Logo
full name
replication factor C subunit 1

synonyms
A1, MHCBFB, PO-GA, RECC1, RFC, RFC140, RFC1, ENSG00000035928

HGNC
HGNC:9969

Entrez Gene
Gene:5981

ENSEMBL
ENSG00000035928

location
chr: 4
start: 39289069
stop: 39368001
strand: -

OMIM
OMIM:102579: RFC1
OMIM:614575: Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome

transcripts
NM_002913.4
NM_001204747.1

pathways
Base Excision Repair [NCBI:1270351] [REACTOME:R-HSA-73884] [PUBMED:11937636] [PUBMED:10583946]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
DNA Damage Bypass [NCBI:1270367] [REACTOME:R-HSA-73893] [PUBMED:21605556] [PUBMED:10925197] [PUBMED:11595180] [PUBMED:12800216] [PUBMED:19225445] [PUBMED:25038291]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA replication [NCBI:83039] [KEGG:hsa03030] [PUBMED:9759502] [PUBMED:8087839]
DNA strand elongation [NCBI:1269784] [REACTOME:R-HSA-69190] [PUBMED:9081985] [PUBMED:1976634] [PUBMED:7623835] [PUBMED:1536007] [PUBMED:8594377]
Dual Incision in GG-NER [NCBI:1309115] [REACTOME:R-HSA-5696400] [PUBMED:19279666]
Dual incision in TC-NER [NCBI:1309119] [REACTOME:R-HSA-6782135] [PUBMED:19279666] [PUBMED:23906714] [PUBMED:8078911] [PUBMED:16246722] [PUBMED:19023283] [PUBMED:11904382] [PUBMED:24402227]
Extension of Telomeres [NCBI:1269857] [REACTOME:R-HSA-180786] [PUBMED:15189140]
FAS (CD95) signaling pathway [NCBI:138081] [Pathway Interaction Database:faspathway] [PUBMED:9765224] [PUBMED:11717445] [PUBMED:9727491] [PUBMED:11279218] [PUBMED:12110583] [PUBMED:11739735] [PUBMED:8521815] [PUBMED:9184224] [PUBMED:20153221] [PUBMED:9126929] [PUBMED:10200443] [PUBMED:16033886] [PUBMED:8681377] [PUBMED:9880544] [PUBMED:9501089] [PUBMED:10535980] [PUBMED:9727492] [PUBMED:7523573] [PUBMED:11101870] [PUBMED:9321399] [PUBMED:9362518] [PUBMED:12724420] [PUBMED:16498403] [PUBMED:11583996] [PUBMED:15557123] [PUBMED:7536343] [PUBMED:12832037] [PUBMED:9576928] [PUBMED:9228058] [PUBMED:7538908] [PUBMED:18635548] [PUBMED:20038679] [PUBMED:10894163] [PUBMED:12545171] [PUBMED:16619028] [PUBMED:9351817] [PUBMED:9045686] [PUBMED:15289496]
Gap-filling DNA repair synthesis and ligation in GG-NER [NCBI:1309116] [REACTOME:R-HSA-5696397] [PUBMED:17643379] [PUBMED:19279666] [PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER [NCBI:1309120] [REACTOME:R-HSA-6782210] [PUBMED:20227374] [PUBMED:19279666] [PUBMED:17643379]
Global Genome Nucleotide Excision Repair (GG-NER) [NCBI:1309112] [REACTOME:R-HSA-5696399] [PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
HDR through Homologous Recombination (HRR) [NCBI:1309102] [REACTOME:R-HSA-5685942] [PUBMED:20965415]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Lagging Strand Synthesis [NCBI:1269788] [REACTOME:R-HSA-69186] [PUBMED:9081985]
Leading Strand Synthesis [NCBI:1269786] [REACTOME:R-HSA-69109] [PUBMED:2175912] [PUBMED:7378348] [PUBMED:9191022]
Mismatch repair [NCBI:83045] [KEGG:hsa03430] [PUBMED:11436301] [PUBMED:18157157] [PUBMED:16612326] [PUBMED:11920679]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
Nucleotide excision repair [NCBI:83044] [KEGG:hsa03420] [PUBMED:11436323] [PUBMED:18018633] [PUBMED:11436316] [PUBMED:17884153] [PUBMED:11436314] [PUBMED:17276014] [PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair [NCBI:1270366] [REACTOME:R-HSA-5651801] [PUBMED:9780000] [PUBMED:11601988] [PUBMED:9214649] [PUBMED:12200445] [PUBMED:10460157] [PUBMED:10559261] [PUBMED:11250913]
Polymerase switching [NCBI:1269787] [REACTOME:R-HSA-69091] [PUBMED:1967833] [PUBMED:1671046] [PUBMED:1670772]
Polymerase switching on the C-strand of the telomere [NCBI:1269861] [REACTOME:R-HSA-174411] [PUBMED:1967833] [PUBMED:1671046] [PUBMED:1670772]
Recognition of DNA damage by PCNA-containing replication complex [NCBI:1270368] [REACTOME:R-HSA-110314] [PUBMED:15916957] [PUBMED:12226657]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway [NCBI:1270364] [REACTOME:R-HSA-110373] [PUBMED:10583946] [PUBMED:9214649] [PUBMED:10559261] [PUBMED:10460157] [PUBMED:11440997] [PUBMED:11601988]
Resolution of Abasic Sites (AP sites) [NCBI:1270359] [REACTOME:R-HSA-73933] [PUBMED:11601988] [PUBMED:15260972] [PUBMED:17395641] [PUBMED:19329425] [PUBMED:9804798] [PUBMED:15556996] [PUBMED:9214649] [PUBMED:7608159] [PUBMED:11440997] [PUBMED:15871698] [PUBMED:9207062] [PUBMED:16982218] [PUBMED:8978692]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis [NCBI:1269859] [REACTOME:R-HSA-174417] [PUBMED:15189140]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]
Termination of translesion DNA synthesis [NCBI:1270374] [REACTOME:R-HSA-5656169] [PUBMED:24768535] [PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) [NCBI:1309117] [REACTOME:R-HSA-6781827] [PUBMED:24954209] [PUBMED:11823795] [PUBMED:19023283] [PUBMED:23906714] [PUBMED:3466163]
Translesion Synthesis by POLH [NCBI:1270371] [REACTOME:R-HSA-110320] [PUBMED:10369688] [PUBMED:10856253]
Translesion synthesis by POLI [NCBI:1270373] [REACTOME:R-HSA-5656121] [PUBMED:10984059] [PUBMED:15254543] [PUBMED:20159559] [PUBMED:15657443] [PUBMED:23143872] [PUBMED:15189446] [PUBMED:14657033] [PUBMED:16357261] [PUBMED:16819516] [PUBMED:18242152]
Translesion synthesis by POLK [NCBI:1270372] [REACTOME:R-HSA-5655862] [PUBMED:12444249] [PUBMED:11006276] [PUBMED:12145297] [PUBMED:15475561] [PUBMED:11058110] [PUBMED:22772988] [PUBMED:22721435] [PUBMED:11784855] [PUBMED:24648516] [PUBMED:20660785] [PUBMED:19492058] [PUBMED:19170759]
Translesion synthesis by REV1 [NCBI:1270370] [REACTOME:R-HSA-110312] [PUBMED:19153606] [PUBMED:10760286] [PUBMED:8658138] [PUBMED:22859296] [PUBMED:17517887] [PUBMED:16344468] [PUBMED:10536157] [PUBMED:24449906] [PUBMED:20164194] [PUBMED:23143872]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template [NCBI:1270369] [REACTOME:R-HSA-110313] [PUBMED:10583946] [PUBMED:10856253] [PUBMED:24716551]