full name
KIT proto-oncogene receptor tyrosine kinase
synonyms
C-Kit, CD117, PBT, SCFR, KIT, ENSG00000157404
HGNC
HGNC:6342
Entrez Gene
Gene:3815
ENSEMBL
ENSG00000157404
location
chr: 4
start: 55524095
stop: 55606881
strand: +
OMIM
OMIM:164920:
KIT
(Autosomal dominant inheritance,Sporadic)
OMIM:606764:
Gastrointestinal stromal tumor, familial
OMIM:273300:
Germ cell tumors, somatic
OMIM:601626:
Leukemia, acute myeloid, somatic
OMIM:154800:
Mastocytosis, cutaneous
OMIM:154800:
Mastocytosis, systemic, somatic
OMIM:172800:
Piebaldism
transcripts
NM_000222.2
NM_001093772.1
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Acute myeloid leukemia
[NCBI:83117]
[KEGG:hsa05221]
[PUBMED:12951584]
[PUBMED:12563308]
[PUBMED:16352814]
[PUBMED:16236521]
[PUBMED:16146838]
[PUBMED:16642045]
[PUBMED:15625120]
[PUBMED:11721960]
[PUBMED:17554387]
[PUBMED:12468433]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Breast cancer
[NCBI:1435207]
[KEGG:hsa05224]
[PUBMED:24649067]
[PUBMED:26040571]
[PUBMED:11879567]
[PUBMED:22722193]
[PUBMED:26028978]
[PUBMED:25013431]
[PUBMED:11737884]
[PUBMED:23702927]
[PUBMED:21076461]
[PUBMED:21898546]
[PUBMED:27390604]
[PUBMED:24291072]
[PUBMED:26968398]
[PUBMED:20087430]
[PUBMED:23000897]
[PUBMED:25544707]
[PUBMED:24596345]
[PUBMED:23988612]
[PUBMED:24111892]
[PUBMED:25907219]
[PUBMED:15343273]
[PUBMED:21965336]
[PUBMED:23881035]
[PUBMED:23196196]
[PUBMED:22178455]
[PUBMED:20436504]
[PUBMED:19088017]
[PUBMED:16113099]
[PUBMED:20971825]
C-MYB transcription factor network
[NCBI:138073]
[Pathway Interaction Database:cmyb_pathway]
[PUBMED:17152050]
[PUBMED:1944282]
[PUBMED:7964503]
[PUBMED:8598284]
[PUBMED:15608679]
[PUBMED:10619021]
[PUBMED:2233716]
[PUBMED:9244354]
[PUBMED:8654374]
[PUBMED:10590070]
[PUBMED:17587615]
[PUBMED:12424255]
[PUBMED:1679531]
[PUBMED:17077080]
[PUBMED:8946914]
[PUBMED:16055116]
[PUBMED:11259163]
[PUBMED:9659917]
[PUBMED:9135152]
[PUBMED:7721782]
[PUBMED:11290610]
[PUBMED:12244173]
[PUBMED:11792321]
[PUBMED:17242210]
[PUBMED:10722757]
[PUBMED:8264615]
[PUBMED:15687240]
[PUBMED:14761981]
[PUBMED:10542314]
[PUBMED:12673198]
[PUBMED:11779867]
[PUBMED:8756344]
[PUBMED:11427482]
[PUBMED:9809063]
[PUBMED:10523863]
[PUBMED:11094072]
[PUBMED:15356292]
[PUBMED:11781241]
[PUBMED:15778089]
[PUBMED:9096387]
[PUBMED:17931383]
[PUBMED:14576818]
[PUBMED:11259170]
[PUBMED:8491193]
[PUBMED:11581319]
[PUBMED:10644988]
[PUBMED:7565722]
[PUBMED:9490676]
[PUBMED:9244356]
[PUBMED:17641686]
[PUBMED:16407849]
[PUBMED:1594249]
[PUBMED:17822556]
[PUBMED:15867358]
[PUBMED:17959653]
[PUBMED:7509358]
[PUBMED:11287612]
[PUBMED:15082531]
[PUBMED:10766162]
[PUBMED:8756629]
[PUBMED:11115410]
[PUBMED:7684005]
[PUBMED:9566892]
Central carbon metabolism in cancer
[NCBI:1059538]
[KEGG:hsa05230]
[PUBMED:16982728]
[PUBMED:21127244]
[PUBMED:22349059]
[PUBMED:19270154]
[PUBMED:24113830]
[PUBMED:22156302]
[PUBMED:21801601]
[PUBMED:15916903]
[PUBMED:18177721]
[PUBMED:22237205]
[PUBMED:20520704]
[PUBMED:23018234]
[PUBMED:23897900]
[PUBMED:24398961]
[PUBMED:24079832]
[PUBMED:18538731]
[PUBMED:19460998]
[PUBMED:22307140]
[PUBMED:18766298]
[PUBMED:22101401]
[PUBMED:23071355]
[PUBMED:21508971]
[PUBMED:24738035]
[PUBMED:22750268]
[PUBMED:21258394]
[PUBMED:23279446]
[PUBMED:21340684]
Constitutive Signaling by Aberrant PI3K in Cancer
[NCBI:1268880]
[REACTOME:R-HSA-2219530]
[PUBMED:18317450]
[PUBMED:19962665]
[PUBMED:20009532]
[PUBMED:20713702]
[PUBMED:21478295]
[PUBMED:16339315]
[PUBMED:18079394]
[PUBMED:17626883]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Cytokine-cytokine receptor interaction
[NCBI:83051]
[KEGG:hsa04060]
[PUBMED:11071910]
[PUBMED:12072446]
[PUBMED:7791754]
[PUBMED:15032600]
[PUBMED:12651226]
[PUBMED:11252892]
[PUBMED:11796220]
[PUBMED:11312110]
[PUBMED:9862719]
[PUBMED:12421671]
[PUBMED:12039028]
[PUBMED:9759503]
[PUBMED:9395284]
[PUBMED:11166270]
[PUBMED:10714678]
[PUBMED:12651221]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR)
[NCBI:1269185]
[REACTOME:R-HSA-1168372]
[PUBMED:17052215]
[PUBMED:19909372]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GAB1 signalosome
[NCBI:1269384]
[REACTOME:R-HSA-180292]
[PUBMED:15550174]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Hematopoietic cell lineage
[NCBI:83078]
[KEGG:hsa04640]
[PUBMED:15629410]
[PUBMED:15738953]
[PUBMED:11905810]
[PUBMED:15156179]
[PUBMED:12415312]
[PUBMED:14985712]
[PUBMED:9927518]
[PUBMED:15771582]
[PUBMED:14670296]
[PUBMED:12360214]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
Melanogenesis
[NCBI:83092]
[KEGG:hsa04916]
[PUBMED:11041354]
[PUBMED:10347209]
[PUBMED:15016298]
[PUBMED:11023702]
[PUBMED:11602344]
[PUBMED:12753399]
[PUBMED:10841026]
[PUBMED:16822996]
[PUBMED:15383650]
[PUBMED:9263329]
[PUBMED:16246839]
[PUBMED:10643996]
[PUBMED:12894244]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Negative regulation of the PI3K/AKT network
[NCBI:1269191]
[REACTOME:R-HSA-199418]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
PI3K/AKT Signaling in Cancer
[NCBI:1268879]
[REACTOME:R-HSA-2219528]
[PUBMED:20713702]
[PUBMED:10555148]
[PUBMED:19644473]
[PUBMED:17611497]
[PUBMED:21478295]
[PUBMED:17626883]
[PUBMED:16339315]
[PUBMED:18317450]
[PUBMED:18079394]
[PUBMED:9467011]
[PUBMED:17604717]
[PUBMED:9326929]
[PUBMED:18954143]
[PUBMED:20009532]
[PUBMED:19962665]
[PUBMED:21430697]
[PUBMED:19487573]
[PUBMED:10866302]
PI3K/AKT activation
[NCBI:1269473]
[REACTOME:R-HSA-198203]
[PUBMED:10579926]
[PUBMED:12123609]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
[NCBI:1383020]
[REACTOME:R-HSA-6811558]
[PUBMED:12422219]
[PUBMED:16979564]
[PUBMED:19805105]
[PUBMED:17200115]
[PUBMED:21827948]
[PUBMED:19576174]
[PUBMED:18753295]
[PUBMED:19896968]
[PUBMED:16456541]
[PUBMED:25495341]
[PUBMED:15464023]
[PUBMED:23758345]
[PUBMED:9367159]
[PUBMED:9211928]
[PUBMED:17245604]
PIP3 activates AKT signaling
[NCBI:1269188]
[REACTOME:R-HSA-1257604]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Phospholipase D signaling pathway
[NCBI:1311074]
[KEGG:hsa04072]
[PUBMED:9310372]
[PUBMED:9119890]
[PUBMED:15310762]
[PUBMED:18936782]
[PUBMED:24990952]
[PUBMED:14769825]
[PUBMED:21936578]
[PUBMED:10666319]
[PUBMED:17210675]
[PUBMED:19264150]
[PUBMED:23076158]
[PUBMED:17054901]
[PUBMED:16622417]
[PUBMED:10807766]
[PUBMED:12217395]
[PUBMED:11042115]
[PUBMED:19815110]
[PUBMED:24995811]
[PUBMED:16143829]
[PUBMED:8135758]
[PUBMED:11991733]
[PUBMED:19410013]
[PUBMED:17245604]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Rap1 signaling pathway
[NCBI:868086]
[KEGG:hsa04015]
[PUBMED:17624944]
[PUBMED:12351703]
[PUBMED:10579920]
[PUBMED:19159611]
[PUBMED:18363565]
[PUBMED:12765839]
[PUBMED:12508104]
[PUBMED:11331911]
[PUBMED:17182900]
[PUBMED:15803158]
[PUBMED:19615876]
[PUBMED:21402149]
[PUBMED:17624948]
[PUBMED:17383543]
[PUBMED:14607972]
[PUBMED:15780587]
[PUBMED:19710505]
Ras signaling pathway
[NCBI:868085]
[KEGG:hsa04014]
[PUBMED:23506953]
[PUBMED:18437264]
[PUBMED:15062121]
[PUBMED:22189424]
[PUBMED:22233291]
[PUBMED:12778136]
[PUBMED:11313946]
[PUBMED:17428555]
[PUBMED:19091743]
[PUBMED:18568040]
[PUBMED:20420946]
[PUBMED:12217381]
[PUBMED:14663478]
[PUBMED:21686117]
[PUBMED:12642680]
[PUBMED:21196257]
[PUBMED:16869784]
[PUBMED:21111786]
[PUBMED:16966426]
[PUBMED:10712923]
[PUBMED:22020205]
[PUBMED:17384584]
[PUBMED:15572660]
[PUBMED:18413813]
Regulation of KIT signaling
[NCBI:1269488]
[REACTOME:R-HSA-1433559]
[PUBMED:10582339]
[PUBMED:16483568]
Role of LAT2/NTAL/LAB on calcium mobilization
[NCBI:1269302]
[REACTOME:R-HSA-2730905]
[PUBMED:17993265]
[PUBMED:20643813]
[PUBMED:17420272]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling by the B Cell Receptor (BCR)
[NCBI:1269183]
[REACTOME:R-HSA-983705]
[PUBMED:1702903]
[PUBMED:2011584]
[PUBMED:1081164]
[PUBMED:19065780]
[PUBMED:16849466]
[PUBMED:1375264]
[PUBMED:7538118]
[PUBMED:11901194]
[PUBMED:8580068]
[PUBMED:19249086]
[PUBMED:18596693]
[PUBMED:10648173]
[PUBMED:4589993]
[PUBMED:8163536]
[PUBMED:1376928]
[PUBMED:7688784]
[PUBMED:6335036]
[PUBMED:17052215]
[PUBMED:18818202]
[PUBMED:20206686]
[PUBMED:7592958]
[PUBMED:7524079]
[PUBMED:15489917]
[PUBMED:15509800]
[PUBMED:18187424]
[PUBMED:7927516]
[PUBMED:803528]
[PUBMED:19909372]
[PUBMED:20192804]
[PUBMED:8306975]
Signaling events mediated by Stem cell factor receptor (c-Kit)
[NCBI:138068]
[Pathway Interaction Database:kitpathway]
[PUBMED:12909618]
[PUBMED:10364466]
[PUBMED:10673502]
[PUBMED:15315962]
[PUBMED:12192036]
[PUBMED:12444928]
[PUBMED:15504549]
[PUBMED:8950973]
[PUBMED:11071635]
[PUBMED:12149208]
[PUBMED:11369651]
[PUBMED:9038210]
[PUBMED:10679268]
[PUBMED:15465815]
[PUBMED:10523831]
[PUBMED:8611693]
[PUBMED:15676208]
[PUBMED:11805142]
[PUBMED:10637471]
[PUBMED:9872323]
[PUBMED:11809791]
[PUBMED:11520784]
[PUBMED:12691919]
[PUBMED:10397721]
[PUBMED:15611091]
[PUBMED:12356726]
[PUBMED:9528781]
[PUBMED:1381360]
[PUBMED:9651683]
[PUBMED:10849422]
[PUBMED:9355737]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
[NCBI:1427841]
[REACTOME:R-HSA-8866910]
[PUBMED:14744778]
[PUBMED:9162057]
[PUBMED:22735262]
[PUBMED:26832794]
[PUBMED:10648798]
[PUBMED:10497269]
[PUBMED:9850080]
[PUBMED:9687504]
[PUBMED:7891714]
[PUBMED:15870067]
[PUBMED:9182571]
[PUBMED:8895516]
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
[NCBI:1427839]
[REACTOME:R-HSA-8864260]
[PUBMED:2010091]
[PUBMED:11744733]
[PUBMED:24469049]
[PUBMED:23382213]
[PUBMED:19798054]
[PUBMED:9162057]
[PUBMED:21084835]
[PUBMED:22735262]
[PUBMED:21375726]
[PUBMED:14744778]
[PUBMED:10648798]
[PUBMED:26832794]
[PUBMED:24835590]
[PUBMED:9687504]
[PUBMED:20805990]
[PUBMED:10497269]
[PUBMED:16420676]
[PUBMED:12072434]
[PUBMED:9850080]
[PUBMED:9182571]
[PUBMED:8988173]
[PUBMED:1998122]
[PUBMED:22371483]
[PUBMED:15870067]
[PUBMED:12586840]
[PUBMED:8895516]
[PUBMED:7891714]
[PUBMED:11694877]
[PUBMED:19115315]
[PUBMED:15475956]
[PUBMED:25114211]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]
