full name
inositol polyphosphate-5-phosphatase D

synonyms
hp51CN, SHIP, SHIP-1, SHIP1, SIP-145, INPP5D, ENSG00000168918

HGNC
HGNC:6079

Entrez Gene
Gene:3635

ENSEMBL
ENSG00000168918

location
chr: 2
start: 233925036
stop: 233995881
strand: +
chr: 2
start: 234054795
stop: 234116549
strand: +

transcripts
NM_001017915.1
NM_005541.3

pathways
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) [NCBI:545332] [BIOCYC:HUMAN_PWY-6362] [PUBMED:1371119] [PUBMED:10390371] [PUBMED:9334307] [PUBMED:2584198] [PUBMED:15531582] [PUBMED:10683435] [PUBMED:9838040] [PUBMED:1849645] [PUBMED:3426614] [PUBMED:3010126] [PUBMED:1684044] [PUBMED:8435066] [PUBMED:9114007] [PUBMED:7814377] [PUBMED:7829485] [PUBMED:12223481]
3-phosphoinositide degradation [NCBI:545349] [BIOCYC:HUMAN_PWY-6368]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
B cell receptor signaling pathway [NCBI:83081] [KEGG:hsa04662] [PUBMED:15626471] [PUBMED:12119152] [PUBMED:15886119] [PUBMED:12461567] [PUBMED:9697839] [PUBMED:15752555] [PUBMED:11163197] [PUBMED:18086859] [PUBMED:15364057] [PUBMED:15457440] [PUBMED:15322145] [PUBMED:15771577] [PUBMED:12033741] [PUBMED:15886112] [PUBMED:10358768]
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
D-myo-inositol (1,3,4)-trisphosphate biosynthesis [NCBI:545328] [BIOCYC:HUMAN_PWY-6364] [PUBMED:3010126] [PUBMED:1659392] [PUBMED:6285891] [PUBMED:6095097] [PUBMED:7637787] [PUBMED:9038348]
Downstream TCR signaling [NCBI:1269176] [REACTOME:R-HSA-202424] [PUBMED:15084594]
Fc epsilon RI signaling pathway [NCBI:83082] [KEGG:hsa04664] [PUBMED:16470226] [PUBMED:12145654] [PUBMED:11079101] [PUBMED:10586892] [PUBMED:14630197] [PUBMED:12360215] [PUBMED:11449275]
Fc gamma R-mediated phagocytosis [NCBI:114228] [KEGG:hsa04666] [PUBMED:11304556] [PUBMED:11244038] [PUBMED:10755615] [PUBMED:17308335] [PUBMED:12821647] [PUBMED:15466916] [PUBMED:17050193] [PUBMED:11228151] [PUBMED:12488490] [PUBMED:10224668] [PUBMED:11708889] [PUBMED:9581795] [PUBMED:10586078] [PUBMED:9417101] [PUBMED:15485887] [PUBMED:18322649] [PUBMED:10577498] [PUBMED:10376013] [PUBMED:10601359] [PUBMED:9545263]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Inositol phosphate metabolism [NCBI:82987] [KEGG:hsa00562] [NCBI:1269988] [REACTOME:R-HSA-1483249] [PUBMED:17943301] [PUBMED:18310071] [PUBMED:20414202] [PUBMED:11331907] [PUBMED:20359876] [PUBMED:14993306] [PUBMED:16781889]
Interleukin receptor SHC signaling [NCBI:1269322] [REACTOME:R-HSA-912526] [PUBMED:8294403]
Interleukin-2 signaling [NCBI:1269321] [REACTOME:R-HSA-451927] [PUBMED:17936914] [PUBMED:18817510] [PUBMED:19543225] [PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
PECAM1 interactions [NCBI:1269375] [REACTOME:R-HSA-210990] [PUBMED:12681475] [PUBMED:14619965]
PI Metabolism [NCBI:1270073] [REACTOME:R-HSA-1483255] [PUBMED:17035995] [PUBMED:18216768] [PUBMED:17330069] [PUBMED:15170460] [PUBMED:16828287] [PUBMED:18726176] [PUBMED:20861159] [PUBMED:19196647] [PUBMED:20043944] [PUBMED:20192774] [PUBMED:18784754] [PUBMED:20559318] [PUBMED:18216767] [PUBMED:17605038] [PUBMED:15269334]
Phosphatidylinositol signaling system [NCBI:83052] [KEGG:hsa04070] [PUBMED:19439500] [PUBMED:19580826]
Phospholipid metabolism [NCBI:1270053] [REACTOME:R-HSA-1483257] [PUBMED:9242906]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Synthesis of IP3 and IP4 in the cytosol [NCBI:1269989] [REACTOME:R-HSA-1855204] [PUBMED:11331907] [PUBMED:20414202]
Synthesis of PIPs at the plasma membrane [NCBI:1270077] [REACTOME:R-HSA-1660499] [PUBMED:16399794] [PUBMED:12646134] [PUBMED:10224048] [PUBMED:9113989] [PUBMED:9211928] [PUBMED:12536145] [PUBMED:22647598] [PUBMED:11733541] [PUBMED:9660759] [PUBMED:19896968]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism [NCBI:545325] [BIOCYC:HUMAN_PWY-6358]
superpathway of inositol phosphate compounds [NCBI:547492] [BIOCYC:HUMAN_PWY-6371]