full name
glypican 1

synonyms
glypican, GPC1, ENSG00000063660

HGNC
HGNC:4449

Entrez Gene
Gene:2817

ENSEMBL
ENSG00000063660

location
chr: 2
start: 241375115
stop: 241407495
strand: +

transcripts
NM_002081.2

pathways
A tetrasaccharide linker sequence is required for GAG synthesis [NCBI:1269981] [REACTOME:R-HSA-1971475] [PUBMED:4139221] [PUBMED:17239764]
Activation of Rac [NCBI:1270321] [REACTOME:R-HSA-428540]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Chondroitin sulfate/dermatan sulfate metabolism [NCBI:1269984] [REACTOME:R-HSA-1793185] [PUBMED:12512856] [PUBMED:12213784] [PUBMED:17239764]
Defective B3GALT6 causes EDSP2 and SEMDJL1 [NCBI:1309217] [REACTOME:R-HSA-4420332] [PUBMED:23664117] [PUBMED:23664118]
Defective B3GAT3 causes JDSSDHD [NCBI:1269015] [REACTOME:R-HSA-3560801] [PUBMED:1640425] [PUBMED:14779259] [PUBMED:21763480] [PUBMED:4626580]
Defective B4GALT7 causes EDS, progeroid type [NCBI:1269014] [REACTOME:R-HSA-3560783] [PUBMED:10506123]
Defective EXT1 causes exostoses 1, TRPS2 and CHDS [NCBI:1269021] [REACTOME:R-HSA-3656253] [PUBMED:7711731] [PUBMED:6496574] [PUBMED:8558565] [PUBMED:2783565] [PUBMED:7726168] [PUBMED:6015756]
Defective EXT2 causes exostoses 2 [NCBI:1269022] [REACTOME:R-HSA-3656237] [PUBMED:2783565] [PUBMED:8558565]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases associated with glycosaminoglycan metabolism [NCBI:1269011] [REACTOME:R-HSA-3560782] [PUBMED:23457301]
Diseases of glycosylation [NCBI:1269010] [REACTOME:R-HSA-3781865] [PUBMED:22983739] [PUBMED:12756558] [PUBMED:22343051] [PUBMED:6543331] [PUBMED:16755287] [PUBMED:19765534] [PUBMED:12409504] [PUBMED:22838182] [PUBMED:2301971] [PUBMED:21384229]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
Glycosaminoglycan metabolism [NCBI:1269972] [REACTOME:R-HSA-1630316] [PUBMED:18201392] [PUBMED:20301236] [PUBMED:820626]
Glypican 1 network [NCBI:138010] [Pathway Interaction Database:glypican_1pathway] [PUBMED:15063764] [PUBMED:18717736] [PUBMED:9949192] [PUBMED:10514475] [PUBMED:16723715] [PUBMED:12972423] [PUBMED:12914968] [PUBMED:15249209] [PUBMED:12649175] [PUBMED:15084524] [PUBMED:16123806] [PUBMED:1400362] [PUBMED:17516498] [PUBMED:10196157] [PUBMED:11375980] [PUBMED:16923158]
Glypican pathway [NCBI:138083] [Pathway Interaction Database:glypicanpathway]
HS-GAG biosynthesis [NCBI:1269982] [REACTOME:R-HSA-2022928] [PUBMED:11102866] [PUBMED:9251237]
HS-GAG degradation [NCBI:1269983] [REACTOME:R-HSA-2024096] [PUBMED:15647514]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Heparan sulfate/heparin (HS-GAG) metabolism [NCBI:1269980] [REACTOME:R-HSA-1638091] [PUBMED:11102866] [PUBMED:19111581] [PUBMED:10716625] [PUBMED:9251237]
Inactivation of Cdc42 and Rac [NCBI:1270320] [REACTOME:R-HSA-428543]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of carbohydrates [NCBI:1269957] [REACTOME:R-HSA-71387]
Metabolism of fat-soluble vitamins [NCBI:1339147] [REACTOME:R-HSA-6806667] [PUBMED:22516726] [PUBMED:15951480] [PUBMED:16011460]
Metabolism of vitamins and cofactors [NCBI:1270144] [REACTOME:R-HSA-196854]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Retinoid metabolism and transport [NCBI:1269624] [REACTOME:R-HSA-975634] [PUBMED:16011460] [PUBMED:11340090]
Role of Abl in Robo-Slit signaling [NCBI:1270322] [REACTOME:R-HSA-428890] [PUBMED:15207236] [PUBMED:12441051] [PUBMED:15207230]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Robo receptor [NCBI:1270318] [REACTOME:R-HSA-376176] [PUBMED:18363568]
Visual phototransduction [NCBI:1269623] [REACTOME:R-HSA-2187338] [PUBMED:15384919] [PUBMED:22074928] [PUBMED:20188572] [PUBMED:21111842] [PUBMED:16688755] [PUBMED:8382952] [PUBMED:22658984] [PUBMED:20430952] [PUBMED:21350678] [PUBMED:22074927] [PUBMED:16011460] [PUBMED:11340090]