full name
TNF superfamily member 10

synonyms
Apo-2L, APO2L, CD253, TL2, TRAIL, TNFSF10, ENSG00000121858

HGNC
HGNC:11925

Entrez Gene
Gene:8743

ENSEMBL
ENSG00000121858

location
chr: 3
start: 172223298
stop: 172241297
strand: -

transcripts
NM_001190942.1
NR_033994.1
NM_003810.3
NM_001190943.1

pathways
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
CASP8 activity is inhibited [NCBI:1270301] [REACTOME:R-HSA-5218900] [PUBMED:9087414] [PUBMED:12181749] [PUBMED:23410748] [PUBMED:21737330]
Caspase activation via extrinsic apoptotic signalling pathway [NCBI:1270263] [REACTOME:R-HSA-5357769] [PUBMED:11048727]
Cytokine-cytokine receptor interaction [NCBI:83051] [KEGG:hsa04060] [PUBMED:11071910] [PUBMED:12072446] [PUBMED:7791754] [PUBMED:15032600] [PUBMED:12651226] [PUBMED:11252892] [PUBMED:11796220] [PUBMED:11312110] [PUBMED:9862719] [PUBMED:12421671] [PUBMED:12039028] [PUBMED:9759503] [PUBMED:9395284] [PUBMED:11166270] [PUBMED:10714678] [PUBMED:12651221]
Death Receptor Signalling [NCBI:1269644] [REACTOME:R-HSA-73887]
Dimerization of procaspase-8 [NCBI:1270265] [REACTOME:R-HSA-69416] [PUBMED:20308068] [PUBMED:19851329] [PUBMED:12620240]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:15005655] [PUBMED:18951090] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:16964248] [PUBMED:18045156] [PUBMED:18403263] [PUBMED:21613825] [PUBMED:21440011] [PUBMED:17470511] [PUBMED:21238503] [PUBMED:17522590] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:15516968]
Influenza A [NCBI:217173] [KEGG:hsa05164] [PUBMED:17267598] [PUBMED:18049471] [PUBMED:16882036] [PUBMED:11907320] [PUBMED:17944269] [PUBMED:20629046] [PUBMED:17072332] [PUBMED:18588994] [PUBMED:19864182] [PUBMED:19290913] [PUBMED:19420020] [PUBMED:17213831] [PUBMED:9060654] [PUBMED:19481124] [PUBMED:16494716] [PUBMED:21147034] [PUBMED:18980544] [PUBMED:20020828] [PUBMED:15502848] [PUBMED:19782761]
Ligand-dependent caspase activation [NCBI:1270264] [REACTOME:R-HSA-140534] [PUBMED:12620240] [PUBMED:14644197] [PUBMED:20308068] [PUBMED:19851329] [PUBMED:12620239]
Measles [NCBI:213306] [KEGG:hsa05162] [PUBMED:16237742] [PUBMED:12804771] [PUBMED:19198562] [PUBMED:20376484] [PUBMED:11385511] [PUBMED:16963735] [PUBMED:19198566] [PUBMED:18922877] [PUBMED:19203114] [PUBMED:12620806] [PUBMED:16690907] [PUBMED:17720800] [PUBMED:20636817] [PUBMED:12410527] [PUBMED:11582511] [PUBMED:19203109] [PUBMED:19203113] [PUBMED:14585342] [PUBMED:12805463]
Natural killer cell mediated cytotoxicity [NCBI:83079] [KEGG:hsa04650] [PUBMED:12530970] [PUBMED:15567854] [PUBMED:8942070] [PUBMED:11905813] [PUBMED:9143705] [PUBMED:9862693] [PUBMED:11895890] [PUBMED:12205470] [PUBMED:11836514] [PUBMED:15607806] [PUBMED:16002670] [PUBMED:15618404] [PUBMED:11390470] [PUBMED:11062493] [PUBMED:14710949] [PUBMED:12752668] [PUBMED:15607802] [PUBMED:16109839] [PUBMED:12766758] [PUBMED:16177799]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
RIPK1-mediated regulated necrosis [NCBI:1270299] [REACTOME:R-HSA-5213460] [PUBMED:24773756] [PUBMED:24452471]
Regulated Necrosis [NCBI:1270298] [REACTOME:R-HSA-5218859] [PUBMED:23770045] [PUBMED:24563506] [PUBMED:24452471]
Regulation by c-FLIP [NCBI:1270266] [REACTOME:R-HSA-3371378] [PUBMED:9217161] [PUBMED:21235526] [PUBMED:19416807]
Regulation of necroptotic cell death [NCBI:1270300] [REACTOME:R-HSA-5675482] [PUBMED:18570872] [PUBMED:21737330] [PUBMED:18621737] [PUBMED:12110583] [PUBMED:20218968] [PUBMED:15701649]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
TRAIL signaling [NCBI:1269648] [REACTOME:R-HSA-75158] [PUBMED:14634624]
TRAIL signaling pathway [NCBI:137920] [Pathway Interaction Database:trail_pathway] [PUBMED:10958661] [PUBMED:9430226] [PUBMED:9311998] [PUBMED:16227629] [PUBMED:10521396] [PUBMED:9242610] [PUBMED:12668516] [PUBMED:15105837] [PUBMED:11461927] [PUBMED:16319225] [PUBMED:9082980] [PUBMED:9430227] [PUBMED:16980609] [PUBMED:10894160] [PUBMED:16940186] [PUBMED:16636669] [PUBMED:10783243] [PUBMED:11278665] [PUBMED:11376335] [PUBMED:9314565] [PUBMED:10521444] [PUBMED:10894161]