full name
insulin receptor substrate 1

synonyms
HIRS-1, IRS1, ENSG00000169047

HGNC
HGNC:6125

Entrez Gene
Gene:3667

ENSEMBL
ENSG00000169047

location
chr: 2
start: 227596033
stop: 227664545
strand: -

OMIM
OMIM:147545: IRS1
OMIM:125853: {Diabetes mellitus, noninsulin-dependent}

transcripts
NM_005544.2

pathways
AMPK signaling pathway [NCBI:989139] [KEGG:hsa04152] [PUBMED:22885100] [PUBMED:18725075] [PUBMED:22700795] [PUBMED:19724019] [PUBMED:19584320] [PUBMED:16644802] [PUBMED:20010958] [PUBMED:16479585] [PUBMED:19197243] [PUBMED:23565491] [PUBMED:20357764] [PUBMED:16723978] [PUBMED:16054041] [PUBMED:19393004] [PUBMED:23899560] [PUBMED:17307971] [PUBMED:15509864] [PUBMED:23024365] [PUBMED:23747347] [PUBMED:19629071]
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Adipocytokine signaling pathway [NCBI:83093] [KEGG:hsa04920] [PUBMED:12829246] [PUBMED:10905472] [PUBMED:15980064] [PUBMED:12754525] [PUBMED:12368907] [PUBMED:11557972] [PUBMED:15856064] [PUBMED:9671776] [PUBMED:10766253] [PUBMED:15733744] [PUBMED:15058305] [PUBMED:14716305] [PUBMED:11479627] [PUBMED:14679176]
Aldosterone-regulated sodium reabsorption [NCBI:130626] [KEGG:hsa04960] [PUBMED:17332888] [PUBMED:12943727] [PUBMED:11208606] [PUBMED:18197893] [PUBMED:19549592] [PUBMED:12649599] [PUBMED:16286565] [PUBMED:15590995] [PUBMED:11850323] [PUBMED:17309947] [PUBMED:18174920] [PUBMED:16002531]
Autophagy - animal [NCBI:83058] [KEGG:hsa04140] [PUBMED:16200202] [PUBMED:15325588] [PUBMED:24343578] [PUBMED:15978794] [PUBMED:19802558] [PUBMED:16099218] [PUBMED:11099404] [PUBMED:19653858] [PUBMED:15325584] [PUBMED:20034776] [PUBMED:15928708] [PUBMED:21801009] [PUBMED:25948417] [PUBMED:16125113] [PUBMED:21187343]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Constitutive Signaling by Aberrant PI3K in Cancer [NCBI:1268880] [REACTOME:R-HSA-2219530] [PUBMED:18317450] [PUBMED:19962665] [PUBMED:20009532] [PUBMED:20713702] [PUBMED:21478295] [PUBMED:16339315] [PUBMED:18079394] [PUBMED:17626883]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR) [NCBI:1269185] [REACTOME:R-HSA-1168372] [PUBMED:17052215] [PUBMED:19909372]
FCERI mediated MAPK activation [NCBI:1269299] [REACTOME:R-HSA-2871796] [PUBMED:19290926] [PUBMED:19909365] [PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:15005655] [PUBMED:18951090] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:16964248] [PUBMED:18045156] [PUBMED:18403263] [PUBMED:21613825] [PUBMED:21440011] [PUBMED:17470511] [PUBMED:21238503] [PUBMED:17522590] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:15516968]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
GAB1 signalosome [NCBI:1269384] [REACTOME:R-HSA-180292] [PUBMED:15550174]
GRB2 events in EGFR signaling [NCBI:1269382] [REACTOME:R-HSA-179812] [PUBMED:11706405] [PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Growth hormone receptor signaling [NCBI:1269327] [REACTOME:R-HSA-982772] [PUBMED:15601831] [PUBMED:8548048] [PUBMED:17488973] [PUBMED:20664532]
IGF1 pathway [NCBI:137992] [Pathway Interaction Database:igf1_pathway] [PUBMED:15003536] [PUBMED:10576742] [PUBMED:8621590] [PUBMED:9346240] [PUBMED:16932738] [PUBMED:8662827] [PUBMED:15976035] [PUBMED:11572799] [PUBMED:14550766] [PUBMED:15070696] [PUBMED:9346905] [PUBMED:10490655] [PUBMED:1378290] [PUBMED:9480911] [PUBMED:9442079] [PUBMED:7534289] [PUBMED:8265614] [PUBMED:9748296] [PUBMED:11884618] [PUBMED:12538620] [PUBMED:8798417] [PUBMED:8764099] [PUBMED:8505282] [PUBMED:7540132] [PUBMED:12048182] [PUBMED:15611085] [PUBMED:14604996] [PUBMED:7642582] [PUBMED:11836447] [PUBMED:8776723] [PUBMED:7513703] [PUBMED:9506989]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IL2-mediated signaling events [NCBI:137976] [Pathway Interaction Database:il2_1pathway] [PUBMED:7568005] [PUBMED:10962026] [PUBMED:1545122] [PUBMED:10602027] [PUBMED:15170389] [PUBMED:9092570] [PUBMED:7509794] [PUBMED:15356145] [PUBMED:9973481] [PUBMED:10899310] [PUBMED:9195132] [PUBMED:7544001] [PUBMED:7777534] [PUBMED:12681450] [PUBMED:7665592] [PUBMED:8702919] [PUBMED:1708096] [PUBMED:8643566] [PUBMED:7988557] [PUBMED:7737351] [PUBMED:1532814] [PUBMED:8262551] [PUBMED:8025955] [PUBMED:10993906] [PUBMED:3095922] [PUBMED:8805624] [PUBMED:9391116] [PUBMED:7973658] [PUBMED:11331873] [PUBMED:10421845] [PUBMED:8119884] [PUBMED:7781605] [PUBMED:12543077] [PUBMED:9133424] [PUBMED:1618313] [PUBMED:1940342] [PUBMED:9382798] [PUBMED:10514520] [PUBMED:7973659] [PUBMED:1639773] [PUBMED:9029085] [PUBMED:7760801] [PUBMED:1460037] [PUBMED:9202126] [PUBMED:1652056] [PUBMED:12393431] [PUBMED:8397196] [PUBMED:2047859] [PUBMED:7688728] [PUBMED:8700888] [PUBMED:7528668] [PUBMED:9305919] [PUBMED:2303462] [PUBMED:7568001] [PUBMED:9822600] [PUBMED:7543676] [PUBMED:7499365] [PUBMED:10843677] [PUBMED:7600304] [PUBMED:7719937] [PUBMED:9590209] [PUBMED:9794391] [PUBMED:10849428] [PUBMED:8294403] [PUBMED:10373548] [PUBMED:2590941] [PUBMED:9512511] [PUBMED:6434688] [PUBMED:9697832] [PUBMED:10982827] [PUBMED:10214954] [PUBMED:10825200] [PUBMED:1535827] [PUBMED:10369681] [PUBMED:7719938] [PUBMED:1655887] [PUBMED:8376945] [PUBMED:1996324] [PUBMED:7479881] [PUBMED:10962581] [PUBMED:7973657] [PUBMED:1631559] [PUBMED:10066828] [PUBMED:9169478] [PUBMED:8552611] [PUBMED:8483935] [PUBMED:2106566] [PUBMED:16199887]
IL4-mediated signaling events [NCBI:137933] [Pathway Interaction Database:il4_2pathway] [PUBMED:8602263] [PUBMED:15199062] [PUBMED:7705411] [PUBMED:11160325] [PUBMED:8557643] [PUBMED:8134361] [PUBMED:1948049] [PUBMED:10843732] [PUBMED:11034397] [PUBMED:8624802] [PUBMED:14557412] [PUBMED:1997653] [PUBMED:10586089] [PUBMED:14634100] [PUBMED:17541284] [PUBMED:8124718] [PUBMED:16210622] [PUBMED:7822337] [PUBMED:11572871] [PUBMED:2147202] [PUBMED:10228008] [PUBMED:7675087] [PUBMED:12574343] [PUBMED:14603527] [PUBMED:15659391] [PUBMED:11160269] [PUBMED:7760829] [PUBMED:7973658] [PUBMED:10072514] [PUBMED:9013879] [PUBMED:8624803] [PUBMED:10490661] [PUBMED:14978013] [PUBMED:10364072] [PUBMED:12459556] [PUBMED:11714803] [PUBMED:8602264] [PUBMED:9811885] [PUBMED:12776189] [PUBMED:15728454] [PUBMED:10601358] [PUBMED:11739727] [PUBMED:11160275] [PUBMED:9852037] [PUBMED:9670964] [PUBMED:15004182] [PUBMED:8266078] [PUBMED:3144043] [PUBMED:8992992] [PUBMED:8089482] [PUBMED:9651359] [PUBMED:16810739] [PUBMED:7499365] [PUBMED:7721786] [PUBMED:9065461] [PUBMED:11241672] [PUBMED:10950967] [PUBMED:8810328] [PUBMED:8624821] [PUBMED:9110977] [PUBMED:8609418] [PUBMED:15187136] [PUBMED:9414268] [PUBMED:8916957] [PUBMED:10201892] [PUBMED:17200144] [PUBMED:8458387] [PUBMED:11544308] [PUBMED:10657944] [PUBMED:15153491] [PUBMED:7544011] [PUBMED:8266076] [PUBMED:11801631] [PUBMED:12044779] [PUBMED:8621475] [PUBMED:9697832] [PUBMED:12242343] [PUBMED:7694370] [PUBMED:9380721] [PUBMED:9541585] [PUBMED:7807002] [PUBMED:16537510] [PUBMED:8258319] [PUBMED:9799097] [PUBMED:12023955] [PUBMED:8085155]
IRS activation [NCBI:1269430] [REACTOME:R-HSA-74713]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin Pathway [NCBI:138026] [Pathway Interaction Database:insulin_pathway] [PUBMED:8491186] [PUBMED:9111325] [PUBMED:7629070] [PUBMED:10499514] [PUBMED:11121405] [PUBMED:10660596] [PUBMED:8196603] [PUBMED:11096081] [PUBMED:8524328] [PUBMED:9891043] [PUBMED:12242347] [PUBMED:2123524] [PUBMED:9369444] [PUBMED:1375946] [PUBMED:9348199] [PUBMED:8826975] [PUBMED:8316835] [PUBMED:8999839] [PUBMED:8449939] [PUBMED:10807907] [PUBMED:1599438] [PUBMED:8265614] [PUBMED:11171109] [PUBMED:11821390] [PUBMED:12687004] [PUBMED:7806540] [PUBMED:11154281] [PUBMED:8244979] [PUBMED:8798417] [PUBMED:1381348] [PUBMED:7581368] [PUBMED:15787604] [PUBMED:8385105] [PUBMED:11551902] [PUBMED:8114695] [PUBMED:11997497] [PUBMED:11001060] [PUBMED:11309621] [PUBMED:9109420] [PUBMED:8383963] [PUBMED:12147684] [PUBMED:8144662] [PUBMED:12036959] [PUBMED:14734537] [PUBMED:7983051] [PUBMED:9083103] [PUBMED:15210700] [PUBMED:9065430] [PUBMED:11297536] [PUBMED:10544179] [PUBMED:1321126] [PUBMED:11502760] [PUBMED:8978681] [PUBMED:8999972] [PUBMED:14690593] [PUBMED:11832334] [PUBMED:9447983] [PUBMED:15192089] [PUBMED:8524413] [PUBMED:7685165] [PUBMED:10329736] [PUBMED:11287630] [PUBMED:15486046] [PUBMED:10330191] [PUBMED:8626723]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
Integrins in angiogenesis [NCBI:137999] [Pathway Interaction Database:avb3_integrin_pathway] [PUBMED:10837460] [PUBMED:9182576] [PUBMED:12642872] [PUBMED:15711558] [PUBMED:10037797] [PUBMED:10196194] [PUBMED:11877390] [PUBMED:16418218] [PUBMED:16600665] [PUBMED:16982628] [PUBMED:15479743] [PUBMED:16720645] [PUBMED:11684710] [PUBMED:10821695] [PUBMED:12237112] [PUBMED:12750158] [PUBMED:11551924] [PUBMED:8794870] [PUBMED:10022831] [PUBMED:15187087] [PUBMED:16195423] [PUBMED:16760434] [PUBMED:12682293] [PUBMED:9420328] [PUBMED:15247219] [PUBMED:9490736] [PUBMED:11313365]
Interleukin receptor SHC signaling [NCBI:1269322] [REACTOME:R-HSA-912526] [PUBMED:8294403]
Interleukin-2 signaling [NCBI:1269321] [REACTOME:R-HSA-451927] [PUBMED:17936914] [PUBMED:18817510] [PUBMED:19543225] [PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
Longevity regulating pathway [NCBI:1319989] [KEGG:hsa04211] [PUBMED:21779512] [PUBMED:23594965] [PUBMED:25654554] [PUBMED:25832544] [PUBMED:24997879] [PUBMED:22618766] [PUBMED:20336132] [PUBMED:24905167] [PUBMED:25601466] [PUBMED:20103737] [PUBMED:18692468] [PUBMED:20395504] [PUBMED:25824609] [PUBMED:17701476] [PUBMED:23939249] [PUBMED:20848587] [PUBMED:22983298] [PUBMED:19262508] [PUBMED:20357764] [PUBMED:18946478] [PUBMED:23061800]
Longevity regulating pathway - multiple species [NCBI:1340713] [KEGG:hsa04213] [PUBMED:26682004] [PUBMED:20098959] [PUBMED:17684529] [PUBMED:14534077] [PUBMED:16304601] [PUBMED:17701476] [PUBMED:20395504] [PUBMED:18373439] [PUBMED:20336132] [PUBMED:21909281] [PUBMED:26525455] [PUBMED:22094419] [PUBMED:12610293] [PUBMED:15768047] [PUBMED:23615258] [PUBMED:18946478] [PUBMED:20097433] [PUBMED:21841070] [PUBMED:25153840]
MAPK family signaling cascades [NCBI:1269501] [REACTOME:R-HSA-5683057] [PUBMED:21167873] [PUBMED:17161475] [PUBMED:22535895] [PUBMED:21372320]
MAPK1/MAPK3 signaling [NCBI:1269502] [REACTOME:R-HSA-5684996] [PUBMED:25378393] [PUBMED:18199641] [PUBMED:17496909] [PUBMED:21779496] [PUBMED:15520807] [PUBMED:16393692] [PUBMED:19520853] [PUBMED:17496910] [PUBMED:22569528]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
NCAM signaling for neurite out-growth [NCBI:1270312] [REACTOME:R-HSA-375165] [PUBMED:18760361] [PUBMED:12587671] [PUBMED:15662836] [PUBMED:17975827] [PUBMED:15153429] [PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Negative regulation of the PI3K/AKT network [NCBI:1269191] [REACTOME:R-HSA-199418]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
Non-alcoholic fatty liver disease (NAFLD) [NCBI:862188] [KEGG:hsa04932] [PUBMED:21038418] [PUBMED:17498512] [PUBMED:19352614] [PUBMED:23299992] [PUBMED:22570745] [PUBMED:9285483] [PUBMED:12891546] [PUBMED:18061659] [PUBMED:22705006] [PUBMED:16364488] [PUBMED:18242193] [PUBMED:16374858] [PUBMED:22940046] [PUBMED:20619513] [PUBMED:20303879] [PUBMED:14685853] [PUBMED:16406828] [PUBMED:23545492] [PUBMED:21145844]
PI3K Cascade [NCBI:1269432] [REACTOME:R-HSA-109704]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
PI3K/AKT Signaling in Cancer [NCBI:1268879] [REACTOME:R-HSA-2219528] [PUBMED:20713702] [PUBMED:10555148] [PUBMED:19644473] [PUBMED:17611497] [PUBMED:21478295] [PUBMED:17626883] [PUBMED:16339315] [PUBMED:18317450] [PUBMED:18079394] [PUBMED:9467011] [PUBMED:17604717] [PUBMED:9326929] [PUBMED:18954143] [PUBMED:20009532] [PUBMED:19962665] [PUBMED:21430697] [PUBMED:19487573] [PUBMED:10866302]
PI3K/AKT activation [NCBI:1269473] [REACTOME:R-HSA-198203] [PUBMED:10579926] [PUBMED:12123609]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [NCBI:1383020] [REACTOME:R-HSA-6811558] [PUBMED:12422219] [PUBMED:16979564] [PUBMED:19805105] [PUBMED:17200115] [PUBMED:21827948] [PUBMED:19576174] [PUBMED:18753295] [PUBMED:19896968] [PUBMED:16456541] [PUBMED:25495341] [PUBMED:15464023] [PUBMED:23758345] [PUBMED:9367159] [PUBMED:9211928] [PUBMED:17245604]
PIP3 activates AKT signaling [NCBI:1269188] [REACTOME:R-HSA-1257604]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
RAF/MAP kinase cascade [NCBI:1269285] [REACTOME:R-HSA-5673001] [PUBMED:21167873] [PUBMED:24937142] [PUBMED:20674547] [PUBMED:17496910] [PUBMED:22177953] [PUBMED:17496919] [PUBMED:22569528] [PUBMED:22535895] [PUBMED:12068308] [PUBMED:17496923] [PUBMED:19091303] [PUBMED:21372320] [PUBMED:21388974] [PUBMED:15520807]
RET signaling [NCBI:1427866] [REACTOME:R-HSA-8853659] [PUBMED:15013219] [PUBMED:17036197]
Regulation of lipolysis in adipocytes [NCBI:1222950] [KEGG:hsa04923] [PUBMED:24676492] [PUBMED:21241784] [PUBMED:17313320] [PUBMED:21900692] [PUBMED:20025992] [PUBMED:19375517] [PUBMED:22298655] [PUBMED:19464318] [PUBMED:24872083] [PUBMED:19136990] [PUBMED:19796963] [PUBMED:18762440] [PUBMED:17878492] [PUBMED:24731595] [PUBMED:17218471]
Role of LAT2/NTAL/LAB on calcium mobilization [NCBI:1269302] [REACTOME:R-HSA-2730905] [PUBMED:17993265] [PUBMED:20643813] [PUBMED:17420272]
S1P2 pathway [NCBI:138059] [Pathway Interaction Database:s1p_s1p2_pathway] [PUBMED:9854026] [PUBMED:10617617] [PUBMED:17431187] [PUBMED:12588974] [PUBMED:11094076] [PUBMED:15240112] [PUBMED:11853542] [PUBMED:12810709]
SHC1 events in EGFR signaling [NCBI:1269383] [REACTOME:R-HSA-180336] [PUBMED:11498013] [PUBMED:8755247]
SOS-mediated signalling [NCBI:1269440] [REACTOME:R-HSA-112412]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signal attenuation [NCBI:1269441] [REACTOME:R-HSA-74749]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:22211890] [PUBMED:23562747] [PUBMED:20600241] [PUBMED:21622208] [PUBMED:23579596] [PUBMED:22458591] [PUBMED:21489811] [PUBMED:19724019] [PUBMED:21331644] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:20198122] [PUBMED:21677426] [PUBMED:20029269] [PUBMED:22249808] [PUBMED:22991412] [PUBMED:21527729] [PUBMED:17937601] [PUBMED:20553370] [PUBMED:21713385] [PUBMED:23565489] [PUBMED:22289780]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling by VEGF [NCBI:1269480] [REACTOME:R-HSA-194138] [PUBMED:15585754] [PUBMED:13678960] [PUBMED:16336962] [PUBMED:16835467]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]
Signaling events mediated by PTP1B [NCBI:138017] [Pathway Interaction Database:ptp1bpathway] [PUBMED:12414790] [PUBMED:8223493] [PUBMED:12857726] [PUBMED:8999839] [PUBMED:14766979] [PUBMED:9355745] [PUBMED:11579209] [PUBMED:8940134] [PUBMED:12802338] [PUBMED:10807907] [PUBMED:15866871] [PUBMED:10751417] [PUBMED:11346638] [PUBMED:11970899] [PUBMED:9083103] [PUBMED:7693694] [PUBMED:11900546] [PUBMED:7983051] [PUBMED:11694501] [PUBMED:10514492] [PUBMED:12176037] [PUBMED:16644720] [PUBMED:16388599] [PUBMED:9624118] [PUBMED:9786960] [PUBMED:14966267] [PUBMED:15894168] [PUBMED:11773439] [PUBMED:11864611] [PUBMED:8548812] [PUBMED:16477024] [PUBMED:9418872] [PUBMED:9050838] [PUBMED:12424235] [PUBMED:12748279] [PUBMED:1383688] [PUBMED:8782827] [PUBMED:8626723] [PUBMED:11007774] [PUBMED:10993888] [PUBMED:15226396] [PUBMED:10066179] [PUBMED:10660596] [PUBMED:12554649] [PUBMED:11970898] [PUBMED:9566916]
Signaling events regulated by Ret tyrosine kinase [NCBI:137915] [Pathway Interaction Database:ret_pathway] [PUBMED:11002419] [PUBMED:17050626] [PUBMED:11360177] [PUBMED:7478523] [PUBMED:12176011] [PUBMED:12771945] [PUBMED:14607833] [PUBMED:7665556] [PUBMED:8631863] [PUBMED:11470823] [PUBMED:15966897] [PUBMED:12087092] [PUBMED:16820412] [PUBMED:15657578] [PUBMED:10208419] [PUBMED:9182757] [PUBMED:8662982] [PUBMED:9047383] [PUBMED:12063395] [PUBMED:15569713] [PUBMED:15286081] [PUBMED:10448070] [PUBMED:16227613] [PUBMED:11390647] [PUBMED:15351743] [PUBMED:8674117] [PUBMED:11313948] [PUBMED:2181380] [PUBMED:9047384] [PUBMED:8570170] [PUBMED:11886862] [PUBMED:9632781] [PUBMED:16153436] [PUBMED:11000521]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
Type II diabetes mellitus [NCBI:83094] [KEGG:hsa04930] [PUBMED:12480546] [PUBMED:15759102] [PUBMED:9011569] [PUBMED:11078440] [PUBMED:11390407] [PUBMED:15258147] [PUBMED:15823385] [PUBMED:11272200] [PUBMED:11325516] [PUBMED:15733744] [PUBMED:9974390] [PUBMED:7491105] [PUBMED:15585596]
VEGFA-VEGFR2 Pathway [NCBI:1269483] [REACTOME:R-HSA-4420097] [PUBMED:17344076] [PUBMED:16633338] [PUBMED:19230644] [PUBMED:13678960]
VEGFR2 mediated cell proliferation [NCBI:1269485] [REACTOME:R-HSA-5218921] [PUBMED:22866201] [PUBMED:22180219] [PUBMED:22762016]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:17277771] [PUBMED:15341740] [PUBMED:12172553] [PUBMED:15718470] [PUBMED:14651849] [PUBMED:15268862] [PUBMED:15306821] [PUBMED:26046644] [PUBMED:12869586] [PUBMED:24556838] [PUBMED:17928295] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:26658722] [PUBMED:24842496] [PUBMED:23465396] [PUBMED:17709744] [PUBMED:17599906] [PUBMED:16919458] [PUBMED:10364159] [PUBMED:15342917] [PUBMED:11500364] [PUBMED:19812304] [PUBMED:12482958] [PUBMED:11729323] [PUBMED:16962653] [PUBMED:18952604] [PUBMED:9465032] [PUBMED:1496022] [PUBMED:10567431] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:18604198] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:17461779] [PUBMED:9445476] [PUBMED:18497260] [PUBMED:12604610] [PUBMED:15071500] [PUBMED:18925875] [PUBMED:12906785] [PUBMED:11287630] [PUBMED:15004009] [PUBMED:16756488] [PUBMED:17043309] [PUBMED:18198340] [PUBMED:12820960] [PUBMED:12747827] [PUBMED:17053147] [PUBMED:15851026] [PUBMED:15467718] [PUBMED:18762023] [PUBMED:25242279] [PUBMED:24698685] [PUBMED:11175345] [PUBMED:27304501] [PUBMED:18411301] [PUBMED:11500365] [PUBMED:17693255] [PUBMED:23694989] [PUBMED:12231510] [PUBMED:19446321] [PUBMED:11418588] [PUBMED:19258318] [PUBMED:18439900] [PUBMED:19225151] [PUBMED:26185979] [PUBMED:10357815] [PUBMED:26269525] [PUBMED:23421405] [PUBMED:9271440] [PUBMED:16915281] [PUBMED:17141160] [PUBMED:15249583] [PUBMED:12912989] [PUBMED:27027448] [PUBMED:18423201] [PUBMED:19211835] [PUBMED:9204908] [PUBMED:26700098] [PUBMED:18566587] [PUBMED:17386266]