full name
cell division cycle 25A

synonyms
CDC25A2, CDC25A, ENSG00000164045

HGNC
HGNC:1725

Entrez Gene
Gene:993

ENSEMBL
ENSG00000164045

location
chr: 3
start: 48198668
stop: 48230153
strand: -

transcripts
NM_201567.1
NM_001789.2

pathways
Activation of ATR in response to replication stress [NCBI:1269757] [REACTOME:R-HSA-176187] [PUBMED:12791985]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cell cycle [NCBI:83054] [KEGG:hsa04110] [PUBMED:7973727] [PUBMED:17568790] [PUBMED:9832503] [PUBMED:16936746] [PUBMED:9029154] [PUBMED:12573239] [PUBMED:19020303] [PUBMED:9618481] [PUBMED:12809600] [PUBMED:8242749] [PUBMED:10385618] [PUBMED:17426725] [PUBMED:17018296] [PUBMED:16212951] [PUBMED:12925736] [PUBMED:11099028] [PUBMED:15568976] [PUBMED:15838516] [PUBMED:15838523] [PUBMED:15876871] [PUBMED:7908906] [PUBMED:9889196]
Cyclin A/B1 associated events during G2/M transition [NCBI:1269800] [REACTOME:R-HSA-69273] [PUBMED:18228324]
Cyclin A:Cdk2-associated events at S phase entry [NCBI:1269778] [REACTOME:R-HSA-69656] [PUBMED:7629134] [PUBMED:11231585] [PUBMED:1396589] [PUBMED:15014502] [PUBMED:10454565] [PUBMED:11907280]
Cyclin B2 mediated events [NCBI:1269802] [REACTOME:R-HSA-157881] [PUBMED:10395539] [PUBMED:11238451] [PUBMED:7737117] [PUBMED:17533373]
Cyclin E associated events during G1/S transition [NCBI:1269769] [REACTOME:R-HSA-69202]
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [NCBI:1457789] [REACTOME:R-HSA-8862803] [PUBMED:8090221] [PUBMED:12684440] [PUBMED:22899714] [PUBMED:10830966] [PUBMED:7592934] [PUBMED:19519302]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
E2F mediated regulation of DNA replication [NCBI:1269774] [REACTOME:R-HSA-113510] [PUBMED:12393009] [PUBMED:12726857] [PUBMED:12473340]
E2F transcription factor network [NCBI:137934] [Pathway Interaction Database:e2f_pathway] [PUBMED:15175242] [PUBMED:11034215] [PUBMED:8832394] [PUBMED:7479977] [PUBMED:12077144] [PUBMED:11274364] [PUBMED:8618861] [PUBMED:11857079] [PUBMED:7958837] [PUBMED:15014447] [PUBMED:9774682] [PUBMED:9704927] [PUBMED:9271400] [PUBMED:8334989] [PUBMED:16288221] [PUBMED:10766737] [PUBMED:8657141] [PUBMED:8552092] [PUBMED:11101847] [PUBMED:12757710] [PUBMED:17704056] [PUBMED:7705662] [PUBMED:15897886] [PUBMED:9192872] [PUBMED:9778043] [PUBMED:12766778] [PUBMED:15510213] [PUBMED:11418595] [PUBMED:10454584] [PUBMED:10783242] [PUBMED:11904439] [PUBMED:16179649] [PUBMED:7791762] [PUBMED:11719808] [PUBMED:12389032] [PUBMED:8264596] [PUBMED:19491197] [PUBMED:15713665] [PUBMED:16357170] [PUBMED:9689056] [PUBMED:12748276] [PUBMED:2524830] [PUBMED:14633988] [PUBMED:12697828] [PUBMED:12101096] [PUBMED:11799067] [PUBMED:15133492] [PUBMED:16892051] [PUBMED:8943353] [PUBMED:9724731] [PUBMED:10030670] [PUBMED:11459832] [PUBMED:8114719] [PUBMED:9520412] [PUBMED:18348985] [PUBMED:9020173] [PUBMED:11389439] [PUBMED:16211008] [PUBMED:12411495] [PUBMED:7958836] [PUBMED:12909625] [PUBMED:15306814] [PUBMED:10688648] [PUBMED:12611887] [PUBMED:9191053] [PUBMED:10373518] [PUBMED:10187822]
E2F-enabled inhibition of pre-replication complex formation [NCBI:1269776] [REACTOME:R-HSA-113507] [PUBMED:11090133]
G0 and Early G1 [NCBI:1269765] [REACTOME:R-HSA-1538133]
G1/S DNA Damage Checkpoints [NCBI:1269743] [REACTOME:R-HSA-69615]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
G1/S-Specific Transcription [NCBI:1269772] [REACTOME:R-HSA-69205]
G2/M Checkpoints [NCBI:1269753] [REACTOME:R-HSA-69481]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Neurodegenerative Diseases [NCBI:1457788] [REACTOME:R-HSA-8863678] [PUBMED:26848654]
Polo-like kinase mediated events [NCBI:1269804] [REACTOME:R-HSA-156711] [PUBMED:15692562] [PUBMED:22391450] [PUBMED:15654331] [PUBMED:15070733] [PUBMED:23109430] [PUBMED:19160488]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Progesterone-mediated oocyte maturation [NCBI:119304] [KEGG:hsa04914] [PUBMED:10497333] [PUBMED:12084906] [PUBMED:12045215] [PUBMED:11063930] [PUBMED:12477927] [PUBMED:11148128] [PUBMED:11730319] [PUBMED:12374568]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A [NCBI:1269752] [REACTOME:R-HSA-69601] [PUBMED:10828887]
Validated targets of C-MYC transcriptional activation [NCBI:169351] [Pathway Interaction Database:myc_activpathway] [PUBMED:18987359] [PUBMED:16537449] [PUBMED:9924025] [PUBMED:17643117] [PUBMED:8356088] [PUBMED:10688915] [PUBMED:1562593] [PUBMED:19020761] [PUBMED:10823814] [PUBMED:12637527] [PUBMED:9178906] [PUBMED:17967894] [PUBMED:15723053] [PUBMED:16508012] [PUBMED:8700224] [PUBMED:12091391] [PUBMED:20173740] [PUBMED:11522645] [PUBMED:15774466] [PUBMED:12776737] [PUBMED:12011429] [PUBMED:12138190] [PUBMED:10022128] [PUBMED:11511539] [PUBMED:12177005] [PUBMED:17599065] [PUBMED:6438521] [PUBMED:19745813] [PUBMED:8196628] [PUBMED:10891489] [PUBMED:8934531] [PUBMED:15723054] [PUBMED:9192621] [PUBMED:18042711] [PUBMED:10779353] [PUBMED:1989881] [PUBMED:8861962] [PUBMED:12529648] [PUBMED:16269333] [PUBMED:16172399] [PUBMED:8494784] [PUBMED:15282543] [PUBMED:8297793] [PUBMED:12776177] [PUBMED:9811896] [PUBMED:11103792] [PUBMED:17170079] [PUBMED:18593934] [PUBMED:11673469] [PUBMED:18408012] [PUBMED:1340466] [PUBMED:17088530] [PUBMED:8327497] [PUBMED:16423995] [PUBMED:12816956] [PUBMED:11598121] [PUBMED:14724288] [PUBMED:17848523] [PUBMED:10508165] [PUBMED:12695333] [PUBMED:17822678] [PUBMED:10606642] [PUBMED:9869632] [PUBMED:9212167] [PUBMED:19211792] [PUBMED:16287840] [PUBMED:18978814] [PUBMED:11511535] [PUBMED:15944709] [PUBMED:11604407] [PUBMED:11909865]
p53-Independent DNA Damage Response [NCBI:1269751] [REACTOME:R-HSA-69610] [PUBMED:11298456]
p53-Independent G1/S DNA damage checkpoint [NCBI:1269750] [REACTOME:R-HSA-69613] [PUBMED:10827953]