full name
replication factor C subunit 1
synonyms
A1, MHCBFB, PO-GA, RECC1, RFC, RFC140, RFC1, ENSG00000035928
HGNC
HGNC:9969
Entrez Gene
Gene:5981
ENSEMBL
ENSG00000035928
location
chr: 4
start: 39289069
stop: 39368001
strand: -
OMIM
OMIM:102579:
RFC1
OMIM:614575:
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome
transcripts
NM_002913.4
NM_001204747.1
pathways
Base Excision Repair
[NCBI:1270351]
[REACTOME:R-HSA-73884]
[PUBMED:11937636]
[PUBMED:10583946]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Chromosome Maintenance
[NCBI:1269853]
[REACTOME:R-HSA-73886]
DNA Damage Bypass
[NCBI:1270367]
[REACTOME:R-HSA-73893]
[PUBMED:21605556]
[PUBMED:10925197]
[PUBMED:11595180]
[PUBMED:12800216]
[PUBMED:19225445]
[PUBMED:25038291]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA replication
[NCBI:83039]
[KEGG:hsa03030]
[PUBMED:9759502]
[PUBMED:8087839]
DNA strand elongation
[NCBI:1269784]
[REACTOME:R-HSA-69190]
[PUBMED:9081985]
[PUBMED:1976634]
[PUBMED:7623835]
[PUBMED:1536007]
[PUBMED:8594377]
Dual Incision in GG-NER
[NCBI:1309115]
[REACTOME:R-HSA-5696400]
[PUBMED:19279666]
Dual incision in TC-NER
[NCBI:1309119]
[REACTOME:R-HSA-6782135]
[PUBMED:19279666]
[PUBMED:23906714]
[PUBMED:8078911]
[PUBMED:16246722]
[PUBMED:19023283]
[PUBMED:11904382]
[PUBMED:24402227]
Extension of Telomeres
[NCBI:1269857]
[REACTOME:R-HSA-180786]
[PUBMED:15189140]
FAS (CD95) signaling pathway
[NCBI:138081]
[Pathway Interaction Database:faspathway]
[PUBMED:9765224]
[PUBMED:11717445]
[PUBMED:9727491]
[PUBMED:11279218]
[PUBMED:12110583]
[PUBMED:11739735]
[PUBMED:8521815]
[PUBMED:9184224]
[PUBMED:20153221]
[PUBMED:9126929]
[PUBMED:10200443]
[PUBMED:16033886]
[PUBMED:8681377]
[PUBMED:9880544]
[PUBMED:9501089]
[PUBMED:10535980]
[PUBMED:9727492]
[PUBMED:7523573]
[PUBMED:11101870]
[PUBMED:9321399]
[PUBMED:9362518]
[PUBMED:12724420]
[PUBMED:16498403]
[PUBMED:11583996]
[PUBMED:15557123]
[PUBMED:7536343]
[PUBMED:12832037]
[PUBMED:9576928]
[PUBMED:9228058]
[PUBMED:7538908]
[PUBMED:18635548]
[PUBMED:20038679]
[PUBMED:10894163]
[PUBMED:12545171]
[PUBMED:16619028]
[PUBMED:9351817]
[PUBMED:9045686]
[PUBMED:15289496]
Gap-filling DNA repair synthesis and ligation in GG-NER
[NCBI:1309116]
[REACTOME:R-HSA-5696397]
[PUBMED:17643379]
[PUBMED:19279666]
[PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER
[NCBI:1309120]
[REACTOME:R-HSA-6782210]
[PUBMED:20227374]
[PUBMED:19279666]
[PUBMED:17643379]
Global Genome Nucleotide Excision Repair (GG-NER)
[NCBI:1309112]
[REACTOME:R-HSA-5696399]
[PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
[NCBI:1309100]
[REACTOME:R-HSA-5693567]
[PUBMED:20965415]
HDR through Homologous Recombination (HRR)
[NCBI:1309102]
[REACTOME:R-HSA-5685942]
[PUBMED:20965415]
Homology Directed Repair
[NCBI:1309099]
[REACTOME:R-HSA-5693538]
[PUBMED:11242102]
[PUBMED:20965415]
[PUBMED:11376695]
[PUBMED:12427531]
Lagging Strand Synthesis
[NCBI:1269788]
[REACTOME:R-HSA-69186]
[PUBMED:9081985]
Leading Strand Synthesis
[NCBI:1269786]
[REACTOME:R-HSA-69109]
[PUBMED:2175912]
[PUBMED:7378348]
[PUBMED:9191022]
Mismatch repair
[NCBI:83045]
[KEGG:hsa03430]
[PUBMED:11436301]
[PUBMED:18157157]
[PUBMED:16612326]
[PUBMED:11920679]
Nucleotide Excision Repair
[NCBI:1309111]
[REACTOME:R-HSA-5696398]
[PUBMED:11900249]
[PUBMED:23906714]
[PUBMED:14599765]
[PUBMED:10583946]
[PUBMED:24954209]
[PUBMED:19023283]
Nucleotide excision repair
[NCBI:83044]
[KEGG:hsa03420]
[PUBMED:11436323]
[PUBMED:18018633]
[PUBMED:11436316]
[PUBMED:17884153]
[PUBMED:11436314]
[PUBMED:17276014]
[PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair
[NCBI:1270366]
[REACTOME:R-HSA-5651801]
[PUBMED:9780000]
[PUBMED:11601988]
[PUBMED:9214649]
[PUBMED:12200445]
[PUBMED:10460157]
[PUBMED:10559261]
[PUBMED:11250913]
Polymerase switching
[NCBI:1269787]
[REACTOME:R-HSA-69091]
[PUBMED:1967833]
[PUBMED:1671046]
[PUBMED:1670772]
Polymerase switching on the C-strand of the telomere
[NCBI:1269861]
[REACTOME:R-HSA-174411]
[PUBMED:1967833]
[PUBMED:1671046]
[PUBMED:1670772]
Recognition of DNA damage by PCNA-containing replication complex
[NCBI:1270368]
[REACTOME:R-HSA-110314]
[PUBMED:15916957]
[PUBMED:12226657]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
[NCBI:1270364]
[REACTOME:R-HSA-110373]
[PUBMED:10583946]
[PUBMED:9214649]
[PUBMED:10559261]
[PUBMED:10460157]
[PUBMED:11440997]
[PUBMED:11601988]
Resolution of Abasic Sites (AP sites)
[NCBI:1270359]
[REACTOME:R-HSA-73933]
[PUBMED:11601988]
[PUBMED:15260972]
[PUBMED:17395641]
[PUBMED:19329425]
[PUBMED:9804798]
[PUBMED:15556996]
[PUBMED:9214649]
[PUBMED:7608159]
[PUBMED:11440997]
[PUBMED:15871698]
[PUBMED:9207062]
[PUBMED:16982218]
[PUBMED:8978692]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis
[NCBI:1269859]
[REACTOME:R-HSA-174417]
[PUBMED:15189140]
Telomere Maintenance
[NCBI:1269856]
[REACTOME:R-HSA-157579]
[PUBMED:16166375]
[PUBMED:4507727]
[PUBMED:14685173]
[PUBMED:642006]
[PUBMED:15189140]
[PUBMED:3907856]
[PUBMED:2463488]
[PUBMED:4754905]
Termination of translesion DNA synthesis
[NCBI:1270374]
[REACTOME:R-HSA-5656169]
[PUBMED:24768535]
[PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
[NCBI:1309117]
[REACTOME:R-HSA-6781827]
[PUBMED:24954209]
[PUBMED:11823795]
[PUBMED:19023283]
[PUBMED:23906714]
[PUBMED:3466163]
Translesion Synthesis by POLH
[NCBI:1270371]
[REACTOME:R-HSA-110320]
[PUBMED:10369688]
[PUBMED:10856253]
Translesion synthesis by POLI
[NCBI:1270373]
[REACTOME:R-HSA-5656121]
[PUBMED:10984059]
[PUBMED:15254543]
[PUBMED:20159559]
[PUBMED:15657443]
[PUBMED:23143872]
[PUBMED:15189446]
[PUBMED:14657033]
[PUBMED:16357261]
[PUBMED:16819516]
[PUBMED:18242152]
Translesion synthesis by POLK
[NCBI:1270372]
[REACTOME:R-HSA-5655862]
[PUBMED:12444249]
[PUBMED:11006276]
[PUBMED:12145297]
[PUBMED:15475561]
[PUBMED:11058110]
[PUBMED:22772988]
[PUBMED:22721435]
[PUBMED:11784855]
[PUBMED:24648516]
[PUBMED:20660785]
[PUBMED:19492058]
[PUBMED:19170759]
Translesion synthesis by REV1
[NCBI:1270370]
[REACTOME:R-HSA-110312]
[PUBMED:19153606]
[PUBMED:10760286]
[PUBMED:8658138]
[PUBMED:22859296]
[PUBMED:17517887]
[PUBMED:16344468]
[PUBMED:10536157]
[PUBMED:24449906]
[PUBMED:20164194]
[PUBMED:23143872]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
[NCBI:1270369]
[REACTOME:R-HSA-110313]
[PUBMED:10583946]
[PUBMED:10856253]
[PUBMED:24716551]