full name
isocitrate dehydrogenase (NADP(+)) 1, cytosolic

synonyms
IDCD, IDH, IDP, IDPC, PICD, IDH1, ENSG00000138413

HGNC
HGNC:5382

Entrez Gene
Gene:3417

ENSEMBL
ENSG00000138413

location
chr: 2
start: 209100951
stop: 209120478
strand: -

OMIM
OMIM:147700: IDH1
OMIM:137800: {Glioma, susceptibility to, somatic}

transcripts
NM_005896.2

pathways
2-Oxocarboxylic acid metabolism [NCBI:714485] [KEGG:hsa01210]
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate [NCBI:1269009] [REACTOME:R-HSA-2978092] [PUBMED:18772396] [PUBMED:19935646]
Biosynthesis of amino acids [NCBI:790012] [KEGG:hsa01230]
Carbon metabolism [NCBI:814926] [KEGG:hsa01200]
Central carbon metabolism in cancer [NCBI:1059538] [KEGG:hsa05230] [PUBMED:16982728] [PUBMED:21127244] [PUBMED:22349059] [PUBMED:19270154] [PUBMED:24113830] [PUBMED:22156302] [PUBMED:21801601] [PUBMED:15916903] [PUBMED:18177721] [PUBMED:22237205] [PUBMED:20520704] [PUBMED:23018234] [PUBMED:23897900] [PUBMED:24398961] [PUBMED:24079832] [PUBMED:18538731] [PUBMED:19460998] [PUBMED:22307140] [PUBMED:18766298] [PUBMED:22101401] [PUBMED:23071355] [PUBMED:21508971] [PUBMED:24738035] [PUBMED:22750268] [PUBMED:21258394] [PUBMED:23279446] [PUBMED:21340684]
Citrate cycle (TCA cycle) [NCBI:82927] [KEGG:hsa00020]
Citrate cycle (TCA cycle, Krebs cycle) [NCBI:855811] [KEGG:hsa_M00009]
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [NCBI:413347] [KEGG:hsa_M00010]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of metabolism [NCBI:1268939] [REACTOME:R-HSA-5668914]
Glutathione metabolism [NCBI:82973] [KEGG:hsa00480] [PUBMED:18395526] [PUBMED:15537651] [PUBMED:12466271] [PUBMED:9677355] [PUBMED:11157967] [PUBMED:12675513] [PUBMED:18482986] [PUBMED:8892297] [PUBMED:12751784] [PUBMED:12750367] [PUBMED:14982633] [PUBMED:11150302] [PUBMED:12121990] [PUBMED:15610825] [PUBMED:17922848] [PUBMED:12049631] [PUBMED:12949079] [PUBMED:7813456] [PUBMED:9851611] [PUBMED:6798961] [PUBMED:10713147] [PUBMED:12967709] [PUBMED:14583094] [PUBMED:12446213]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
NADPH regeneration [NCBI:1270036] [REACTOME:R-HSA-389542] [PUBMED:10521434]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Peroxisomal lipid metabolism [NCBI:1270031] [REACTOME:R-HSA-390918] [PUBMED:16756494]
Peroxisome [NCBI:131226] [KEGG:hsa04146] [PUBMED:17055079] [PUBMED:16631601] [PUBMED:17055078] [PUBMED:17010456]