full name
toll like receptor 1

synonyms
CD281, rsc786, TIL, TIL., TLR1, ENSG00000174125

HGNC
HGNC:11847

Entrez Gene
Gene:7096

ENSEMBL
ENSG00000174125

location
chr: 4
start: 38797876
stop: 38806814
strand: -

OMIM
OMIM:601194: TLR1
OMIM:613223: {Leprosy, protection against}
OMIM:613223: {Leprosy, susceptibility to, 5}

transcripts
NM_003263.3

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing-Cross presentation [NCBI:1269195] [REACTOME:R-HSA-1236975] [PUBMED:17157489] [PUBMED:20171863] [PUBMED:16181333] [PUBMED:15761154] [PUBMED:16181335] [PUBMED:19218463]
Antimicrobial peptides [NCBI:1457777] [REACTOME:R-HSA-6803157] [PUBMED:12615953] [PUBMED:24287494]
Beta defensins [NCBI:1269267] [REACTOME:R-HSA-1461957] [PUBMED:16710608]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Defensins [NCBI:1269265] [REACTOME:R-HSA-1461973] [PUBMED:15372083]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases associated with the TLR signaling cascade [NCBI:1269157] [REACTOME:R-HSA-5602358] [PUBMED:23622315] [PUBMED:21734245] [PUBMED:22610250] [PUBMED:16176658]
Diseases of Immune System [NCBI:1269156] [REACTOME:R-HSA-5260271] [PUBMED:24795713] [PUBMED:22165913]
ER-Phagosome pathway [NCBI:1269197] [REACTOME:R-HSA-1236974] [PUBMED:16213220] [PUBMED:20171863] [PUBMED:14508490] [PUBMED:17027300] [PUBMED:14561893] [PUBMED:15845646] [PUBMED:22915823] [PUBMED:18006660] [PUBMED:14508489] [PUBMED:12151002] [PUBMED:15728715]
IRAK4 deficiency (TLR2/4) [NCBI:1269158] [REACTOME:R-HSA-5603041] [PUBMED:18669862] [PUBMED:12637671] [PUBMED:24316379] [PUBMED:15069402]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
MyD88 deficiency (TLR2/4) [NCBI:1269160] [REACTOME:R-HSA-5602498] [PUBMED:18669862] [PUBMED:24316379] [PUBMED:15069402]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
Regulation of TLR by endogenous ligand [NCBI:1427857] [REACTOME:R-HSA-5686938] [PUBMED:25391648] [PUBMED:20706656] [PUBMED:20629986] [PUBMED:20179153]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Toll-like receptor signaling pathway [NCBI:83076] [KEGG:hsa04620] [PUBMED:16924467] [PUBMED:17395581] [PUBMED:17637696] [PUBMED:12734364] [PUBMED:17507094] [PUBMED:14698224] [PUBMED:11101877] [PUBMED:16497588] [PUBMED:14751764] [PUBMED:17275323] [PUBMED:17457343] [PUBMED:16932750]
Tuberculosis [NCBI:213780] [KEGG:hsa05152] [PUBMED:20199890] [PUBMED:21274449] [PUBMED:17359235] [PUBMED:20415982] [PUBMED:18541216] [PUBMED:19369951] [PUBMED:15083155] [PUBMED:11378475] [PUBMED:15228522] [PUBMED:19634703] [PUBMED:21274433] [PUBMED:19563525] [PUBMED:18407066] [PUBMED:18288961] [PUBMED:16200082] [PUBMED:17785780] [PUBMED:11932234]