Logo
full name
dishevelled segment polarity protein 1

synonyms
DVL, DVL1L1, DVL1P1, DVL1, ENSG00000107404

HGNC
HGNC:3084

Entrez Gene
Gene:1855

ENSEMBL
ENSG00000107404

location
chr: 1
start: 1270658
stop: 1284509
strand: -

OMIM
OMIM:601365: DVL1
OMIM:616331: Robinow syndrome, autosomal dominant 2

transcripts
NM_004421.2

pathways
Adipogenesis [NCBI:198832] [WikiPathways:WP236] [PUBMED:11031233]
Basal cell carcinoma [NCBI:83113] [KEGG:hsa05217] [PUBMED:15948971] [PUBMED:15978322] [PUBMED:15468170] [PUBMED:11276000] [PUBMED:11130178] [PUBMED:14737121] [PUBMED:16306523] [PUBMED:15270885] [PUBMED:14556242] [PUBMED:15656799] [PUBMED:16054233] [PUBMED:12588368] [PUBMED:16881963] [PUBMED:11736900]
Beta-catenin independent WNT signaling [NCBI:1269610] [REACTOME:R-HSA-3858494] [PUBMED:22935904] [PUBMED:21903638] [PUBMED:23256519] [PUBMED:8065359] [PUBMED:7739543] [PUBMED:23140633]
Canonical Wnt signaling pathway [NCBI:138032] [Pathway Interaction Database:wnt_canonical_pathway] [PUBMED:16849322] [PUBMED:10228155] [PUBMED:19061640] [PUBMED:10074433] [PUBMED:9554852] [PUBMED:11007767] [PUBMED:10023673] [PUBMED:16263762] [PUBMED:10196136] [PUBMED:17529994] [PUBMED:19309792] [PUBMED:16890161] [PUBMED:17569865] [PUBMED:16341017] [PUBMED:10421629] [PUBMED:20177058] [PUBMED:11751573] [PUBMED:15024404] [PUBMED:16314428] [PUBMED:10092233] [PUBMED:12000790] [PUBMED:16547521] [PUBMED:9482734] [PUBMED:10684251] [PUBMED:16303557] [PUBMED:11274398] [PUBMED:9566905] [PUBMED:19556239] [PUBMED:11834740] [PUBMED:15459103] [PUBMED:18929646] [PUBMED:9312064] [PUBMED:15327768] [PUBMED:12554650] [PUBMED:16341016] [PUBMED:17510365] [PUBMED:18772438] [PUBMED:19107203] [PUBMED:18077588] [PUBMED:14966280] [PUBMED:19561074] [PUBMED:19801552]
DNA damage response (only ATM dependent) [NCBI:198827] [WikiPathways:WP710] [PUBMED:15343279] [PUBMED:16921403] [PUBMED:15339658] [PUBMED:17568790] [PUBMED:18004398] [PUBMED:15719025] [PUBMED:14993903] [PUBMED:15545627] [PUBMED:17380161] [PUBMED:16805667] [PUBMED:17943134] [PUBMED:14634621] [PUBMED:15668327] [PUBMED:15688066] [PUBMED:17060944] [PUBMED:17768402] [PUBMED:19111245]
Degradation of DVL [NCBI:1269605] [REACTOME:R-HSA-4641258] [PUBMED:20006983] [PUBMED:22826439] [PUBMED:16547521] [PUBMED:11970895] [PUBMED:14684739] [PUBMED:16446366]
Disassembly of the destruction complex and recruitment of AXIN to the membrane [NCBI:1269601] [REACTOME:R-HSA-4641262] [PUBMED:10581160] [PUBMED:14551908] [PUBMED:15084453] [PUBMED:19619488] [PUBMED:14731402] [PUBMED:22363759] [PUBMED:18234723] [PUBMED:15459103] [PUBMED:17318175] [PUBMED:11336703] [PUBMED:10421629] [PUBMED:17569865] [PUBMED:10647780] [PUBMED:19759537] [PUBMED:16341017]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:16436385] [PUBMED:17446673] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:16155605] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:18702816] [PUBMED:11244044] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:16155611] [PUBMED:10602469] [PUBMED:9325311] [PUBMED:19014483] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16036567]
Hippo signaling pathway [NCBI:749777] [KEGG:hsa04390] [PUBMED:18955139] [PUBMED:21138973] [PUBMED:20439427] [PUBMED:20951342] [PUBMED:18328423] [PUBMED:21324984] [PUBMED:22750148] [PUBMED:23034192] [PUBMED:21084559] [PUBMED:21808241] [PUBMED:17975546] [PUBMED:19846288] [PUBMED:22895435] [PUBMED:22683405] [PUBMED:22658639] [PUBMED:20945341] [PUBMED:22153608] [PUBMED:22830020] [PUBMED:21874053] [PUBMED:21376238]
Melanogenesis [NCBI:83092] [KEGG:hsa04916] [PUBMED:11041354] [PUBMED:15016298] [PUBMED:10347209] [PUBMED:10841026] [PUBMED:16822996] [PUBMED:12753399] [PUBMED:11023702] [PUBMED:11602344] [PUBMED:15383650] [PUBMED:16246839] [PUBMED:9263329] [PUBMED:12894244] [PUBMED:10643996]
MicroRNAs in cardiomyocyte hypertrophy [NCBI:198784] [WikiPathways:WP1544] [PUBMED:10615383] [PUBMED:10189350] [PUBMED:9253712] [PUBMED:9488659] [PUBMED:10827130] [PUBMED:11055975] [PUBMED:9568714] [PUBMED:19018142] [PUBMED:20407820] [PUBMED:11101507] [PUBMED:10864911] [PUBMED:10698680] [PUBMED:16936699] [PUBMED:17468766] [PUBMED:18342376] [PUBMED:8621626] [PUBMED:10086361]
Negative regulation of TCF-dependent signaling by DVL-interacting proteins [NCBI:1269609] [REACTOME:R-HSA-5368598] [PUBMED:14750955] [PUBMED:20006983] [PUBMED:11113207] [PUBMED:22643886] [PUBMED:19619488] [PUBMED:21031079]
Neural Crest Differentiation [NCBI:672460] [WikiPathways:WP2064] [PUBMED:14973296] [PUBMED:21108791] [PUBMED:16845469] [PUBMED:21784065] [PUBMED:15944192] [PUBMED:16402914] [PUBMED:19575671] [PUBMED:20083100]
Noncanonical Wnt signaling pathway [NCBI:169354] [Pathway Interaction Database:wnt_noncanonical_pathway] [PUBMED:11408485] [PUBMED:10391247] [PUBMED:12482967] [PUBMED:15509575] [PUBMED:18667433] [PUBMED:10777564] [PUBMED:18162551] [PUBMED:19720827] [PUBMED:17101698] [PUBMED:12839624] [PUBMED:19910923] [PUBMED:10395542] [PUBMED:17952062] [PUBMED:16880514] [PUBMED:12771126] [PUBMED:15121866] [PUBMED:11779461] [PUBMED:18606138] [PUBMED:20457807] [PUBMED:17646398] [PUBMED:18215320] [PUBMED:18615587]
Notch Signaling Pathway [NCBI:198891] [WikiPathways:WP268] [PUBMED:9245493]
Notch signaling pathway [NCBI:83062] [KEGG:hsa04330] [NCBI:169345] [Pathway Interaction Database:notch_pathway] [PUBMED:17658278] [PUBMED:11459941] [PUBMED:11825871] [PUBMED:12682059] [PUBMED:15998794] [PUBMED:18490439] [PUBMED:10206645] [PUBMED:11101851] [PUBMED:9694793] [PUBMED:11150244] [PUBMED:19686683] [PUBMED:17392792] [PUBMED:19704010] [PUBMED:11585921] [PUBMED:16137758] [PUBMED:15288258] [PUBMED:18676613] [PUBMED:8749394] [PUBMED:18043734] [PUBMED:15274632] [PUBMED:19567869] [PUBMED:14566063] [PUBMED:15965470] [PUBMED:11777909] [PUBMED:17658279] [PUBMED:10593990] [PUBMED:10958687] [PUBMED:12015972] [PUBMED:15067010] [PUBMED:10028969] [PUBMED:9315665] [PUBMED:15300010] [PUBMED:8643690] [PUBMED:11782429] [PUBMED:12826675] [PUBMED:17575125] [PUBMED:9653148] [PUBMED:10882062] [PUBMED:19726682] [PUBMED:12374742] [PUBMED:11486031] [PUBMED:17296795] [PUBMED:12464310] [PUBMED:12297508] [PUBMED:16492672] [PUBMED:15082708] [PUBMED:16061358] [PUBMED:9244302] [PUBMED:12681948] [PUBMED:11425854] [PUBMED:15272268] [PUBMED:9620803] [PUBMED:16287852] [PUBMED:16847353] [PUBMED:16000382] [PUBMED:11604511] [PUBMED:11432830] [PUBMED:10882063] [PUBMED:14567914] [PUBMED:17107962] [PUBMED:12814948] [PUBMED:11896183] [PUBMED:15585829] [PUBMED:11518718] [PUBMED:15652348] [PUBMED:16144902] [PUBMED:15288257] [PUBMED:17434929] [PUBMED:11006133] [PUBMED:12417415] [PUBMED:18077452] [PUBMED:15288260] [PUBMED:12913000] [PUBMED:17114293] [PUBMED:10837024] [PUBMED:10940313] [PUBMED:18628966] [PUBMED:12794186] [PUBMED:16107360] [PUBMED:12551931] [PUBMED:18417156] [PUBMED:12370315]
PCP/CE pathway [NCBI:1269611] [REACTOME:R-HSA-4086400] [PUBMED:23140633] [PUBMED:10811221] [PUBMED:18848778] [PUBMED:19365405] [PUBMED:9598355] [PUBMED:21983142] [PUBMED:17433286] [PUBMED:19204114] [PUBMED:20004982]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:16001072] [PUBMED:16699851] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:15156182] [PUBMED:15310786] [PUBMED:21193867] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:12951584] [PUBMED:11071626] [PUBMED:9834202] [PUBMED:15721476] [PUBMED:11895903] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:11477132] [PUBMED:15724144] [PUBMED:10647931] [PUBMED:16700615] [PUBMED:11527574] [PUBMED:16339096] [PUBMED:12545153] [PUBMED:15942304] [PUBMED:16352814] [PUBMED:15656799] [PUBMED:10740269] [PUBMED:16881963] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:17287871] [PUBMED:15557758] [PUBMED:10944551] [PUBMED:11170304] [PUBMED:12154354] [PUBMED:15639402] [PUBMED:16326109] [PUBMED:11276000] [PUBMED:15573119] [PUBMED:15625120] [PUBMED:15109562] [PUBMED:11160144] [PUBMED:15611513] [PUBMED:15349822] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:16551846] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:11130178] [PUBMED:14580692] [PUBMED:14634372] [PUBMED:12407699] [PUBMED:12588368] [PUBMED:15009714] [PUBMED:16001050] [PUBMED:16112428] [PUBMED:9643506] [PUBMED:15468170] [PUBMED:16248975] [PUBMED:12946833] [PUBMED:11057895] [PUBMED:11559746] [PUBMED:16306523] [PUBMED:16064138] [PUBMED:15479695] [PUBMED:11900250] [PUBMED:9422516] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:12894244] [PUBMED:11103787] [PUBMED:12878745] [PUBMED:16702400] [PUBMED:14685170] [PUBMED:16189154] [PUBMED:11720739] [PUBMED:15122209] [PUBMED:11078609] [PUBMED:12243753] [PUBMED:14982876] [PUBMED:16642045] [PUBMED:12563308] [PUBMED:11407945] [PUBMED:14586404] [PUBMED:15270885] [PUBMED:16095998] [PUBMED:15948971] [PUBMED:16484590] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11459867] [PUBMED:10505543] [PUBMED:15746962] [PUBMED:16146838] [PUBMED:15947972] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:15841168] [PUBMED:11463388] [PUBMED:16474624] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:14556242] [PUBMED:10453277] [PUBMED:11721960] [PUBMED:11905738] [PUBMED:10403855] [PUBMED:12741677] [PUBMED:12616528] [PUBMED:15823750] [PUBMED:12737309] [PUBMED:14695152] [PUBMED:16750612] [PUBMED:11807782] [PUBMED:12351585] [PUBMED:14737121] [PUBMED:12801837] [PUBMED:11431710] [PUBMED:11165748] [PUBMED:11750244] [PUBMED:11224709] [PUBMED:16110317] [PUBMED:16508724] [PUBMED:15948711] [PUBMED:16870043] [PUBMED:7585656] [PUBMED:12379883] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:14747944] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:17158541] [PUBMED:12468433] [PUBMED:16042571] [PUBMED:16557281] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:16189702] [PUBMED:8069858] [PUBMED:12951588] [PUBMED:16242838] [PUBMED:15082523] [PUBMED:17211469] [PUBMED:12711111] [PUBMED:15284264] [PUBMED:11223406] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:16946003] [PUBMED:12762887] [PUBMED:16054233] [PUBMED:16822996] [PUBMED:17554387] [PUBMED:17028294]
Presenilin action in Notch and Wnt signaling [NCBI:137914] [Pathway Interaction Database:ps1pathway] [PUBMED:10391247] [PUBMED:11357136] [PUBMED:11921277] [PUBMED:15620650] [PUBMED:10359821] [PUBMED:11739397] [PUBMED:15292388] [PUBMED:12794186] [PUBMED:8923452] [PUBMED:15327768] [PUBMED:11266469] [PUBMED:10882062] [PUBMED:12857724] [PUBMED:9171444] [PUBMED:15747065] [PUBMED:12554650] [PUBMED:12050670] [PUBMED:10201374]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:11018042] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:19513348] [PUBMED:12778124] [PUBMED:11804587] [PUBMED:16507994] [PUBMED:18006505] [PUBMED:21351730] [PUBMED:24969695] [PUBMED:23875749] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:12635176] [PUBMED:24128008] [PUBMED:10072071] [PUBMED:8543060] [PUBMED:1660188] [PUBMED:12221077] [PUBMED:14595335] [PUBMED:10753910] [PUBMED:10652353] [PUBMED:17151359] [PUBMED:10591629] [PUBMED:12783890] [PUBMED:9751706] [PUBMED:8107774] [PUBMED:11948177] [PUBMED:8756646] [PUBMED:14514689] [PUBMED:10619026] [PUBMED:18237546] [PUBMED:16636067] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:8816443] [PUBMED:16979770] [PUBMED:23444367] [PUBMED:16762923] [PUBMED:10975528] [PUBMED:15546864] [PUBMED:12110184] [PUBMED:9199170] [PUBMED:19737400] [PUBMED:12514133] [PUBMED:12732141] [PUBMED:9368021] [PUBMED:7559638] [PUBMED:8798539] [PUBMED:11162552] [PUBMED:24914801] [PUBMED:16431929] [PUBMED:9988689] [PUBMED:8769096] [PUBMED:8571126] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:10559936] [PUBMED:12473120] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:11689693]
RHO GTPases Activate Formins [NCBI:1269519] [REACTOME:R-HSA-5663220] [PUBMED:15507212] [PUBMED:20233848] [PUBMED:11779461] [PUBMED:16292343] [PUBMED:12906795] [PUBMED:21397845] [PUBMED:12577064] [PUBMED:17198702] [PUBMED:20101212] [PUBMED:16472745] [PUBMED:15944396] [PUBMED:16943183] [PUBMED:10678165] [PUBMED:24914801] [PUBMED:16439214] [PUBMED:12732141] [PUBMED:9497258] [PUBMED:15085137] [PUBMED:21576392] [PUBMED:15006353] [PUBMED:10958683] [PUBMED:21868368]
Regulation of Microtubule Cytoskeleton [NCBI:755439] [WikiPathways:WP2038]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:19648010] [PUBMED:17604717] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:15863030] [PUBMED:21252999] [PUBMED:19379690] [PUBMED:19536106] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:15450248] [PUBMED:15520807] [PUBMED:16939974] [PUBMED:18483217] [PUBMED:18043707] [PUBMED:19762341] [PUBMED:21781017] [PUBMED:17084981] [PUBMED:19619488] [PUBMED:17496910]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:23256519] [PUBMED:19365405] [PUBMED:17143292] [PUBMED:19619488] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:20576942] [PUBMED:16099039] [PUBMED:10858654] [PUBMED:12967557]
Signaling pathways regulating pluripotency of stem cells [NCBI:1026136] [KEGG:hsa04550] [PUBMED:20705693] [PUBMED:17211451] [PUBMED:22649650] [PUBMED:24910449] [PUBMED:22298652] [PUBMED:24315442] [PUBMED:17647265] [PUBMED:18295576] [PUBMED:16153702] [PUBMED:18414030] [PUBMED:23370346] [PUBMED:18220859] [PUBMED:24957798] [PUBMED:24147644] [PUBMED:19571885] [PUBMED:23585347] [PUBMED:23653415] [PUBMED:16518401] [PUBMED:19551525] [PUBMED:19427042]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
TGF-beta Receptor Signaling Pathway [NCBI:198774] [WikiPathways:WP366]
WNT mediated activation of DVL [NCBI:1269600] [REACTOME:R-HSA-201688] [PUBMED:18093802] [PUBMED:15935773] [PUBMED:11336703] [PUBMED:10990458] [PUBMED:11433294] [PUBMED:22017973] [PUBMED:20006983] [PUBMED:17529994] [PUBMED:14636582] [PUBMED:15459103] [PUBMED:18772438] [PUBMED:19561074] [PUBMED:9214626]
Wnt Signaling Pathway [NCBI:198789] [WikiPathways:WP428] [PUBMED:15686623]
Wnt Signaling Pathway NetPath [NCBI:198799] [WikiPathways:WP363]
Wnt Signaling Pathway and Pluripotency [NCBI:198847] [WikiPathways:WP399] [PUBMED:16881513] [PUBMED:17372190] [PUBMED:16894029] [PUBMED:18957414] [PUBMED:18483421] [PUBMED:22539006]
Wnt signaling pathway [NCBI:83061] [KEGG:hsa04310] [PUBMED:14745971] [PUBMED:14530294] [PUBMED:12446114] [PUBMED:15102436] [PUBMED:14635791] [PUBMED:23256519] [PUBMED:19482104] [PUBMED:11433294] [PUBMED:18838381] [PUBMED:12967557]