full name
PPARG coactivator 1 alpha
synonyms
LEM6, PGC-1%28alpha%29, PGC-1v, PGC1, PGC1A, PPARGC1, PPARGC1A, ENSG00000109819
HGNC
HGNC:9237
Entrez Gene
Gene:10891
ENSEMBL
ENSG00000109819
location
chr: 4
start: 23793644
stop: 24474394
strand: -
transcripts
NM_013261.3
pathways
AMPK signaling pathway
[NCBI:989139]
[KEGG:hsa04152]
[PUBMED:22885100]
[PUBMED:18725075]
[PUBMED:22700795]
[PUBMED:19724019]
[PUBMED:19584320]
[PUBMED:16644802]
[PUBMED:20010958]
[PUBMED:16479585]
[PUBMED:19197243]
[PUBMED:23565491]
[PUBMED:20357764]
[PUBMED:16723978]
[PUBMED:16054041]
[PUBMED:19393004]
[PUBMED:23899560]
[PUBMED:17307971]
[PUBMED:15509864]
[PUBMED:23024365]
[PUBMED:23747347]
[PUBMED:19629071]
ATF-2 transcription factor network
[NCBI:138006]
[Pathway Interaction Database:atf2_pathway]
[PUBMED:12048217]
[PUBMED:19255142]
[PUBMED:11739785]
[PUBMED:7624151]
[PUBMED:19822663]
[PUBMED:17590016]
[PUBMED:7535770]
[PUBMED:18396163]
[PUBMED:20507983]
[PUBMED:19422799]
[PUBMED:7824938]
[PUBMED:11713276]
[PUBMED:17258390]
[PUBMED:10454570]
[PUBMED:20067572]
[PUBMED:10364225]
[PUBMED:12121977]
[PUBMED:12110590]
[PUBMED:19176525]
[PUBMED:16511568]
[PUBMED:17079470]
[PUBMED:17267404]
[PUBMED:10777595]
[PUBMED:2516827]
[PUBMED:18397884]
[PUBMED:10207054]
[PUBMED:9436983]
[PUBMED:7737130]
[PUBMED:10982836]
[PUBMED:9006914]
[PUBMED:19592489]
[PUBMED:17158955]
[PUBMED:17189429]
[PUBMED:11566021]
[PUBMED:17626013]
[PUBMED:17036053]
[PUBMED:20702711]
[PUBMED:10085140]
[PUBMED:20032511]
[PUBMED:17219413]
[PUBMED:17337306]
[PUBMED:9511728]
[PUBMED:12196528]
[PUBMED:19304750]
[PUBMED:17700520]
[PUBMED:16373341]
[PUBMED:12833146]
[PUBMED:1827203]
[PUBMED:17699753]
[PUBMED:9990041]
[PUBMED:15304344]
[PUBMED:11231009]
[PUBMED:18385943]
[PUBMED:18387947]
[PUBMED:18638549]
[PUBMED:15767263]
[PUBMED:10777545]
[PUBMED:14630918]
[PUBMED:18802055]
[PUBMED:10037779]
[PUBMED:12052888]
[PUBMED:8943243]
[PUBMED:20181929]
[PUBMED:19647037]
[PUBMED:8382609]
[PUBMED:16405968]
[PUBMED:1641004]
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
[NCBI:1268840]
[REACTOME:R-HSA-2151209]
[PUBMED:19276888]
[PUBMED:19262508]
[PUBMED:20933024]
[PUBMED:21543634]
[PUBMED:21757760]
Adipocytokine signaling pathway
[NCBI:83093]
[KEGG:hsa04920]
[PUBMED:12829246]
[PUBMED:10905472]
[PUBMED:15980064]
[PUBMED:12754525]
[PUBMED:12368907]
[PUBMED:11557972]
[PUBMED:15856064]
[PUBMED:9671776]
[PUBMED:10766253]
[PUBMED:15733744]
[PUBMED:15058305]
[PUBMED:14716305]
[PUBMED:11479627]
[PUBMED:14679176]
Apelin signaling pathway
[NCBI:1492886]
[KEGG:hsa04371]
[PUBMED:23973488]
[PUBMED:16182514]
[PUBMED:21725702]
[PUBMED:22842084]
[PUBMED:27825851]
[PUBMED:27650065]
[PUBMED:22140623]
[PUBMED:23943882]
[PUBMED:26944568]
[PUBMED:24055369]
[PUBMED:26385179]
[PUBMED:26143239]
[PUBMED:22028387]
[PUBMED:26254105]
[PUBMED:26756969]
[PUBMED:22995518]
[PUBMED:27979574]
[PUBMED:23924696]
[PUBMED:21464822]
[PUBMED:25914650]
[PUBMED:24990699]
[PUBMED:26607438]
[PUBMED:25164121]
[PUBMED:25275559]
[PUBMED:25139773]
[PUBMED:25931124]
[PUBMED:19093215]
[PUBMED:20539939]
[PUBMED:25652330]
[PUBMED:18272138]
[PUBMED:23603510]
BMAL1:CLOCK,NPAS2 activates circadian gene expression
[NCBI:1269872]
[REACTOME:R-HSA-1368108]
[PUBMED:12868535]
[PUBMED:9616112]
Circadian Clock
[NCBI:1269871]
[REACTOME:R-HSA-400253]
[PUBMED:18775307]
[PUBMED:18802415]
[PUBMED:18786386]
[PUBMED:16987893]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Fatty acid, triacylglycerol, and ketone body metabolism
[NCBI:1270010]
[REACTOME:R-HSA-535734]
Glucagon signaling pathway
[NCBI:1144996]
[KEGG:hsa04922]
[PUBMED:20735177]
[PUBMED:19912989]
[PUBMED:21941300]
[PUBMED:22249520]
[PUBMED:12626323]
[PUBMED:16601267]
[PUBMED:18669612]
[PUBMED:24393785]
[PUBMED:21346730]
[PUBMED:22550228]
[PUBMED:16479585]
[PUBMED:24692138]
[PUBMED:22495310]
[PUBMED:22796337]
[PUBMED:22004992]
[PUBMED:24238363]
[PUBMED:22503562]
Huntington's disease
[NCBI:83100]
[KEGG:hsa05016]
[PUBMED:15336977]
[PUBMED:11738471]
[PUBMED:11807533]
[PUBMED:15996546]
[PUBMED:14526190]
[PUBMED:15242639]
[PUBMED:17041811]
[PUBMED:15996541]
[PUBMED:18951640]
[PUBMED:15459747]
[PUBMED:16288298]
[PUBMED:17081970]
[PUBMED:15695335]
[PUBMED:12372277]
[PUBMED:11839795]
Insulin resistance
[NCBI:1272486]
[KEGG:hsa04931]
[PUBMED:17130651]
[PUBMED:20466550]
[PUBMED:16364488]
[PUBMED:12765939]
[PUBMED:15166380]
[PUBMED:7666792]
[PUBMED:16756496]
[PUBMED:23647930]
[PUBMED:10923637]
[PUBMED:17141630]
[PUBMED:9886945]
[PUBMED:8048519]
[PUBMED:18309108]
[PUBMED:15107844]
[PUBMED:20526383]
[PUBMED:22360800]
[PUBMED:16186396]
[PUBMED:22675355]
[PUBMED:22677645]
Insulin signaling pathway
[NCBI:83090]
[KEGG:hsa04910]
[PUBMED:11742412]
[PUBMED:11343120]
[PUBMED:15733744]
[PUBMED:11282018]
[PUBMED:10196204]
[PUBMED:18291668]
[PUBMED:9609110]
[PUBMED:10567225]
[PUBMED:12791379]
[PUBMED:9748166]
[PUBMED:15624019]
[PUBMED:9445476]
[PUBMED:9346240]
[PUBMED:14635525]
[PUBMED:16288289]
[PUBMED:12867054]
[PUBMED:15229476]
[PUBMED:17344645]
[PUBMED:9609111]
Longevity regulating pathway
[NCBI:1319989]
[KEGG:hsa04211]
[PUBMED:21779512]
[PUBMED:23594965]
[PUBMED:25654554]
[PUBMED:25832544]
[PUBMED:24997879]
[PUBMED:22618766]
[PUBMED:20336132]
[PUBMED:24905167]
[PUBMED:25601466]
[PUBMED:20103737]
[PUBMED:18692468]
[PUBMED:20395504]
[PUBMED:25824609]
[PUBMED:17701476]
[PUBMED:23939249]
[PUBMED:20848587]
[PUBMED:22983298]
[PUBMED:19262508]
[PUBMED:20357764]
[PUBMED:18946478]
[PUBMED:23061800]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins
[NCBI:1270001]
[REACTOME:R-HSA-556833]
Mitochondrial biogenesis
[NCBI:1268839]
[REACTOME:R-HSA-1592230]
[PUBMED:18430751]
[PUBMED:19262508]
[PUBMED:22265687]
[PUBMED:20533901]
[PUBMED:20933024]
[PUBMED:21757760]
[PUBMED:19575678]
[PUBMED:19008463]
[PUBMED:21629705]
[PUBMED:21543634]
[PUBMED:22817841]
[PUBMED:20649548]
[PUBMED:22146081]
[PUBMED:19276888]
[PUBMED:19682549]
[PUBMED:15744310]
[PUBMED:19076454]
Organelle biogenesis and maintenance
[NCBI:1268838]
[REACTOME:R-HSA-1852241]
[PUBMED:8608592]
[PUBMED:16103713]
PPARA activates gene expression
[NCBI:1270030]
[REACTOME:R-HSA-1989781]
[PUBMED:10529898]
[PUBMED:18288277]
[PUBMED:11330046]
[PUBMED:20936127]
[PUBMED:14999402]
RORA activates gene expression
[NCBI:1269873]
[REACTOME:R-HSA-1368082]
[PUBMED:7926749]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
[NCBI:1270029]
[REACTOME:R-HSA-400206]
[PUBMED:18288277]
[PUBMED:10529898]
[PUBMED:16476485]
[PUBMED:16503871]
Signaling events mediated by HDAC Class III
[NCBI:137972]
[Pathway Interaction Database:hdac_classiii_pathway]
[PUBMED:11672522]
[PUBMED:16788062]
[PUBMED:15213244]
[PUBMED:15126506]
[PUBMED:15719057]
[PUBMED:15632193]
[PUBMED:12006491]
[PUBMED:15744310]
[PUBMED:11672523]
[PUBMED:12867036]
[PUBMED:16618798]
[PUBMED:15692560]
[PUBMED:16790548]
[PUBMED:12887892]
[PUBMED:16166628]
[PUBMED:15691653]
[PUBMED:15205477]
[PUBMED:16648462]
[PUBMED:14980222]
[PUBMED:16012755]
[PUBMED:15469825]
[PUBMED:12620231]
Signaling mediated by p38-alpha and p38-beta
[NCBI:138012]
[Pathway Interaction Database:p38alphabetadownstreampathway]
[PUBMED:11909979]
[PUBMED:7923353]
[PUBMED:14612426]
[PUBMED:12138194]
[PUBMED:9069290]
[PUBMED:9130707]
[PUBMED:10362538]
[PUBMED:9155018]
[PUBMED:11239470]
[PUBMED:9685422]
[PUBMED:9628874]
[PUBMED:9873047]
[PUBMED:10978317]
[PUBMED:11741533]
[PUBMED:7923354]
[PUBMED:9468497]
[PUBMED:9647257]
[PUBMED:8910365]
[PUBMED:8626550]
[PUBMED:9776729]
[PUBMED:10581204]
[PUBMED:7839144]
[PUBMED:7750577]
[PUBMED:11604491]
[PUBMED:11792706]
[PUBMED:7535770]
[PUBMED:10212189]
[PUBMED:10747897]
[PUBMED:9687510]
[PUBMED:11777913]
[PUBMED:9155017]
[PUBMED:7737130]
[PUBMED:9792677]
[PUBMED:11532965]
[PUBMED:9822687]
[PUBMED:8650547]
[PUBMED:9582321]
[PUBMED:9858528]
Transcriptional activation of mitochondrial biogenesis
[NCBI:1268841]
[REACTOME:R-HSA-2151201]
[PUBMED:22265687]
[PUBMED:20933024]
[PUBMED:19575678]
[PUBMED:22817841]
[PUBMED:19682549]
Transcriptional regulation of white adipocyte differentiation
[NCBI:1270345]
[REACTOME:R-HSA-381340]
[PUBMED:21082419]
[PUBMED:17956727]
[PUBMED:17475546]
[PUBMED:1840554]
[PUBMED:17139329]
[PUBMED:15860371]
[PUBMED:18518822]
[PUBMED:10603305]
[PUBMED:7531665]
[PUBMED:20054179]
[PUBMED:7838715]
[PUBMED:16054042]
[PUBMED:17060461]
[PUBMED:17011499]
[PUBMED:16380219]
[PUBMED:8970730]
mTOR signaling pathway
[NCBI:83059]
[KEGG:hsa04150]
[NCBI:138001]
[Pathway Interaction Database:mtor_4pathway]
[PUBMED:17277771]
[PUBMED:15341740]
[PUBMED:12172553]
[PUBMED:15718470]
[PUBMED:14651849]
[PUBMED:15268862]
[PUBMED:15306821]
[PUBMED:26046644]
[PUBMED:12869586]
[PUBMED:24556838]
[PUBMED:17928295]
[PUBMED:9427642]
[PUBMED:18046414]
[PUBMED:12912918]
[PUBMED:16286006]
[PUBMED:26658722]
[PUBMED:24842496]
[PUBMED:23465396]
[PUBMED:17709744]
[PUBMED:17599906]
[PUBMED:16919458]
[PUBMED:10364159]
[PUBMED:15342917]
[PUBMED:11500364]
[PUBMED:19812304]
[PUBMED:12482958]
[PUBMED:11729323]
[PUBMED:16962653]
[PUBMED:18952604]
[PUBMED:9465032]
[PUBMED:1496022]
[PUBMED:10567431]
[PUBMED:19114562]
[PUBMED:17510057]
[PUBMED:18604198]
[PUBMED:15545625]
[PUBMED:11914378]
[PUBMED:17461779]
[PUBMED:9445476]
[PUBMED:18497260]
[PUBMED:12604610]
[PUBMED:15071500]
[PUBMED:18925875]
[PUBMED:12906785]
[PUBMED:11287630]
[PUBMED:15004009]
[PUBMED:16756488]
[PUBMED:17043309]
[PUBMED:18198340]
[PUBMED:12820960]
[PUBMED:12747827]
[PUBMED:17053147]
[PUBMED:15851026]
[PUBMED:15467718]
[PUBMED:18762023]
[PUBMED:25242279]
[PUBMED:24698685]
[PUBMED:11175345]
[PUBMED:27304501]
[PUBMED:18411301]
[PUBMED:11500365]
[PUBMED:17693255]
[PUBMED:23694989]
[PUBMED:12231510]
[PUBMED:19446321]
[PUBMED:11418588]
[PUBMED:19258318]
[PUBMED:18439900]
[PUBMED:19225151]
[PUBMED:26185979]
[PUBMED:10357815]
[PUBMED:26269525]
[PUBMED:23421405]
[PUBMED:9271440]
[PUBMED:16915281]
[PUBMED:17141160]
[PUBMED:15249583]
[PUBMED:12912989]
[PUBMED:27027448]
[PUBMED:18423201]
[PUBMED:19211835]
[PUBMED:9204908]
[PUBMED:26700098]
[PUBMED:18566587]
[PUBMED:17386266]