full name
myosin light chain kinase
synonyms
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK, MYLK, ENSG00000065534
HGNC
HGNC:7590
Entrez Gene
Gene:4638
ENSEMBL
ENSG00000065534
location
chr: 3
start: 123331143
stop: 123603149
strand: -
OMIM
OMIM:600922:
MYLK
(Autosomal dominant inheritance)
OMIM:613780:
Aortic aneurysm, familial thoracic 7
transcripts
NM_053028.3
NM_053026.3
NM_053027.3
NM_053025.3
NM_053031.2
NM_053032.2
pathways
Apelin signaling pathway
[NCBI:1492886]
[KEGG:hsa04371]
[PUBMED:23973488]
[PUBMED:16182514]
[PUBMED:21725702]
[PUBMED:22842084]
[PUBMED:27825851]
[PUBMED:27650065]
[PUBMED:22140623]
[PUBMED:23943882]
[PUBMED:26944568]
[PUBMED:24055369]
[PUBMED:26385179]
[PUBMED:26143239]
[PUBMED:22028387]
[PUBMED:26254105]
[PUBMED:26756969]
[PUBMED:22995518]
[PUBMED:27979574]
[PUBMED:23924696]
[PUBMED:21464822]
[PUBMED:25914650]
[PUBMED:24990699]
[PUBMED:26607438]
[PUBMED:25164121]
[PUBMED:25275559]
[PUBMED:25139773]
[PUBMED:25931124]
[PUBMED:19093215]
[PUBMED:20539939]
[PUBMED:25652330]
[PUBMED:18272138]
[PUBMED:23603510]
Aurora B signaling
[NCBI:138080]
[Pathway Interaction Database:aurora_b_pathway]
[PUBMED:14960279]
[PUBMED:15249581]
[PUBMED:17129783]
[PUBMED:15263015]
[PUBMED:15854913]
[PUBMED:14605209]
[PUBMED:12689593]
[PUBMED:15499654]
[PUBMED:17483322]
[PUBMED:15316025]
[PUBMED:11350965]
[PUBMED:11516652]
[PUBMED:11976319]
[PUBMED:16222246]
[PUBMED:12925766]
[PUBMED:15260989]
[PUBMED:16764853]
[PUBMED:15796717]
[PUBMED:16916643]
[PUBMED:14667408]
[PUBMED:17389228]
[PUBMED:16687578]
[PUBMED:14722118]
[PUBMED:12082625]
[PUBMED:17356064]
[PUBMED:16222244]
[PUBMED:11756469]
[PUBMED:17457057]
[PUBMED:15350530]
[PUBMED:17322402]
[PUBMED:11856369]
[PUBMED:17199039]
[PUBMED:17129782]
[PUBMED:12419797]
[PUBMED:16046481]
[PUBMED:15064709]
[PUBMED:12458200]
[PUBMED:15064354]
[PUBMED:14674694]
[PUBMED:16179162]
[PUBMED:17543862]
[PUBMED:17215513]
[PUBMED:12686604]
[PUBMED:16537398]
Calcium signaling pathway
[NCBI:83050]
[KEGG:hsa04020]
[PUBMED:11080247]
[PUBMED:14572802]
[PUBMED:11413485]
[PUBMED:22129055]
[PUBMED:10508738]
[PUBMED:15000521]
[PUBMED:9235901]
[PUBMED:7861177]
[PUBMED:9149541]
[PUBMED:14517314]
[PUBMED:15111104]
[PUBMED:11698232]
[PUBMED:10331643]
[PUBMED:12838335]
[PUBMED:8125957]
[PUBMED:19172794]
[PUBMED:10997573]
[PUBMED:21338471]
[PUBMED:11299192]
[PUBMED:22002090]
[PUBMED:12972622]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Gastric acid secretion
[NCBI:154409]
[KEGG:hsa04971]
[PUBMED:17928547]
[PUBMED:18474247]
[PUBMED:20148676]
[PUBMED:15703676]
[PUBMED:15579540]
[PUBMED:18626068]
[PUBMED:20331540]
[PUBMED:19889964]
[PUBMED:12500969]
[PUBMED:16391411]
[PUBMED:9307437]
[PUBMED:18061403]
Muscle contraction
[NCBI:1269868]
[REACTOME:R-HSA-397014]
Oxytocin signaling pathway
[NCBI:952859]
[KEGG:hsa04921]
[PUBMED:23356278]
[PUBMED:9219843]
[PUBMED:20626426]
[PUBMED:18555543]
[PUBMED:22190926]
[PUBMED:21981277]
[PUBMED:9575824]
[PUBMED:22227279]
[PUBMED:19840865]
[PUBMED:11861513]
[PUBMED:9326674]
[PUBMED:12433531]
[PUBMED:18655881]
[PUBMED:23335873]
[PUBMED:22902539]
[PUBMED:16156781]
[PUBMED:20141572]
[PUBMED:14715914]
[PUBMED:12009385]
[PUBMED:16787565]
[PUBMED:16966388]
Platelet activation
[NCBI:952858]
[KEGG:hsa04611]
[PUBMED:20002545]
[PUBMED:18363565]
[PUBMED:18544684]
[PUBMED:18174460]
[PUBMED:23106920]
[PUBMED:18550847]
[PUBMED:22119499]
[PUBMED:19630797]
[PUBMED:19286885]
[PUBMED:17158345]
[PUBMED:20089227]
[PUBMED:22701130]
[PUBMED:21071698]
[PUBMED:23805129]
[PUBMED:16149014]
[PUBMED:18641368]
RHO GTPase Effectors
[NCBI:1269509]
[REACTOME:R-HSA-195258]
[PUBMED:9694656]
[PUBMED:18066052]
[PUBMED:11018042]
[PUBMED:10470034]
[PUBMED:8702756]
[PUBMED:21730051]
[PUBMED:8571126]
[PUBMED:19513348]
[PUBMED:17244649]
[PUBMED:11145705]
[PUBMED:24128008]
[PUBMED:23716662]
[PUBMED:8617235]
[PUBMED:8543060]
[PUBMED:11804587]
[PUBMED:24969695]
[PUBMED:12635176]
[PUBMED:12778124]
[PUBMED:18006505]
[PUBMED:1660188]
[PUBMED:21351730]
[PUBMED:16507994]
[PUBMED:14595335]
[PUBMED:10072071]
[PUBMED:10591629]
[PUBMED:10753910]
[PUBMED:23875749]
[PUBMED:17151359]
[PUBMED:10652353]
[PUBMED:12221077]
[PUBMED:10559936]
[PUBMED:12783890]
[PUBMED:11948177]
[PUBMED:18237546]
[PUBMED:16079795]
[PUBMED:10924361]
[PUBMED:14514689]
[PUBMED:8107774]
[PUBMED:8756646]
[PUBMED:16979770]
[PUBMED:16636067]
[PUBMED:9751706]
[PUBMED:10619026]
[PUBMED:23444367]
[PUBMED:15546864]
[PUBMED:12473120]
[PUBMED:8816443]
[PUBMED:9199170]
[PUBMED:12514133]
[PUBMED:16762923]
[PUBMED:12110184]
[PUBMED:16431929]
[PUBMED:10975528]
[PUBMED:10940294]
[PUBMED:9535855]
[PUBMED:7559638]
[PUBMED:11162552]
[PUBMED:19737400]
[PUBMED:9988689]
[PUBMED:12732141]
[PUBMED:8798539]
[PUBMED:24914801]
[PUBMED:11689693]
[PUBMED:8769096]
[PUBMED:9368021]
RHO GTPases activate PAKs
[NCBI:1269511]
[REACTOME:R-HSA-5627123]
[PUBMED:7559638]
[PUBMED:9535855]
[PUBMED:19513348]
[PUBMED:16204230]
[PUBMED:10470034]
[PUBMED:22340718]
[PUBMED:11804587]
[PUBMED:21098037]
[PUBMED:11278486]
[PUBMED:8107774]
[PUBMED:10975528]
Regulation of actin cytoskeleton
[NCBI:83089]
[KEGG:hsa04810]
[PUBMED:11152757]
[PUBMED:11082272]
[PUBMED:10574699]
[PUBMED:11082269]
[PUBMED:14657486]
[PUBMED:14744429]
[PUBMED:12700767]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
Smooth Muscle Contraction
[NCBI:1269870]
[REACTOME:R-HSA-445355]
[PUBMED:14627618]
Vascular smooth muscle contraction
[NCBI:96530]
[KEGG:hsa04270]
[PUBMED:16870827]
[PUBMED:10911373]
[PUBMED:11679404]
[PUBMED:16339747]
[PUBMED:10221985]
[PUBMED:12689814]
[PUBMED:11165670]
[PUBMED:18552454]
[PUBMED:12060106]
[PUBMED:9458738]
[PUBMED:15725705]
[PUBMED:18040024]
[PUBMED:12693609]
[PUBMED:11773611]
[PUBMED:17158339]
[PUBMED:17458653]
[PUBMED:15026027]
[PUBMED:19120701]
[PUBMED:15269340]
[PUBMED:18703404]
[PUBMED:11709400]
[PUBMED:17200683]
cGMP-PKG signaling pathway
[NCBI:983748]
[KEGG:hsa04022]
[PUBMED:18006449]
[PUBMED:9003029]
[PUBMED:18040025]
[PUBMED:19306895]
[PUBMED:21666108]
[PUBMED:12524221]
[PUBMED:16460276]
[PUBMED:20716671]
[PUBMED:22785374]
[PUBMED:11522789]
[PUBMED:16439998]
[PUBMED:16371594]
[PUBMED:20388537]
[PUBMED:18757523]
[PUBMED:16815627]
[PUBMED:23212367]
[PUBMED:21685243]
[PUBMED:20024580]
[PUBMED:15894227]
[PUBMED:22965426]
[PUBMED:17643091]
[PUBMED:19176601]
[PUBMED:19961855]