full name
protein S (alpha)

synonyms
PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, PROS1, ENSG00000184500

HGNC
HGNC:9456

Entrez Gene
Gene:5627

ENSEMBL
ENSG00000184500

location
chr: 3
start: 93591881
stop: 93692934
strand: -

OMIM
OMIM:176880: PROS1 (Autosomal dominant inheritance)
OMIM:612336: Thrombophilia due to protein S deficiency, autosomal dominant
OMIM:614514: Thrombophilia due to protein S deficiency, autosomal recessive

transcripts
NM_000313.3

pathways
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Common Pathway of Fibrin Clot Formation [NCBI:1269371] [REACTOME:R-HSA-140875] [PUBMED:1931959]
Complement and coagulation cascades [NCBI:83073] [KEGG:hsa04610] [PUBMED:23564577] [PUBMED:25309880] [PUBMED:26082779] [PUBMED:23110467] [PUBMED:20027185] [PUBMED:25568220] [PUBMED:26324800] [PUBMED:25705421] [PUBMED:21811895] [PUBMED:23911436] [PUBMED:23564578] [PUBMED:24924409] [PUBMED:26489954] [PUBMED:17635716]
Complement cascade [NCBI:1269241] [REACTOME:R-HSA-166658] [PUBMED:3052276] [PUBMED:11044372] [PUBMED:11213801] [PUBMED:15476920] [PUBMED:14698228]
Formation of Fibrin Clot (Clotting Cascade) [NCBI:1269368] [REACTOME:R-HSA-140877] [PUBMED:1931959] [PUBMED:12524220]
Gamma carboxylation, hypusine formation and arylsulfatase activation [NCBI:1268702] [REACTOME:R-HSA-163841]
Gamma-carboxylation of protein precursors [NCBI:1268704] [REACTOME:R-HSA-159740] [PUBMED:10917896] [PUBMED:10068650] [PUBMED:11071668] [PUBMED:11513608] [PUBMED:9845520]
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins [NCBI:1268703] [REACTOME:R-HSA-159854]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet degranulation [NCBI:1269367] [REACTOME:R-HSA-114608] [PUBMED:14630798]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Regulation of Complement cascade [NCBI:1269250] [REACTOME:R-HSA-977606] [PUBMED:19730437] [PUBMED:20720586] [PUBMED:15476920]
Removal of aminoterminal propeptides from gamma-carboxylated proteins [NCBI:1268706] [REACTOME:R-HSA-159782] [PUBMED:8846780] [PUBMED:1629222] [PUBMED:8473289] [PUBMED:9108399] [PUBMED:8463288]
Response to elevated platelet cytosolic Ca2+ [NCBI:1269365] [REACTOME:R-HSA-76005] [PUBMED:8424766]
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus [NCBI:1268705] [REACTOME:R-HSA-159763] [PUBMED:11252894]