full name
solute carrier family 11 member 1

synonyms
LSH, NRAMP, NRAMP1, SLC11A1, ENSG00000018280

HGNC
HGNC:10907

Entrez Gene
Gene:6556

ENSEMBL
ENSG00000018280

location
chr: 2
start: 219246752
stop: 219261617
strand: +

OMIM
OMIM:600266: SLC11A1
OMIM:610446: {Buruli ulcer, susceptibility to}
OMIM:607948: {Mycobacterium tuberculosis, susceptibility to infection by}

transcripts
NM_000578.3

pathways
Antimicrobial peptides [NCBI:1457777] [REACTOME:R-HSA-6803157] [PUBMED:12615953] [PUBMED:24287494]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Ion influx/efflux at host-pathogen interface [NCBI:1457779] [REACTOME:R-HSA-6803544] [PUBMED:25211180] [PUBMED:26055725]
Lysosome [NCBI:99052] [KEGG:hsa04142] [PUBMED:2943218] [PUBMED:12628346] [PUBMED:1883197] [PUBMED:18635948] [PUBMED:15987739]
Metal ion SLC transporters [NCBI:1269930] [REACTOME:R-HSA-425410] [PUBMED:12827356] [PUBMED:15157936] [PUBMED:16908340] [PUBMED:14530973] [PUBMED:17215883] [PUBMED:17374385] [PUBMED:16675045] [PUBMED:17439925] [PUBMED:12836025] [PUBMED:19164095] [PUBMED:12748861] [PUBMED:16825786] [PUBMED:16720382]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
ROS, RNS production in phagocytes [NCBI:1269138] [REACTOME:R-HSA-1222556] [PUBMED:23617726] [PUBMED:19369951]
SLC-mediated transmembrane transport [NCBI:1269907] [REACTOME:R-HSA-425407] [PUBMED:14624363] [PUBMED:19164095]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds [NCBI:1269923] [REACTOME:R-HSA-425366] [PUBMED:12811562] [PUBMED:12748858] [PUBMED:12750891] [PUBMED:19164095]
Validated targets of C-MYC transcriptional repression [NCBI:169353] [Pathway Interaction Database:myc_represspathway] [PUBMED:17082179] [PUBMED:11282029] [PUBMED:9869632] [PUBMED:15021909] [PUBMED:16167342] [PUBMED:18056446] [PUBMED:18045875] [PUBMED:1670896] [PUBMED:18393360] [PUBMED:7556187] [PUBMED:11313917] [PUBMED:17471507] [PUBMED:12418961] [PUBMED:9927431] [PUBMED:9924025] [PUBMED:18483244] [PUBMED:14716294] [PUBMED:15506972] [PUBMED:15616584] [PUBMED:12729735] [PUBMED:19219026] [PUBMED:12747840] [PUBMED:2182320] [PUBMED:12545156] [PUBMED:15367674] [PUBMED:11283613] [PUBMED:12384701] [PUBMED:18066065] [PUBMED:18455888] [PUBMED:10920185] [PUBMED:17881732] [PUBMED:20190815] [PUBMED:16352593] [PUBMED:17050536] [PUBMED:11283614] [PUBMED:16391002] [PUBMED:11804592] [PUBMED:7870572] [PUBMED:16940161] [PUBMED:12695333] [PUBMED:17159920] [PUBMED:8972190] [PUBMED:9312026] [PUBMED:17485441] [PUBMED:16288014]