:14599765]
[PUBMED:10583946]
[PUBMED:24954209]
[PUBMED:19023283]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
Processing and activation of SUMO
[NCBI:1268739]
[REACTOME:R-HSA-3215018]
[PUBMED:16253240]
[PUBMED:17591783]
[PUBMED:11896061]
[PUBMED:19923268]
[PUBMED:16738315]
[PUBMED:12192048]
[PUBMED:20462400]
[PUBMED:17099700]
[PUBMED:17768054]
[PUBMED:20674646]
[PUBMED:21102611]
[PUBMED:17099698]
[PUBMED:16738331]
[PUBMED:14563852]
Processing of DNA double-strand break ends
[NCBI:1309101]
[REACTOME:R-HSA-5693607]
[PUBMED:25122754]
[PUBMED:18171670]
[PUBMED:20965415]
[PUBMED:22231403]
[PUBMED:25558984]
[PUBMED:19357644]
[PUBMED:21325134]
[PUBMED:21240188]
[PUBMED:21659603]
[PUBMED:23468639]
[PUBMED:25659039]
RNA transport
[NCBI:177876]
[KEGG:hsa03013]
[PUBMED:10872469]
[PUBMED:17401408]
[PUBMED:20733056]
[PUBMED:11018020]
[PUBMED:15519698]
[PUBMED:16314458]
[PUBMED:15901496]
[PUBMED:9548260]
[PUBMED:18313922]
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
[NCBI:1309098]
[REACTOME:R-HSA-5693565]
[PUBMED:18483401]
[PUBMED:21293379]
[PUBMED:10866324]
[PUBMED:9488723]
[PUBMED:18001825]
[PUBMED:18006705]
[PUBMED:11571274]
[PUBMED:12364621]
[PUBMED:22234877]
[PUBMED:10802669]
[PUBMED:17553757]
[PUBMED:10550055]
[PUBMED:23333306]
[PUBMED:20023648]
[PUBMED:18077395]
[PUBMED:19203578]
[PUBMED:22373579]
[PUBMED:19203579]
[PUBMED:19234442]
[PUBMED:16377563]
[PUBMED:15201865]
[PUBMED:19092802]
[PUBMED:17525340]
[PUBMED:22589545]
[PUBMED:11025670]
[PUBMED:16651405]
[PUBMED:19001859]
[PUBMED:18001824]
Regulation of IFNG signaling
[NCBI:1269315]
[REACTOME:R-HSA-877312]
[PUBMED:10526574]
[PUBMED:18031232]
[PUBMED:12645661]
SUMO E3 ligases SUMOylate target proteins
[NCBI:1268743]
[REACTOME:R-HSA-3108232]
[PUBMED:20674646]
[PUBMED:17763827]
[PUBMED:19471022]
[PUBMED:23746258]
[PUBMED:24016193]
[PUBMED:23503365]
[PUBMED:21252943]
[PUBMED:17000644]
[PUBMED:24273646]
[PUBMED:22811915]
[PUBMED:21693764]
[PUBMED:23277067]
[PUBMED:21102611]
SUMO is conjugated to E1 (UBA2:SAE1)
[NCBI:1268741]
[REACTOME:R-HSA-3065676]
[PUBMED:20164921]
[PUBMED:19923268]
[PUBMED:21102611]
[PUBMED:20674646]
SUMO is proteolytically processed
[NCBI:1268740]
[REACTOME:R-HSA-3065679]
[PUBMED:20462400]
[PUBMED:16608850]
[PUBMED:21102611]
[PUBMED:20674646]
[PUBMED:14563852]
[PUBMED:16253240]
[PUBMED:16738331]
[PUBMED:11896061]
[PUBMED:17591783]
[PUBMED:19923268]
[PUBMED:12192048]
[PUBMED:16738315]
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
[NCBI:1268742]
[REACTOME:R-HSA-3065678]
[PUBMED:20462400]
[PUBMED:20674646]
[PUBMED:21102611]
[PUBMED:19923268]
SUMOylation
[NCBI:1268738]
[REACTOME:R-HSA-2990846]
[PUBMED:21102611]
[PUBMED:20674646]
[PUBMED:23514139]
[PUBMED:19923268]
[PUBMED:20462400]
[PUBMED:17768054]
SUMOylation of DNA damage response and repair proteins
[NCBI:1268744]
[REACTOME:R-HSA-3108214]
[PUBMED:22018829]
[PUBMED:24926426]
[PUBMED:23122649]
[PUBMED:23781231]
[PUBMED:23416108]
[PUBMED:21486569]
[PUBMED:23746258]
[PUBMED:21896653]
[PUBMED:22357966]
[PUBMED:21664912]
SUMOylation of DNA replication proteins
[NCBI:1339113]
[REACTOME:R-HSA-4615885]
[PUBMED:22812528]
[PUBMED:17031663]
[PUBMED:22918591]
[PUBMED:22732495]
[PUBMED:16368276]
SUMOylation of RNA binding proteins
[NCBI:1339112]
[REACTOME:R-HSA-4570464]
[PUBMED:23979992]
[PUBMED:15161980]
SUMOylation of transcription factors
[NCBI:1339110]
[REACTOME:R-HSA-3232118]
[PUBMED:16095902]
[PUBMED:21892772]
[PUBMED:19107415]
[PUBMED:19616654]
[PUBMED:15209380]
[PUBMED:18031228]
Signaling events mediated by HDAC Class I
[NCBI:137997]
[Pathway Interaction Database:hdac_classi_pathway]
[PUBMED:9885572]
[PUBMED:14701748]
[PUBMED:10888618]
[PUBMED:12393750]
[PUBMED:9804427]
[PUBMED:9139820]
[PUBMED:12408818]
[PUBMED:16809764]
[PUBMED:12788099]
[PUBMED:11533489]
[PUBMED:15831498]
[PUBMED:15701600]
[PUBMED:11532945]
[PUBMED:12183469]
[PUBMED:16428440]
[PUBMED:9150134]
[PUBMED:12972430]
[PUBMED:11486036]
[PUBMED:15920470]
[PUBMED:9150135]
[PUBMED:9651585]
[PUBMED:11960997]
[PUBMED:9326634]
[PUBMED:11278251]
[PUBMED:14521922]
[PUBMED:9197243]
[PUBMED:9346952]
[PUBMED:16371367]
[PUBMED:10444591]
[PUBMED:15653507]
[PUBMED:15920471]
[PUBMED:11919195]
Signaling events mediated by HDAC Class II
[NCBI:138062]
[Pathway Interaction Database:hdac_classii_pathway]
[PUBMED:15916966]
[PUBMED:10869435]
[PUBMED:10898795]
[PUBMED:16051668]
[PUBMED:12032081]
[PUBMED:12606581]
[PUBMED:11804585]
[PUBMED:11466315]
[PUBMED:11567998]
[PUBMED:16767219]
[PUBMED:12024216]
[PUBMED:16166628]
[PUBMED:16221676]
[PUBMED:11948178]
[PUBMED:10220385]
[PUBMED:12663674]
[PUBMED:14668799]
[PUBMED:16236793]
Sumoylation by RanBP2 regulates transcriptional repression
[NCBI:138029]
[Pathway Interaction Database:ranbp2pathway]
[PUBMED:11960997]
[PUBMED:12393906]
[PUBMED:8978815]
[PUBMED:9456312]
[PUBMED:12032081]
[PUBMED:9019411]
[PUBMED:9427648]
[PUBMED:9108047]
[PUBMED:12393750]
[PUBMED:10892746]
[PUBMED:9323132]
[PUBMED:10454574]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
[NCBI:1427839]
[REACTOME:R-HSA-8864260]
[PUBMED:2010091]
[PUBMED:11744733]
[PUBMED:24469049]
[PUBMED:23382213]
[PUBMED:19798054]
[PUBMED:9162057]
[PUBMED:21084835]
[PUBMED:22735262]
[PUBMED:21375726]
[PUBMED:14744778]
[PUBMED:10648798]
[PUBMED:26832794]
[PUBMED:24835590]
[PUBMED:9687504]
[PUBMED:20805990]
[PUBMED:10497269]
[PUBMED:16420676]
[PUBMED:12072434]
[PUBMED:9850080]
[PUBMED:9182571]
[PUBMED:8988173]
[PUBMED:1998122]
[PUBMED:22371483]
[PUBMED:15870067]
[PUBMED:12586840]
[PUBMED:8895516]
[PUBMED:7891714]
[PUBMED:11694877]
[PUBMED:19115315]
[PUBMED:15475956]
[PUBMED:25114211]
