full name
tumor protein p63

synonyms
AIS, B%28p51A%29, B%28p51B%29, EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP73L, TP63, ENSG00000073282

HGNC
HGNC:15979

Entrez Gene
Gene:8626

ENSEMBL
ENSG00000073282

location
chr: 3
start: 189348942
stop: 189615068
strand: +

OMIM
OMIM:603273: TP63 (Autosomal dominant inheritance)
OMIM:103285: ADULT syndrome
OMIM:604292: Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3
OMIM:106260: Hay-Wells syndrome
OMIM:603543: Limb-mammary syndrome
OMIM:618149: Orofacial cleft 8
OMIM:129400: Rapp-Hodgkin syndrome
OMIM:605289: Split-hand/foot malformation 4

transcripts
NM_003722.4
NM_001114978.1
NM_001114979.1
NM_001114980.1
NM_001114981.1
NM_001114982.1

pathways
Activation of BH3-only proteins [NCBI:1270270] [REACTOME:R-HSA-114452] [PUBMED:12209154] [PUBMED:14634621]
Activation of PUMA and translocation to mitochondria [NCBI:1270273] [REACTOME:R-HSA-139915] [PUBMED:14684737] [PUBMED:11463392]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Direct p53 effectors [NCBI:137939] [Pathway Interaction Database:p53downstreampathway] [PUBMED:7479001] [PUBMED:19626115] [PUBMED:10692390] [PUBMED:15289308] [PUBMED:14688482] [PUBMED:16301995] [PUBMED:11850816] [PUBMED:12370809] [PUBMED:16260627] [PUBMED:15186775] [PUBMED:15580302] [PUBMED:10748162] [PUBMED:10919640] [PUBMED:19011621] [PUBMED:12438652] [PUBMED:11559530] [PUBMED:11641774] [PUBMED:11971958] [PUBMED:9659898] [PUBMED:9343394] [PUBMED:10716435] [PUBMED:17146433] [PUBMED:17719542] [PUBMED:17938176] [PUBMED:17409421] [PUBMED:11032029] [PUBMED:15781865] [PUBMED:11463392] [PUBMED:9736732] [PUBMED:17268548] [PUBMED:8570655] [PUBMED:18046411] [PUBMED:12944906] [PUBMED:16249378] [PUBMED:15273740] [PUBMED:15598651] [PUBMED:10618379] [PUBMED:15958553] [PUBMED:17189187] [PUBMED:17145718] [PUBMED:11988847] [PUBMED:8119988] [PUBMED:12089322] [PUBMED:16286009] [PUBMED:12890671] [PUBMED:12402042] [PUBMED:10618714] [PUBMED:14730312] [PUBMED:12857899] [PUBMED:14963330] [PUBMED:11278953] [PUBMED:11973653] [PUBMED:12692263] [PUBMED:10984493] [PUBMED:10640990] [PUBMED:11545734] [PUBMED:16151013] [PUBMED:12372430] [PUBMED:16651407] [PUBMED:9891062] [PUBMED:12606722] [PUBMED:12453409] [PUBMED:15377670] [PUBMED:12667443] [PUBMED:17707234] [PUBMED:9920903] [PUBMED:14992722] [PUBMED:15790310] [PUBMED:15831478] [PUBMED:11314010] [PUBMED:10329733] [PUBMED:17264218] [PUBMED:11511362] [PUBMED:11919562] [PUBMED:11814693] [PUBMED:17554199] [PUBMED:18250150] [PUBMED:10518217] [PUBMED:10891498] [PUBMED:10973264] [PUBMED:15077116] [PUBMED:16230375] [PUBMED:18485870] [PUBMED:7796420] [PUBMED:15710382] [PUBMED:17409411] [PUBMED:8319905] [PUBMED:10684646] [PUBMED:7566179] [PUBMED:8887630] [PUBMED:11807984] [PUBMED:9841917] [PUBMED:12654245] [PUBMED:9023107] [PUBMED:15103385] [PUBMED:11684014] [PUBMED:17110336] [PUBMED:11278253] [PUBMED:14576823] [PUBMED:8418500] [PUBMED:11350971] [PUBMED:11840333] [PUBMED:7651818] [PUBMED:7651386] [PUBMED:15378026] [PUBMED:15607964] [PUBMED:11279192] [PUBMED:10777218] [PUBMED:15334053] [PUBMED:12138177] [PUBMED:9619826] [PUBMED:16278683] [PUBMED:17189186] [PUBMED:16140933] [PUBMED:10094469] [PUBMED:9926927] [PUBMED:17719541] [PUBMED:15735003] [PUBMED:12853982] [PUBMED:14707288] [PUBMED:10777207]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Intrinsic Pathway for Apoptosis [NCBI:1270268] [REACTOME:R-HSA-109606] [PUBMED:12042762] [PUBMED:11711427] [PUBMED:15077149]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Activity through Association with Co-factors [NCBI:1383081] [REACTOME:R-HSA-6804759] [PUBMED:17719541] [PUBMED:20673990] [PUBMED:15186775] [PUBMED:22864287] [PUBMED:20679336] [PUBMED:11684014] [PUBMED:20691894] [PUBMED:18719709] [PUBMED:18278067] [PUBMED:25356872] [PUBMED:10329733] [PUBMED:17719542] [PUBMED:12524540] [PUBMED:15598651] [PUBMED:17145718] [PUBMED:14729977]
TP53 Regulates Metabolic Genes [NCBI:1269655] [REACTOME:R-HSA-5628897] [PUBMED:19822145] [PUBMED:12453409] [PUBMED:18344994] [PUBMED:11545734] [PUBMED:16839880] [PUBMED:20399660] [PUBMED:15105503] [PUBMED:13298683] [PUBMED:15665293] [PUBMED:18198340] [PUBMED:18692468] [PUBMED:12203114] [PUBMED:17409411] [PUBMED:11959846] [PUBMED:16728594] [PUBMED:17486094] [PUBMED:23484829] [PUBMED:22682249] [PUBMED:19696408] [PUBMED:9926927] [PUBMED:22864287] [PUBMED:20378837] [PUBMED:18391940] [PUBMED:24366874] [PUBMED:19439913] [PUBMED:15059920] [PUBMED:10716435] [PUBMED:17540029]
TP53 Regulates Transcription of Caspase Activators and Caspases [NCBI:1383069] [REACTOME:R-HSA-6803207] [PUBMED:15580302] [PUBMED:14688482] [PUBMED:10973264] [PUBMED:11278253] [PUBMED:12089322] [PUBMED:11559530] [PUBMED:17284521]
TP53 Regulates Transcription of Cell Death Genes [NCBI:1383066] [REACTOME:R-HSA-5633008] [PUBMED:20353938] [PUBMED:18676979] [PUBMED:11511362] [PUBMED:11919562] [PUBMED:10973264] [PUBMED:15797384] [PUBMED:17442733] [PUBMED:15607964] [PUBMED:11278253] [PUBMED:23059823] [PUBMED:19549844] [PUBMED:11684014] [PUBMED:7566179] [PUBMED:17349958] [PUBMED:24739573] [PUBMED:18719709] [PUBMED:17284521] [PUBMED:23703390] [PUBMED:10807576] [PUBMED:10733530] [PUBMED:12402042] [PUBMED:12851404] [PUBMED:14729977] [PUBMED:18431400] [PUBMED:15377670] [PUBMED:12089322] [PUBMED:15273740] [PUBMED:11382926] [PUBMED:12606722] [PUBMED:14623878] [PUBMED:15577913] [PUBMED:16230375] [PUBMED:26122615] [PUBMED:11559530] [PUBMED:11054413] [PUBMED:22766503] [PUBMED:11463392] [PUBMED:16249378] [PUBMED:9326928] [PUBMED:14614825] [PUBMED:19615968] [PUBMED:16140933] [PUBMED:7834749] [PUBMED:16135520] [PUBMED:15126337] [PUBMED:15580302] [PUBMED:15289308] [PUBMED:10777207] [PUBMED:23365256] [PUBMED:19040420] [PUBMED:15735003] [PUBMED:14688482]
TP53 Regulates Transcription of Death Receptors and Ligands [NCBI:1383067] [REACTOME:R-HSA-6803211] [PUBMED:15289308] [PUBMED:19615968] [PUBMED:7566179] [PUBMED:9326928] [PUBMED:23365256] [PUBMED:10777207] [PUBMED:14623878] [PUBMED:20353938] [PUBMED:16230375] [PUBMED:11382926]
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release [NCBI:1383068] [REACTOME:R-HSA-6803204] [PUBMED:12606722] [PUBMED:18676979] [PUBMED:11511362] [PUBMED:11463392] [PUBMED:10807576] [PUBMED:12851404] [PUBMED:12402042] [PUBMED:15273740] [PUBMED:14729977] [PUBMED:15735003] [PUBMED:15126337] [PUBMED:23365256] [PUBMED:22766503] [PUBMED:11684014] [PUBMED:15607964] [PUBMED:7834749]
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain [NCBI:1383070] [REACTOME:R-HSA-6803205] [PUBMED:10733530] [PUBMED:16249378] [PUBMED:14729977] [PUBMED:15377670] [PUBMED:15577913] [PUBMED:19040420] [PUBMED:11054413] [PUBMED:17442733] [PUBMED:14614825] [PUBMED:16140933] [PUBMED:11919562] [PUBMED:19549844] [PUBMED:23059823] [PUBMED:11684014]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]