full name
phosphoinositide-3-kinase regulatory subunit 4

synonyms
p150, VPS15, PIK3R4, ENSG00000196455

HGNC
HGNC:8982

Entrez Gene
Gene:30849

ENSEMBL
ENSG00000196455

location
chr: 3
start: 130397778
stop: 130465696
strand: -

transcripts
NM_014602.2

pathways
3-phosphoinositide biosynthesis [NCBI:545314] [BIOCYC:HUMAN_PWY-6352] [PUBMED:9632630] [PUBMED:7798235] [PUBMED:2553693] [PUBMED:8086005] [PUBMED:9247130]
Apelin signaling pathway [NCBI:1492886] [KEGG:hsa04371] [PUBMED:23973488] [PUBMED:16182514] [PUBMED:21725702] [PUBMED:22842084] [PUBMED:27825851] [PUBMED:27650065] [PUBMED:22140623] [PUBMED:23943882] [PUBMED:26944568] [PUBMED:24055369] [PUBMED:26385179] [PUBMED:26143239] [PUBMED:22028387] [PUBMED:26254105] [PUBMED:26756969] [PUBMED:22995518] [PUBMED:27979574] [PUBMED:23924696] [PUBMED:21464822] [PUBMED:25914650] [PUBMED:24990699] [PUBMED:26607438] [PUBMED:25164121] [PUBMED:25275559] [PUBMED:25139773] [PUBMED:25931124] [PUBMED:19093215] [PUBMED:20539939] [PUBMED:25652330] [PUBMED:18272138] [PUBMED:23603510]
Autophagy - animal [NCBI:83058] [KEGG:hsa04140] [PUBMED:16200202] [PUBMED:15325588] [PUBMED:24343578] [PUBMED:15978794] [PUBMED:19802558] [PUBMED:16099218] [PUBMED:11099404] [PUBMED:19653858] [PUBMED:15325584] [PUBMED:20034776] [PUBMED:15928708] [PUBMED:21801009] [PUBMED:25948417] [PUBMED:16125113] [PUBMED:21187343]
Autophagy - other [NCBI:1510434] [KEGG:hsa04136] [PUBMED:22764279] [PUBMED:20962583] [PUBMED:26614870] [PUBMED:22242963] [PUBMED:24563201] [PUBMED:26598298] [PUBMED:21660427]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Macroautophagy [NCBI:1270432] [REACTOME:R-HSA-1632852] [PUBMED:24296784]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
PI Metabolism [NCBI:1270073] [REACTOME:R-HSA-1483255] [PUBMED:17035995] [PUBMED:18216768] [PUBMED:17330069] [PUBMED:15170460] [PUBMED:16828287] [PUBMED:18726176] [PUBMED:20861159] [PUBMED:19196647] [PUBMED:20043944] [PUBMED:20192774] [PUBMED:18784754] [PUBMED:20559318] [PUBMED:18216767] [PUBMED:17605038] [PUBMED:15269334]
PI3K Cascade [NCBI:1269432] [REACTOME:R-HSA-109704]
Phospholipid metabolism [NCBI:1270053] [REACTOME:R-HSA-1483257] [PUBMED:9242906]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases Activate NADPH Oxidases [NCBI:1269521] [REACTOME:R-HSA-5668599] [PUBMED:16507994] [PUBMED:1660188] [PUBMED:17237347] [PUBMED:11145705] [PUBMED:23875749] [PUBMED:10072071] [PUBMED:16636067] [PUBMED:12480817] [PUBMED:16762923] [PUBMED:19628035]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Synthesis of PIPs at the Golgi membrane [NCBI:1270075] [REACTOME:R-HSA-1660514] [PUBMED:11279162] [PUBMED:17556371] [PUBMED:10766823] [PUBMED:10559940] [PUBMED:10805725] [PUBMED:14527956] [PUBMED:18950639]
Synthesis of PIPs at the early endosome membrane [NCBI:1270079] [REACTOME:R-HSA-1660516] [PUBMED:18950639] [PUBMED:11733541] [PUBMED:18524850] [PUBMED:17556371] [PUBMED:17651088] [PUBMED:10805725]
Synthesis of PIPs at the late endosome membrane [NCBI:1270082] [REACTOME:R-HSA-1660517] [PUBMED:18524850] [PUBMED:17556371] [PUBMED:17651088] [PUBMED:10805725] [PUBMED:11733541] [PUBMED:18950639]
Toll Like Receptor 9 (TLR9) Cascade [NCBI:1269233] [REACTOME:R-HSA-168138] [PUBMED:14751759]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
superpathway of inositol phosphate compounds [NCBI:547492] [BIOCYC:HUMAN_PWY-6371]