full name
karyopherin subunit alpha 1

synonyms
IPOA5, NPI-1, RCH2, SRP1, KPNA1, ENSG00000114030

HGNC
HGNC:6394

Entrez Gene
Gene:3836

ENSEMBL
ENSG00000114030

location
chr: 3
start: 122140748
stop: 122233786
strand: -

transcripts
NM_002264.3
NR_026698.1

pathways
Activation of DNA fragmentation factor [NCBI:1270293] [REACTOME:R-HSA-211227] [PUBMED:9422506] [PUBMED:12748178] [PUBMED:10318789] [PUBMED:10713148] [PUBMED:15723341]
Antiviral mechanism by IFN-stimulated genes [NCBI:1269316] [REACTOME:R-HSA-1169410]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Apoptosis induced DNA fragmentation [NCBI:1270292] [REACTOME:R-HSA-140342] [PUBMED:15723341]
Apoptotic execution phase [NCBI:1270287] [REACTOME:R-HSA-75153] [PUBMED:12655297]
Class I PI3K signaling events mediated by Akt [NCBI:138020] [Pathway Interaction Database:pi3kciaktpathway] [PUBMED:10102273] [PUBMED:9812896] [PUBMED:15718470] [PUBMED:10485710] [PUBMED:16919458] [PUBMED:16213228] [PUBMED:11154276] [PUBMED:16962653] [PUBMED:9346240] [PUBMED:12244301] [PUBMED:15057270] [PUBMED:10217147] [PUBMED:17407381] [PUBMED:8524413] [PUBMED:16982699] [PUBMED:12637568] [PUBMED:18024423] [PUBMED:10358075] [PUBMED:9637919] [PUBMED:12244302] [PUBMED:9094314] [PUBMED:10576741] [PUBMED:11864996] [PUBMED:11777915] [PUBMED:12244303] [PUBMED:9381178] [PUBMED:11231573] [PUBMED:10949026] [PUBMED:15262962] [PUBMED:9512493] [PUBMED:10783894]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Early Phase of HIV Life Cycle [NCBI:1269059] [REACTOME:R-HSA-162594] [PUBMED:12091904]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
HIV Life Cycle [NCBI:1269058] [REACTOME:R-HSA-162587] [PUBMED:9188609] [PUBMED:9759480]
Host Interactions of HIV factors [NCBI:1269091] [REACTOME:R-HSA-162909]
Host Interactions with Influenza Factors [NCBI:1269130] [REACTOME:R-HSA-168253]
ISG15 antiviral mechanism [NCBI:1269317] [REACTOME:R-HSA-1169408] [PUBMED:20153823] [PUBMED:12582176] [PUBMED:16009940] [PUBMED:20946978] [PUBMED:15970528]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Influenza A [NCBI:217173] [KEGG:hsa05164] [PUBMED:17267598] [PUBMED:18049471] [PUBMED:16882036] [PUBMED:11907320] [PUBMED:17944269] [PUBMED:20629046] [PUBMED:17072332] [PUBMED:18588994] [PUBMED:19864182] [PUBMED:19290913] [PUBMED:19420020] [PUBMED:17213831] [PUBMED:9060654] [PUBMED:19481124] [PUBMED:16494716] [PUBMED:21147034] [PUBMED:18980544] [PUBMED:20020828] [PUBMED:15502848] [PUBMED:19782761]
Influenza Infection [NCBI:1269108] [REACTOME:R-HSA-168254]
Influenza Life Cycle [NCBI:1269109] [REACTOME:R-HSA-168255]
Integration of provirus [NCBI:1269065] [REACTOME:R-HSA-162592] [PUBMED:16291214]
Interactions of Vpr with host cellular proteins [NCBI:1269092] [REACTOME:R-HSA-176033] [PUBMED:10620603] [PUBMED:10958988] [PUBMED:15817944] [PUBMED:11531413] [PUBMED:8041786] [PUBMED:11815283] [PUBMED:16354571] [PUBMED:8709199] [PUBMED:7474100] [PUBMED:9436978] [PUBMED:7474080] [PUBMED:9582382] [PUBMED:9188632] [PUBMED:10684278]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
NS1 Mediated Effects on Host Pathways [NCBI:1269131] [REACTOME:R-HSA-168276]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Transport of Ribonucleoproteins into the Host Nucleus [NCBI:1269114] [REACTOME:R-HSA-168271]
Vpr-mediated nuclear import of PICs [NCBI:1269094] [REACTOME:R-HSA-180910]