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Genes
LCK
Gene - LCK
full name
LCK proto-oncogene, Src family tyrosine kinase
synonyms
LSK, p56lck, pp58lck, YT16, LCK, ENSG00000182866
HGNC
HGNC:6524
Entrez Gene
Gene:3932
ENSEMBL
ENSG00000182866
location
chr: 1
start: 32716840
stop: 32751766
strand: +
OMIM
OMIM:153390
: LCK
OMIM:615758
: ?Immunodeficiency 22
transcripts
NM_005356.3
NM_001042771.1
pathways
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Alpha-synuclein signaling
[NCBI:137913]
[Pathway Interaction Database:alphasynuclein_pathway]
[PUBMED:12551928]
[PUBMED:15671022]
[PUBMED:12887682]
[PUBMED:14991825]
[PUBMED:11431533]
[PUBMED:11588587]
[PUBMED:16030137]
[PUBMED:15845543]
[PUBMED:11590439]
[PUBMED:12096713]
[PUBMED:11687285]
[PUBMED:15978696]
[PUBMED:10407019]
[PUBMED:11078745]
[PUBMED:16403519]
[PUBMED:14985429]
[PUBMED:14645218]
[PUBMED:12787066]
[PUBMED:11292651]
[PUBMED:12421356]
[PUBMED:15944382]
[PUBMED:10567343]
[PUBMED:11744621]
[PUBMED:15935068]
[PUBMED:12928483]
[PUBMED:11821392]
[PUBMED:10852916]
Atypical NF-kappaB pathway
[NCBI:137946]
[Pathway Interaction Database:nfkappabatypicalpathway]
[PUBMED:1501714]
[PUBMED:9892650]
[PUBMED:16308565]
[PUBMED:14534291]
[PUBMED:8330739]
[PUBMED:8622692]
[PUBMED:9724653]
[PUBMED:1639070]
[PUBMED:8668171]
[PUBMED:8404857]
[PUBMED:12711606]
[PUBMED:12429743]
[PUBMED:14580335]
[PUBMED:12870650]
CD28 co-stimulation
[NCBI:1269178]
[REACTOME:R-HSA-389356]
[PUBMED:8649453]
[PUBMED:8609386]
[PUBMED:12165654]
CD28 dependent PI3K/Akt signaling
[NCBI:1269179]
[REACTOME:R-HSA-389357]
[PUBMED:12670391]
[PUBMED:15046602]
CD28 dependent Vav1 pathway
[NCBI:1269180]
[REACTOME:R-HSA-389359]
[PUBMED:15886116]
[PUBMED:12670394]
[PUBMED:10849438]
CTLA4 inhibitory signaling
[NCBI:1269181]
[REACTOME:R-HSA-389513]
[PUBMED:11905831]
[PUBMED:10374692]
[PUBMED:16551244]
[PUBMED:12876557]
CXCR4-mediated signaling events
[NCBI:137910]
[Pathway Interaction Database:cxcr4_pathway]
[PUBMED:18799424]
[PUBMED:17537990]
[PUBMED:10881171]
[PUBMED:17675482]
[PUBMED:11157475]
[PUBMED:12077227]
[PUBMED:11544290]
[PUBMED:8752280]
[PUBMED:12535795]
[PUBMED:19380820]
[PUBMED:10952719]
[PUBMED:16230460]
[PUBMED:12682230]
[PUBMED:16503409]
[PUBMED:10644702]
[PUBMED:9722546]
[PUBMED:11784854]
[PUBMED:10491003]
[PUBMED:10521508]
[PUBMED:10606629]
[PUBMED:15615703]
[PUBMED:17568820]
[PUBMED:10753828]
[PUBMED:12519755]
[PUBMED:12032308]
[PUBMED:8752281]
[PUBMED:10570282]
[PUBMED:11369622]
[PUBMED:15728464]
[PUBMED:12590707]
[PUBMED:16038794]
[PUBMED:14662753]
[PUBMED:18596232]
[PUBMED:17056591]
[PUBMED:14602072]
[PUBMED:15994292]
[PUBMED:16919488]
[PUBMED:15872091]
[PUBMED:10506573]
[PUBMED:12036857]
[PUBMED:15618472]
[PUBMED:14704365]
[PUBMED:18227351]
[PUBMED:11641392]
[PUBMED:18319399]
[PUBMED:12133960]
[PUBMED:15630457]
Cell surface interactions at the vascular wall
[NCBI:1269373]
[REACTOME:R-HSA-202733]
[PUBMED:17525755]
[PUBMED:11282294]
[PUBMED:10798271]
[PUBMED:8578462]
[PUBMED:14615387]
[PUBMED:16115029]
Class I PI3K signaling events
[NCBI:138022]
[Pathway Interaction Database:pi3kcipathway]
[PUBMED:9072969]
[PUBMED:15296756]
[PUBMED:12780340]
[PUBMED:11154281]
[PUBMED:9326591]
[PUBMED:10357815]
[PUBMED:10586033]
[PUBMED:9824312]
[PUBMED:11001876]
[PUBMED:9593664]
[PUBMED:10770799]
[PUBMED:9442017]
[PUBMED:8643691]
[PUBMED:7627555]
[PUBMED:11102801]
[PUBMED:9307042]
[PUBMED:10506192]
[PUBMED:11804589]
[PUBMED:15879121]
[PUBMED:11226282]
[PUBMED:18024423]
[PUBMED:8629002]
[PUBMED:9550703]
[PUBMED:14688341]
[PUBMED:16418224]
[PUBMED:8945478]
[PUBMED:10333475]
[PUBMED:10764758]
[PUBMED:9417041]
[PUBMED:8052307]
Constitutive Signaling by Aberrant PI3K in Cancer
[NCBI:1268880]
[REACTOME:R-HSA-2219530]
[PUBMED:18317450]
[PUBMED:19962665]
[PUBMED:20009532]
[PUBMED:20713702]
[PUBMED:21478295]
[PUBMED:16339315]
[PUBMED:18079394]
[PUBMED:17626883]
Costimulation by the CD28 family
[NCBI:1269177]
[REACTOME:R-HSA-388841]
[PUBMED:10374692]
[PUBMED:14647476]
[PUBMED:11905831]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downstream TCR signaling
[NCBI:1269176]
[REACTOME:R-HSA-202424]
[PUBMED:15084594]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR)
[NCBI:1269185]
[REACTOME:R-HSA-1168372]
[PUBMED:17052215]
[PUBMED:19909372]
EPHA forward signaling
[NCBI:138041]
[Pathway Interaction Database:epha_fwdpathway]
[PUBMED:16491080]
[PUBMED:15848800]
[PUBMED:12356866]
[PUBMED:14660665]
[PUBMED:11416136]
[PUBMED:11870224]
[PUBMED:12496371]
[PUBMED:12775584]
[PUBMED:14664814]
[PUBMED:12681484]
[PUBMED:15848799]
[PUBMED:12794130]
[PUBMED:15254079]
[PUBMED:9886291]
[PUBMED:8755474]
[PUBMED:10769020]
[PUBMED:17494698]
[PUBMED:11336673]
Ephrin B reverse signaling
[NCBI:138052]
[Pathway Interaction Database:ephrinbrevpathway]
[PUBMED:15351694]
[PUBMED:11557983]
[PUBMED:14576067]
[PUBMED:7973638]
[PUBMED:8755474]
[PUBMED:15536074]
[PUBMED:14988728]
[PUBMED:8878483]
[PUBMED:8918835]
[PUBMED:11983165]
[PUBMED:12709432]
[PUBMED:8761303]
[PUBMED:14499344]
[PUBMED:11301003]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
GAB1 signalosome
[NCBI:1269384]
[REACTOME:R-HSA-180292]
[PUBMED:15550174]
GPVI-mediated activation cascade
[NCBI:1269357]
[REACTOME:R-HSA-114604]
[PUBMED:16102042]
[PUBMED:11943772]
Generation of second messenger molecules
[NCBI:1269175]
[REACTOME:R-HSA-202433]
[PUBMED:15084594]
Glypican 1 network
[NCBI:138010]
[Pathway Interaction Database:glypican_1pathway]
[PUBMED:15063764]
[PUBMED:18717736]
[PUBMED:9949192]
[PUBMED:10514475]
[PUBMED:16723715]
[PUBMED:12972423]
[PUBMED:12914968]
[PUBMED:15249209]
[PUBMED:12649175]
[PUBMED:15084524]
[PUBMED:16123806]
[PUBMED:1400362]
[PUBMED:17516498]
[PUBMED:10196157]
[PUBMED:11375980]
[PUBMED:16923158]
HIV Infection
[NCBI:1269057]
[REACTOME:R-HSA-162906]
[PUBMED:16354571]
[PUBMED:9759480]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Host Interactions of HIV factors
[NCBI:1269091]
[REACTOME:R-HSA-162909]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
IL2 signaling events mediated by PI3K
[NCBI:137938]
[Pathway Interaction Database:il2_pi3kpathway]
[PUBMED:15271800]
[PUBMED:8617294]
[PUBMED:7543780]
[PUBMED:9092570]
[PUBMED:9162082]
[PUBMED:7737351]
[PUBMED:9108028]
[PUBMED:11486019]
[PUBMED:1614535]
[PUBMED:15843522]
[PUBMED:7760801]
[PUBMED:9029085]
[PUBMED:1652056]
[PUBMED:11994454]
[PUBMED:12393431]
[PUBMED:9771966]
[PUBMED:10373522]
[PUBMED:12525482]
[PUBMED:3523754]
[PUBMED:7736574]
[PUBMED:10982827]
[PUBMED:7589144]
[PUBMED:7528328]
IL2 signaling events mediated by STAT5
[NCBI:137988]
[Pathway Interaction Database:il2_stat5pathway]
[PUBMED:11160217]
[PUBMED:16645171]
[PUBMED:9121484]
[PUBMED:17182565]
[PUBMED:14607901]
[PUBMED:9104808]
[PUBMED:11485747]
[PUBMED:14614860]
[PUBMED:10679091]
[PUBMED:12196288]
[PUBMED:10072077]
[PUBMED:10544201]
[PUBMED:15004274]
[PUBMED:9390691]
[PUBMED:9395528]
[PUBMED:10514006]
[PUBMED:14500638]
[PUBMED:16757175]
[PUBMED:9541574]
[PUBMED:8617294]
IL2-mediated signaling events
[NCBI:137976]
[Pathway Interaction Database:il2_1pathway]
[PUBMED:7568005]
[PUBMED:10962026]
[PUBMED:1545122]
[PUBMED:10602027]
[PUBMED:15170389]
[PUBMED:9092570]
[PUBMED:7509794]
[PUBMED:15356145]
[PUBMED:9973481]
[PUBMED:10899310]
[PUBMED:9195132]
[PUBMED:7544001]
[PUBMED:7777534]
[PUBMED:12681450]
[PUBMED:7665592]
[PUBMED:8702919]
[PUBMED:1708096]
[PUBMED:8643566]
[PUBMED:7988557]
[PUBMED:7737351]
[PUBMED:1532814]
[PUBMED:8262551]
[PUBMED:8025955]
[PUBMED:10993906]
[PUBMED:3095922]
[PUBMED:8805624]
[PUBMED:9391116]
[PUBMED:7973658]
[PUBMED:11331873]
[PUBMED:10421845]
[PUBMED:8119884]
[PUBMED:7781605]
[PUBMED:12543077]
[PUBMED:9133424]
[PUBMED:1618313]
[PUBMED:1940342]
[PUBMED:9382798]
[PUBMED:10514520]
[PUBMED:7973659]
[PUBMED:1639773]
[PUBMED:9029085]
[PUBMED:7760801]
[PUBMED:1460037]
[PUBMED:9202126]
[PUBMED:1652056]
[PUBMED:12393431]
[PUBMED:8397196]
[PUBMED:2047859]
[PUBMED:7688728]
[PUBMED:8700888]
[PUBMED:7528668]
[PUBMED:9305919]
[PUBMED:2303462]
[PUBMED:7568001]
[PUBMED:9822600]
[PUBMED:7543676]
[PUBMED:7499365]
[PUBMED:10843677]
[PUBMED:7600304]
[PUBMED:7719937]
[PUBMED:9590209]
[PUBMED:9794391]
[PUBMED:10849428]
[PUBMED:8294403]
[PUBMED:10373548]
[PUBMED:2590941]
[PUBMED:9512511]
[PUBMED:6434688]
[PUBMED:9697832]
[PUBMED:10982827]
[PUBMED:10214954]
[PUBMED:10825200]
[PUBMED:1535827]
[PUBMED:10369681]
[PUBMED:7719938]
[PUBMED:1655887]
[PUBMED:8376945]
[PUBMED:1996324]
[PUBMED:7479881]
[PUBMED:10962581]
[PUBMED:7973657]
[PUBMED:1631559]
[PUBMED:10066828]
[PUBMED:9169478]
[PUBMED:8552611]
[PUBMED:8483935]
[PUBMED:2106566]
[PUBMED:16199887]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Infectious disease
[NCBI:1269056]
[REACTOME:R-HSA-5663205]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
NF-kappa B signaling pathway
[NCBI:634527]
[KEGG:hsa04064]
[PUBMED:22119011]
[PUBMED:16264088]
[PUBMED:21187855]
[PUBMED:15546385]
[PUBMED:17607554]
[PUBMED:21135871]
[PUBMED:16984817]
[PUBMED:17047224]
[PUBMED:19203223]
[PUBMED:20300215]
[PUBMED:14657271]
[PUBMED:17431096]
[PUBMED:15134788]
[PUBMED:16356770]
[PUBMED:21772278]
[PUBMED:12654254]
[PUBMED:22390971]
[PUBMED:22017435]
[PUBMED:17183360]
[PUBMED:21173796]
[PUBMED:15905862]
[PUBMED:19302050]
[PUBMED:17098202]
[PUBMED:21872579]
[PUBMED:22152226]
[PUBMED:18613837]
[PUBMED:19489733]
[PUBMED:11875461]
[PUBMED:19726767]
[PUBMED:22017430]
[PUBMED:21232019]
[PUBMED:18832076]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Nef Mediated CD4 Down-regulation
[NCBI:1269105]
[REACTOME:R-HSA-167590]
[PUBMED:11264384]
[PUBMED:2014052]
[PUBMED:8124721]
[PUBMED:7831289]
[PUBMED:8756680]
Nef and signal transduction
[NCBI:1269101]
[REACTOME:R-HSA-164944]
[PUBMED:12853962]
[PUBMED:8570619]
[PUBMED:10618429]
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
[NCBI:1269102]
[REACTOME:R-HSA-164938]
[PUBMED:9811606]
[PUBMED:11208076]
[PUBMED:9564030]
[PUBMED:9586638]
[PUBMED:12486136]
[PUBMED:9811611]
[PUBMED:9384576]
[PUBMED:9736718]
Negative regulation of the PI3K/AKT network
[NCBI:1269191]
[REACTOME:R-HSA-199418]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
PD-1 signaling
[NCBI:1269182]
[REACTOME:R-HSA-389948]
[PUBMED:18759926]
[PUBMED:18173375]
PDGFR-beta signaling pathway
[NCBI:138071]
[Pathway Interaction Database:pdgfrbpathway]
[PUBMED:7545675]
[PUBMED:16769879]
[PUBMED:12652307]
[PUBMED:10463951]
[PUBMED:9742401]
[PUBMED:8086421]
[PUBMED:10391677]
[PUBMED:7739538]
[PUBMED:9989826]
[PUBMED:10734138]
[PUBMED:15753096]
[PUBMED:7692233]
[PUBMED:11489946]
[PUBMED:10837138]
[PUBMED:10229199]
[PUBMED:10821867]
[PUBMED:11709084]
[PUBMED:11389443]
[PUBMED:12958184]
[PUBMED:10734113]
[PUBMED:15161943]
[PUBMED:12149261]
[PUBMED:16456542]
[PUBMED:16224065]
[PUBMED:8619809]
[PUBMED:15494217]
[PUBMED:1849073]
[PUBMED:11085978]
[PUBMED:2544881]
[PUBMED:7622571]
[PUBMED:10779329]
[PUBMED:15944146]
[PUBMED:11027258]
[PUBMED:1708307]
[PUBMED:8940081]
[PUBMED:11854295]
[PUBMED:8195171]
[PUBMED:12424235]
[PUBMED:7935392]
[PUBMED:14966296]
[PUBMED:16537894]
PECAM1 interactions
[NCBI:1269375]
[REACTOME:R-HSA-210990]
[PUBMED:12681475]
[PUBMED:14619965]
PI3K/AKT Signaling in Cancer
[NCBI:1268879]
[REACTOME:R-HSA-2219528]
[PUBMED:20713702]
[PUBMED:10555148]
[PUBMED:19644473]
[PUBMED:17611497]
[PUBMED:21478295]
[PUBMED:17626883]
[PUBMED:16339315]
[PUBMED:18317450]
[PUBMED:18079394]
[PUBMED:9467011]
[PUBMED:17604717]
[PUBMED:9326929]
[PUBMED:18954143]
[PUBMED:20009532]
[PUBMED:19962665]
[PUBMED:21430697]
[PUBMED:19487573]
[PUBMED:10866302]
PI3K/AKT activation
[NCBI:1269473]
[REACTOME:R-HSA-198203]
[PUBMED:10579926]
[PUBMED:12123609]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
[NCBI:1383020]
[REACTOME:R-HSA-6811558]
[PUBMED:12422219]
[PUBMED:16979564]
[PUBMED:19805105]
[PUBMED:17200115]
[PUBMED:21827948]
[PUBMED:19576174]
[PUBMED:18753295]
[PUBMED:19896968]
[PUBMED:16456541]
[PUBMED:25495341]
[PUBMED:15464023]
[PUBMED:23758345]
[PUBMED:9367159]
[PUBMED:9211928]
[PUBMED:17245604]
PIP3 activates AKT signaling
[NCBI:1269188]
[REACTOME:R-HSA-1257604]
Phosphorylation of CD3 and TCR zeta chains
[NCBI:1269173]
[REACTOME:R-HSA-202427]
[PUBMED:10375551]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Primary immunodeficiency
[NCBI:83125]
[KEGG:hsa05340]
[PUBMED:11941303]
[PUBMED:18093537]
[PUBMED:11058677]
[PUBMED:17952897]
[PUBMED:14699405]
[PUBMED:15661024]
[PUBMED:14647478]
[PUBMED:17960151]
[PUBMED:16261175]
Regulation of KIT signaling
[NCBI:1269488]
[REACTOME:R-HSA-1433559]
[PUBMED:10582339]
[PUBMED:16483568]
Regulation of p38-alpha and p38-beta
[NCBI:137964]
[Pathway Interaction Database:p38alphabetapathway]
[PUBMED:16461893]
[PUBMED:7997261]
[PUBMED:16943189]
[PUBMED:14585994]
[PUBMED:10391943]
[PUBMED:14661019]
[PUBMED:11359773]
[PUBMED:7914033]
[PUBMED:8910287]
[PUBMED:7744004]
[PUBMED:10190877]
[PUBMED:7592586]
[PUBMED:16849316]
[PUBMED:7693711]
[PUBMED:11847341]
[PUBMED:7839144]
[PUBMED:9790884]
[PUBMED:7499279]
[PUBMED:14592977]
[PUBMED:12110590]
[PUBMED:14634666]
[PUBMED:8107774]
[PUBMED:8622669]
[PUBMED:8798750]
[PUBMED:11278799]
[PUBMED:15864310]
[PUBMED:16407200]
Role of LAT2/NTAL/LAB on calcium mobilization
[NCBI:1269302]
[REACTOME:R-HSA-2730905]
[PUBMED:17993265]
[PUBMED:20643813]
[PUBMED:17420272]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by the B Cell Receptor (BCR)
[NCBI:1269183]
[REACTOME:R-HSA-983705]
[PUBMED:1702903]
[PUBMED:2011584]
[PUBMED:1081164]
[PUBMED:19065780]
[PUBMED:16849466]
[PUBMED:1375264]
[PUBMED:7538118]
[PUBMED:11901194]
[PUBMED:8580068]
[PUBMED:19249086]
[PUBMED:18596693]
[PUBMED:10648173]
[PUBMED:4589993]
[PUBMED:8163536]
[PUBMED:1376928]
[PUBMED:7688784]
[PUBMED:6335036]
[PUBMED:17052215]
[PUBMED:18818202]
[PUBMED:20206686]
[PUBMED:7592958]
[PUBMED:7524079]
[PUBMED:15489917]
[PUBMED:15509800]
[PUBMED:18187424]
[PUBMED:7927516]
[PUBMED:803528]
[PUBMED:19909372]
[PUBMED:20192804]
[PUBMED:8306975]
Signaling events mediated by PTP1B
[NCBI:138017]
[Pathway Interaction Database:ptp1bpathway]
[PUBMED:12414790]
[PUBMED:8223493]
[PUBMED:12857726]
[PUBMED:8999839]
[PUBMED:14766979]
[PUBMED:9355745]
[PUBMED:11579209]
[PUBMED:8940134]
[PUBMED:12802338]
[PUBMED:10807907]
[PUBMED:15866871]
[PUBMED:10751417]
[PUBMED:11346638]
[PUBMED:11970899]
[PUBMED:9083103]
[PUBMED:7693694]
[PUBMED:11900546]
[PUBMED:7983051]
[PUBMED:11694501]
[PUBMED:10514492]
[PUBMED:12176037]
[PUBMED:16644720]
[PUBMED:16388599]
[PUBMED:9624118]
[PUBMED:9786960]
[PUBMED:14966267]
[PUBMED:15894168]
[PUBMED:11773439]
[PUBMED:11864611]
[PUBMED:8548812]
[PUBMED:16477024]
[PUBMED:9418872]
[PUBMED:9050838]
[PUBMED:12424235]
[PUBMED:12748279]
[PUBMED:1383688]
[PUBMED:8782827]
[PUBMED:8626723]
[PUBMED:11007774]
[PUBMED:10993888]
[PUBMED:15226396]
[PUBMED:10066179]
[PUBMED:10660596]
[PUBMED:12554649]
[PUBMED:11970898]
[PUBMED:9566916]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
T cell receptor signaling pathway
[NCBI:83080]
[KEGG:hsa04660]
[PUBMED:17395537]
[PUBMED:15308211]
[PUBMED:15928679]
[PUBMED:14656980]
[PUBMED:17187070]
[PUBMED:15084594]
[PUBMED:16799472]
[PUBMED:12669022]
[PUBMED:15286727]
[PUBMED:15122199]
[PUBMED:19132916]
[PUBMED:15489916]
[PUBMED:11905831]
[PUBMED:12195013]
[PUBMED:15343367]
[PUBMED:12133805]
[PUBMED:14647476]
[PUBMED:15771581]
[PUBMED:15099566]
[PUBMED:14617194]
[PUBMED:19290929]
[PUBMED:15345216]
TCR signaling
[NCBI:1269172]
[REACTOME:R-HSA-202403]
[PUBMED:10375551]
[PUBMED:12876557]
[PUBMED:9989491]
TCR signaling in naive CD4+ T cells
[NCBI:137998]
[Pathway Interaction Database:tcr_pathway]
[PUBMED:11376344]
[PUBMED:9094314]
[PUBMED:8083187]
[PUBMED:11994416]
[PUBMED:16365455]
[PUBMED:10072079]
[PUBMED:12361955]
[PUBMED:12755691]
[PUBMED:8642247]
[PUBMED:15125833]
[PUBMED:7509360]
[PUBMED:11353765]
[PUBMED:12941616]
[PUBMED:8700169]
[PUBMED:11120819]
[PUBMED:15899849]
[PUBMED:8990121]
[PUBMED:8702662]
[PUBMED:8164687]
[PUBMED:2141684]
[PUBMED:11567141]
[PUBMED:9846481]
[PUBMED:9489702]
[PUBMED:10811803]
[PUBMED:11368773]
[PUBMED:14557276]
[PUBMED:2548204]
[PUBMED:10318843]
[PUBMED:15536066]
[PUBMED:10652356]
[PUBMED:7568038]
[PUBMED:11175263]
[PUBMED:9438848]
[PUBMED:9692882]
[PUBMED:10209031]
[PUBMED:7509083]
[PUBMED:12874226]
[PUBMED:8673706]
[PUBMED:16733527]
[PUBMED:9822663]
[PUBMED:12738795]
[PUBMED:11904433]
[PUBMED:8084588]
[PUBMED:8114715]
[PUBMED:9312162]
[PUBMED:8790380]
[PUBMED:9677202]
[PUBMED:15802604]
[PUBMED:14702343]
[PUBMED:10903746]
[PUBMED:10807788]
[PUBMED:8176201]
[PUBMED:9207119]
[PUBMED:10790433]
[PUBMED:8892604]
[PUBMED:9665884]
[PUBMED:1639064]
[PUBMED:12421919]
[PUBMED:8246987]
[PUBMED:9710204]
[PUBMED:8146197]
[PUBMED:2190221]
[PUBMED:10229072]
[PUBMED:10021361]
[PUBMED:9924026]
[PUBMED:12186560]
[PUBMED:16649996]
[PUBMED:11287959]
[PUBMED:12917261]
[PUBMED:7545666]
[PUBMED:11250890]
[PUBMED:12842872]
[PUBMED:15879121]
[PUBMED:11567140]
[PUBMED:10209041]
[PUBMED:10556826]
[PUBMED:8183372]
[PUBMED:12397360]
[PUBMED:10506192]
[PUBMED:10861059]
[PUBMED:12507424]
[PUBMED:12845325]
[PUBMED:10745081]
[PUBMED:8195151]
[PUBMED:12024036]
[PUBMED:7524075]
[PUBMED:1464315]
[PUBMED:12138205]
[PUBMED:7544353]
[PUBMED:16906149]
[PUBMED:9637919]
[PUBMED:2470098]
[PUBMED:3919143]
[PUBMED:16005298]
[PUBMED:10918068]
[PUBMED:8636141]
[PUBMED:16921383]
[PUBMED:8479536]
[PUBMED:7556092]
[PUBMED:16582901]
[PUBMED:8805223]
[PUBMED:15933714]
[PUBMED:10224278]
[PUBMED:9819387]
[PUBMED:12881521]
[PUBMED:14988727]
[PUBMED:16849481]
[PUBMED:11390650]
TCR signaling in naive CD8+ T cells
[NCBI:138055]
[Pathway Interaction Database:cd8tcrpathway]
[PUBMED:9094314]
[PUBMED:15125833]
[PUBMED:11994416]
[PUBMED:7509360]
[PUBMED:12755691]
[PUBMED:8642247]
[PUBMED:12361955]
[PUBMED:11956228]
[PUBMED:10072079]
[PUBMED:8977171]
[PUBMED:2141684]
[PUBMED:8700169]
[PUBMED:8164687]
[PUBMED:9489702]
[PUBMED:8702662]
[PUBMED:2548204]
[PUBMED:11175263]
[PUBMED:8114715]
[PUBMED:10209031]
[PUBMED:15536066]
[PUBMED:7678351]
[PUBMED:8673703]
[PUBMED:7830771]
[PUBMED:7509083]
[PUBMED:16733527]
[PUBMED:9438848]
[PUBMED:8790380]
[PUBMED:1639064]
[PUBMED:15980863]
[PUBMED:8084588]
[PUBMED:14702343]
[PUBMED:10790433]
[PUBMED:10807788]
[PUBMED:16169499]
[PUBMED:15802604]
[PUBMED:8892604]
[PUBMED:2114552]
[PUBMED:12421919]
[PUBMED:12917261]
[PUBMED:8146197]
[PUBMED:1335364]
[PUBMED:10021361]
[PUBMED:8183372]
[PUBMED:8627172]
[PUBMED:8898939]
[PUBMED:2190221]
[PUBMED:9710204]
[PUBMED:11287959]
[PUBMED:14764585]
[PUBMED:12954628]
[PUBMED:10209041]
[PUBMED:1464315]
[PUBMED:12507424]
[PUBMED:12732656]
[PUBMED:8195151]
[PUBMED:12138205]
[PUBMED:16005298]
[PUBMED:9312149]
[PUBMED:7544353]
[PUBMED:16906149]
[PUBMED:9637919]
[PUBMED:12845325]
[PUBMED:2470098]
[PUBMED:10918068]
[PUBMED:16116204]
[PUBMED:16921383]
[PUBMED:10562325]
[PUBMED:9819387]
[PUBMED:16582901]
[PUBMED:8034711]
[PUBMED:8479536]
[PUBMED:10640739]
[PUBMED:3919143]
[PUBMED:10224278]
[PUBMED:10811865]
Th1 and Th2 cell differentiation
[NCBI:1458885]
[KEGG:hsa04658]
[PUBMED:15819694]
[PUBMED:12171942]
[PUBMED:19165228]
[PUBMED:23336087]
[PUBMED:26044597]
[PUBMED:19151746]
[PUBMED:19362457]
[PUBMED:22044277]
[PUBMED:11752608]
[PUBMED:23405903]
[PUBMED:19375293]
[PUBMED:24113868]
[PUBMED:19151747]
[PUBMED:23624818]
[PUBMED:22566933]
[PUBMED:11121747]
[PUBMED:20969597]
[PUBMED:20065998]
Th17 cell differentiation
[NCBI:1469482]
[KEGG:hsa04659]
[PUBMED:23325835]
[PUBMED:23036716]
[PUBMED:20488727]
[PUBMED:21151104]
[PUBMED:21084214]
[PUBMED:20054607]
[PUBMED:22754770]
[PUBMED:22640807]
[PUBMED:19379825]
[PUBMED:22133865]
[PUBMED:22324470]
[PUBMED:17768419]
[PUBMED:18408735]
[PUBMED:21776333]
[PUBMED:26253381]
[PUBMED:16200068]
[PUBMED:18362914]
[PUBMED:24325586]
[PUBMED:19381306]
[PUBMED:18166487]
The role of Nef in HIV-1 replication and disease pathogenesis
[NCBI:1269100]
[REACTOME:R-HSA-164952]
[PUBMED:16354571]
Thromboxane A2 receptor signaling
[NCBI:138060]
[Pathway Interaction Database:txa2pathway]
[PUBMED:15100160]
[PUBMED:11160627]
[PUBMED:16859489]
[PUBMED:7476920]
[PUBMED:12193606]
[PUBMED:8474027]
[PUBMED:16595906]
[PUBMED:11748077]
[PUBMED:8948507]
[PUBMED:11055976]
[PUBMED:15884057]
[PUBMED:1825698]
[PUBMED:9054415]
[PUBMED:1851174]
[PUBMED:9862451]
[PUBMED:11901221]
[PUBMED:14976202]
[PUBMED:9915793]
[PUBMED:12796499]
[PUBMED:16212421]
[PUBMED:16956790]
[PUBMED:8034687]
[PUBMED:17466390]
[PUBMED:12183468]
[PUBMED:10085139]
[PUBMED:9649216]
[PUBMED:11873244]
[PUBMED:12038794]
[PUBMED:10771086]
[PUBMED:11015313]
[PUBMED:9417126]
[PUBMED:12626493]
[PUBMED:10827090]
[PUBMED:7969066]
[PUBMED:8119906]
[PUBMED:11389977]
[PUBMED:16876780]
[PUBMED:16126723]
[PUBMED:8636072]
[PUBMED:8894620]
[PUBMED:11526402]
[PUBMED:17229546]
[PUBMED:10037795]
[PUBMED:15845539]
[PUBMED:10670835]
[PUBMED:14530262]
[PUBMED:8290554]
[PUBMED:11443056]
[PUBMED:10800962]
[PUBMED:9560198]
[PUBMED:11389883]
[PUBMED:7961988]
[PUBMED:10212262]
[PUBMED:8245033]
[PUBMED:8613548]
[PUBMED:7591017]
[PUBMED:12187125]
[PUBMED:11516166]
[PUBMED:10318854]
Translocation of ZAP-70 to Immunological synapse
[NCBI:1269174]
[REACTOME:R-HSA-202430]
[PUBMED:10375551]
amb2 Integrin signaling
[NCBI:137945]
[Pathway Interaction Database:amb2_neutrophils_pathway]
[PUBMED:15004192]
[PUBMED:16260637]
[PUBMED:8874219]
[PUBMED:12736251]
[PUBMED:12824186]
[PUBMED:17202407]
[PUBMED:15458976]
[PUBMED:12208882]
[PUBMED:10985384]
[PUBMED:8598477]
[PUBMED:8157977]
[PUBMED:14530377]
[PUBMED:16567504]
[PUBMED:7836767]
[PUBMED:17003381]
[PUBMED:10899906]
[PUBMED:15741160]
[PUBMED:9920836]
[PUBMED:12941957]
[PUBMED:12773513]
[PUBMED:15283855]
[PUBMED:16854414]
[PUBMED:15217824]
[PUBMED:15090462]
[PUBMED:14769799]
[PUBMED:16905120]
[PUBMED:9831565]
[PUBMED:12194823]
[PUBMED:17268551]
[PUBMED:17133598]
[PUBMED:15153528]
[PUBMED:11418469]
[PUBMED:14623906]
[PUBMED:12036876]
[PUBMED:16391519]
[PUBMED:15304494]
[PUBMED:16093349]
[PUBMED:16403785]