full name
Cbl proto-oncogene B

synonyms
Cbl-b, Nbla00127, RNF56, CBLB, ENSG00000114423

HGNC
HGNC:1542

Entrez Gene
Gene:868

ENSEMBL
ENSG00000114423

location
chr: 3
start: 105374306
stop: 105589354
strand: -

transcripts
NM_170662.3

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [NCBI:1269184] [REACTOME:R-HSA-983695] [PUBMED:8163536] [PUBMED:18818202] [PUBMED:15489917] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:6335036] [PUBMED:8918697] [PUBMED:7688784] [PUBMED:1376928] [PUBMED:1550550] [PUBMED:15509800] [PUBMED:7524079] [PUBMED:7927516] [PUBMED:9341187] [PUBMED:18187424] [PUBMED:803528] [PUBMED:20192804] [PUBMED:7929028] [PUBMED:10770799] [PUBMED:16849466] [PUBMED:8306975] [PUBMED:11606584] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:7538118] [PUBMED:19065780] [PUBMED:1375264] [PUBMED:1081164] [PUBMED:15161916] [PUBMED:11901194] [PUBMED:18596693] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:9468499] [PUBMED:11226282] [PUBMED:12456653] [PUBMED:10648173] [PUBMED:9697839] [PUBMED:4589993]
Antigen processing: Ubiquitination & Proteasome degradation [NCBI:1269193] [REACTOME:R-HSA-983168] [PUBMED:12648452] [PUBMED:11917093] [PUBMED:19489725] [PUBMED:14734113] [PUBMED:20351195] [PUBMED:17145306]
Bacterial invasion of epithelial cells [NCBI:149807] [KEGG:hsa05100] [PUBMED:17298394] [PUBMED:16406780] [PUBMED:19185531] [PUBMED:19157959] [PUBMED:17719540] [PUBMED:19296488]
CD40/CD40L signaling [NCBI:138061] [Pathway Interaction Database:cd40_pathway] [PUBMED:11967542] [PUBMED:11304555] [PUBMED:11714736] [PUBMED:17878343] [PUBMED:12354380] [PUBMED:11406619] [PUBMED:9133417] [PUBMED:7527023] [PUBMED:18997794] [PUBMED:1374165] [PUBMED:1385114] [PUBMED:12958312] [PUBMED:10764746] [PUBMED:11909853] [PUBMED:10318845] [PUBMED:7533327] [PUBMED:16260598] [PUBMED:18997792] [PUBMED:12818164] [PUBMED:10748139] [PUBMED:9718306] [PUBMED:10395671] [PUBMED:17878362] [PUBMED:7544915] [PUBMED:12370254] [PUBMED:8910514] [PUBMED:17143273] [PUBMED:10433725] [PUBMED:14981114] [PUBMED:16622006] [PUBMED:12122011] [PUBMED:12133933]
Calcineurin-regulated NFAT-dependent transcription in lymphocytes [NCBI:137993] [Pathway Interaction Database:nfat_tfpathway] [PUBMED:11254715] [PUBMED:11356833] [PUBMED:12121669] [PUBMED:10878360] [PUBMED:11786533] [PUBMED:8284217] [PUBMED:10816557] [PUBMED:11956291] [PUBMED:7510691] [PUBMED:9195954] [PUBMED:8240350] [PUBMED:12452838] [PUBMED:8623163] [PUBMED:15834410] [PUBMED:10894164] [PUBMED:10970869] [PUBMED:10755616] [PUBMED:14607827] [PUBMED:12705856] [PUBMED:12086671] [PUBMED:7982959] [PUBMED:9047239] [PUBMED:12374808] [PUBMED:14573767] [PUBMED:12560487] [PUBMED:10570264] [PUBMED:8397339] [PUBMED:12055628] [PUBMED:15308098] [PUBMED:12065418] [PUBMED:7891702] [PUBMED:7749982] [PUBMED:14973438] [PUBMED:8674125] [PUBMED:16873067] [PUBMED:12453415] [PUBMED:8441422] [PUBMED:1737937] [PUBMED:10671476] [PUBMED:8376940] [PUBMED:9545284]
Chronic myeloid leukemia [NCBI:83116] [KEGG:hsa05220] [PUBMED:22286129] [PUBMED:12801837] [PUBMED:11160144] [PUBMED:15719031] [PUBMED:10403855] [PUBMED:9834202] [PUBMED:11071626] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16484590] [PUBMED:14982876]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
ErbB signaling pathway [NCBI:83049] [KEGG:hsa04012] [PUBMED:16377102] [PUBMED:14967450] [PUBMED:9642287] [PUBMED:9872057] [PUBMED:10880430] [PUBMED:12851486] [PUBMED:16729045] [PUBMED:15863494] [PUBMED:15864276] [PUBMED:17000658] [PUBMED:16729043] [PUBMED:10490623] [PUBMED:11252954] [PUBMED:14744244] [PUBMED:16829981]
Fc-epsilon receptor I signaling in mast cells [NCBI:138050] [Pathway Interaction Database:fcer1pathway] [PUBMED:9556577] [PUBMED:8629002] [PUBMED:12217401] [PUBMED:15010370] [PUBMED:15608142] [PUBMED:7561053] [PUBMED:7537741] [PUBMED:7963537] [PUBMED:8947047] [PUBMED:1384468] [PUBMED:14757742] [PUBMED:16174756] [PUBMED:10583594] [PUBMED:7513150] [PUBMED:12089510] [PUBMED:10811803] [PUBMED:9268346] [PUBMED:12640123] [PUBMED:9108083] [PUBMED:8602265] [PUBMED:11340169] [PUBMED:12953098] [PUBMED:11465115] [PUBMED:7730640] [PUBMED:9550384] [PUBMED:7518558] [PUBMED:11137136] [PUBMED:15282299] [PUBMED:14634134] [PUBMED:8534912] [PUBMED:16002993] [PUBMED:12192036] [PUBMED:7608202] [PUBMED:11714805] [PUBMED:11970986] [PUBMED:10903718] [PUBMED:15265912] [PUBMED:15477350]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
Internalization of ErbB1 [NCBI:138013] [Pathway Interaction Database:erbb1_internalization_pathway] [PUBMED:9733512] [PUBMED:9950686] [PUBMED:12839496] [PUBMED:10953014] [PUBMED:17052190] [PUBMED:15212941] [PUBMED:19460345] [PUBMED:18316398] [PUBMED:11823423] [PUBMED:18657070] [PUBMED:12242303] [PUBMED:17940017] [PUBMED:15465819] [PUBMED:17121848] [PUBMED:15772153] [PUBMED:18508924] [PUBMED:18031739] [PUBMED:16914641] [PUBMED:11408594] [PUBMED:11099046] [PUBMED:16543144] [PUBMED:11703925] [PUBMED:11894095] [PUBMED:15282549] [PUBMED:9851973] [PUBMED:16554368] [PUBMED:12897150] [PUBMED:11983899] [PUBMED:18362181] [PUBMED:15475003] [PUBMED:12631709] [PUBMED:15701692] [PUBMED:16862145] [PUBMED:16735510] [PUBMED:18694561] [PUBMED:14505571] [PUBMED:10567412] [PUBMED:15635092] [PUBMED:15210722] [PUBMED:16892055] [PUBMED:1645724] [PUBMED:16407834] [PUBMED:17363458] [PUBMED:16382132] [PUBMED:10428778] [PUBMED:15314065] [PUBMED:16120644] [PUBMED:7925272] [PUBMED:12234920] [PUBMED:8175702] [PUBMED:10085141] [PUBMED:11375397] [PUBMED:10635327] [PUBMED:19723633] [PUBMED:10788520] [PUBMED:12218189] [PUBMED:19054389]
Measles [NCBI:213306] [KEGG:hsa05162] [PUBMED:16237742] [PUBMED:12804771] [PUBMED:19198562] [PUBMED:20376484] [PUBMED:11385511] [PUBMED:16963735] [PUBMED:19198566] [PUBMED:18922877] [PUBMED:19203114] [PUBMED:12620806] [PUBMED:16690907] [PUBMED:17720800] [PUBMED:20636817] [PUBMED:12410527] [PUBMED:11582511] [PUBMED:19203109] [PUBMED:19203113] [PUBMED:14585342] [PUBMED:12805463]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]
T cell receptor signaling pathway [NCBI:83080] [KEGG:hsa04660] [PUBMED:17395537] [PUBMED:15308211] [PUBMED:15928679] [PUBMED:14656980] [PUBMED:17187070] [PUBMED:15084594] [PUBMED:16799472] [PUBMED:12669022] [PUBMED:15286727] [PUBMED:15122199] [PUBMED:19132916] [PUBMED:15489916] [PUBMED:11905831] [PUBMED:12195013] [PUBMED:15343367] [PUBMED:12133805] [PUBMED:14647476] [PUBMED:15771581] [PUBMED:15099566] [PUBMED:14617194] [PUBMED:19290929] [PUBMED:15345216]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]