full name
SRY-box 2

synonyms
ANOP3, MCOPS3, SOX2, ENSG00000181449

HGNC
HGNC:11195

Entrez Gene
Gene:6657

ENSEMBL
ENSG00000181449

location
chr: 3
start: 181429712
stop: 181432224
strand: +

OMIM
OMIM:184429: SOX2 (Autosomal dominant inheritance)
OMIM:206900: Microphthalmia, syndromic 3
OMIM:206900: Optic nerve hypoplasia and abnormalities of the central nervous system

transcripts
NM_003106.3

pathways
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Deactivation of the beta-catenin transactivating complex [NCBI:1269604] [REACTOME:R-HSA-3769402] [PUBMED:18632669] [PUBMED:12408825] [PUBMED:18573912] [PUBMED:11080158] [PUBMED:15525529] [PUBMED:16510874] [PUBMED:12712206] [PUBMED:18077326] [PUBMED:19364920] [PUBMED:12408824] [PUBMED:10898789]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Hippo signaling pathway [NCBI:749777] [KEGG:hsa04390] [PUBMED:18955139] [PUBMED:20439427] [PUBMED:20951342] [PUBMED:21138973] [PUBMED:18328423] [PUBMED:21324984] [PUBMED:23034192] [PUBMED:21808241] [PUBMED:17975546] [PUBMED:22750148] [PUBMED:21084559] [PUBMED:19846288] [PUBMED:22895435] [PUBMED:22683405] [PUBMED:22658639] [PUBMED:22153608] [PUBMED:20945341] [PUBMED:22830020] [PUBMED:21874053] [PUBMED:21376238]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interleukin-4 and 13 signaling [NCBI:1470923] [REACTOME:R-HSA-6785807] [PUBMED:12704343] [PUBMED:10358772]
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation [NCBI:1270347] [REACTOME:R-HSA-2892247] [PUBMED:16846370] [PUBMED:16153702] [PUBMED:17183653] [PUBMED:17068183] [PUBMED:15110706] [PUBMED:19604364] [PUBMED:20505756] [PUBMED:17204602] [PUBMED:16819296]
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation [NCBI:1270348] [REACTOME:R-HSA-2892245] [PUBMED:15110706] [PUBMED:20505756] [PUBMED:19604364] [PUBMED:17204602] [PUBMED:16819296] [PUBMED:17068183] [PUBMED:16153702] [PUBMED:17183653] [PUBMED:16846370]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
Signaling pathways regulating pluripotency of stem cells [NCBI:1026136] [KEGG:hsa04550] [PUBMED:20705693] [PUBMED:23653415] [PUBMED:16518401] [PUBMED:17211451] [PUBMED:22649650] [PUBMED:24910449] [PUBMED:19551525] [PUBMED:22298652] [PUBMED:23370346] [PUBMED:24315442] [PUBMED:18414030] [PUBMED:17647265] [PUBMED:18295576] [PUBMED:24957798] [PUBMED:24147644] [PUBMED:16153702] [PUBMED:19427042] [PUBMED:18220859] [PUBMED:19571885] [PUBMED:23585347]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
Transcriptional regulation of pluripotent stem cells [NCBI:1270346] [REACTOME:R-HSA-452723] [PUBMED:17093407] [PUBMED:17204602] [PUBMED:17068183] [PUBMED:22394165] [PUBMED:19128516] [PUBMED:19604364] [PUBMED:23166394] [PUBMED:20300647] [PUBMED:22443931] [PUBMED:22909387] [PUBMED:16153702] [PUBMED:19480567] [PUBMED:18029452] [PUBMED:22122341] [PUBMED:16819296] [PUBMED:12923055] [PUBMED:19755485] [PUBMED:22083510] [PUBMED:17572666] [PUBMED:17183653] [PUBMED:16978057] [PUBMED:16846370] [PUBMED:18923680] [PUBMED:23306458] [PUBMED:15493035] [PUBMED:20207225] [PUBMED:18035408] [PUBMED:20027182] [PUBMED:15110706] [PUBMED:22463982] [PUBMED:21044011] [PUBMED:23248145]